• 教师拼音名称：
  chenguozhong
• 入职时间：
  2023-08-30
• 所在单位：
  微生物技术研究院
• 学历：
  研究生(博士)毕业
• 办公地点：
  会文北楼C区403
• 性别：
  男
• 联系方式：
  13153199161
• 学位：
  理学博士学位
• 在职信息：
  在职
• 毕业院校：
  华中科技大学

GUOZHONG CHEN

13153199161@163.com

(86)-13153199161

College of life science & technology

Huazhong University of Science and Technology

Luoyu Road 1037, Wuhan, China

EDUCATION

l  Sept.2017 – Jul.2023 Ph.D. in Microbiology, Huazhong University of Science and Technology, Wuhan, China

l  Sept.2014 – Jul.2017 M.S. in Microbiology, Qingdao Agricultural University, Qingdao, China

l  Sept.2010 – Jul.2014 B.S. in Biotechnology, Qingdao Agricultural University, Qingdao, China

RESEARCH INTERESTS

Culturomics of Gut Microbes

Development and Application of Gut Microbes

Gut Microbiota Interact with Host

Engineering of Probiotics

EXPERTISES

Molecular cloning techniques, Protein Purification, WB

Construction of plasmid and genomic DNA library

High throughput screening (e.g. FRET method, Bioreactor)

Analysis of transcriptome data and WGCNA

Flow Cytometry, TEM, Fluorescent microscope

PROJECTS

n  2014-2016 Associate professor of Yanjiao Zhang

Participated in “Classification, diversity and protease diversity of protease producing bacteria from the Yellow Sea, China”

n  2014-2017 Professor of Shiyong Chen

Participated in “Study on the Lol system and lipoprotein transport function of Vibrio vulnificus”

n  2018-2021 Professor of Zhi Liu

Participated in “Chemical-signal exchanges between Vibrio cholerae and gut microbes promotes its fitness in natural habitats”

n  2018-2021 Professor of Jun Zhu (Jay)

Participated in “Enterococcus faecium H1 initiates Vibrio cholerae VPI-1/TCP Island horizontal transfer in gut environment”

n  2020-2020 Professor of Zhi Liu

Participated in “Screening substances for inhibiting Novel coronavirus infection from intestinal microecological resources”

PUBLICATIONS

[1]     Yan-Jiao Zhang^#, Guozhong Chen^#, Huiyuan Lin, Pan Wang, Baozhi Kuang, Jing Liu, Shiyong Chen*. Development of a regulatable expression system for the functional study of Vibrio vulnificus essential gene. Antonie van Leeuwenhoek. (IF=1.944)

[2]     Zhiyuan Zhang^#, Guozhong Chen^#, Jun Hu, Wajid Hussain, Fenxia Fan, Yalin Yang, Zhigang Zhou, Xiaodong Fang, Jun Zhu, Wei-Hua Chen*, Zhi Liu*. Mr. Vc: a database of microarray and RNA-seq of Vibrio cholerae. Database: The Journal of Biological Databases and Curation, 2019, 2019(1): baz069. (IF=4.462)

[3]     Zixin Qin^#, Xiaoman Yang^#, Guozhong Chen^#, Chaiwoo Park, Zhi Liu*. Crosstalks between gut microbiota and Vibrio cholerae. Frontiers in Cellular and Infection Microbiology, 2020, 10: 582554. (IF=6.073)

[4]     Mei Luo^#, Guozhong Chen^#, Chunrong Yi, Baoshuai Xue, Xiaoman Yang, Yao Ma, Zixin Qin, Jin Yan, Xiaoyun Liu*, Zhi Liu*. Dps-dependent in vivo mutation enhances long-term host adaptation in Vibrio cholerae. PLoS Pathogens, 2023, 19(3): e1011250. (IF=7.464)

[5]     Zi-Xin Qin^#, Guozhong Chen^#, Qian-Qian Yang, Ying-Jian Wu, Chuqing Sun, Xiaoman Yang, Mei Luo, Chunrong Yi, Zhu Jun, Wei-Hua Chen*, Zhi Liu*. Cross-platform transcriptomic data integration, profiling and mining in Vibrio cholerae. Microbiology Spectrum, 2023. (IF=9.043)

[6]     Guozhong Chen^#, Mei Luo^#, Zixin Qin^#, Hongou Wang, Xiaoman Yang, Liwen Yi, Chunrong Yi, Jun Zhu, Wei Li*, Xiaoyun Liu*, Zhi Liu*. Anti-σ²⁸ factor FlgM secretion regulates Vibrio cholerae colonization in adult mouse through quorum sensing and methionine metabolism. (Advanced Science，Under Review, IF=14.3)

[7]     Yan-Jiao Zhang^#, Jia-Rui Zhao^#, Xi-Ying Zhang, Guo-Zhong Chen, Ming-Yang Zhou, Xu-Hua Mo, Hai-Lun He, Shiyong Chen*. Euzebyella marina sp. nov., isolated from seawater. International Journal of Systematic and Evolutionary Microbiology. 2017, 67(4):920-924. (IF= 2.439)

[8]     Linlin Shi^#, Jianyong Sheng^#, Guozhong Chen, Peng Zhu, Changping Shi, Bei Li, Chaiwoo Park, Jingyi Wang, Bixiang Zhang*, Zhi Liu*, Xiangliang Yang*. Combining IL-2-based immunotherapy with commensal probiotics produces enhanced antitumor immune response and tumor clearance. Journal for ImmunoTherapy of Cancer, 2020, 8(2): e000973. (IF=10.252)

[9]     Yao Ma^#, Xiaoman Yang^#, Hongou Wang, Zixin Qin, Chunrong Yi, Changping Shi, Mei Luo, Guozhong Chen, Jin Yan, Xiaoyun Liu*, Zhi Liu*. CBS-derived H₂S facilitates host colonization of Vibrio cholerae by promoting the iron-dependent catalase activity of KatB. PLoS Pathogens, 2021, 17(7): e1009763. (IF=7.464)

[10] Zhiyuan Zhang, Guozhong Chen, Wajid Hussain, Zixin Qin, Juntong Liu, Yang Su, Hao Zhang, Mingquan Ye*. Mr. Vc v2: An updated version of database with increased data of transcriptome and experimental validated interactions. Frontiers in Microbiology, 2022, 13: 1047259. (IF=6.604)

[11] Yao Ma^#, Mei Luo^#, Yusheng Deng^#, Xiaoman Yang, Xionglue Wang, Guozhong Chen, Zixin Qin, Yun Deng, Meiling Nan, Yang Chen, Peihui Wang, Hong Wei, Lijuan Han*, Xiaodong Fang*, Zhi Liu*. Antibiotic-Induced Primary Biles Inhibit SARS-CoV-2 Endoribonuclease Nsp15 Activity in Mouse Gut. Frontiers in Cellular and Infection Microbiology, 2022, 12: 896504. (IF=6.073)

[12] Hong Zhou, Xi Tan, Guozhong Chen, Xinxin Liu, Aiping Feng, Zhi Liu, Wei Liu. Extracellular vesicles of commensal skin microbiota alleviate cutaneous inflammation in atopic dermatitis mouse model by reestablishing skin homeostasis. Journal of Investigative Dermatology, 2023, doi: 10.1016/j.jid.2023.02.023. (IF=7.590)

[13] Xiaoman Yang^#, Mingjie Qian^#, Zixin Qin, Mei Luo, Guozhong Chen, Chunrong Yi, Zhi Liu*. Thiol-based modification of MarR protein VnrR regulates resistance towards nitrofuran in Vibrio cholerae by promoting the expression of a novel nitroreductase VnrA and of NO-detoxifying enzyme HmpA. Antioxidants and Redox Signaling, 2023. (IF=6.6)

[14] Zhiyuan Zhang*, Yuanyuan Pan, Wajid Hussain, Guozhong Chen, Erguang Li*. BBSdb, an open resource for bacterial biofilm-associated proteins. Front Cell Infect Microbiol. 2024.(IF=5.7)

PATENTS

[1]     一种用于恶性肿瘤免疫治疗的药盒及其应用。刘智，杨祥良，石林林，盛剑勇，陈国忠，张白。发明专利，CN108653341B

[2]     牛磺胆酸及其水溶性盐对新冠病毒的核糖核酸内切酶活性抑制作用的应用。刘智，马遥，罗美，陈国忠，秦子鑫。发明专利，CN114796235A

OTHER EXPERIENCE

[1]     2014-2015 Followed the scientific research ship "Dong fang hong 2" from Ocean University of China to conduct scientific research experiments in the Yellow Sea and Bohai Sea.

[2]     2017 The first Conference on Human Gut Microbiology and Health, Beijing, China

[3]     2021 First International Fusobacteria Symposium (Vritual).

[4]     2018- Present  Writer of in Mr.Gut Daliy (热心肠日报)、an evidence-based probiotics (益生菌循证库) and The intestinal industry (肠道产业)

[5]  Reviewer of  Computational and Structural Biotechnology Journal（中科院Q2）&  Engineering Microbiology

PAPER IN PREPARANTION

Mechanism of Vibrio cholerae Fitness in the Host Gut by FlgM Secretion

REFEREES

Prof. Shuangjiang Liu

E-mail:  liusj@sdu.edu.cn

State Key Laboratory of Microbial Technology

Shandong University

Binhai Road 72, Qingdao, China

Prof. Zhi Liu

E-mail:  zhiliu@hust.edu.cn

College of life science &technology

Huazhong University of Science and Technology

Luoyu Road 1037, Wuhan, China

Prof. Jun Zhu (Jay)

E-mail:  junzhu@mail.med.upenn.edu

211A Johnson Pavilion

3610 Hamilton Walk

University of Pennsylvania

Philadelphia, PA 19104 USA