李单单，博士，硕士生导师、助理研究员。主要从事微生物生态学研究，基于微生物组学大数据分析糖苷水解酶的全球分布和生态作用。发表SCI论文14篇，其中，以第一或通讯作者发表期刊论文7篇，主要包括Microbiome、Nucleic Acids Research、Global Ecology and Biogeography、Environmental Microbiology等期刊。作为主持人主持国家自然科学基金青年项目1项，中国博士后科学基金面上项目1项，青岛市应用研究项目1项。作为项目骨干参与了5项包括国家自然科学基金、国家科技重大专项等在内的国家级科研项目。

• 2014/09/01-2020/06/15
  北京生命科学研究所/中国农业大学
  生物化学与分子生物学
• 2010/09/01-2013/06/30
  山东大学
  微生物学
• 2006/09/01-2010/06/30
  山东大学
  生物技术

• 2020-08 — 2023-03
  山东大学
  博士后
• 2023-03 — Now
  海洋研究院山东大学
  助理研究员
• 2017-02 — 2018-05
  Michigan State University
  访问学者

1. 多糖降解微生物群落；生物信息学​

(1)Dan-dan Li, Jianing Wang, Yiru Jiang, Peng Zhang, Ya Liu, Yue-zhong Li, Zheng Zhang. Quantifying functional redundancy in polysaccharide-degrading prokaryotic communities .Microbiome .2024 ,12 (1)

(2)Zhuo Pan, Dan-dan Li, Peng Li, Yu Geng, Yiru Jiang, Ya Liu, Yue-zhong Li, Zheng Zhang. GDPF: a data resource for the distribution of prokaryotic protein families across the global biosphere .Nucleic Acids Research .2024 ,52 (D1):D724-D731

(3)Dan‐dan Li, Zheng Zhang, Peng Zhang, Jia‐ning Wang, Ya Liu, Yue‐zhong Li. Deterministic assembly processes shaping habitat-specific glycoside hydrolase composition .Global Ecology and Biogeography .2024 ,33 :189-202

(4)Dan‐dan Li, Zheng Zhang, Jia‐ning Wang, Peng Zhang, Ya Liu, Yue‐zhong Li. Estimate of the degradation potentials of cellulose, xylan, and chitin across global prokaryotic communities .Environmental Microbiology .2023 (25):397-409

(5) Machine Learning Advances in Microbiology: A Review of Methods and Applications .Frontiers in Microbiology .2022 ,13 :925454

(6)Dan-dan Li, Jin-lan Wang, Ya Liu, Yue-zhong Li, Zheng Zhang. Expanded analyses of the functional correlations within structural classifications of glycoside hydrolases .Computational and Structural Biotechnology Journal .2021 ,19 :5931–5942

(7)Dan-dan Li, Jinlan Wang, Zichen Jin, Zheng Zhang. Structural and evolutionary characteristics of dynamin-related GTPase OPA1 .PeerJ .2019 ,7 :e7285

(8) PAT: a comprehensive database of prokaryotic antimicrobial toxins .Nucleic Acids Research .2023 (51):D452-D459

(9) Docking-guided rational engineering of a macrolide glycosyltransferase glycodiversifies epothilone B .Communications Biology .2022 ,5 :1-11

(10) PAAR proteins are versatile clips that enrich the antimicrobial weapon arsenals of prokaryotes .mSystems .2021 ,6 :e00953-21

(11) Identification of type VI secretion system toxic effectors using an adaptor as a marker .Computational and Structural Biotechnology Journal .2020 ,18 :3723-3733

(12) Bacteriophytochrome from Magnetospirillum magneticum affects phototactic behavior in response to light .FEMS Microbiology Letters .2020 ,367

(13) Subsite-specific contributions of different aromatic residues in the active site architecture of glycoside hydrolase family 12 .Scientific Reports .2015 ,5 :18357

(14) Determination of the action modes of cellulases from hydrolytic profiles over a time course using fluorescence-assisted carbohydrate electrophoresis .Electrophoresis .2015 ,36 :910-917

1. （包干项目）基于海洋宏基因组大数据高通量挖掘微生物多糖降解酶研究, 2025/01/01-2027/12/31

2. （包干项目）全球原核生物群落功能冗余的定量评估及形成机制研究, 2023/08/24-2026/12/31