刘博洋，男，内蒙古呼和浩特人，博士，副研究员，硕士生导师。山东省泰山学者青年专家，山东省优秀青年科学基金（海外）获得者。2016年毕业于德国哥廷根大学发育生物学专业，获自然科学博士学位。长期从事早期胚胎发育调控机制方面的研究，主要关注人类胚胎发育调控异常导致的妊娠失败和生殖障碍。累计发表SCI论文10余篇，目前承担国家重点研发计划项目1项、国家自然科学基金青年项目1项、山东省自然科学基金青年项目1项。
1.早期胚胎发育的代谢调控规律
2.围植入期胚胎细胞谱系分化调控机制
3.胚胎发育异常与生殖障碍
(1) 张传鑫.2-bromoacetamide exposure impairs oocyte maturation in mice and humans primarily via disrupting the cytoskeleton.Ecotoxicology and Environmental Safety.2024,272
(2) 陈晓蕾.Calcium ionophore improves embryonic development and pregnancy outcomes in patients with previous developmental problems in ICSI cycles.BMC PREGNANCY AND CHILDBIRTH.2022,22 (1)
(3) 吴克良.Proteomic analysis implicates that postovulatory aging leads to aberrant geneexpression, biosynthesis, RNA metabolism and cell cycle in mouse oocytes.JOURNAL OF OVARIAN RESEARCH.2022 (112)
(4) 宋劲竹.Functional substitution of zona pellucida with modified sodium hyaluronate gel in human embryos.JOURNAL OF ASSISTED REPRODUCTION AND GENETICS.2022
(5) Zou, Zhuoning.Translatome and transcriptome co-profiling reveals a role of TPRXs in human zygotic genome activation..2022 :eabo7923
(6) 刘博洋.Temporal Gradients Controlling Embryonic Cell Cycle.BIOLOGY-BASEL.2021,10 (6)
(7) 刘博洋.Fluorescence Fluctuation Analysis Reveals PpV Dependent Cdc25 Protein Dynamics in Living Embryos.PLOS Genetics.2020,16 (4)
(8) 刘博洋.A Link between Deoxyribonucleotide Metabolites and Embryonic Cell-Cycle Control.Current Biology.2019,29 (7)
(9) 刘博洋.The Role of dNTP Metabolites in Control of the Embryonic Cell Cycle.Cell Cycle.2019,18 (21)
(10) 刘博洋.Multiple Functions of the Essential Gene PpV in Drosophila Early Development.G3-Genes Genomes Genetics.2019,9 (11)
(11) 刘博洋.Link of Zygotic Genome Activation and Cell Cycle Control.Meth Mol Biol.2017,1605
1. 基于微流控技术的体外人类胚胎培养体系建立, 2022/09/30-2024/12/31
2. （包干项目）哺乳动物胚胎早期发育的代谢调控, 2022/03/30-2025/03/31
3. 类器官研究、人类胚胎研究、 基因编辑动物研究的伦理规则, 2022/08/18-2023/05/15
4. 人类胚胎着床过程中的细胞分化机制研究-2024/11/30
5. 丝氨酸羟甲基转移酶在哺乳动物胚胎母源-合子过渡过程中的调控机制研究-2024/12/31
6. 哺乳动物胚胎早期发育的代谢调控-2025/03/31
7. SHMT2代谢酶在小鼠早期胚胎发育中的代谢调控机制研究-2024/12/31
1.邓田田
