博士后

2023.9-至今

林遇溪

博士后

linyuxi@sdu.edu.cn

林遇溪，山东大学，微生物改造技术全国重点实验室（研究院），博士后。主要研究方向为天然免疫抗病毒抗肿瘤靶点发现与药物筛选。

教育经历

2015.9-2023.6  兰州大学  细胞生物学  博士

2011.9-2015.6  西南交通大学  生物工程  学士

科研与学术工作经历

2023.9-至今，山东大学，微生物改造技术全国重点实验室，博士后

已发表文章

1. Lin Y, Zang R, Ma Y, Wang Z, Li L, Ding S, Zhang R, Wei Z, Yang J, Wang X. Xanthohumol Is a Potent Pan-Inhibitor of Coronaviruses Targeting Main Protease. Int J Mol Sci. 2021 Nov 9;22(22):12134, IF:5. 942. (期刊论文，第一作者)

2. Wang Y, Song Q, Huang W, Lin Y, Wang X, Wang C, Willard B, Zhao C, Nan J, Holvey-Bates E, Wang Z, Taylor D, Yang J, Stark GR. A virus-induced conformational switch of STAT1-STAT2 dimers boosts antiviral defenses. Cell Res. 2021 Feb;31(2):206-218, IF:25.617.

3. Li Z, Lin Y, Huang YY, Liu R, Zhan CG, Wang X, Luo HB. Reply to Ma and Wang: Reliability of various in vitro activity assays on SARS-CoV-2 main protease inhibitors. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2024937118, IF:11.205. (期刊论文，共同第一作者)

4. Zhu N, Zhang J, Du Y, Qin X, Miao R, Nan J, Chen X, Sun J, Zhao R, Zhang X, Shi L, Li X, Lin Y, Wei W, Mao A, Zhang Z, Stark GR, Wang Y, Yang J. Loss of ZIP facilitates JAK2-STAT3 activation in tamoxifen-resistant breast cancer. Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):15047-15054, IF:11.205.

5. Zhang L, Song Q, Zhang X, Li L, Xu X, Xu X, Li X, Wang Z, Lin Y, Li X, Li M, Su F, Wang X, Qiu P, Guan H, Tang Y, Xu W, Yang J, Zhao C. Zelnorm, an agonist of 5-Hydroxytryptamine 4-receptor, acts as a potential antitumor drug by targeting JAK/STAT3 signaling. Invest New Drugs. 2020 Apr;38(2):311-320,IF:3.850.

6. Li X, Zhang XX, Lin YX, Xu XM, Li L, Yang JB. Virtual Screening Based on Ensemble Docking Targeting Wild-Type p53 for Anticancer Drug Discovery. Chem Biodivers. 2019 Jul;16(7):e1900170, IF:2.408.

7. Li Z, Li X, Huang YY, Wu Y, Liu R, Zhou L, Lin Y, Wu D, Zhang L, Liu H, Xu X, Yu K, Zhang Y, Cui J, Zhan CG, Wang X, Luo HB. Identify potent SARS-CoV-2 main protease inhibitors via accelerated free energy perturbation-based virtual screening of existing drugs. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27381-27387, IF: 11.205.