GUOZHONG CHEN
(86)-13153199161
State Key Laboratory of Microbial Technology
Shandong University
Qingdao, 266237, China
EDUCATION
l Sept.2023 - Postdoc in Microbiology, Shandong University，Qingdao, China
l Sept.2017 - Jul.2023 PhD in Microbiology, Huazhong University of Science and Technology, Wuhan, China
l Sept.2014 - Jul.2017 M.S. in Microbiology, Qingdao Agricultural University, Qingdao, China
l Sept.2010 - Jul.2014 B.S. in Biotechnology, Qingdao Agricultural University, Qingdao, China
RESEARCH INTERESTS
Chinese Traditional Medicine with Disease
Gut Microbiota Interact with Host (e.g. Cancer)
Engineering of Probiotic
EXPERTISES
Molecular cloning techniques, Protein Purification, WB
Construction of plasmid and genomic DNA library
High throughput screening (e.g. FRET method, Bioreactor)
Flow Cytometry, TEM, Fluorescent microscope
Analysis of transcriptome data and WGCNA
Metagenomic& Metabolomics analysis
PROJECTS
n 2025-2027 Guozhong Chen
The molecular mechanism of geraniol derived from Bifidobacterium bifidum SJ-7 in alleviating chronic fatigue syndrome. Shandong Provincial Department of Science and Technology. Shandong Provincial Natural Science Foundation Youth Program. Project number: ZR2024QC312
n 2023-2027 Guozhong Chen
Probiotics and chronic fatigue syndrome. State Key Laboratory of Microbial Technology, Shandong University. Postdoctoral daily expenses. Project number: 10000082392231
n 2015-2017 Guozhong Chen
Functional studies of the LolA and LolB annotated as lipoproteins’ receptor in Vibrio vulnificus. Qingdao Agricultural University. The Qingdao Agricultural University Graduate Student Innovation Plan. Project number: QYC201512
n 2014-2016 Associate professor of Yanjiao Zhang
Participated in “Classification, diversity and protease diversity of protease producing bacteria from the Yellow Sea, China”
n 2014-2017 Professor of Shiyong Chen
Participated in “Study on the Lol system and lipoprotein transport function of Vibrio vulnificus”
n 2018-2021 Professor of Zhi Liu
Participated in “Chemical-signal exchanges between Vibrio cholerae and gut microbes promotes its fitness in natural habitats”
n 2018-2021 Professor of Jun Zhu
Participated in “Enterococcus faecium H1 initiates Vibrio cholerae VPI-1/TCP Island horizontal transfer in gut environment”
n 2020-2020 Professor of Zhi Liu
Participated in “Screening substances for inhibiting Novel coronavirus infection from intestinal microecological resources”
PUBLICATIONS (https://www.researchgate.net/profile/Guozhong-Chen-3)
[1] Guozhong Chen#, Zixin Qin#, Fenxia Fan#, Mei Luo#, Hongou Wang, Baoshuai Xue, Shucheng Li, Xiaoman Yang, Xiang Mao, Liwen Yi, Chunrong Yi, Wei Li*, Xiaoyun Liu*, Biao Kan*, Zhi Liu*. Anti-σ28 factor FlgM secretion regulates Vibrio cholerae adaptability in adult mice through quorum sensing and methionine metabolism. (中科院1区Top, IF=14.3, 2024, Advanced Science, Revision Submitted to the Journal)
[2] Mei Luo#, Guozhong Chen#, Chunrong Yi, Baoshuai Xue, Xiaoman Yang, Yao Ma, Zixin Qin, Jin Yan, Xiaoyun Liu*, Zhi Liu*. Dps-dependent in vivo mutation enhances long-term host adaptation in Vibrio cholerae. PLoS Pathogens, 2023, 19(3): e1011250. (中科院1区Top, IF=7.464)
[3] Zi-Xin Qin#, Guozhong Chen#, Qian-Qian Yang, Ying-Jian Wu, Chuqing Sun, Xiaoman Yang, Mei Luo, Chunrong Yi, Zhu Jun, Wei-Hua Chen*, Zhi Liu*. Cross-platform transcriptomic data integration, profiling and mining in Vibrio cholerae. Microbiology Spectrum, 2023. 11(3):e0536922. (中科院2区, IF = 9.043)
[4] Zhiyuan Zhang#, Guozhong Chen#, Jun Hu, Wajid Hussain, Fenxia Fan, Yalin Yang, Zhigang Zhou, Xiaodong Fang, Jun Zhu, Wei-Hua Chen*, Zhi Liu*. Mr. Vc: a database of microarray and RNA-seq of Vibrio cholerae. Database: The Journal of Biological Databases and Curation, 2019, 2019(1): baz069. (中科院2区, IF=4.462)
[5] Zixin Qin#, Xiaoman Yang#, Guozhong Chen#, Chaiwoo Park, Zhi Liu*. Crosstalks between gut microbiota and Vibrio cholerae. Frontiers in Cellular and Infection Microbiology, 2020, 10: 582554. (中科院2区, IF=6.073)
[6] Yan-Jiao Zhang#, Guozhong Chen#, Huiyuan Lin, Pan Wang, Baozhi Kuang, Jing Liu, Shiyong Chen*. Development of a regulatable expression system for the functional study of Vibrio vulnificus essential gene. Antonie van Leeuwenhoek. 2017 Apr;110(4):607-614. (中科院3区, IF=2.6)
[7] 陈国忠,张燕娇,陈师勇*.革兰氏阴性菌脂蛋白Lol系统转运蛋白的功能及表面展示分泌机制. 微生物学报. 201757(12):1769-1777 (中文核心)
[8] 陈国忠,潘云军,王文泽,林慧媛,张燕娇*.一株深海细菌Idiomarina sp.406-6的微生物学特征分析.《青岛农业大学学报(自然科学版)》.2017, 34(1):027-033.
[9] Linlin Shi#, Jianyong Sheng#, Guozhong Chen, Peng Zhu, Changping Shi, Bei Li, Chaiwoo Park, Jingyi Wang, Bixiang Zhang*, Zhi Liu*, Xiangliang Yang*. Combining IL-2-based immunotherapy with commensal probiotics produces enhanced antitumor immune response and tumor clearance. Journal for ImmunoTherapy of Cancer, 2020, 8(2): e000973. (中科院1区Top，IF=10.252)
[10] Zi Xin Qin, Guozhong Chen, Wei Bao, Yao Ma, Xiaoman Yang, Chunrong Yi, Mei Luo, Jun Hu, Zhi Liu*. Magnetic chitin beads (MCB) coated with Vibrio cholerae reveals transcriptome dynamics in adult mice with a complex gut microbiota. Gut Microbes. 2023; 15(2) :2274125. (中科院1区Top，IF=12.2)
[11] Zhiyuan Zhang, Guozhong Chen, Wajid Hussain, Zixin Qin, Juntong Liu, Yang Su, Hao Zhang, Mingquan Ye*. Mr. Vc v2: An updated version of database with increased data of transcriptome and experimental validated interactions. Frontiers in Microbiology, 2022, 13: 1047259. (中科院2区Top, IF=6.604)
[12] Yanjiao Zhang#, Jiarui Zhao#, Xiying Zhang, Guozhong Chen, Mingyang Zhou, Xuhua Mo, Hailun He, Shiyong Chen*. Euzebyella marina sp. nov., isolated from seawater. International Journal of Systematic and Evolutionary Microbiology. 2017, 67(4):920-924. (中科院3区，IF= 2.439)
[13] Yao Ma#, Xiaoman Yang#, Hongou Wang, Zixin Qin, Chunrong Yi, Changping Shi, Mei Luo, Guozhong Chen, Jin Yan, Xiaoyun Liu*, Zhi Liu*. CBS-derived H2S facilitates host colonization of Vibrio cholerae by promoting the iron-dependent catalase activity of KatB. PLoS Pathogens, 2021, 17(7): e1009763. (中科院1区Top , IF=7.464)
[14] Yao Ma#, Mei Luo#, Yusheng Deng#, Xiaoman Yang, Xionglue Wang, Guozhong Chen, Zixin Qin, Yun Deng, Meiling Nan, Yang Chen, Peihui Wang, Hong Wei, Lijuan Han*, Xiaodong Fang*, Zhi Liu*. Antibiotic-Induced Primary Biles Inhibit SARS-CoV-2 Endoribonuclease Nsp15 Activity in Mouse Gut. Frontiers in Cellular and Infection Microbiology, 2022, 12: 896504. (中科院2区, IF=6.073)
[15] Xiaoman Yang#, Mingjie Qian#, Zixin Qin, Mei Luo, Guozhong Chen, Chunrong Yi, Zhi Liu*. Thiol-based modification of MarR protein VnrR regulates resistance towards nitrofuran in Vibrio cholerae by promoting the expression of a novel nitroreductase VnrA and of NO-detoxifying enzyme HmpA. Antioxidants and Redox Signaling, 2024;40(16-18):926-942. doi: 10.1089/ars.2022.0205. (中科院2区, IF=6.6)
[16] Zhiyuan Zhang*, Yuanyuan Pan, Wajid Hussain, Guozhong Chen, Erguang Li*. BBSdb, an open resource for bacterial biofilm-associated proteins. Frontiers in Cellular and Infection Microbiology. 2024, 1;14:1428784. doi:10.3389/fcimb. 2024.1428784. (中科院2区, IF=5.7)
[17] Zhiyuan Zhang*, Guozhong Chen, Erguang Li*. A statistical-based method for the construction and analysis of gene network: application to bacteria. (2024, Submitted)
PATENTS
[1] 一种用于恶性肿瘤免疫治疗的药盒及其应用。刘智，杨祥良，石林林，盛剑勇，陈国忠，张白。发明专利，CN108653341B
[2] 牛磺胆酸及其水溶性盐对新冠病毒的核糖核酸内切酶活性抑制作用的应用。刘智，马遥，罗美，陈国忠，秦子鑫。发明专利，CN114796235A
OTHER EXPERIENCE
[1] 2014-2015 Followed the scientific research ship "Dong fang hong 2" from Ocean University of China to conduct scientific research experiments in the Yellow Sea and Bohai Sea.
[2] 2017 The first Conference on Human Gut Microbiology and Health, Beijing, China
[3] 2021 First International Fusobacteria Symposium (Vritual);
[4] 2015-2023 短科普宣传：丁香园网站博主、帮研网技术顾问、Writer of in Mr.Gut Daliy (热心肠日报)、an evidence-based probiotics (益生菌循证库) and The intestinal industry (肠道产业)
[5] Computational and Structural Biotechnology Journal (中科院Q2)、Engineering Microbiology期刊审稿人、iMeta (IF =23.8)青年编委、中国微生态学杂志评审专家
[6] 在Engineering Microbiology微信公众号供稿，被评为月度优秀稿件。
[7] 2024 第一届环境与健康微生物组学前沿交叉研讨会 (青岛)
[8] 2024 Lion Lake International Microbiome Conference (广州)
REFEREES
Prof. Shuangjiang Liu
E-mail: liusj@sdu.edu.cn
State Key Laboratory of Microbial Technology
Shandong University
Binhai Road 72, Qingdao, China
Prof. Zhi Liu
E-mail: zhiliu@hust.edu.cn
College of life science &technology
Huazhong University of Science and Technology
Luoyu Road 1037, Wuhan, China
Prof. Jun Zhu (Jay)
E-mail: junzhu@mail.med.upenn.edu
211A Johnson Pavilion
3610 Hamilton Walk
University of Pennsylvania
Philadelphia, PA 19104 USA
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