Biography

姜新义，山东大学药学院/齐鲁医院教授，博导，国家杰出青年基金获得者，国家高层次青年人才，国家重点研发计划首席科学家，国家高层次青年人才，国际先进材料协会会士，国家药监局创新药物临床研究与评价重点实验室副主任，山东省靶向递药与高端制剂重点实验室主任，“智能材料与药物精准递送”团队PI。先后承担国家基金委原创探索、国合重点项目，国家重点研发计划重点项目，山东省重点、重大项目等20余项；在Nature Cancer，Science Translational Medicine，Nature Nanotechnology，PNAS等TOP期刊发表原创论文70余篇；申报国家发明专利 50余项、PCT专利4项，美国专利5项，20余项已获授权，成果转让3项。应邀在国际控释协会、中国药学大会等国内外学术会议上做大会报告百余次，获得国际先进材料协会科学家奖等。指导学生获得教育部“博新”人才计划资助（2人）、基金委-博士生项目资助（2人），全国药学专业学位研究生优秀学位论文（1人），山东省研究生优秀成果一等奖（2人）等。



Education
  • 2013/04/02-2017/10/31
    斯坦福大学
    Biomedical Engineering
    Postgraduate (Postdoctoral)
  • 2009/09/01-2012/06/26
    复旦大学
    药剂学
Professional Experience
  • 2017-11 — Now
    齐鲁医学院 药学院山东大学
  • 2013-04 — 2017-10
    医学院斯坦福大学
Publication
Research direction

1. 核酸药物递释系统设计及转化应用； 基于纳米医学的重大疾病诊疗新策略； 生物医学工程

Papers

(1) Implantable Microneedle-Mediated Eradication of Postoperative Tumor Foci Mitigates Glioblastoma Relapse .ADVANCED MATERIALS .2024

(2) mRNA-Laden Lipid-Nanoparticle-Enabled in Situ CAR-Macrophage Engineering for the Eradication of Multidrug-Resistant Bacteria in a Sepsis Mouse Model .ACS nano .2024 ,18 (3):2261-2278

(3) Stimulation of tumoricidal immunity via bacteriotherapy inhibits glioblastoma relapse .NATURE COMMUNICATIONS .2024 ,15 (1)

(4) Realveolarization with inhalable mucus-penetrating lipid nanoparticles for the treatment of pulmonary fibrosis in mice .Science Advances .2024 ,10 (24)

(5) Intracavitary Spraying of Nanoregulator-Encased Hydrogel Modulates Cholesterol Metabolism of Glioma-Supportive Macrophage for Postoperative Glioblastoma Immunotherapy .ADVANCED MATERIALS .2023

(6) Trojan Horse Nanocapsule Enabled In Situ Modulation of the Phenotypic Conversion of Th17 Cells to Treg Cells for the Treatment of Multiple Sclerosis in Mice .ADVANCED MATERIALS .2023 ,35 (11)

(7) Intracavity generation of glioma stem cell–specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy .SCIENCE TRANSLATIONAL MEDICINE .2022 (14)

(8) Cell membrane derived liposomes loaded with DNase I target neutrophil extracellular traps which inhibits colorectal cancer liver metastases .Journal of Controlled Release .2023 ,357 :620-629

(9) Remodeling articular immune homeostasis with an efferocytosis-informed nanoimitator mitigates rheumatoid arthritis in mice .NATURE COMMUNICATIONS .2023 ,14 (1)

(10) In situ MUC1-specific CAR engineering of tumor-supportive macrophages stimulates tumoricidal immunity against pancreatic adenocarcinoma .NANO TODAY .2023 ,49

(11) Metabolic Modulation of Intracellular Ammonia via Intravesical Instillation of Nanoporter-Encased Hydrogel Eradicates Bladder Carcinoma .Advanced Science .2023 ,10 (12)

(12) Surficial nano-deposition locoregionally yielding bactericidal super CAR-macrophages expedites periprosthetic osseointegration .Science Advances .2023 ,9 (22)

(13) Leveraging tumor cell ferroptosis for colorectal cancer treatment via nanoelicitor-activated tumoricidal immunity .Chemical Engineering Journal .2022 ,430

(14) Inhaled mRNA Nanoformulation with Biogenic Ribosomal Protein Reverses Established Pulmonary Fibrosis in a Bleomycin-Induced Murine Model .ADVANCED MATERIALS .2022 ,34 (14):e2107506

(15) Bioinspired nano-painting on orthopedic implants orchestrates periprosthetic anti-infection and osseointegration in a rat model of arthroplasty .Chemical Engineering Journal .2022 ,435

(16)刘毅. Galectin-1 inhibited LPS-induced autophagy and apoptosis of human periodontal ligament stem cells .Inflammation .2021 ,44 (4):1302

(17)高琼琼. Reply to "Comment on 'In Situ Mannosylated Nanotrinity-Mediated Macrophage Remodeling Combats Candida Albicans Infection"' .ACS nano .2021 ,15 (3):3544

(18)Abdalla, Mohnad. Progress in research on the S protein as the target of COVID-19 vaccines .EXPERT REVIEW OF VACCINES .2021

(19)张晶. Immunostimulant hydrogel for the inhibition of malignant glioma relapse post-resection .NATURE NANOTECHNOLOGY .2021

(20)Kong, Degang. Chemoembolizing hepatocellular carcinoma with microsphere cored with arsenic trioxide microcrystal .Drug Delivery .2020 ,27 (1):1729

(21)陈晨. In situ tuning proangiogenic factor-mediated immuno-tolerance synergizes the tumoricidal immunity via a hypoxia-triggerable liposomal bio-nanoreactor .THERANOSTICS .2020 ,10 (26):11998

(22)杜微. Eliciting an immune hot tumor niche with biomimetic drug-based multi-functional nanohybrids augments immune checkpoint blockade-based breast cancer therapy .NANOSCALE .2020 ,12 (5):3317

(23)陈晨. Efficiently restoring the tumoricidal immunity against resistant malignancies via an immune nanomodulator .Journal of Controlled Release .2020 ,324 :574

(24)高琼琼. In Situ Mannosylated Nanotrinity-Mediated Macrophage Remodeling Combats Candida albicans Infection .ACS nano .2020 ,14 (4):3980

(25)Jiang Xinyi. Efficiently Restoring the Tumoricidal Immunity Resistant Malignancies via an Immune Nanomodulator .Journal of Controlled Release .2020

(26)Jiang Xinyi. Eliciting an Immune Hot Tumor Niche with Biomimetic Drug-based Multi-functional Nanohybrids Augments Immune Checkpoint Blockade-based Breast Cancer Therapy .Nanoscale .2020 :3317

(27)Jiang Xinyi. In situ mannosylated nanotrinity-mediated macrophages remodeling combats Candida albicans infection .ACS nano .2020

(28)Jiang Xinyi. Targeting Tumor Hypoxia Using Nanoparticle-engineered CXCR4-overexpressing Adipose-derived Stem Cells .Theranostics .2018

Patens

1. 靶向MRSA嵌合抗原受体、药物递送体、CAR-巨噬细胞及应用

2. 一种基于Tris的可电离脂质及其制备方法与应用

3. 一种碱基可电离脂质及其制备方法与应用

4. 基于1,4-二氧六环-2,5-二酮母核的可电离脂质及其制备方法与应用

5. 基于环己二胺的可电离脂质、脂质纳米颗粒及其制备方法与应用

6. 基于内源性二羧酸的可电离脂质及其制备方法与应用

7. 一种可注射水凝胶的制备方法及其在术后肿瘤治疗中的应用

8. 一种金属多酚纳米复合物及其制备方法和应用

9. 在体生成CAR-巨噬细胞的制备方法及肿瘤免疫治疗中的应用

10. 一种ICD诱导剂-IDO抑制剂及制备方法与应用

11. 一种超分子纳米药物及在制备抗肿瘤制剂中的应用

12. 一种乏氧响应脂质体及在制备抗肿瘤药物中的应用

13. 一种基因与化学小分子共递送系统及在肿瘤治疗中的应用

14. 聚乙二醇化的ICD诱导剂-IDO抑制剂纳米缀合物及制备方法与应用

Research Projects

1. 泌尿男生殖系疾病精准诊疗工程研究中心, 2025/01/01-2027/12/31

2. 巨噬细胞时空可控工程化改造关键技术及转化应用研究, 2024/12/01-2029/11/30

3. 巨噬细胞时空可控工程化改造关键技术及转化应用研究 , 2024/12/01-2029/11/30

4. （包干项目）核酸递释载体与成药性, 2024/08/23-2029/12/31

5. CAR-巨噬细胞在体编辑载体及内吞增效机制研究, 2023/12/28-2026/12/31

6. 纳米肿瘤疫苗关键科学问题及设计原理研究, 2023/01/01-2025/12/31

7. 基于“肿瘤芯片”的siRNA纳米制剂优化及其调控胆固醇代谢治疗脑胶质瘤机制研究, 2021/12/13-2024/09/30

8. 重大核酸创新药物靶向递送载体关键技术研究与开发, 2021/10/29-2024/12/31

9. 基于纳米载体-水凝胶杂合系统的小胶质/巨噬细胞CAR结构编辑及其治疗术后脑胶质瘤免疫机制研究, 2021/08/18-2025/12/31

10. 基于纳米载体-水凝胶杂合系统的小胶质/巨噬细胞CAR结构编辑及其治疗术后脑胶质瘤免疫机制研究, 2021/10/12-2025/12/31

11. 靶向肝癌的 RNAi 智能纳米递送系统设计与研发关键技术, 2019/06/01-2021/12/31

12. 用于乏氧实体瘤治疗的高效给药系统的研发, 2019/07/08-2021/12/31

13. 靶向肝癌的RNAi智能纳米递送系统设计与研发关键技术-1, 2019/11/21-2021/12/31

14. 基于干细胞源性外泌体的恶性实体肿瘤深部递药和克服化疗耐药新策略研究, 2019/07/08-2021/11/30

15. 基于“自体白蛋白修饰”策略构建仿生隐身型小分子自组装纳米药物, 2019/04/26-2022/06/30

Teaching Experience

1. 医学前沿

Student Information
  • 张子阳  2023/09/23 Hits:[] Times
  • 岳啸  2023/09/23 Hits:[] Times
  • 贾臻  2023/09/23 Hits:[] Times
  • 杨贞梅  2023/09/23 Hits:[] Times
  • 唐春伟  2023/09/23 Hits:[] Times
  • 姚子超  2023/09/23 Hits:[] Times
  • 刘妙言  2023/09/23 Hits:[] Times
  • 孙唯一  2023/09/23 Hits:[] Times
  • 孔智超  2023/09/23 Hits:[] Times
  • 郑作林  2023/09/23 Hits:[] Times
  • 刘颖  2023/09/23 Hits:[] Times
  • 付志鹏  2023/09/23 Hits:[] Times
  • 韩坤  2023/09/23 Hits:[] Times
  • 高晋昕  2023/09/23 Hits:[] Times
  • 韩茂森  2023/09/23 Hits:[] Times
  • 王艳  2023/09/23 Hits:[] Times
  • 唐春伟  2023/09/23 Hits:[] Times
  • 杨贞梅  2023/09/23 Hits:[] Times
    • Copyright All Rights Reserved Shandong University Address: No. 27 Shanda South Road, Jinan City, Shandong Province, China: 250100
    Information desk: (86) - 0531-88395114
    On Duty Telephone: (86) - 0531-88364731 Construction and Maintenance: Information Work Office of Shandong University