李单单，博士，硕士生导师、助理研究员。主要从事微生物生态学研究，基于微生物组学大数据分析糖苷水解酶的全球分布和生态作用。发表SCI论文14篇，其中，以第一或通讯作者发表期刊论文7篇，主要包括Microbiome、Nucleic Acids Research、Global Ecology and Biogeography、Environmental Microbiology等期刊。作为主持人主持国家自然科学基金青年项目1项，中国博士后科学基金面上项目1项，青岛市应用研究项目1项。作为项目骨干参与了5项包括国家自然科学基金、国家科技重大专项等在内的国家级科研项目。

• 2014/09/01-2020/06/15
  北京生命科学研究所/中国农业大学
  生物化学与分子生物学
• 2010/09/01-2013/06/30
  山东大学
  微生物学
• 2006/09/01-2010/06/30
  山东大学
  生物技术

• 2020-08 — 2023-03
  山东大学
  博士后
• 2023-03 — Now
  海洋研究院山东大学
  助理研究员
• 2017-02 — 2018-05
  Michigan State University
  访问学者

1. 多糖降解微生物群落；生物信息学​

(1) Quantifying functional redundancy in polysaccharide-degrading prokaryotic communities .MICROBIOME .2024 ,12 (1)

(2)Zhuo Pan†, Dan-dan Li†, Peng Li, Yu Geng, Yiru Jiang, Ya Liu, Yue-zhong Li* and Zheng Zhang*. GDPF: a data resource for the distribution of prokaryotic protein families across the global biosphere .Nucleic Acids Research .2023 ,52 (D1):D724-D731

(3)Dan-dan Li†, Zheng Zhang†*, Peng Zhang, Jia-ning Wang, Ya Liu, Yue-zhong Li*. Deterministic assembly processes shaping habitat-specific glycoside hydrolase composition .Global Ecology and Biogeography .2023 ,33 :189-202

(4)Dan-dan Li, Zheng Zhang*, Jia-ning Wang, Peng Zhang, Ya Liu, Yue-zhong Li*. Estimate of the degradation potentials of cellulose, xylan, and chitin across global prokaryotic communities .Environmental Microbiology .2023 (25):397-409

(5) Machine Learning Advances in Microbiology: A Review of Methods and Applications. .Frontiers in Microbiology .2022 ,13 :925454

(6)Dan-dan Li, Jin-lan Wang, Ya Liu, Yue-zhong Li*, Zheng Zhang*. Expanded analyses of the functional correlations within structural classifications of glycoside hydrolases .Computational and Structural Biotechnology Journal .2021 ,19 :5931–5942

(7)Dan-dan Li, Jinlan Wang, Zichen Jin, Zheng Zhang*. Structural and evolutionary characteristics of dynamin-related GTPase OPA1 .PeerJ .2019 ,7 :e7285

(8) PAT: a comprehensive database of prokaryotic antimicrobial toxins .Nucleic Acids Research .2023 (51):D452-D459

(9) Docking-guided rational engineering of a macrolide glycosyltransferase glycodiversifies epothilone B .Communications Biology .2022 ,5 :1-11

(10) PAAR proteins are versatile clips that enrich the antimicrobial weapon arsenals of prokaryotes .mSystems .2021 ,6 :e00953-21

(11) Identification of type VI secretion system toxic effectors using an adaptor as a marker .Computational and Structural Biotechnology Journal .2020 ,18 :3723-3733

(12) Bacteriophytochrome from Magnetospirillum magneticum affects phototactic behavior in response to light .FEMS Microbiology Letters .2020 ,367

(13) Subsite-specific contributions of different aromatic residues in the active site architecture of glycoside hydrolase family 12 .Scientific Reports .2015 ,5 :18357

(14) Determination of the action modes of cellulases from hydrolytic profiles over a time course using fluorescence-assisted carbohydrate electrophoresis .Electrophoresis .2015 ,36 :910-917

1. （包干项目）全球原核生物群落功能冗余的定量评估及形成机制研究, 2023/08/24-2026/12/31