教师简介

郭婷,医学博士,副主任医师,教授,博士生导师。山东省优青,泰山学者青年专家,山东大学齐鲁青年学者。围绕女性卵巢储备建立和维持的调控机制,开展病理性卵巢衰老的遗传环境病因及干预研究,绘制早发性卵巢功能不全(POI)的遗传变异图谱,累计鉴定30POI致病基因,为POI遗传病因诊断和个体化干预奠定基础。作为第一/通讯作者在Nature MedicineEndocrine ReviewsJournal of Clinical InvestigationJournal of Hazardous MaterialsGenetics in Medicine等杂志发表SCI论文30余篇,获批中国发明专利4件。参与译写《Human Reproductive and Prenatal Genetics(2nd Edition, 2023)、《步步精进: 临床胚胎学与辅助生殖技术》等书籍。多次受邀在国际生育联盟大会(IFFS 2023)、亚太生殖大会(ASPIRE 20162021)等做学术报告。主持国家重点研发计划子课题2项、国家自然科学基金项目3项、山东省重点研发计划1项。荣获山东省医学会青年科技奖一等奖(首届)、国家妇幼健康科学技术奖一等奖、张丽珠生殖医学青年创新奖、第二十届中国青年女科学家团队奖等奖项。兼任中国妇幼健康协会生殖内分泌专业委员会委员、中国遗传学会青年委员会委员、山东省医师协会妇产科分会委员兼秘书,担任Journal of Genetics and GenomicsCell Proliferation等杂志青年编委。


教育经历
  • 2012-9 — 2015-7
    山东大学
    妇产科学
    医学博士学位
  • 2004-9 — 2009-7
    潍坊医学院
    临床医学
    医学学士学位
  • 2009-9 — 2012-7
    山东大学
    妇产科学
    医学硕士学位
工作经历
  • 2017-07 — 2500-01
     山东大学附属生殖医院 
  • 2015-10 — 2017-10
     上海交通大学 
学术兼职
  • 山东省医师协会妇产科分会委员兼秘书
  • 中国遗传学会青年委员会委员
  • 中国妇幼健康协会生殖内分泌专业委员会委员
研究概况

面向生育力保护和促进的国家战略需求,聚焦卵巢衰老的遗传与环境病因及机制,开发生育力保存新技术和综合临床管理策略。

研究方向
论文成果

(1) Landscape of pathogenic mutations in premature ovarian insufficiency.Nature Medicine.2023

(2) Epidemiology, genetic etiology and intervention of premature ovarian insufficiency.Endocrine Reviews.2025

(3) Associations of long-term exposure to fine particulate matter and its components with ovarian aging: Evidence from a cross-sectional study in China.Journal of Hazardous Materials.2025

(4) MGA loss-of-function variants cause premature ovarian insufficiency.The Journal of Clinical Investigation.2024

(5) Pathogenic variants of meiotic double strand break (DSB) formation genes PRDM9 and ANKRD31 in premature ovarian insufficiency.Genetics in medicine.2021

(6) Genome-wide DNA methylation profile and predictive biomarkers in premature ovarian insufficiency.Journal of Genetics and Genomics.2025

(7) Homozygous missense variant in MEIOSIN causes premature ovarian insufficiency-2.HUMAN REPRODUCTION.2023 (38(Supplement_2)):47

(8) Pathogenic variants in TSC2 might cause premature ovarian insufficiency through activated mTOR induced hyperactivation of primordial follicles.Fertility and Sterility.2022

(9) Variations of C14ORF39 and SYCE1 identified in idiopathic premature ovarian insufficiency and nonobstructive azoospermia.The Journal of Clinical Endocrinology & Metabolism.2022

(10) Novel compound heterozygous variants in FANCI cause premature ovarian insufficiency.《HUMAN GENETICS》.2024

(11) Truncated DAZL mutation reduces NANOS3 expression in primordial germ cells and leads to premature ovarian insufficiency.Life Medicine.2024

(12) Bi-allelic SPATA22 variants cause premature ovarian insufficiency and nonobstructive azoospermia due to meiotic arrest.Clinical Genetics.2022

(13) TP63 gain-of-function mutations cause premature ovarian insufficiency by inducing oocyte apoptosis.Journal of Clinical Investigation.2023,133 (5)

(14) DNA repair protein FANCD2 has both ubiquitination- dependent and ubiquitination-independent functions during germ cell development.JOURNAL OF BIOLOGICAL CHEMISTRY.2023,299 (3)

(15) NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance.Cell Reports.2023,42 (12)

专利
教师图片
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