Du Lei
Professor
Visit:
Personal Information:
  • Name (English):
    Du Lei
  • Name (Pinyin):
    Du Lei
  • E-Mail:
    dulei@sdu.edu.cn
  • Date of Employment:
    2020-07-10
  • School/Department:
    微生物技术研究院
  • Business Address:
    山东大学青岛校区K1楼235
  • Gender:
    Male
  • Supervisor of Doctorate Candidates
  • Supervisor of Master's Candidates
Biography

杜磊,研究员,博士生导师,山东省泰山学者青年专家,山东省青创科技计划创新团队学术带头人。就职于山东大学微生物技术研究院微生物技术国家重点实验室。

主要研究方向:微生物合成生物学活性天然产物生物合成酶学与酶工程工业微生物菌种改良等。

近年来取得了一系列具有重要学术价值和应用前景的创新性研究成果,发表论文 20 余篇,专利 10 余项,代表性论文发表于Nat. Catal.JACSPNASAngewACS Catal.Curr. Opin. Biotech.Trends Microbiol.等国际知名期刊。

近年来主持国家、省部级、地方和横向项目 20 余项,包括国家重点研发计划合成生物学重点专项子课题、国家自然科学基金项目(青基、面上)、山东省“泰山学者青年专家项目、山东省自然科学基金重大基础研究项目、山东省“青创科技”支持计划、国家博士后创新人才支持计划(博新计划)、横向项目等。

Education
  • 2015-9 — 2018-1
    中国科学院大学
    微生物学
    Doctor
  • 2009-9 — 2012-7
    天津大学
    制药工程
    Master
  • 2005-9 — 2009-7
    天津大学
    制药工程
    工学学士
Publication
Papers

1. . The Mutually Inspiring Biological and Chemical Synthesis of Fungal Bicyclo[2.2.2]diazaoctane Indole Alkaloids. .Chemical Reviews.2025,125 (4):1718

2. Zhong Li. Molecular insights into the catalytic promiscuity of a bacterial diterpene synthase .NATURE COMMUNICATIONS.2023,14 (1)

3. . Biosynthesis of 4-Acyl-5-aminoimidazole Alkaloids Featuring a New Friedel-Crafts Acyltransferase .Journal of the American Chemical Society.2023 (145)

4. 汤丹丹. Engineered Microbial Consortium for De Novo Production of Sclareolide .Journal of Agricultural and Food Chemistry.2024

5. . Efficient conversion of aromatic and phenylpropanoid alcohols to acids by the cascade biocatalysis of alcohol and aldehyde dehydrogenases .Synth Syst Biotechnol.2024,9 (2):187-195

6. . Asperinamide A, an anti-inflammatory prenylated indole alkaloid possessing an unprecedented bicyclo[2.2.2]diazaoctane fused with substituted piperidine scaffold from Aspergillus sp. TE-65L .Tetrahedron.2023,149

7. . Biosynthesis of 4-Acyl-5-aminoimidazole Alkaloids Featuring a New Friedel-Crafts Acyltransferase .Journal of the American Chemical Society.2023

8. 马莉. Enzymatic synthesis of indigo derivatives by tuning P450 BM3 peroxygenases .Synth Syst Biotechnol.2023 (3)

9. . Three pairs of surrogate redox partners comparison for Class I cytochrome P450 enzyme activity reconstitution. .Communications Biology .2022,5 (1):791

10. 李盛英. Discovery of venediols by activation of a silent type I polyketide biosy nthetic gene cluster in Streptomyces vene zuelae ATCC 15439 .Tetrahedron.2022,126 (无)

11. 郭斐. Diversification of phenolic glucosides by two UDP-glucosyltransferases featuring complementary regioselectivity .Microbial Cell factories.2022 (21):208

12. 马莉. Three pairs of surrogate redox partners comparison for Class I cytochrome P450 enzyme activity reconstitution .Communications Biology .2022 (1)

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