陈静
教授
所属院部: 齐鲁医学院
访问次数:
基本信息
  • 教师拼音名称:
    Chen Jing
  • 电子邮箱:
    jc@email.sdu.edu.cn
  • 所在单位:
    山东大学第二医院/第二临床学院
  • 办公地点:
    千佛山校区创新大厦11层西座
  • 性别:
  • 学位:
    博士
  • 毕业院校:
    里昂大学
  • 博士生导师
  • 硕士生导师
教师简介

      陈静博士,江苏东台人,研究员,PI,博士生导师,山东省泰山学者青年专家。2002-2009年在陕西师范大学求学,先后获得学士(化学)和硕士(高分子化学与物理)学位。2013年在国家公派留学奖学金资助下获得里昂大学博士学位(高分子材料)。后在法国国家科学研究中心(CNRS)植物大分子研究中心(CERMAV)进行博士后科研训练,期间获得欧盟玛丽·居里学者奖学金和欧盟第七框架计划资助。2016-2022年在中国科学院宁波材料技术与工程研究所从事医用高分子材料研究,历任副研究员、研究员、博士生导师。2023年调动至山东大学第二医院/第二临床学院,加入长江学者特聘教授冯世庆领衔的山东大学骨科医学研究中心,组建组织器官修复与再生生物材料课题组围绕组织再生修复临床问题开展新型生物材料研究,聚焦“生物材料如何在人体环境中发挥生物学效应”这一关键科学问题,运用分子工程学思想,从生物活性糖类大分子的结构调控出发,通过物理改性、化学修饰、生物酶工程等分子工程手段,发展了能对糖类大分子的链结构、组装结构、聚集结构、网络结构进行改造和调控的新方法,创制了系列基于糖类生物大分子的新型含糖水凝胶材料,具有动态力学适配、免疫调节、抗菌抗炎、诱导细胞增殖和组织再生等生物活性功能,在动物水平证实能够显著促进皮肤、骨软骨、脊髓等组织再生,正积极推动相关材料临床试验和转化。

      近年来主持国家自然科学基金、法国国家科研署国际合作项目、浙江省自然科学基金重点项目、浙江省医用植介入材料工程研究中心项目、宁波市科技创新2025重大专项以及医用材料产学研项目等20余项。在Chem. Soc. Rev.Green Chem.Carbohydr. Polym.Adv. Healthcare Mater.Chem. Mater.BiomacromoleculesInt. J. Biol. Macromol.Compos. Sci. Technol.J. Mater. Chem. CJ. Mater. Chem. B等重要学术期刊上发表论文60篇(H-index=30),Springer出版的学术专著章节1篇,获中国发明专利授权11项。在第十届海峡两岸纳米材料论坛暨纳米材料国际会议、第十一届先进纤维与聚合物材料国际会议作分会邀请报告,全国高分子学术论文报告会作分会口头报告4次。入选山东省泰山学者、宁波市领军和拔尖人才等培养工程。现担任学术期刊The InnovationMilitary Medical Research青年编委、Smart Materials in Medicine客座编辑,兼任中国生物工程学会干细胞与组织工程专业委员会委员、法国国家科学研究中心高级访问学者和国际评审专家。曾获得法国优秀博士学位论文奖、欧盟第七框架计划"Stars of Europe"科技创新奖(第二完成人)、法国卫生部企业创新科技奖(第二完成人)、法国国家科学研究中心优秀博士后、中科院宁波材料所优秀共产党员、山东大学第二医院十佳科技工作者等荣誉和奖励。

      课题组隶属齐鲁医学院第二临床学院冯世庆教授团队,招收临床医学>外科学>骨外方向学术型博士、硕士生,重点开展脊髓再生修复生物材料研究。依托山东大学第二医院和山东大学骨科医学研究中心,常年招聘高分子、化学、生物材料、生物学、医学等方向博士后、博士、科研助理,开展医-工-材-化-生多学科交叉基础研究和临床转化。

研究领域

      组织缺损和功能障碍严重影响人类健康和患者生活质量。临床上因创伤、疾病、老龄化等原因导致的组织器官损伤数量巨大,我国每年对人体组织再生修复的需求高达1亿人次,是目前临床面临的重大难题。生物材料是实现组织再生的重要元素,其组成、结构和性能对其生物学功能的发挥有着重要作用。研发能够满足临床需求的组织再生生物材料,掌握材料结构与生物学效应的本质关系,是保障人民健康的重大国家需求。生物材料的发展日新月异,但我们对材料在体内如何参与组织修复的过程仍缺乏系统、深入和精细的认识,直接制约着组织再生材料的发展和临床应用。课题组坚持以临床应用为导向的新型生物材料研究理念,致力于运用分子工程手段,对天然来源的糖类生物大分子结构进行精准改造,构建具备动态力学适配性和病灶微环境响应性的含糖水凝胶材料,挖掘含糖水凝胶的生物活性功能,推动其在骨科创面、骨软骨缺损、脊柱脊髓损伤等临床疾病治疗领域的应用。

图片 5.jpg  

科研成果
论文

1.  J. Teng, W. Zhao, S. Zhang, D. Yang, Y. Liu, R. Huang, Y. Ma, L. Jiang, H. Wei*, J. Zhang*, J. Chen*. Injectable nanoparticle-crosslinked xyloglucan/ε-poly-L-lysine composite hydrogel with hemostatic, antimicrobial, and angiogenic properties for infected wound healing. Carbohydrate Polymers 2024, 336, 122102. 

2.  Y. Liu, J. Teng, R. Huang, W. Zhao, D. Yang, Y. Ma, H. Wei*, H. Chen*, J. Zhang, J. Chen*. Injectable plant-derived polysaccharide hydrogels with intrinsic antioxidant bioactivity accelerate wound healing by promoting epithelialization and angiogenesis. International Journal of Biological Macromolecules 2024, 266, 131170. 

3.  J. Li, X. Xu, X. Ma, M. Cui, X. Wang, J. Chen*, J. Zhu, J. Chen*. Antimicrobial nonisocyanate polyurethane foam derived from lignin for wound healing. ACS Applied Bio Materials 2024, 7, 1301-1310. 

4.  W. Wang#, L. Wang#, B. Zhang#, S. Shang, C. Zhao, W. Zhang, J. Chen*, C. Zhou*, H. Zhou*, S. Feng*. 3D printing of personalized magnesium composite bone tissue engineering scaffold for bone and angiogenesis regeneration. Chemical Engineering Journal 2024, 484, 149444. 

5.  X. Xu, Y. Chao, X. Ma, H. Zhang, J. Chen*, J. Zhu, J. Chen*. A photothermally antibacterial Au@Halloysite nanotubes/lignin composite hydrogel for promoting wound healing. International Journal of Biological Macromolecules 2024, 258, 128704. 

6.  M. Cui, S. Li, X. Ma, J. Wang, X. Wang, N. E. Stott, J. Chen*, J. Zhu, J. Chen*. Sustainable Janus lignin-based polyurethane biofoams with robust antibacterial activity and long-term biofilm resistance. International Journal of Biological Macromolecules 2024, 256, 128088. 

7.  D. Yang, H. Chen, H. Wei*, A. Liu*, D.-X. Wei*, J. Chen*. Hydrogel wound dressings containing bioactive compounds originated from traditional Chinese herbs: A review. Smart Materials in Medicine 2024, 5, 153-165. 

8.  K. Wang#, B. Feng#, D. Zhao, K. Xiao, G. Wu, B. Shi, R. Wang, J. Chen, K. Li, L. Li, G. Zuo*, C. Shi*. Noncontact in Bed Measurements of Electrocardiogram Using a Capacitively Coupled Electrode Array Based on Flexible Circuit Board. IEEE Transactions on Instrumentation and Measurement 2023, 72, 4012114. 

9.  P. R. Ebani, J. Chen, M. V. Soares, F. A. A. Soares, S. Halila*, M. A. Villetti*, R. Borsali*. Redox-responsive maltoheptaose-b-polystyrene nanoparticles containing zinc phthalocyanine: Formulation, photophysical properties, release kinetic and toxicity. Journal of Drug Delivery Science and Technology 2023, 88, 104838. 

10.  Z. Wang#, H. Wei#, Y. Huang*, Y. Wei*, J. Chen*. Naturally Sourced Hydrogels: Emerging Fundamental Materials for Next-generation Healthcare Sensing. Chemical Society Reviews 2023, 52, 2992-3034. 

11.  H. Wei, S. Yu, Y. Zhang, H. Zhang, Y. Ma, M. Xu, P. An, Y. Zhou, S. Halila*, Y. Wei*, J Chen*. Injectable chitosan/xyloglucan composite hydrogel with mechanical adaptivity and endogenous bioactivity for skin repair. Carbohydrate Polymers 2023, 313, 121904. 

12.  Y. Chao, S. Yu, H. Zhang, D. Gong*, J. Li, F. Wang, J. Chen*, J. Zhu, J. Chen*. Architecting Lignin/Poly(vinyl alcohol) Hydrogel with Carbon Nanotubes for Photothermal Antibacterial Therapy. ACS Applied Bio Materials 2023, 6, 1525-1535. 

13.  J. Zou#, W. Yang#, W. Cui, C. Li, C. Ma, X. Ji, J. Hong, Z. Qu, J. Chen*, A. Liu*, H. Wu*. Therapeutic potential and mechanisms of mesenchymal stem cell‑derived exosomes as bioactive materials in tendon–bone healing. Journal of Nanobiotechnology 2023, 21, 14. 

14.  S. Yao, R. Brahmi, A. Bouschon, J. Chen*, S. Halila*. Supramolecular carbohydrate-based hydrogels from oxidative hydroxylation of amphiphilic β-C-glycosylbarbiturates and α-glucosidase-induced hydrogelation. Green Chemistry 2023, 25, 330-335. 

15.  M. Sun#, J. Gong#, W. Cui, C. Li, M. Yu, H. Ye, Z. Cui, J. Chen, Y. He*, A. Liu*, H. Wang*. Developments of microfluidics for orthopedic applications: A review. Smart Materials in Medicine 2023, 4, 111-122. 

16.  S.-J. Guo, H.-Y. Chang, M.-J. Xu, C.-X. Wang, H. Wei, D.-D. Li, J. Chen*, Y. Zhou*, Y. Liu*. Co2+-Mediated Hydrogels with Enhanced Mechanical Properties for Flexible Sensing. ACS Applied Polymer Materials 2022, 4, 6403-6413. 

17.  M. Xu, X. Wang, J. Tian, J. Chen*, X. Wei*, W. Li*, A clamp-improved universal amplified system for ratiometric fluorescent detection of single-nucleotide polymorphisms coupled with a novel dual-emissive silver nanocluster. Sensors and Actuators B: Chemical 2022, 367, 132151. 

18.  P. An#, H. Wei#, Y. Zhang, Y. Zhou, H. Zhang*, W. Li, B. Niu*, J. Chen*. A mechanically adaptive “all-sugar” hydrogel for cell-laden injection. European Polymer Journal 2022, 174, 111328. 

19.  B. Feng#, H. Wei#, B. Shi, D. Zhao, S. Ye, G. Wu, R. Wang, G. Zuo, Z. Wu, J. Chen*, C. Shi*. Sleeping Heart Monitoring Using Hydrogel-Textile Capacitive ECG Electrodes. IEEE Sensors Journal 2022, 22, 9255-9267. 

20.  D. Xu#, K. Gan#, Y. Wang, Z. Wu, Y. Wang, S. Zhang, Y. Peng, X. Fang, H. Wei, Y. Zhang, W. Ma*, J. Chen*. A composite deferoxamine/black phosphorus nanosheet/gelatin hydrogel scaffold for ischemic tibial bone repair. International Journal of Nanomedicine 2022, 17, 1015-1030. 

21.  S. Li, Y. Zhang, X. Ma, S. Qiu, J. Chen*, G. Lu, Z. Jia, J. Zhu*, Q. Yang, J. Chen*, Y. Wei. Antimicrobial Lignin-Based Polyurethane/Ag Composite Foams for Improving Wound Healing. Biomacromolecules 2022, 23, 1622-1632. 

22.  J. Chen#, P. An#, H. Zhang*, Y. Zhang, H. Wei, Y. Zhou, Y. Zhu*. Hydrogels with tunable modulus regulate chondrocyte microaggregates growth for cartilage repair. Biomedical Materials 2022, 17, 014106. 

23.  L. Song, J. Chen, B. B. Xu*, Y. Huang*. Flexible Plasmonic Biosensors for Healthcare Monitoring: Progress and Prospects. ACS Nano 2021, 15, 18822−18847. 

24.  S. Yao, R. Brahmi, F. Portier, J.-L. Putaux, J. Chen*, S. Halila*. Hierarchical Self-Assembly of Amphiphilic β-C-Glycosylbarbiturates into Multiresponsive Alginate-Like Supramolecular Hydrogel Fibers and Vesicle Hydrogel. Chemistry - A European Journal 2021, 27, 16716–16721. 

25.  H. Wei#, Z. Wang#, H. Zhang#, Y. Huang*, Z. Wang, Y. Zhou, B. B. Xu*, S. Halila, J. Chen*. Ultrastretchable, highly transparent, self-adhesive, and 3D-printable ionic hydrogel for multimode tactical sensing. Chemistry of Materials 2021, 33, 6731-6742. 

26.  A. R. Osi, H. Zhang, J. Chen, Y. Zhou, R. Wang, J. Fu*, P. Müller-Buschbaum, Q. Zhong. Three-Dimensional-Printable Thermo/Photo-Cross-Linked Methacrylated Chitosan−Gelatin Hydrogel Composites for Tissue Engineering. ACS Appl. Mater. Interfaces 2021, 13, 22902-22913. 

27.  H. Zhang#, T. Xu#, D. Li, T. Cheng, J. Chen*, Y. Zhou*. Gold complexes of bis-indazole-derived N-Heterocyclic carbene: Synthesis, structural characterizations, and catalysis. Journal of Molecular Structure 2021, 1233, 130043. 

28.  H. Wei, H. Zhang, Y. Zhou*, Z. Wang, R. Wang, J. Chen*. Understanding of Growth Mechanism and Structure of Multilayer Thin Films via Layer-by-Layer Hydrogen Bonded Assembly from Polymer Brushes-Grafted Surface. Nanosci. Nanotechnol. Lett. 2020, 12, 890-900. 

29.  H. Zhang, P. Ren*, F. Yang, J. Chen, C. Wang, Y. Zhou, J. Fu*. Biomimetic epidermal sensors assembled from polydopamine-modified reduced graphene oxide/polyvinyl alcohol hydrogels for the real-time monitoring of human motions. Journal of Materials Chemistry B 2020, 8, 10549-10558. 

30.  K. Fang, R. Wang*, H. Zhang, L. Zhou, T. Xu, Y. Xiao, Y. Zhou, G. Gao, J. Chen, D. Liu*, F. Ai, J. Fu*. Mechano-Responsive, Tough, and Antibacterial Zwitterionic Hydrogels with Controllable Drug Release for Wound Healing Applications. ACS Appl. Mater. Interfaces 2020, 12, 52307−52318. 

31.  H. Zhang, P.-G. Ren*, H. Wei, S. Halila, A. R. Osi, Y. Zhou*, Z. Dai, R. Wang, J. Chen*. Reinforced Macromolecular Micelle-crosslinked Hyaluronate Gels Induced by Water/DMSO Binary Solvent. Soft Matter 2020, 16, 8647-8654. 

32.  H. Zhang, Y. Cong, A. R. Osi, Y. Zhou, F. Huang, R. P. Zaccaria, J. Chen, R. Wang, J. Fu. Direct 3D Printed Biomimetic Scaffolds Based on Hydrogel Microparticles for Cell Spheroid Growth. Adv. Funct. Mater. 2020, 30, 1910573. 

33.  Y. Xu, J. Chen*, H. Zhang, H. Wei, L. Zhou, Z. Wang, Y. Pan, X. Su, A. Zhang, J. Fu*. White-Light-Emitting Flexible Display Devices Based on Double Network Hydrogels Crosslinked by YAG:Ce Phosphors. J. Mater. Chem. C 2020, 8, 247-252. 

34.  P. Kannan, J. Chen, F. Su, Z. Guo*, Y. Huang*. Faraday-Cage-Type Electrochemiluminescence Immunoassay: A Rise of Advanced Biosensing Strategy. Anal. Chem. 2019, 91, 14792-14820. 

35.  D. Xu, T. Xu, G. Gao, Y. Xiao, Z. Wang, J. Chen, Y. Zhou, R. Wang*, J. Yin*, J. Fu*. Effect of Solvent-Matrix Interactions on Structures and Mechanical Properties of Micelle-Crosslinked Gels. J. Polym. Sci. Part B Polym. Phys. 2019, 57, 473-483. 

36.  L. Wang, G. Gao, Y. Zhou, T. Xu, J. Chen, R. Wang, R. Zhang*, J. Fu*. Tough, adhesive, self-healable and transparent ionically conductive zwitterionic nanocomposite hydrogels as skin strain. ACS Appl. Mater. Interfaces 2019, 11, 3506-3515. 

37.  G. Gao, L. Wang, Y. Cong, Z. Wang, Y. Zhou, R. Wang, J. Chen, J. Fu*. Synergistic pH and Temperature Driven Actuation of Poly(NIPAM-co-DMAPMA)/Clay Nanocomposite Hydrogel Bilayers. ACS Omega 2018, 3, 17914-17921. 

38.  G. Gao, Z. Wang, D. Xu, L. Wang, T. Xu, H. Zhang, J. Chen, J. Fu*. Snap-Buckling motivated controllable jumping of thermo-responsive hydrogel bilayers. ACS Appl. Mater. Interfaces 2018, 10, 41724-41731. 

39.  Z. Wang, J. Chen, L. Wang, G. Gao, Y. Zhou, R. Wang, T. Xu, J. Yin, J. Fu*, Flexible and wearable strain sensors based on tough and self-adhesive ion conducting hydrogels. J. Mater. Chem. B 2019, 7, 24-29. 

40.  Z. Wang, J. Chen, Y. Cong, H. Zhang, T. Xu, L. Nie, J. Fu*. Ultra-stretchable strain sensors and arrays with high sensitivity and linearity based on super tough conductive hydrogels. Chem. Mater. 2018, 30, 8062-8069. 

41.  Z. Xu, J. Li, G. Gao, Z. Wang, Y. Cong, J. Chen, J. Yin*, L. Nie, J. Fu*. Tough and self-recoverable hydrogels crosslinked by triblock copolymer micelles and Fe3+ coordination. J. Polym. Sci. Part B: Polym. Phys. 2018, 56, 865-876. 

42.  J. Chen, J. Yang, G. Gao, J. Fu*. Responsive bilayered hydrogel actuators assembled by supramolecular recognition. MRS Adv. 2018, 3, 1583-1588. 

43.  J. Li, Z. Xu, Y. Xiao, G. Gao, J. Chen, J. Yin, J. Fu*. Macroscopic assembly of oppositely charged polyelectrolyte hydrogels. J. Mater. Chem. B 2018, 6, 257-264. 

44.  J. Chen, C. Travelet, R. Borsali, S. Halila*. Hemicellulosic polysaccharides mimics: synthesis of tailored bottlebrush-like xyloglucan oligosaccharide glycopolymers as binders of nanocrystalline cellulose. Biomacromolecules 2017, 18, 3410-3417. 

45.  G. Du, Y. Cong, L. Chen, J. Chen, J. Fu*. Tough and multi-responsive hydrogels based on core-shell structured macro-crosslinkers. Chin. J. Polym. Sci. 2017, 35, 1286-1296. 

46.  Y. Wang, C. Song, X. Yu, L. Liu, Y. Han, J. Chen*, J. Fu*. Thermo-responsive hydrogels with tunable transition temperature crosslinked by multifunctional graphene oxide nanosheets. Compos. Sci. Technol. 2017, 151, 139-146. 

47.  Y. Wang, Y. Xiao, G. Gao, J. Chen*, R. Hou, Q. Wang, L. Liu*, J. Fu*. Conductive graphene oxide hydrogels reduced and bridged by L-cysteine to support cell adhesion and growth. J. Mater. Chem. B 2017, 5, 511-516. 

48.  Y. Cai, G. Du, G. Gao, J. Chen*, J. Fu*. Colour-tunable quantum dots/poly(NIPAM-co-AAc) hybrid microgels based on electrostatic interactions. RSC Adv. 2016, 6, 98147-98152. 

49.  J. Chen, J. Duchet, D. Portinha*, A. Charlot*. Layer by Layer H-bonded assembly of P4VP with various hydroxylated PPFS: impact of the donor strength on growth mechanism and surface features. Langmuir 2014, 30, 10740-10750. 

50.  J. Chen, D. Vuluga, B. Crousse, J. Legros, J. Duchet-Rumeau, A. Charlot*, D. Portinha*. Polyfluorinated mercaptoalcohol as a H-bond modifier of poly(2,3,4,5,6-pentafluorostyrene) (PPFS) enhancing miscibility of hydroxylated-PPFS with various acceptor partners. Polymer 2013, 54, 3757-3766. 

51.  J. Chen, L. Dumas, J. Duchet-Rumeau, E. Fleury, A. Charlot*, D. Portinha*. Tuning H-bond capability of hydroxylated poly(2,3,4,5,6-pentafluorostyrene) grafted copolymers prepared by chemoselective and versatile thiol-para-fluoro “click-type” coupling with mercaptoalcohols. J. Polym. Sci., Part A: Polym. Chem. 2012, 50, 3452-3460. 

52.  B. Zhang*, J. Chen, C. Coddet. Microstructure and transformation behavior of in-situ shape memory alloys by selective laser melting Ti-Ni mixed powder. J. Mater. Sci. Technol. 2013, 29, 863-867. 

53.  X. Liu, J. Chen, P. Sun, Z.-W. Liu, Z.-T. Liu*. Grafting modification of ramie fibers with poly(2,2,2-trifluoroethyl methacrylate) via reversible addition-fragmentation chain transfer (RAFT) polymerization in supercritical carbon dioxide. React. Funct. Polym. 2010, 70, 972-979. 

54.  J. Yi, J. Chen, Z.-T. Liu*, Z.-W. Liu. Grafting of polystyrene and poly(p-chlorostyrene) from the surface of ramie fiber via RAFT polymerization. J. Appl. Polym. Sci. 2010, 117, 3551-3557. 

55.  W. Tang, J. Chen, Z.-T. Liu*, Z.-W. Liu. Synthesis and characterization of thermo-responsive poly(N-vinyl-2-pyrrolidinone)-block-poly(N-isopropylacrylamide) micelles. J. Macromol. Sci., Part A: Pure & Appl. Chem. 2010, 47, 1026-1031. 

56.  P. Sun, J. Chen, Z.-W. Liu, Z.-T. Liu*. Poly(vinyl alcohol) functionalized β-cyclodextrin as an inclusion complex. J. Macromol. Sci., Part A: Pure & Appl. Chem. 2009, 46, 533-540. 

57.  J. Chen, J. Yi, P. Sun, Z.-W. Liu, Z.-T. Liu*. Grafting from ramie fiber with poly (MMA) or poly (MA) via reversible addition-fragmentation chain transfer polymerization. Cellulose 2009, 16, 1133-1145. 

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