姓名：李洪凯 

邮箱：lihongkaiyouxiang@163.com

联系地址：济南市市中区二环东路12550号国家健康医疗大数据研究院

李洪凯，国家健康医疗大数据研究院大数据因果推断中心主任，山东大学公共卫生学院正高级研究员，山东省产业技术研究院特聘研究员。中国现场统计研究会因果推断分会常务理事，中国工业统计研究会健康医疗大数据学会理事，山东省脑胶质瘤多学科联合委员会委员。主要研究方向包括未知混杂的控制方法、因果推断框架下的数据整合，中介效应分析，测量误差和选择性偏倚的控制方法以及统计遗传方法学研究。在国际知名杂志发表SCI文章60余篇（JCR一区论文 15 篇），其中第一和通讯作者文章20篇。主要研究成果发表在Plos Genetics, Statistical Methods in Medical Research, Statistics in Medicine，American Journal of Epidemiology等统计理论方法杂志以及British Journal of Cancer, Atherosclerosis，Obesity, Journal of American Heart Association 等临床应用杂志上, 同时也是Plos Medicine, International Journal of Epidemiology等多个杂志审稿人。主持国家自然科学基金和科技部重大专项子课题等7项国家级和省部级课题，参编书籍三部。

欢迎关注微信公众号：因果推断

• 2007/09/01-2011/06/30
  烟台大学
  数学与应用数学
• 2011/09/01-2016/12/30
  山东大学
  流行病与卫生统计专业

• 2019-12 — Now
   因果推断中心  国家健康医疗大数据研究院 
  主任
• 2017-3 — 2019-12
   数学与信息科学学院  北京大学 

1. 主要研究方向包括未知混杂的控制方法、因果推断框架下的数据整合，中介效应分析，测量误差和选择性偏倚的控制方法以及时间序列框架下的因果推断问题。

(1) 吴思佳. Comparative efficacy and safety of glucose-lowering drugs in children and adolescents with type 2 diabetes: A systematic review and network meta-analysis .Frontiers in Endocrinology .2022 ,13 (897776)

(2) 于媛媛. Identification and Estimation of Causal Effects Using a Negative-Control Exposure in Time-Series Studies With Applications to Environmental Epidemiology .AMERICAN JOURNAL OF EPIDEMIOLOGY .2020 (1476-6256):468

(3) 吴雨桐. 基于Apriori算法分析2021年山东省医疗器械不良事件的关联性 .山东大学学报（医学版） .2022 ,60 (12):111

(4) 吴思佳. Comparative efficacy and safety of glucose-lowering drugs in children and adolescents with type 2 diabetes: A systematic review and network meta-analysis .Frontiers in Endocrinology .2022 ,13 (897776)

(5) 司书成. Exploring the Causal Roles of Circulating Remnant Lipid Profile on Cardiovascular and Cerebrovascular Diseases: Mendelian Randomization Study .JOURNAL OF EPIDEMIOLOGY .2022 ,32 (5):205

(6) 刘新辉. Genetically Predicted Insomnia in Relation to 14 Cardiovascular Conditions and 17 Cardiometabolic Risk Factors: A Mendelian Randomization Study .JOURNAL OF THE AMERICAN HEART ASSOCIATION .2021 ,10 (15)

(7)  Causal Mediation Analysis with Multiple Causally Ordered and Non-ordered Mediators based on Summarized Genetic Data .Statistical Methods in Medical Research .2022

(8)  Impact of Nonrandom Selection Mechanisms on the Causal Effect Estimation for Two-sample Mendelian Randomization Methods .Plos Genetics .2022

(9) 侯蕾. Exploring the causal pathway from ischemic stroke to atrial fibrillation: a network Mendelian randomization study .molecular medicine .2020 ,26 (1)

(10) 李洪凯. Causal data fusion methods using summary-level statistics for a continuous outcome .STATISTICS IN MEDICINE .2020 ,39 (8):1054

(11) 司书成. Causal Pathways from Body Components and Regional Fat to Extensive Metabolic Phenotypes: A Mendelian Randomization Study .OBESITY / 27th Annual Scientific Meeting of t .2020 ,28 (8):1536

(12) 魏佳特. Impacts of transportation and meteorological factors on the transmission of COVID-19 .International Journal of Hygiene and Environmental Health .2020 ,230

(13) 司书成. Causal Effect of the Triglyceride-Glucose Index and the Joint Exposure of Higher Glucose and Triglyceride With Extensive Cardio-Cerebrovascular Metabolic Outcomes in the UK Biobank: A Mendelian Randomization Study .2021 ,7

(14) 于媛媛. Identification and Estimation of Causal Effects Using a Negative-Control Exposure in Time-Series Studies With Applications to Environmental Epidemiology .AMERICAN JOURNAL OF EPIDEMIOLOGY .2021 ,190 (3):468

(15) 侯磊. Exploring the causal pathway from bilirubin to CVD and diabetes in the UK biobank cohort study: Observational findings and Mendelian randomization studies .2021 ,320 :112

(16) 于媛媛. Identification and Estimation of Causal Effects Using a Negative-Control Exposure in Time-Series Studies With Applications to Environmental Epidemiology .AMERICAN JOURNAL OF EPIDEMIOLOGY .2020 (1476-6256)

(17) 魏佳特. Impacts of transportation and meteorological factors on the transmission of COVID-19 .INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH .2020 (230：113610)

(18) Yu, Yuanyuan. The alarming problems of confounding equivalence using logistic regression models in the perspective of causal diagrams .BMC MEDICAL RESEARCH METHODOLOGY .2017 , 17

(19) 李洪凯. A novel path-specific effect statistic for identifying the differential specific paths in systems epidemiology .BMC genetics .2020 ,21 (1)

(20) 刘璐. A novel method for controlling unobserved confounding using double confounders .BMC MEDICAL RESEARCH METHODOLOGY .2020 ,20 (1)

(21) Yuanyuan Yu,Hongkai Li. The identification and estimation of causal effect using a Negative control exposure in time series studies with application to environment epidemiology .American Journal of Epidemiology .2021

(22) Hongkai Li,Yuanyuan Yu. A negative control outcome regression method for controlling unobserved confounding and lagged effect in time series .American Journal of Epidemiology .2021

(23) Hongkai Li. Causal data fusion methods using summary-level statistics for a continuous outcome .Statistics in Medicine .2020

(24) Hongkai Li. A causal data fusion method for a general outcome .Statistics in Medicine .2021

(25) Hongkai Li. A novel path-specific effect statistic for identifying the differential specific paths in systems epidemiology .BMC genet .2020

(26) Hongkai Li. A novel Markov Blanket-based repeated-fishing strategy for capturing phenotype-related biomarkers in big omics data .BMC Genet .2016

(27) Hongkai Li. A simulation study on matched case-control designs in the perspective of causal diagrams .BMC Medical Research Methodology .2016

(28) Xinhui Liu,Hongkai Li. Detection, reduction and correlation of unobserved confounding in the presence of an error-prone negative control exposure: bias analysis and correction methods .Epidemiology .2021

(29) Yuanyuan Yu,Hongkai Li. The alarming problems of confounding equivalence using logistic regression models in the perspective of causal diagrams. .BMC Med Res Methodol .2017

(30) Lu Liu,Lei Hou. A novel method for controlling unobserved confounding using double confounders .BMC medical research methodology .2020

(31) Shucheng Si. Exploring the causal roles of circulating remnant lipid profile on cardiovascular and cerebrovascular diseases: Mendelian randomization study .Journal of Epidemiology .2020

(32) Lei Hou,Hongkai Li. Exploring the causal pathway from ischemic stroke to atrial fibrillation: a network Mendelian randomization study .Mol Med .2020

(33) Xinhui Liu,Hongkai Li. Genetically predicted insomnia in relation to 14 cardiovascular conditions and 17 cardiometabolic risk factors: a Mendelian randomization study .Journal of the American Heart Association .2021

(34) Lei Hou,Hongkai Li. Causal Effects of Bilirubin on CVD and Diabetes in the UKBiobank Cohort Study: Observational findings and Mendelianrandomization studies .Atherosclerosis .2021

1. 一种基于因果网络不确定性推理的疾病预测预警系统

1. 有源医疗器械不良事件风险信号挖掘评价方法研究, 2021/10/09-2022/09/30

2. 大数据背景下循证因果迁移学习的统计方法研究, 2021/10/12-2025/12/31

3. 因果机制下系统流行病学的跨组学因果调控网络特定通路推断和多重靶向干预的方法研究, 2020/09/27-2023/12/31

4. 国家自然基金青年基金