韩秋菊
Associate Professor
Visit:
Personal Information:
  • Name (Pinyin):
    hanqiuju
  • Date of Employment:
    2012-04-26
  • School/Department:
    药学院
  • Education Level:
    Postgraduate (Postdoctoral)
  • Gender:
    Female
  • Contact Information:
    hanqiuju@sdu.edu.cn
  • Degree:
    Doctoral Degree in Medicine
  • Status:
    Employed
  • Alma Mater:
    山东大学
  • Supervisor of Doctorate Candidates
  • Supervisor of Master's Candidates
Discipline:
Immunopharmacology;
Honors and Titles:

2012-10-10    中国免疫学会青年学者奖;
Biography

韩秋菊,副教授,博士生导师。2011年毕业于山东大学药学院,师承我国著名免疫学家田志刚院士。2012年起任教于山东大学药学院免疫药物学研究所。曾获中国免疫学会青年学者奖,担任JBCJECC、《生物化学与生物物理进展》、《中国免疫学》审稿专家。

主要研究领域为免疫耗竭机制及免疫治疗策略开发,目前以第一作者/通讯作者在Hepatology、Nature communication等发表SCI论文16篇,合作发表SCI论文20余篇,授权专利5项。为首承担国家自然基金面上项目、国家自然基金青年基金、山东省优秀青年基金、山东省重点研发计划、山东省自然基金、中国博士后基金面上项目、中国博士后特别资助、高校基本科研业务费交叉学科研究项目等课题。

在教学方面,承担多门本科和研究生课程,承担4项校级教研课题。获得全国药学类青年教师教学能力大赛一等奖、全国药学专业微课比赛一等奖、山东省高等医学教育中心优秀论文二等奖、山东大学讲课比赛一等奖,山东大学课程思政案例设计一等奖,山东大学青年教师教学能手称号。


Education
  • 2005-9 — 2011-6
    山东大学
    微生物与生化药学
    Doctoral Degree in Medicine
  • 2001-9 — 2005-6
    山东大学
    药学
    Bachelor's Degree in Science
  • 1998-9 — 2001-7
    临清一中
Publication
Papers

1. . A therapeutic hepatitis B mRNA vaccine with strong immunogenicity and persistent virological suppression .NPJ Vaccines.2024 (9)

2. 赵华俊. CpG-C ODN M362 as an immunoadjuvant for HBV therapeutic vaccine reverses the systemic tolerance against HBV .International Journal of Biological Sciences.2022 (18)

3. 赵华俊. Cholesterol accumulation on dendritic cells reverses chronic hepatitis B virus infection-induced dysfunction .CELLULAR & MOLECULAR IMMUNOLOGY.2022,19 (12):1347

4. 赵华俊. Cholesterol accumulation on dendritic cells reverses chronic hepatitis B virus infection-induced dysfunction .CELLULAR & MOLECULAR IMMUNOLOGY.2022 (19)

5. 张建. Cholesterol accumulation on dendritic cells reverses chronic hepatitis B virus infection-induced dysfunction .Cell Mol Immunol.2022 (15)

6. 张建. Sorafenib combined with STAT3 knockdown triggers ER stress-induced HCC apoptosis and cGAS-STING-mediated anti-tumor immunity . Cancer Letters.2022 (547)

7. 张建. MERS-CoV nsp1 regulates autophagic flux via mTOR signalling and dysfunctional lysosomes .EMERGING MICROBES & INFECTIONS.2022 (1)

8. 战仁慧. Toll-Like Receptor 2 (TLR2) and TLR9 Play Opposing Roles in Host Innate Immunity against Salmonella enterica Serovar Typhimurium Infection .INFECTION AND IMMUNITY.2015,83 (4):1641-1649

9. 隋强君. NK Cells Are the Crucial Antitumor Mediators When STAT3-Mediated Immunosuppression Is Blocked in Hepatocellular Carcinoma .J Immunol .2014,193 (4):2016-2023

10. 赵恒利. Homeobox containing 1 inhibits liver cancer progression by promoting autophagy as well as inhibiting stemness and immune escape .Ocology Report.2018,40 (3):1657-1665

11. 孙晓霞. miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti-tumor immune suppression .cell Cycle.2015,14 (2):243-252

12. 杨丹. 肿瘤雌激素受体信号通路及其与肿瘤免疫应答间的交互作用 .《中国免疫学杂志》.2016,32 (5):748-751

13. 王亚群. 靶向阻断STAT3增强肝癌细胞H22对化疗药物阿霉素的敏感性 .《中国免疫学杂志》.2015,31 (10):1304-1309

14. 李雅. Targeted inhibition of STAT3 induces immunogenic cell death of hepatocellular carcinoma cells via glycolysis. .MOLECULAR ONCOLOGY.2022,16 (15):2861-2880

15. 韩秋菊. 5 '-triphosphate siRNA targeting HBx elicits a potent anti-HBV immune response in pAAV-HBV transfected mice .Antiviral Research.2019,161 :36-45

16. 赵荣荣. Edaravone protects against liver fibrosis progression via decreasing the IL-1β secretion of macrophages .Chemico-Biological Interactions.2022 (368)

17. 李浩浩. Targeting T-cell metabolism to boost immune checkpoint inhibitor therapy .Frontiers in Immunology.2022 (13)

18. 赵华俊. CpG-C ODN M362 as an immunoadjuvant for HBV therapeutic vaccine reverses the systemic tolerance against HBV .INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES.2022,18 (1):154-165

19. 赵华俊. Innate and adaptive immune escape mechanisms of hepatitis B virus .WORLD JOURNAL OF GASTROENTEROLOGY.2022,28 (9):881-896

20. 陆楠. Enhancing anti-tumor efficacy and immune memory by combining 3p-GPC-3 siRNA treatment with PD-1 blockade in hepatocellular carcinoma .ONCOIMMUNOLOGY.2022,11 (1):2010894

21. 潘召义. MERS-CoV nsp1 impairs the cellular metabolic processes by selectively downregulating mRNAs in a novel granules .VIRULENCE.2022,13 (1):355

22. 周岳. Downregulation of Renal MRPs Transporters in Acute Lymphoblastic Leukemia Mediated by the IL-6/STAT3/PXR Signaling Pathway .JOURNAL OF INFLAMMATION RESEARCH.2021,14 :2239

23. 姜鹏. miR-590-5p affects chondrocyte proliferation, apoptosis, and inflammation by targeting FGF18 in osteoarthritis .American journal of translational research.2021,13 (8):8728

24. 姜雨. Promotion of epithelial-mesenchymal transformation by hepatocellular carcinoma-educated macrophages through Wnt2b/beta-catenin/c-Myc signaling and reprogramming glycolysis .JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH.2021,40 (1)

25. 韩秋菊. Fasudil prevents liver fibrosis via activating natural killer cells and suppressing hepatic stellate cells .WORLD JOURNAL OF GASTROENTEROLOGY Journal.2021,27 (24):3581

26. 郑冰清. HBsAg Dampened STING Associated Activation of NK Cells in HBeAg-Negative CHB Patients .INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES .2021,22 (14)

27. 姜雨. The Mechanisms of HBV-Induced Hepatocellular Carcinoma .JOURNAL OF HEPATOCELLULAR CARCINOMA.2021,8 :435

28. 赵华俊. Chitosan Nanovaccines as Efficient Carrier Adjuvant System for IL-12 with Enhanced Protection Against HBV .International Journal of Nanomedicine .2021,16 :4913

29. 周岳. Downregulation of Renal MRPs Transporters in Acute Lymphoblastic Leukemia Mediated by the IL-6/STAT3/PXR Signaling Pathway .Journal of Inflammation Research.2021 (14:2239-2252)

30. 赵家鑫. Emission behavior, enol-keto tautomerism and bioactivity of hydroxy-substituted cyclic chalcone derivatives .材料化学期刊C.2021,9 (3):1000

31. 韩秋菊. 外泌体在肿瘤免疫逃逸和耐受中的作用 .《生物化学与生物物理进展》.2019 (5)

32. 韩秋菊. 肝癌细胞异位过表达IL-12的抗肿瘤作用研究 .《中国免疫学杂志》.2019,35 (23)

33. 张建. STAT3 directly regulates NKp46 transcription in NK cells of HBeAg-negative CHB patients. .J Leukoc Biol..2019 (4)

34. 胡芮. STAT3: A key signaling molecule for converting cold to hot tumors .Cancer letters.2020,489 :29

35. 李雅. Napabucasin Reduces Cancer Stem Cell Characteristics in Hepatocellular Carcinoma .FRONTIERS IN PHARMACOLOGY.2020,11

36. 张建. Hepatocellular carcinoma: Mechanisms of progression and immunotherapy. .World J Gastroenterol..2019 (25)

37. 韩秋菊. Androgen Receptor (AR)-TLR4 Crosstalk Mediates Gender Disparities in Hepatocellular Carcinoma Incidence and Progression .journal of cancer.2020,11 (5):1094

38. 周岳. Drug Elimination Alteration in Acute Lymphoblastic Leukemia Mediated by Renal Transporters and Glomerular Filtration .PHARMACEUTICAL RESEARCH.2020,37 (8)

39. 韩秋菊. Emission behavior, enol–keto tautomerism and bioactivity of hydroxy-substituted cyclic chalcone derivatives .JOURNAL OF MATERIALS CHEMISTRY C.2020 (9)

40. zhangjian  and hanqiuju. Androgen Receptor (AR)-TLR4 Crosstalk Mediates .J Cancer.2020,11 (5)

41. zhaohuajun , hanqiuju , zhangjian  and 王冠. TLR2 Promotes Monocyte/Macrophage Recruitment Into the Liver and Microabscess Formation to Limit the Spread of Listeria Monocytogenes .Frontiers in Immunology.2019,10

42. zhangjian , hanqiuju  and 尹春来. Progress of Mechanism of Tumor Immune Escape and Tolerance Mediated by Exosome .PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS Journal.2019,46 (5):433

43. hanqiuju , zhangjian  and 郑冰清. STAT3 directly regulates NKp46 transcription in NK cells of HBeAg-negative CHB patients .JOURNAL OF LEUKOCYTE BIOLOGY.2019,106 (4):987

44. zhaohuajun , hanqiuju  and zhangjian. Poly I:C-based rHBVvac therapeutic vaccine eliminates HBV via generation of HBV-specific CD8(+) effector memory T cells .2019,68 (11):2032

45. hanqiuju , zhangjian  and 姜雨. Hepatocellular carcinoma: Mechanisms of progression and immunotherapy .WORLD JOURNAL OF GASTROENTEROLOGY Journal.2019,25 (25):3151

46. hanqiuju , zhangjian  and 沈文姝. The Effects of Immune Microenvironment on Cancer Stem Cells .PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS Journal.2019,46 (7):654

47. hanqiuju , zhaohuajun  and zhangjian. HCC-Derived Exosomes: Critical Player and Target for Cancer Immune Escape .CELLS.2019,8 (6)

48. zhaohuajun , hanqiuju  and 张建. Poly I:C-based rHBVvac therapeutic vaccine eliminates HBV via generation of HBV-specific CD8+ effector memory T cells. .Gut.2019,68 (11):2032

49. hanqiuju , zhaohuajun  and 张建. HCC-Derived Exosomes: Critical Player and Target for Cancer Immune Escape. .CELLS.2019 (6)

50. zhaohuajun , hanqiuju  and 张建. TLR2 Promotes Monocyte/Macrophage Recruitment Into the Liver and Microabscess Formation to Limit the Spread of Listeria Monocytogenes. .Front Immunol..2019 (10)

51. zhangcai , hanqiuju , zhangjian  and 刘静. Pim-3 enhances melanoma cell migration and invasion by promoting STAT3 phosphorylation .Cancer Biology & Therapy.2018,19 (3):160

52. hanqiuju , zhangjian , zhangcai  and 于馨. Intestinal Lamina Propria CD4(+) T Cells Promote Bactericidal Activity of Macrophages via Galectin-9 and Tim-3 Interaction during Salmonella enterica Serovar Typhimurium Infection .INFECTION AND IMMUNITY.2018,86 (8)

53. hanqiuju , zhaohuajun , zhangjian  and 王冠. IFN-gamma protects from apoptotic neutrophil-mediated tissue injury during acute Listeria monocytogenes infection .《European Journal of Immunology》.2018,48 (9):1470

54. hanqiuju , zhangjian  and 尹春来. SALL4-mediated upregulation of exosomal miR-146a-5p drives T-cell exhaustion by M2 tumor-associated macrophages in HCC .ONCOIMMUNOLOGY.2019,8 (7)

55. zhangcai , hanqiuju , zhangjian  and tianzhigang. The role of innate immunity in HBV infection .Semin Immunopathol.2013,35 (1):23

56. zhangcai , hanqiuju  and zhangjian. Pim-3 enhances melanoma cell migration and invasion by promoting STAT3 phosphorylation .1538-4047.2018

57. zhangcai , hanqiuju , zhangjian  and tianzhigang. Intestinal lamina propria CD4+T cells promote bactericidal activity of macrophages via galectin-9 and Tim-3 interaction during Salmonella typhimurium infection. .Infection and Immunity.2018

58. hanqiuju , zhangjian  and 赵荣荣. RNAi技术靶向HBV相关宿主因子治疗慢性乙肝的研究进展 .《生物化学与生物物理进展》.2018

59. hanqiuju , zhangcai  and zhangjian. 5'-triphosphate siRNA targeting HBx elicits a potent anti-HBV immune response in pAAV-HBV transfected mice. .抗病毒研究.2019 :23

60. hanqiuju , tianzhigang , zhangjian  and 王冠. IFN-γ protects from apoptotic neutrophil-mediated tissue injury during acute Listeria monocytogenes infection. .《Eur J Immunol》.2018

61. hanqiuju , zhangjian  and 郭全娟. CRISPR/Cas9技术的脱靶效应及优化策略 .《生物化学与生物物理进展》.2018

62. hanqiuju , lunan , zhangjian  and zhaohengli. HMBOX1 in hepatocytes attenuates LPS/D-GalN-induced liver injury by inhibiting macrophage infiltration and activation .Molecular Immunology.2018,101 :303

63. hanqiuju , zhangjian  and wanghaigang. Single dose HBsAg CS-gamma-PGA nanogels induce potent protective immune responses against HBV infection .European Journal of Pharmaceutics and Biopharmaceutics.2018,124 :82

64. zhangjian , zhangcai , hanqiuju  and Sun, Cheng. Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion .NATURE COMMUNICATIONS.2018,9

65. hanqiuju , zhangjian  and zhaohengli. Homeobox containing 1 inhibits liver cancer progression by promoting autophagy as well as inhibiting stemness and immune escape. .Oncol Rep..2018

66. tianzhigang , Hou Xuben , hanqiuju , lunan , zhangjian , zhangcai , 于馨 HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1 beta production via suppressing the NF-kappa B pathway and ROS production .Journal of Hepatology.2017, 66 (4):693

67. zhangcai , hanqiuju , zhangjian  and tianzhigang. HBV suppresses expression of MICA/B on hepatoma cells through up-regulation of transcription factors GATA2 and GATA3 to escape from NK cell surveillance .ONCOTARGET.2016,7 (35):56107

68. hanqiuju , zhangjian  and leihong. Trx系统与肿瘤细胞凋亡及免疫微环境的关系研究 .生命的化学.2017,37 (05):810

69. hanqiuju  and zhangjian. STAT3-blocked whole-cell hepatoma vaccine induces cellular and humoral immune response against HCC .Journal of Experimental & Clinical Cancer Research.2017, 36

70. hanqiuju , zhangcai  and zhangjian. 面向高校文科类专业学生开设《免疫学》通选课的探索 .《中国免疫学杂志》.2017,33 (06):922

71. hanqiuju , zhangjian , tianzhigang  and zhangcai. Reversal of hepatitis B virus-induced systemic immune tolerance by intrinsic innate immune stimulation. .J Gastroenterol Hepatol..2013

72. zhangjian , hanqiuju , zhangcai  and 张建. TLR2 and TLR9 play opposing roles in host innate immunity against Salmonella enterica Serovar Typhimurium infection. .Infect Immun.2015

73. zhangjian , hanqiuju , zhangcai  and 张建. Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a. .SCI REP.2016

74. zhangjian , hanqiuju , zhangcai , tianzhigang  and 张建. Poly(I:C) exhibits an anti-cancer effect in human gastric adenocarcinoma cells which is dependent on RLRs. .Int Immunopharmacol..2013,17 (3):814

75. hanqiuju , zhangjian  and 王亚群. 靶向阻断STAT3 增强肝癌细胞H22 对化疗药物阿霉素的敏感性 .《中国免疫学杂志》.2015

76. zhangjian , hanqiuju  and 张建. 肿瘤雌激素受体信号通路及其与肿瘤免疫应答间的交互作 .《中国免疫学杂志》.2016

77. zhangjian , hanqiuju , zhangcai  and 张建. TLR4 signaling promotes a COX-2/PGE2/STAT3 positive feedback loop in hepatocellular carcinoma (HCC) cells. .Oncoimmunology.2016,5 (2):e1074376.

78. zhangjian , hanqiuju , zhangcai  and 张建. Targeting blockage of STAT3 inhibits hepatitis B virus-related hepatocellular carcinoma .Cancer Biol Ther.2016

79. zhangjian , hanqiuju , zhangcai  and 张建. miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti-tumor immune suppression. .Cell Cycle.2015

80. zhangjian , hanqiuju , zhangcai  and 张建. Intracellular poly(I:C) initiated gastric adenocarcinoma cell apoptosis and subsequently ameliorated NK cell functions .J Interferon Cytokine Res.2014,34 (1):52

81. zhangjian , zhangcai , hanqiuju  and 张建. NK cells are the crucial antitumor mediators when STAT3-mediated immunosuppression is blocked in hepatocellular carcinoma. .J Immunol.2014,193 (4):2016

82. hanqiuju , zhangjian , tianzhigang  and zhangcai. The role of innate immunity in HBV infection .Semin Immunopathol.2013,35 (1):23

83. zhangcai , hanqiuju , zhangjian  and tianzhigang. Therapeutic recovery of HBV-induced hepatocyte-intrinsic immune defect reverses systemic adaptive immune tolerance. .Hepatology.2013

84. zhangjian , hanqiuju , zhangcai  and 张建. The anti-HBV effect mediated by a novel recombinant eukaryotic expression vector for IFN-α. .Virol J..2013,10 (270)

85. hanqiuju , zhangcai , zhangjian  and 徐东青. miR-146a negatively regulates NK cell functions via STAT1 signaling .CELLULAR & MOLECULAR IMMUNOLOGY.2017, 14 (8):712

86. zhangjian , hanqiuju  and leihong. Inhibiting TrxR suppresses liver cancer by inducing apoptosis and eliciting potent antitumor immunity .Oncology reports.2018,40 (6):3447

87. zhangjian , hanqiuju , zhangcai  and 张建. miR146a impairs the IFN-induced anti-HBV immune response by downregulating STAT1 in hepatocytes .Liver Int..2014,34 (1):58

88. hanqiuju , zhangjian  and zhangcai. Pim-3 enhances melanoma cell migration and invasion by promoting STAT3 phosphorylation .1538-4047.2018

89. hanqiuju , zhangjian , tianzhigang  and zhangcai. Intestinal lamina propria CD4+T cells promote bactericidal activity of macrophages via galectin-9 and Tim-3 interaction during Salmonella typhimurium infection. .Infection and Immunity.2018

90. zhangjian , zhangcai , hanqiuju  and Sun, Cheng. Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion .NATURE COMMUNICATIONS.2018,9

91. hanqiuju , zhangjian , tianzhigang  and zhangcai. HBV suppresses expression of MICA/B on hepatoma cells through up-regulation of transcription factors GATA2 and GATA3 to escape from NK cell surveillance .ONCOTARGET.2016,7 (35):56107

92. hanqiuju , zhangcai  and 张建. Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a. .SCI REP.2016

93. hanqiuju  and 张建. 肿瘤雌激素受体信号通路及其与肿瘤免疫应答间的交互作 .《中国免疫学杂志》.2016

94. hanqiuju , zhangcai  and 张建. miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti-tumor immune suppression. .Cell Cycle.2015

95. hanqiuju , zhangcai  and 张建. Intracellular poly(I:C) initiated gastric adenocarcinoma cell apoptosis and subsequently ameliorated NK cell functions .J Interferon Cytokine Res.2014,34 (1):52

96. zhangcai , hanqiuju  and 张建. NK cells are the crucial antitumor mediators when STAT3-mediated immunosuppression is blocked in hepatocellular carcinoma. .J Immunol.2014,193 (4):2016

97. hanqiuju , zhangjian , tianzhigang  and zhangcai. Therapeutic recovery of HBV-induced hepatocyte-intrinsic immune defect reverses systemic adaptive immune tolerance. .Hepatology.2013

98. hanqiuju , zhangcai  and 张建. TLR4 signaling promotes a COX-2/PGE2/STAT3 positive feedback loop in hepatocellular carcinoma (HCC) cells. .Oncoimmunology.2016,5 (2):e1074376.

99. hanqiuju , zhangjian , tianzhigang  and zhangcai. HBV suppresses expression of MICA/B on hepatoma cells through up-regulation of transcription factors GATA2 and GATA3 to escape from NK cell surveillance .ONCOTARGET.2016,7 (35):56107

100. zhangcai , hanqiuju  and 张建. NK cells are the crucial antitumor mediators when STAT3-mediated immunosuppression is blocked in hepatocellular carcinoma. .J Immunol.2014,193 (4):2016

101. hanqiuju , zhangcai  and 张建. Targeting blockage of STAT3 inhibits hepatitis B virus-related hepatocellular carcinoma .Cancer Biol Ther.2016

102. hanqiuju , zhangcai  and 张建. miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti-tumor immune suppression. .Cell Cycle.2015

103. hanqiuju , zhangcai  and 张建. Intracellular poly(I:C) initiated gastric adenocarcinoma cell apoptosis and subsequently ameliorated NK cell functions .J Interferon Cytokine Res.2014,34 (1):52

104. hanqiuju , zhangcai  and 张建. The anti-HBV effect mediated by a novel recombinant eukaryotic expression vector for IFN-α. .Virol J..2013,10 (270)

105. hanqiuju , zhangcai , tianzhigang  and 张建. Poly(I:C) exhibits an anti-cancer effect in human gastric adenocarcinoma cells which is dependent on RLRs. .Int Immunopharmacol..2013,17 (3):814

106. zhangjian , zhangcai  and 于馨. HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1 beta production via suppressing the NF-kappa B pathway and ROS production .Journal of Hepatology.2017, 66 (4):693

107. zhangjian , hanqiuju  and leihong. Inhibiting TrxR suppresses liver cancer by inducing apoptosis and eliciting potent antitumor immunity .Oncology reports.2018,40 (6):3447

108. hanqiuju  and 张建. 肿瘤雌激素受体信号通路及其与肿瘤免疫应答间的交互作 .《中国免疫学杂志》.2016

109. hanqiuju , zhangcai  and 张建. Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a. .SCI REP.2016

110. hanqiuju , zhangcai  and 张建. TLR2 and TLR9 play opposing roles in host innate immunity against Salmonella enterica Serovar Typhimurium infection. .Infect Immun.2015

111. hanqiuju , zhangcai  and 张建. miR146a impairs the IFN-induced anti-HBV immune response by downregulating STAT1 in hepatocytes .Liver Int..2014,34 (1):58

112. zhangjian , zhangcai , hanqiuju  and Sun, Cheng. Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion .NATURE COMMUNICATIONS.2018,9

113. hanqiuju , zhangjian  and zhaohengli. Homeobox containing 1 inhibits liver cancer progression by promoting autophagy as well as inhibiting stemness and immune escape. .Oncol Rep..2018

114. zhangjian , hanqiuju  and zhangcai. Pim-3 enhances melanoma cell migration and invasion by promoting STAT3 phosphorylation .1538-4047.2018

115. hanqiuju , tianzhigang , zhangjian  and 王冠. IFN-γ protects from apoptotic neutrophil-mediated tissue injury during acute Listeria monocytogenes infection. .《Eur J Immunol》.2018

116. hanqiuju , zhangjian  and 王亚群. 靶向阻断STAT3 增强肝癌细胞H22 对化疗药物阿霉素的敏感性 .《中国免疫学杂志》.2015

117. hanqiuju , zhangjian , tianzhigang  and zhangcai. Therapeutic recovery of HBV-induced hepatocyte-intrinsic immune defect reverses systemic adaptive immune tolerance. .Hepatology.2013

118. hanqiuju , zhangjian , tianzhigang  and zhangcai. The role of innate immunity in HBV infection .Semin Immunopathol.2013,35 (1):23

119. hanqiuju , zhangjian  and leihong. Trx系统与肿瘤细胞凋亡及免疫微环境的关系研究 .生命的化学.2017,37 (05):810

120. hanqiuju , zhangjian , tianzhigang  and zhangcai. Intestinal lamina propria CD4+T cells promote bactericidal activity of macrophages via galectin-9 and Tim-3 interaction during Salmonella typhimurium infection. .Infection and Immunity.2018

121. hanqiuju , lunan , zhangjian  and zhaohengli. HMBOX1 in hepatocytes attenuates LPS/D-GalN-induced liver injury by inhibiting macrophage infiltration and activation .Molecular Immunology.2018,101 :303

122. hanqiuju , zhangjian  and 赵荣荣. RNAi技术靶向HBV相关宿主因子治疗慢性乙肝的研究进展 .《生物化学与生物物理进展》.2018

123. hanqiuju , zhangjian  and 郭全娟. CRISPR/Cas9技术的脱靶效应及优化策略 .《生物化学与生物物理进展》.2018

124. hanqiuju , zhangcai , zhangjian  and 徐东青. miR-146a negatively regulates NK cell functions via STAT1 signaling .CELLULAR & MOLECULAR IMMUNOLOGY.2017, 14 (8):712

125. hanqiuju , zhangjian  and wanghaigang. Single dose HBsAg CS-gamma-PGA nanogels induce potent protective immune responses against HBV infection .European Journal of Pharmaceutics and Biopharmaceutics.2018,124 :82

126. zhangjian , zhangcai , tianzhigang  and hanqiuju. Reversal of hepatitis B virus-induced systemic immune tolerance by intrinsic innate immune stimulation. .J Gastroenterol Hepatol..2013

127. zhangcai , zhangjian  and hanqiuju. 面向高校文科类专业学生开设《免疫学》通选课的探索 .《中国免疫学杂志》.2017,33 (06):922

128. zhangcai , zhangjian  and hanqiuju. 5'-triphosphate siRNA targeting HBx elicits a potent anti-HBV immune response in pAAV-HBV transfected mice. .抗病毒研究.2019 :23

129. zhangjian  and hanqiuju. STAT3-blocked whole-cell hepatoma vaccine induces cellular and humoral immune response against HCC .Journal of Experimental & Clinical Cancer Research.2017, 36

Patens
Research project

1. 细胞培养耗材性能验证, 2023/10/30-2025/12/31

2. 霜桑叶质量标志物调控巨噬细胞免疫应答机制研究, 2023/11/17-2025/12/31

3. 桑叶提取物免疫调控机制研究, 2023/08/09-2024/08/14

4. (包干项目)HBV 慢性感染与代谢重编程, 2022/11/01-2025/12/30

5. 鲑降钙素注射液免疫原性研究, 2022/09/27-2023/08/24

6. 桑叶提取物免疫分子机制研究, 2022/06/01-2022/10/01

7. 间充质干细胞及外泌体分离鉴定技术指导, 2022/03/08-2023/03/08

8. 嵌合抗原受体(CAR)靶向细胞免疫治疗通用性技术的建立(原创CAR-NK细胞研发), 2022/01/10-2024/01/09

9. 介导HBV肝脏免疫耐受/耗竭的关键卡控点分子的发现与验证, 2021/12/21-2024/11/30

10. SALL4介导的糖酵解在肝癌免疫逃逸中的调控作用及分子机制, 2019/08/16-2023/12/31

11. 靶向B7-H6嵌合型抗原受体技术修饰NK细胞(CAR-NK)的建立及抗肿瘤作用研究, 2019/07/08-2021/12/31

12. 基于肿瘤干细胞标志物APN/CD13为靶标的抗癌先导物的发现, 2013/08/15-2017/12/31

13. 癌胚蛋白SALL4再激活诱导免疫细胞耗竭及机制探讨, 2017/08/17-2021/12/31

14. 肝脏γδT细胞的区域免疫学特性及在维持肝脏免疫耐受中的作用, 2015/01/01-2017/12/31

15. NK细胞免疫编辑参与肝脏肿瘤的发生发展及其机制探讨, 2014/08/15-2018/12/31

16. 靶向HBx的双功能shRNA纠正HBV免疫耐受及分子机制, 2012/08/17-2016/12/31

17. HBV感染再激活SALL4诱导T细胞耗竭的分子机制探讨, 2017/08/01-2019/12/31

18. 5′-triphosphate-siRNA逆转HBV诱导的NK细胞功能低下的机制研究, 2012/08/17-2015/12/31

Research Group
Title
炎症性疾病与免疫治疗
Description of Research Group:
Members
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