凤志慧山东大学主页平台管理系统--中文主页

教师简介

山东大学公共卫生学院教授，博士/硕士研究生导师，北京大学医学部博士，哈佛大学博士后。兼任中国环境诱变剂学会常务理事、中国环境诱变剂学会辐射与健康专委会常委、中国毒理学会特种医学专委会常委、中国毒理学会放射毒理专委会常委、山东省预防医学会劳动卫生与职业病分会副主委/放射医学与防护分会副主委等。在多项国家自然科学基金和山东省重点研发计划等项目资助下，从事放射损伤/放射防护、环境有害因素/健康损害的研究。研究成果发表在PNAS、Nucleic Acid Research、Cell Death and Disease、Frontier in Immunology等国际期刊。发表在PNAS杂志文章被F1000推荐为“必读”、同期PNAS杂志发表对该论文的专题评论。

研究方向：

电离辐射诱导的DNA损伤修复、辐射敏感性、肿瘤放射增敏剂、放射防护剂

环境有害因素所致健康损害

代表性论文：

(1) Zhihui Feng, Shaun P. Scott, Wendy Bussen, Girdhar G. Sharma, Gongshe Guo, Tej K. Pandita, Simon N. Powell; Rad52 inactivation is Synthetically Lethal with BRCA2-deficiency. Proc Natl Acad Sci U S A. 2011 Jan 11;108 (2):686-91.

--专题评论：The Commentary in Proc Natl Acad Sci U S A，Who's who in human recombination: BRCA2 and RAD52, 2011 108 (2) 441-442.

-- “Faculty of 1000”评为“must read，必读”.

(2)Zhihui Feng, Junran Zhang, A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest; Nucleic Acids Res. 2012 Jan;40(2):726-38.

(3)Benyu Su, David Lim , Chenyang Qi, Zhongwei Zhang, Junxiao Wang, Fengmei Zhang, Chao Dong, Zhihui Feng(通讯作者), VPA mediates bidirectional regulation of cell cycle progression through the PPP2R2A-Chk1 signaling axis in response to HU, Cell Death and Disease, (2023)14:114; 41419-023-05649-8

(4)Zuchao Cai, David Lim, Guochao Liu, Chen Chen, Liya Jin, Wenhua Duan, Chenxia Ding, Qingjie Sun, Junxuan Peng, Chao Dong, Fengmei Zhang and Zhihui Feng (通讯作者). Valproic Acid-Like Compounds Enhance and Prolong the Radiotherapy Effect on Breast Cancer by Activating and Maintaining Anti-Tumor Immune Function, Frontiers in Immunology, 12 May 2021 646384.

(5)Chen Chen, David Lim, Zuchao Cai, Fengmei Zhang, Guochao Liu, Chao Dong, Zhihui Feng(通讯作者), HDAC inhibitor HPTA initiates anti-tumor response by CXCL9/10-recruited CXCR3+CD4+T cells against PAHs carcinogenicity, Food and Chemical Toxicology 176 (2023) 113783.

(6)Yisha Zhang, David Lim, Zuchao Cai, Junxuan Peng, Beidi Jia. Guoliang Chu, Fengmei Zhang, Chao Dong, Zhihui Feng(通讯作者). Valproic acid counteracts polycyclic aromatic hydrocarbons (PAHs)-induced tumorigenic effects by regulating the polarization of macrophages, Ecotoxicology and Environmental Safety, Volume 241, August 2022, 113779.

(7)Yanling Yao, Chen Chen, Zuchao Cai, Guochao Liu, Chenxia Ding, David Lim, Dong Chao, Zhihui Feng(通讯作者), Screen identifies fasudil as a radioprotector on human fibroblasts, Toxicol Res (Camb). 2022 Jul 2;11(4):662-672.

(8)Zhihui Feng, L Kachnic, J Zhang, SN Powell and F Xia：DNA damage induces p53-dependent BRCA1 nuclear export, J.B.C. 2004 Jul 2;279 (27):28574-84.