Name of Research Group:当前成员
Team members Introduction:
2019.8-至今
教育经历
2010/09—2014/10 大连理工大学 有机化学专业 博士
2007/09—2010/07 辽宁大学 有机化学专业 硕士
2003/09—2007/07 辽宁大学 应用化学专业 学士
科研与学术工作经历
2019/8—至今 山东大学(青岛) 助理研究员
2017/7—2019/7 中国科学院海洋研究所 助理研究员
2014/12—2017/6 中国科学院海洋研究所 博士后
主持课题科研项目
1.国家青年科学基金,项目批准号:81703354,项目名称:选择性PTP1B抑制剂的设计、合成、筛选和降血糖活性研究,主持。
2.山东省重点研发项目,项目批准号:2018GSF118200,项目名称:新型海洋药物拮抗PTP1B改善胰岛素抵抗的分子机制研究,主持。
3.中国博士后基金,项目批准号:2015KY11-4,主持;
4.青岛市博士后应用项目资助,项目批准号:2016KY01-11,主持。
研究方向:海洋溴代化合物的抗肿瘤活性研究
邮箱:lixiangqian@sdu.edu.cn
已发表论文及专利
Xiangqian Li, Qi Xu, Chao Li, Jiao Luo, Xiuxue Li, Lijun Wang, b, Bo Jiang, Dayong Shi, Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors,European Journal of Medicinal Chemistry. 2019,166,178-185.
Xiang-Qian Li, Qi Xu, Jiao Luo, Li-Jun Wang, Bo Jiang, Ren-Shuai Zhang and Da-Yong Shi. Design, synthesis and biological evaluation of uncharged catechol derivatives as selective inhibitors of PTP1B. European Journal of Medicinal Chemistry. 2017, 136, 348-359.
XiangQian Li, LiJun Wang, DaYong Shi. The design strategy of selective PTP1Binhibitors over TCPTP, Bioorganic & Medicinal Chemistry 2016, 24, 3343–3352.
Xiangqian Li, Ziqian Wang, Yingang Feng, Ting Song, Pengchen Su, Chengbin Chen, Gaobo Chai, Ying Yang, Zhichao Zhang. Two-face, two-turn α-helix mimetics based on a cross-acridine scaffold: analogs of the Bim BH3 domain. Chembiochem 2014, 15, 1280–1285.
Xiangqian Li , Xiaomeng Liang, Xiaomeng Liang, Ting Song, Pengchen Su, Zhichao Zhang. Design, synthesis and structure–activity relationships studies of small molecule inhibitors that antagonize Mcl-1/Bcl-2. Bioorganic Medicinal Chemistry 2014, 22, 5738–5746.
Ting Son†, Xiangqian Li†, Xilong Chang, Xiaomeng Liang, Yan Zhao, Guiye Wu, Shenghui Xie, Pengchen Su, Zhiyong Wu, Yingang Feng, Zhichao Zhang*. 3-thiomorpholin-8-oxo-8H-acenaphtho [1, 2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1. Bioorganic Medicinal Chemistry 2013, 21, 11-20.
Zhichao Zhang, Xiangqian Li, Ting Song,Yan Zhao, and Yingang Feng. An Anthraquinone Scaffold for Putative, Two-Face Bim BH3 α‑HelixMimic. Journal of Medicinal Chemistry 2012, 55, 10735 − 10741.
张志超,李祥乾。一类蒽醌类化合物及其应用。专利号:ZL201210218670.1,
张志超,李祥乾。一类吖啶类化合物及其应用。专利号:ZL201410150928.8,
史大永, 李祥乾,溴酚-噁唑类化合物及其在治疗2型糖尿病药物中的应用,申请号: 201611096704.9.
史大永,李祥乾,噁二唑类化合物及其在制备预防和/或治疗2型糖尿病药物中的应用,申请号: 201611175726.4
史大永,李祥乾, 海藻胶植物性软胶囊囊壳及制备方法。申请号:201611150751.7.
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