神经病学医学博士，研究员，博士研究生导师，齐鲁青年学者，山东省海外科技人才。2016-2020耶鲁大学博士后；2021年入职山东大学齐鲁医院，在以第一或通讯作者在Molecular Psychiatry、Cell Reports、Neurology Neuroimmunology & Neuroinflammation等发表多篇学术论文。主持及参与多项国家及省部级研究课题。目前，本课题组已经建立1000余例神经遗传、变性疾病的成纤维细胞及iPSC库。主要研究领域为运用iPSC来源的神经细胞及3D类器官模型探究神经遗传、变性病（特别是肌萎缩侧索硬化、PolyQ疾病）的分子病理机制，并运用分子生物学、生物信息学方法筛选有效治疗药物。

发表论文

1.     Liu W, Wang Y, Yang Y, Wang Y, Tang Y, Jiao Y, Shan D, Zhan Z, Zhang R, Wang D, Sun X, Sun P, Sun X, Yan C, Liu F#. Establishment of an induced pluripotent stem cell (iPSC) line (INNDSUi005-A) from a healthy female Chinese Han. Stem Cell Res. 2024 Mar 12;77:103386. doi: 10.1016/j.scr.2024.103386. Epub ahead of print. PMID: 38484449.

2.     Zhang N, Liu F, Zhao Y, Sun X, Wen B, Lu JQ, Yan C, Li D. Defect in degradation of glycogenin-exposed residual glycogen in lysosomes is the fundamental pathomechanism of Pompe disease. J Pathol. 2024 Feb 9. doi: 10.1002/path.6255. Epub ahead of print. PMID: 38332735.

3.     Jiao YC, Wang YX, Liu WZ, Xu JW, Zhao YY, Yan CZ, Liu F#. Advances in the differentiation of pluripotent stem cells into vascular cells. World J Stem Cells. 2024 Feb 26;16(2):137-150. doi: 10.4252/wjsc.v16.i2.137. PMID: 38455095; PMCID: PMC10915963.

4.     Zhao Y, Lin Y, Wang B, Liu F, Zhao D, Wang W, Ren H, Wang J, Xu Z, Yan C, Ji K. A Missense Variant in AIFM1 Caused Mitochondrial Dysfunction and Intolerance to Riboflavin Deficiency. Neuromolecular Med. 2023 Dec;25(4):489-500. doi: 10.1007/s12017-023-08750-5. Epub 2023 Aug 21. PMID: 37603145.

5.     Xu L, Wang Y, Wang W, Zhang R, Zhao D, Yun Y, Liu F, Zhao Y, Yan C, Lin P. Novel TFG mutation causes autosomal-dominant spastic paraplegia and defects in autophagy. J Med Genet. 2024 Mar 21;61(4):325-331. doi: 10.1136/jmg-2023-109485. PMID: 37890998.

6.     Lin Y, Wang J, Ren H, Ma X, Wang W, Zhao Y, Xu Z, Liu S, Wang W, Xu X, Wang B, Zhao D, Wang D, Li W, Liu F, Zhao Y, Lu J, Yan C, Ji K. Mitochondrial myopathy without extraocular muscle involvement: a unique clinicopathologic profile. J Neurol. 2024 Feb;271(2):864-876. doi: 10.1007/s00415-023-12005-5. Epub 2023 Oct 17. PMID: 37847292.

7.     Du J, Zhang C, Liu F, Liu X, Wang D, Zhao D, Shui G, Zhao Y, Yan C. Distinctive metabolic remodeling in TYMP deficiency beyond mitochondrial dysfunction. J Mol Med (Berl). 2023 Oct;101(10):1237-1253. doi: 10.1007/s00109-023-02358-9. Epub 2023 Aug 21. PMID: 37603049.

8.     Zhang C, Wang D, Wang Y, Sun P, Zhao D, Zhao X, Zhao Y, Liu F, Xu J, Yan C. Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi002-A) from a patient with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency. Stem Cell Res. 2023 Jun;69:103067. doi: 10.1016/j.scr.2023.103067. Epub 2023 Mar 13. PMID: 37019029.

9.     Wang W, Zhao Y, Xu X, Ma X, Sun Y, Lin Y, Zhao Y, Xu Z, Wang J, Ren H, Wang B, Zhao D, Wang D, Liu F, Li W, Yan C, Ji K. A different pattern of clinical, muscle pathology and brain MRI findings in MELAS with mt-ND variants. Ann Clin Transl Neurol. 2023 Jun;10(6):1035-1045. doi: 10.1002/acn3.51787. Epub 2023 May 23. PMID: 37221696; PMCID: PMC10270267.

10.  Tang Y, Liu F#. SPEAC-seq: A new method to investigate astrocyte-microglia crosstalk. Brain-X. June 2023, June: e22

11.  Zhao B, Dai T, Zhao D, Ma X, Zhao C, Li L, Sun Y, Zhang Y, Yan Y, Lu JQ, Liu F#, Yan C#. Clinicopathologic Profiles of Sporadic Late-Onset Nemaline Myopathy: Practical Importance of Anti-α-Actinin Immunostaining. Neurol Neuroimmunol Neuroinflamm. 2022 May 17;9(4):e1184. 

12.  Wang D, Zhang R, Wang Y, Sun P, Ji X, Sun X, Xu J, Zhao D, Yan C#, Liu F#. Establishment of an induced pluripotent stem cell (iPSC) line (INNDSUi001-A) from a healthy female Chinese Han. Stem Cell Res. 2022 May 23;62:102819 

13.  Ji X, Wang Y, Sun P, Wang D, Sun X, Zhang R, Xu J, Li W, Liu F#, Yan C#. Generation of a human induced pluripotent stem cell line (INNDSUi003-A) derived from patient with Becker muscular dystrophy (BMD). Stem Cell Res. 2022 Apr 27;62:102794

14.  Phan Q. Duy, Stefan C. Weise, Claudia Marini, Xiao-Jun Li, Dan Liang, Peter J. Dahl, Shaojie Ma, Ana Spajic, Weilai Dong, Jane Juusola, Emre Kiziltug, Adam J. Kundishora, Sunil Koundal, Maysam Z. Pedram, Lucia A. Torres-Fernández, Kristian Händler, Elena De Domenico, Matthias Becker, Thomas Ulas, Stefan A. Juranek, Elisa Cuevas, Le Thi Hao, Bettina Jux, André M. M. Sousa, Fuchen Liu, Suel-Kee Kim, Mingfeng Li, Yiying Yang, Yutaka Takeo, Alvaro Duque, Carol Nelson-Williams, Yonghyun Ha, Kartiga Selvaganesan, Stephanie M. Robert, Amrita K. Singh, Garrett Allington, Charuta G. Furey, Andrew T. Timberlake, Benjamin C. Reeves, Hannah Smith, Ashley Dunbar, Tyrone DeSpenza Jr., June Goto, Arnaud Marlier, Andres Moreno-De-Luca, Xin Yu, William E. Butler, Bob S. Carter, Evelyn M. R. Lake, R. Todd Constable, Pasko Rakic, Haifan Lin, Engin Deniz, Helene Benveniste, Nikhil S. Malvankar, Juvianee I. Estrada-Veras, Christopher A. Walsh, Seth L. Alper, Joachim L. Schultze, Katrin Paeschke, Angelika Doetzlhofer, F. Gregory Wulczyn, Sheng Chih Jin, Richard P. Lifton, Nenad Sestan, Waldemar Kolanus & Kristopher T. Kahle. Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus.2022 Nature Neuroscience. Apr;25(4):458-473. doi: 10.1038/s41593-022-01043-3 

15.  Wang D, Zhao D, Li Y, Dai T, Liu F, Yan C. TGM2 positively regulates myoblast differentiation via enhancing the mTOR signaling. Biochim Biophys Acta Mol Cell Res. 2022 Mar;1869(3):119173. doi: 10.1016/j.bbamcr.2021.119173. Epub 2021 Dec 11. PMID: 34902478.

16.  Jiang W, Geng H, Lv X, Ma J, Liu F, Lin P, Yan C. Idebenone Protects against Atherosclerosis in Apolipoprotein E-Deficient Mice Via Activation of the SIRT3-SOD2-mtROS Pathway. Cardiovasc Drugs Ther. 2021 Dec;35(6):1129-1145. doi: 10.1007/s10557-020-07018-5. PMID: 32557012.

17.  Lin Y, Du J, Wang W, Ren H, Zhao D, Liu F, Lin P, Ji K, Zhao Y, Yan C. Novel biallelic mutations in POLG gene: large deletion and missense variant associated with PEO. Neurol Sci. 2021 Oct;42(10):4271-4280. doi: 10.1007/s10072-021-05380-2. Epub 2021 Jun 29. PMID: 34189666.

18.  Lin Y, Xu X, Wang W, Liu F, Zhao D, Li D, Ji K, Li W, Zhao Y, Yan C. A mitochondrial myopathy-associated tRNASer(UCN) 7453G>A mutation alters tRNA metabolism and mitochondrial function. Mitochondrion. 2021 Mar;57:1-8. doi: 10.1016/j.mito.2020.11.015. Epub 2020 Dec 3. PMID: 33279600.

19.  Lv X, Gao F, Dai T, Zhao D, Jiang W, Geng H, Liu F, Lin P, Yan C. Distal myopathy due to TCAP variants in four unrelated Chinese patients. Neurogenetics. 2021 Mar;22(1):1-10. doi: 10.1007/s10048-020-00623-4. Epub 2020 Aug 6. PMID: 32761539.

20.  Kunqian Ji, Wei Wang, Yan Lin, Fuchen Liu, Xuebi Xu, Dongdong Wang, Yuying Zhao, Chuanzhu Yan. Mitochondrial Disease Due to a Novel Mitochondrial Pathogenic tRNAGln m.4349C>T Variants. Annals of Clinical and Translational Neurology 2020 7(6):980-991

21.  Zheng R, Wang Q, Li M, Liu F, Zhang Y, Zhao B, Sun Y, Zhang D, Yan C, Zhao Y, Li W. Reversible Neuropsychiatric Disturbances Caused by Nitrous Oxide Toxicity: Clinical, Imaging and Electrophysiological Profiles of 21 Patients with 6-12 Months Follow-up. Neuropsychiatr Dis Treat. 2020 Nov 23;16:2817-2825. doi: 10.2147/NDT.S270179. PMID: 33262596; PMCID: PMC7695601.

22.  Ji K, Zhao B, Lin Y, Wang W, Liu F, Li W, Zhao Y, Yan C. "Myo-neuropathy" is commonly associated with mitochondrial tRNALysine mutation. J Neurol. 2020 Nov;267(11):3319-3328. doi: 10.1007/s00415-020-10017-z. Epub 2020 Jun 23. PMID: 32577866.

23.  Lin Y, Xu X, Zhao D, Liu F, Luo Y, Du J, Wang D, Ji K, Zhao Y, Yan C. A novel m.11406 T > A mutation in mitochondrial ND4 gene causes MELAS syndrome. Mitochondrion. 2020 Sep;54:57-64. doi: 10.1016/j.mito.2020.06.011. Epub 2020 Jul 10. PMID: 32659360.

24.  Ji K, Wang W, Lin Y, Xu X, Liu F, Wang D, Zhao Y, Yan C. Mitochondrial encephalopathy Due to a Novel Pathogenic Mitochondrial tRNAGln m.4349C>T Variant. Ann Clin Transl Neurol. 2020 Jun;7(6):980-991. doi: 10.1002/acn3.51069. PMID: 32588991; PMCID: PMC7318088.

25.  Duy PQ, Paranjpe MD, Antwi P, Diab NS, Wang JK, Kim DN, Moushey AM, David WB, Kapadia K, Agarwal AA, Huang J, Sheth AH, Mekbib K, Chen HA, Negoita S, Liu F, Takeo Y, Paranjpe I, Manna S, Mehta SK, Gerrard JL. Preresidency Publication Productivity of U.S. Neurosurgery Interns. World Neurosurg. 2020 May;137:e291-e297. doi: 10.1016/j.wneu.2020.01.173. Epub 2020 Jan 31. PMID: 32014543; PMCID: PMC7202965.

26.  Fuchen Liu, Zhang Y, Liang Z, Sun Q, Liu H, Zhao J, Xu J, Zheng J, Yun Y, Yu X, Song W, Sun X. Cleavage of potassium channel Kv2.1 by BACE2 reduces neuronal apoptosis. Molecular Psychiatry 2018 Jul;23(7):1542-1554

27.  Onorati M, Li Z, Fuchen Liu (co-first author), Sousa AMM, Nakagawa N, Li M, Dell'Anno MT, Gulden FO, Pochareddy S, Tebbenkamp ATN, Han W, Pletikos M, Gao T, Zhu Y, Bichsel C, Varela L, Szigeti-Buck K, Lisgo S, Zhang Y, Testen A, Gao XB, Mlakar J, Popovic M, Flamand M, Strittmatter SM, Kaczmarek LK, Anton ES, Horvath TL, Lindenbach BD, Sestan N. Zika virus disrupts phospho-TBK1 localization and mitosis in human neuroepithelial stem cells and radial glia. Cell Reports 2016 Sep 6;16(10):2576-2592

28.  Anahita Amiri, Gianfilippo Coppola, Soraya Scuderi, Feinan Wu, Tanmoy Roychowdhury, Fuchen Liu, Sirisha Pochareddy, Yurae Shin, Alexias Safi, Lingyun Song, Ying Zhu, André M. M. Sousa, The PsychENCODE Consortium, Mark Gerstein, Gregory E. Crawford, Nenad Sestan, Alexej Abyzov, Flora M. Vaccarino. Transcriptome and epigenome landscape of human cortical development modeled in organoids. Science 2018 Dec 14;362(6420).

29.  Fuchen Liu, Liang Z, Xu J, Li W, Zhao D, Zhao Y, & Yan C. Activation of the wnt/β-Catenin Signaling Pathway in Polymyositis, Dermatomyositis and Duchenne Muscular Dystrophy. Journal of Clinical Neurology 2016 Jul;12(3):351-60

30.  Fuchen Liu, Lou J, Zhao D, Li W, Zhao Y, Sun X, & Yan C. Dysferlinopathy: mitochondrial abnormalities in human skeletal muscle. International Journal of Neuroscience 2016 Jun;126(6):499-509

31.  Andrew T.N. Tebbenkamp, Luis Varela, Jinmyung Choi, Miguel I. Paredes, Alice M. Giani, Jae Eun Song, Matija Sestan-Pesa, Daniel Franjic, André M.M. Sousa, Zhong-Wu Liu, Mingfeng Li, Candace Bichsel, Marco Koch, Klara Szigeti-Buck, Fuchen Liu, Zhuo Li, Yuka I. Kawasawa, Constantinos D. Paspalas, Yann S. Mineur, Paolo Prontera, Giuseppe Merla, Marina R. Picciotto, Amy F.T. Arnsten, Tamas L. Horvath, Nenad Sestan. The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain Development. Cell. 2018 Nov 1;175(4):1088-1104.e23

32.  Jingwen Xu, Duoling Li, Jingwei Lv, Xuebi Xu, Bing Wen, Pengfei Lin, Fuchen Liu, Kunqian Ji, Jingli Shan, Honghao Li, Wei Li, Yuying Zhao, Dandan Zhao, Joo Young Pok, Chuanzhu Yan. Both ETFDH mutations and FAD disturbance are essential for developing RR-MADD. Annals of Neurology. 2018 Nov;84(5):659-673

33.  Mingfeng Li, Gabriel Santpere1, Yuka Kawasawa, Oleg Evgrafov, Forrest Gulden, Sirisha Pochareddy, Susan Sunkin, Zhen Li, Yurae Shin, Ying Zhu, Andre Sousa, Donna Werling, Robert Kitchen, Hyo Jung Kang, Mihovil Pletikos, Jinmyung Choi, Sydney Muchnik, Xuming Xu, Daifeng Wang, Belen Lorente-Galdos, Shuang Liu, Paola Giusti-Rodríguez, Hyejung Won, Christiaan Leeuw, Antonio Pardiñas, BrainSpan Consortium, PsychENCODE Consortium, PsychENCODE Developmental Subgroup, Ming Hu, Fulai Jin, Yun Li, Michael Owen, Michael O’Donovan, James Walters, Danielle Posthuma, Patt Levitt, Daniel Weinberger, Joel Kleinman, Daniel Geschwind, Michael Hawrylycz, Matthew State, Stephan Sanders, Patrick Sullivan, Mark Gerstein, Ed Lein, James Knowles, Nenad Sestan. Integrative functional genomic analysis of human brain development and neuropsychiatric risks. Science. 2018 Dec 14;362(6420)

34.  Maria Teresa Dell'Anno, Xingxing Wang, Marco Onorati, Mingfeng Li, Francesca Talpo, Yuichi Sekine, Shaojie Ma, Fuchen Liu, William Cafferty, Nenad Sestan, and Stephen Strittmatter. Human Neuroepithelial Stem Cell Regional Specificity Enables Spinal Cord Repair through a Relay Circuit. Nature Communications 2018 Aug 24;9(1):3419

35.  Sousa AMM, Zhu Y, Raghanti MA, Kitchen RR, Onorati M, Tebbenkamp ATN, Stutz B, Meyer KA, Li M, Kawasawa YI, Fuchen Liu, Perez RG, Mele M, Carvalho T, Skarica M, Gulden FO, Pletikos M, Shibata A, Stephenson AR, Edler MK, Ely JJ, Elsworth JD, Horvath TL, Hof PR, Hyde TM, Kleinman JE, Weinberger DR, Reimers M, Lifton RP, Mane SM, Noonan JP, State MW, Lein ES, Knowles JA, Marques-Bonet T, Sherwood CC, Gerstein MB, Sestan N. Molecular and cellular reorganization of neural circuits in the human lineage. Science 2017 Nov 24;358(6366):1027-1032

36.  Gu Z, Kalambogias J, Yoshioka S, Han W, Li Z, Kawasawa YI, Pochareddy S, Li Z, Fuchen Liu, Xu X, Wijeratne HRS, Ueno M, Blatz E, Salomone J, Kumanogoh A, Rasin MR, Gebelein B, Weirauch MT, Sestan N, Martin JH, Yoshida Y. Control of species-dependent cortico-motoneuronal connections underlying manual dexterity. Science 2017 Jul 28;357(6349):400-404

37.  Zheng J, Liang Z, Hou Y, Fuchen Liu, Hu Y, Lin P, Yan C. A novel Kir2. 6 mutation associated with Hypokalemic Periodic Paralysis. Clinical Neurophysiology 2016 Jun;127(6):2503-8

38.  Fuchen Liu, Zhang D, Yan C. Expanding the clinical spectrum of myopathy, encephalopathy, lactic acidosis, and stroke-like (MELAS) episode: A case with A3243G mitochondrial DNA mutation presenting as MELAS and congenital melanocytic naevi overlap. Neurology India 2016 Mar-Apr;64(2):336-8 

39.  Xu J, Fuchen Liu, Li W, Zhao Y, Zhao D, Luo Y, Lu J, Yan C. Cylindrical spirals in skeletal muscles originate from the longitudinal sarcoplasmic reticulum. Journal of Neuropathology & Experimental Neurology 2016 Feb;75(2):148-55

40.  Yu X, Fuchen Liu, Li H, Yan C. Expression of adenosine receptors in muscle tissues from patients with idiopathic inflammatory myopathies. International Journal of Clinical and Experimental Pathology 2016;9(4):4226-4233 

41.  Peng L, Zhang X, Cui X, Zhu D, Wu J, Sun D, Yue Q, Li Z, Liu H, Li G, Zhang J, Xu H, Fuchen Liu, Qin C, Li M, Sun J. Paliperidone protects SK-N-SH cells against glutamate toxicity via Akt1/GSK3β signaling pathway. Schizophrenia research 2014 Aug;157(1-3):120-7

42.  Ji K, Zheng J, Sun B, Fuchen Liu, Shan J, Li D, Luo Y, Zhao Y, Yan C. Novel mitochondrial C15620A variant may modulate the phenotype of mitochondrial G11778A mutation in a Chinese family with Leigh syndrome. Neuromolecular medicine 2014 Mar;16(1):119-26

43.  Li H, Chen Q, Fuchen Liu, Zhang X, Li W, Liu S, Zhao Y, Gong Y, Yan C. Unfolded protein response and activated degradative pathways regulation in GNE myopathy. PLoS One 2013;8(3):e58116

44.  Li H, Chen Q, Fuchen Liu, Zhang X, Liu T, Li W, Liu S, Zhao Y, Wen B, Dai T, Lin P, Gong Y, Yan C. Clinical and molecular genetic analysis in Chinese patients with Distal Myopathy with Rimmed Vacuoles. Journal of human genetics 2011 Apr;56(4):335-8

通讯/办公地址 : 山东大学神经肌肉及变性疾病研究所（齐鲁医院博施楼2楼）

移动电话 : 18560084407

邮箱 : fuchen.liu@email.sdu.edu.cn

2020.11 -- 至今

山东大学      山东大学齐鲁医院      研究员      在职

2015.7 -- 2020.9

耶鲁大学      神经科学系      博士后      离职