Gender:Female
Date of Employment:2006-07-16

Contact Information:liangxiaohong@sdu.edu.cn
Discipline:Immunology
Discipline:Immunology

梁晓红

Professor

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Degree:博士
Education Level:Postgraduate (Doctoral)
Alma Mater:山东大学
Status:Employed
Title:Professor
School/Department:Shandong University

Biography

Xiaohong Liang Ph.D Department of Immunology, Shandong UniversityTaishan Scholars Distinguished ExpertsOutstanding Young and Middle-aged Scholars of Shandong University Xiaohong Liang research group focuses on regulation of cancer immune microenvironment. The goal is to explore the novel strategies of tumor immunotherapy. Much of the focus is on how innate immune cells, including macrophages and NK cells, is manipulated in tumor microenvironment and involve in tumor development. Scientific publications, 7 selected1. Tian P, Yang W, Guo X, Wang T, Tan S, Sun R, Xiao R, Wang Y, Jiao D, Xu Y, Wei Y, Wu Z, Li C, Gao L, Ma C*, Liang X*. Early life gut microbiota sustains liver-resident natural killer cells maturation via the butyrate-IL-18 axis. Nat Commun. 2023 Mar 27;14(1):1710.2. Guo X#, Tan S, Wang T, Sun R, Li S, Tian P, Li M, Wang Y, Zhang Y, Yan Y, Dong Z, Yan L, Yue X, Wu Z, Li C, Yamagata K, Gao L, Ma C, Li T*, Liang X*. NAD+ salvage governs mitochondrial metabolism, invigorating natural killer cell antitumor immunity. Hepatology . 2023 Aug 1;78(2):468-485.3. Jiao D#, Sun R, Ren X, Wang Y, Tian P, Wang Y, Yuan D, Yue X, Wu Z, Li C, Gao L, Ma C*, Liang X*. Lipid accumulation-mediated histone hypoacetylation drives persistent NK cell dysfunction in anti-tumor immunity. Cell Rep. 2023 Oct 3;42(10):113211.4. Tan S, Wang Z, Li N, Guo X, Zhang Y, Ma H, Peng X, Zhao Y, Li C, Gao L, Li T, Liang X*, Ma C*. Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response. Cell Death Differ. 2023 Sep;30(9):2104-2119.5. Xiao R#, Tian Y#, Zhang J, Li N, Qi M, Liu L, Wang J, Li Z, Zhang J, Zhao F, Wang T, Tan S, Li C, Wu Z, Yu M, Jiang X, Zhan P, Gao L, Han B*, Liu X*, Liang X*, Ma C*. Increased Siglec-9/Siglec-9L interactions on NK cells predict poor HCC prognosis and present a targetable checkpoint for immunotherapy. J Hepatol. 2024 Feb 7:S0168-8278(24)00106-5.6. Wang T#, Zhang J#, Li N, Li M, Ma S, Tan S, Guo X, Wang Z, Wu Z, Gao L, Ma C*, Liang X*. Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development. Mol Ther. 2022 Mar 2;30(3):1135-11487. Cheng, Y.#, Bai, F.#, Ren, X.#, Sun, R., Guo, X., Liu, W., Wang, B., Yang, Y., Zhang, X., Xu, Y., Li, C., Yang, X., Gao, L., Ma, C., Li, X.*, & Liang, X*. (2022). Phosphoinositide-Binding Protein TIPE1 Promotes Alternative Activation of Macrophages and Tumor Progression via PIP3/Akt/TGFβ Axis. Cancer research, 82(8), 1603–1616. Contact：liangxiaohong@sdu.edu.cn

Education
  • 2001.7 -- 2006.7
    山东大学 , 医学免疫学  , Doctoral Degree in Medicine
  • 1996.9 -- 2001.7
    山西省长治医学院 , 临床医学  , Bachelor
Professional Experience
  • 2013.12 -- Now
    山东大学
  • 2013.01 -- 2013.12
    美国宾夕法尼亚大学
  • 2008.10 -- 2013.01
    山东大学
  • 2006.07 -- 2008.10
    山东大学
Social Affiliations
  • 2023.6 -- 2024.5
    山东省免疫学会基础专业委员会
Research Focus
Research Group

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