近日，课题组发表在 ACS Chem Biol. 2023, 18(12):2474-2484 (doi: 10.1021/acschembio.3c00368)上的多环聚酮化合物 shuangdaolides 被 Natural Product Reports (Nat. Prod. Rep., 2024,41, 157-161)评选为热点化合物（Hot off the Press）。

Nat Prod Rep 由英国皇家化学会主办，是天然产物化学领域顶级学术期刊。其中的Hot off the Press（热点化合物）是该刊的著名品牌栏目，每两个月出版一篇，遴选近期报道的天然产物进行扼要评述（一般为32篇文献），以期引起研究人员的关注。入选热点化合物的价值得到了业内普遍认同，它已成为显示作者、研究机构及发表期刊学术影响力的重要标志之一。

原文如下：Systematic gene inactivation of the sdl biosynthetic gene cluster that generates macrocyclic polyketides, which possess rare internal 2-hydroxycyclopentenone moieties such as shaungdaolide D 26 has allowed the characterisation of several key enzymes and a proposed biosynthetic pathway.26 The studies revealed the role of the multidomain protein, SdlR that catalyses 16,17-epoxidation during chain elongation and the tailoring of oxidation enzymes, SdlB and SdlQ..

全文链接：Hot off the press - Natural Product Reports (RSC Publishing)

[26] ACS Catalysis论文链接：Biosynthesis of trans-AT PKS-Derived Shuangdaolides Featuring a trans-acting Enzyme for Online Epoxidation | ACS Chemical Biology