教育背景

2009/09-2015/06    中国科学技术大学      生物化学与分子生物学      博士

2005/09-2009/07    安徽大学                     生物技术                           学士     

工作经历

2021/08-今              山东大学微生物技术研究院                      副研究员

2017/08-2021/07      中国科学院青岛生物能源与过程研究所   博士后

2015/06-2017/07     中国科学技术大学                                    博士后研究员

研究方向

细菌基因编辑方法

蛋白质工程与定向进化

大肠杆菌及耐热酵母的代谢工程

多组学的生物信息学分析

联系方式

电话：0532-58632386

邮箱：jichaow(AT)sdu.edu.cn; wangjichao(AT)ustc.edu     (将“(AT)”替换为“@”）

个人主页

ResearchGate:    https://www.researchgate.net/profile/Jichao-Wang-7 

ORCID:              https://orcid.org/0000-0002-1883-7576

新闻报道

中国科学院    光明网   中国科学院英文网站

主持项目

更通用的细菌基因编辑方法研究，山东省自然学基金青年基金（ZR2022QC123），15.00万元，2023.01.01- 2025.12.30，主持。

生物基橡胶绿色制造关键技术-生物基单体制备关键技术-子任务3，国家重点研发计划-绿色生物制造专项（2022YFC2104701），50万元，2022.11-2026.10，骨干（主持子任务3）。

马克斯克鲁维酵母高效生物合3-羟基丙酸及关键酶的迭代定向进化研究，广东省基础与应用基础研究基金-区域联合基金（粤深）-青年基金（2022A1515110047），10万元，2022.10-2025.09，主持。

发明专利

 赵广、咸漠、王纪超、隋新悦。一种基因编辑工具及其制备方法与多轮基因编辑的方法。专利号：ZL202010517318.2 。（授权日期 2022年3月22日）

代表论文

Zhang, Jia^#; Su, Xiaolu^#; Wang, Yefei; Wang, Xiaohang; Zhou, Shiqi; Jia, Hui; Jing, Xiaoyan; Gong, Yanhai; Wang, Jichao*; Xu, Jian*. Improved single-cell genome amplification by a high-efficiency phi29 DNA polymerase. Frontiers in Bioengineering and Biotechnology, 2023, 11:1233856. (among the topmost viewed and downloaded this year's articles)

Zhang, Jia; Xu, Teng; Wang, Xiaohang; Jing, Xiaoyan; Zhang, Jia; Hong, Jiong; Xu, Jian; Wang, Jichao*. Lignocellulosic xylitol production from corncob waste by engineered Kluyveromyces marxianus. Frontiers in Bioengineering and Biotechnology, 2022, 10:1029203.

Zhao, Zhe; Xu, Ying; Jiang, Bo; Qi, Qingsheng; Tang, Ya-Jie; Xian, Mo; Wang, Jichao*; Zhao, Guang*. Systematic Identification of CpxRA-Regulated Genes and Their Roles in Escherichia coli Stress Response. mSystems, 2022, e00419-22.

Hu, Shenglin; Wang, Zhefan; Wang, Dongmei; Wang, Jichao*; Hong, Jiong*. The development of a heterologous gene expression system in thermophilic fungus Thermoascus aurantiacus. 3 Biotech, 2021, 11(9): 1-15.

Li, Shihua^#; Yu, Kai^#; Wu, Guandi^#; Zhang, Qingfeng; Wang, Panqin; Zheng, Jian; Liu, Ze-Xian; Wang, Jichao^*; Gao, Xinjiao^*; Cheng, Han^*. pCysMod: Prediction of Multiple Cysteine Modifications Based on Deep Learning Framework. Frontiers in Cell and Developmental Biology, 2021, 9:617366.. 

Wang, Jichao^#; Sui, Xinyue^#; Ding, Yamei; Fu, Yingxin; Feng, Xinjun; Liu, Min; Zhang, Youming; Xian, Mo^*; Zhao, Guang^*. A fast and robust iterative genome-editing method based on a Rock-Paper-Scissors strategy. Nucleic Acids Research, 2021, 49(2): e12-e12. 

Liu, Xiutao; Feng, Xinjun; Ding, Yamei; Gao, Wenjie; Xian, Mo; Wang, Jichao^*; Zhao, Guang^*. Characterization and directed evolution of propionyl-CoA carboxylase and its application in succinate biosynthetic pathway with two CO₂ fixation reactions. Metabolic Engineering, 2020, 62: 42-50. 

Yu, Xiao; Afreen, Shagufta; Kong, Qingshan^*; Wang, Jichao^*. Study on Self-Assembled Morphology and Structure Regulation of alpha-Zein in Ethanol-Water Mixtures. Langmuir, 2020, 36(40): 11975-11984. 

Wang, Jichao; Zhang, Tongchuan; Liu, Ruicun; Song, Meilin; Wang, Juncheng; Hong, Jiong; Chen, Quan^*; Liu, Haiyan^*. Recurring sequence-structure motifs in (βα)₈-barrel proteins and experimental optimization of a chimeric protein designed based on such motifs. Biochimica et Biophysica Acta-Proteins and Proteomics, 2017, 1865(2): 165-175. 

其它论文

Liu, Ruicun; Wang, Jichao; Xiong, Peng; Chen, Quan^*; Liu, Haiyan^*. De novo sequence redesign of a functional Ras binding domain globally inverted the surface charge distribution and led to extreme thermostability. Biotechnology and Bioengineering, 2021, 1-12. 

Zhou, Yifei; Ding, Yamei; Gao, Wenjie; Wang, Jichao; Liu, Xiutao; Xian, Mo; Feng, Xinjun^*; Zhao,Guang^*. Biosynthesis of acetylacetone inspired by its biodegradation. Biotechnology for Biofuels, 2020, 13: 1-10.

Zhang, Jia; Wang, Yefei; Chai, Baihui; Wang, Jichao; Li, Lulu; Liu, Min; Zhao, Guang; Yao, Lishan; Gao, Xiaolian; Yin, Yifeng; Xu, Jian^*. Efficient and Low-Cost Error Removal in DNA Synthesis by a High-Durability MutS. ACS Synthetic Biology, 2020, 9(4): 940-952.

Xu, Ying^#; Zhao, Zhe^#; Tong, Wenhua; Ding, Yamei; Liu, Bin; Shi, Yixin; Wang, Jichao; Sun, Shenmei; Liu, Min; Wang, Yuhui; Qi, Qingsheng; Xian, Mo^*; Zhao, Guang^*. An acid-tolerance response system protecting exponentially growing Escherichia coli. Nature Communications, 2020, 11(1): 1-13.

Hua, Yan; Wang, Jichao; Zhu, Yelin; Zhang, Biao; Kong, Xin; Li, Wenjie; Wang, Dongmei; Hong, Jiong^*. Release of glucose repression on xylose utilization in Kluyveromyces marxianus to enhance glucose-xylose co-utilization and xylitol production from corncob hydrolysate. Microbial Cell Factories, 2019, 18(1): 1-18.

Zhang, Guorong; Lu, Min; Wang, Jichao; Wang, Dongmei; Gao, Xiaolian; Hong, Jiong^*. Identification of hexose kinase genes in Kluyveromyces marxianus and thermo-tolerant one step producing glucose-free fructose strain construction. Scientific Reports, 2017, 7(1): 1-11.

Ma, Rui; Wang, Jichao; Hou, Zhonghuai^*; Liu, Haiyan^*. Small-Number Effects: A Third Stable State in a Genetic Bistable Toggle Switch. Physical Review Letters, 2012, 109(24): 248107.