研究方向

1. 生殖医学

论文

1.  . CWF19L2 is Essential for Male Fertility and Spermatogenesis by Regulating Alternative Splicing.  Advanced Science,  2024. 

2.  刘伊宁. MORN2 regulates the morphology and energy metabolism of mitochondria and is required for male fertility in mice.  JOURNAL OF TRANSLATIONAL MEDICINE,  2024. 

3.  王子奇. The deubiquitinase cofactor UAF1 interacts with USP1 and plays an essential role in spermiogenesis.  eScience,  2024. 

4.  王子奇. TTC6-Mediated Stabilization of the Flagellum Annulus Ensures the Rapid and Directed Motion of Sperm.  CELLS,  12,  2023. 

5.  . The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots.  GENOME BIOLOGY,  23,  187, 2022. 

6.  . Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation.  Cell Death and Differentiation,  2023. 

7.  . Absence of murine CFAP61 causes male infertility due to multiple morphological abnormalities of the flagella.  Science bulletin,  2020. 

8.  . The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair.  Elife,  2020. 

9.  . Spliceosome component Usp39 contributes to hepatic lipid homeostasis through the regulation of autophagy.  NATURE COMMUNICATIONS,  14,  2023. 

10.  . TOX3 deficiency mitigates hyperglycemia by suppressing hepatic gluconeogenesis through FoxO1.  METABOLISM-CLINICAL AND EXPERIMENTAL,  152,  2024. 

11.  . THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic β-cell function and preserving β-cell mass.  NATURE COMMUNICATIONS,  14,  2023. 

12.  . MEIOK21: A New Component of Meiotic Recombination Bridges Required for Spermatogenesis.  Nucleic Acid Research,  2020. 

13.  . Deficiency of the Tmem232 Gene Causes Male Infertility with Morphological Abnormalities of the Sperm Flagellum in Mice.  12,  2023. 

14.  . Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation.  Cell Death and Differentiation,  184, 2023. 

15.  王子翔. Splicing factor BUD31 promotes ovarian cancer progression through sustaining the expression of anti-apoptotic BCL2L12.  NATURE COMMUNICATIONS,  2022. 

16.  Wu, Bingbing. Essential Role of CFAP53 in Sperm Flagellum Biogenesis.  Front. Cell Dev. Biol.,  9,  2021. 

17.  袁慎立. The histone modification reader ZCWPW1 promotes double strand break repair by regulating cross talk of histone modifications and chromatin accessibility at meiotic hotspots.  GENOME BIOLOGY,  2022. 

18.  于小宸. Does ICSI outcome in obstructive azoospermia differ according to the origin of retrieved spermatozoa or the cause of epididymal obstruction? A comparative study.  International urology and nephrology,  2022. 

19.  秦君超. Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation.  Cell Death and Differentiation,  2022. 

20.  吕跃. RBM46 is essential for gametogenesis and functions in posttranscriptional roles affecting meiotic cohesin subunits.  Protein & Cell,  2022. 

21.  尹莹莹. LRRC46 Accumulates at the Midpiece of Sperm Flagella and Is Essential for Spermiogenesis and Male Fertility in Mouse. International Journal of Molecular Sciences.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES ,  2022. 

22.  万彦伶. IGF2 reduces meiotic defects in oocytes from obese mice and improves embryonic developmental competency..  Reproductive Biology and Endocrinology,  20,  101, 2022. 

23.  李婧博. microRNA183在PCOS胰岛素抵抗中的表达及其临床意义.  山东大学学报(医学版),  55,  69,

24.  贾月月. 多囊卵巢综合征患者颗粒细胞microRNA200b的表达及影响.  山东大学学报(医学版),  55,  63,

25.  石玉华. Comprehensive assessment the expression of core elements related to IGFIR/PI3K pathway in granulosa cells of women with polycystic ovary syndrome.  Eur J Obstet Gynecol Reprod Biol,  233,  134,

26.  秦君超. RAD51 is essential for spermatogenesis and male fertility in mice.  CELL DEATH DISCOVERY,  8,  118, 2022. 

27.  游力. Common variant rs9939609 in gene FTO confers risk to polycystic ovary syndrome .  Plos one,  2013. 

28.  曹连宝. Hormone-Like Effects of 4-Vinylcyclohexene Diepoxide on Follicular Development.  Front. Cell Dev. Biol.,  8,  2020. 

29.  zhang xu. Mutational analysis of the GATA4 gene in Chinese men with nonobstructive azoospermia.  Asian Journal of Andrology,  23,  205, 2021. 

30.  曹连宝. Hormone-Like Effects of 4-Vinylcyclohexene Diepoxide on Follicular Development (vol 8, 587, 2020).  Front. Cell Dev. Biol.,  8,  2020. 

31.  曹连宝. Systemic changes in a mouse model of VCD-induced premature ovarian failure.  Life Sciences,  262,  2020. 

32.  赵世刚. Family-based analysis of eight susceptibility loci in polycystic ovary syndrome.  Scientific Reports,  2015. 

33.  吕跃，路钢，蔡玉玲. RBM46 is essential for gametogenesis and functions in post-transcriptional roles affecting meiotic cohesin subunits.  Protein & Cell,  2022. 

34.  秦君超，黄涛，王子翔. Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation.  Cell Death Differ,  2022. 

35.  黄涛. The histone modification reader ZCWPW1 promotes double‑strand break repair by regulating cross‑talk of histone modifications and chromatin accessibility at meiotic hotspots.  Genome Biology,  23,  2022. 

36.  于小宸. Does ICSI outcome in obstructive azoospermia differ according to the origin of retrieved spermatozoa or the cause of epididymal obstruction? A comparative study.  International Urology and Nephrology,  2022. 

37.  尹莹. LRRC46 Accumulates at the Midpiece of Sperm Flagella and Is Essential for Spermiogenesis and Male Fertility in Mouse.  International Journal of Molecular Sciences,  23,  2022. 

38.  万彦伶  and Muhammad T. IGF2 reduces meiotic defects in oocytes from obese mice and improves embryonic developmental competency.  Reproductive Biology and Endocrinology,  20,  2022. 

39.  Song, Ting. ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis.  EMBO Reports,  23,  2022. 

40.  于小宸. A new TEX11 mutation causes azoospermia and testicular meiotic arrest.  Asian Journal of Andrology,  2021. 

41.  Liu, Chao. Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans.  EMBO Journal,  40,  2021. 

42.  刘洪彬. Essential role of CFAP53 in sperm flagellum biogenesis.  Front. Cell Dev. Biol.,  2021. 

43.  Muhammad, Tahir. IGF2 improves the developmental competency and meiotic structure of oocytes from aged mice.  Aging-US,  13,  2118, 2021. 

44.  高雪莹. Role of Androgen Receptor for Reconsidering the "True" Polycystic Ovarian Morphology in PCOS.  Scientific reports,  10,  2020. 

45.  尚永亮. MEIOK21: a new component of meiotic recombination bridges required for spermatogenesis.  Nucleic Acids Research,  48,  6624, 2020. 

46.  张栩. Mutational analysis of the GATA4 gene in Chinese men with nonobstructive azoospermia.  Asian Journal of Andrology,  2020. 

47.  黄涛. Absence of murine CFAP61 causes male infertility due to multiple morphological abnormalities of the flagella.  Science Bulletin,  65,  854, 2020. 

48.  黄涛. The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair.  Elife,  9,  2020. 

49.  Muhammad, Tahir. Roles of insulin-like growth factor II in regulating female reproductive physiology.  Science China-life sciences,  63,  849, 2020. 

50.  王顺心 , 张亮然 , 刘洪彬  and 陈子江. Per-Nucleus Crossover Covariation and Implications for Evolution.  细胞,  2019. 

51.  王顺心 , 张亮然 , 刘洪彬  and 陈子江. Per-Nucleus Crossover Covariation and Implications for Evolution.  Cell,  177,  326, 2019. 

52.  陈子江 , 刘洪彬 , 马金龙  and 李苗. The histone modification reader ZCWPW1 is required for meiosis prophase I in male but not in female mice.  Science Advances,  5,  2019. 

53.  刘洪彬 , 石玉华  and 贺婷婷. MicroRNA-141 and MicroRNA-200c Are Overexpressed in Granulosa Cells of Polycystic Ovary Syndrome Patients.  FRONTIERS IN MEDICINE,  5,  2018. 

54.  刘洪彬 , 张亮然  and 陈子江. SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice.  Nucleic Acids Research,  47,  5670, 2019. 

55.  赵世刚 , 陈子江 , 刘洪彬 , 赵涵 , 魏代敏 , 赵跃然  and 颜磊. The HMGA2-IMP2 Pathway Promotes Granulosa Cell Proliferation in Polycystic Ovary Syndrome.  J Clin Endocrinol Metab,  2019. 

56.  赵世刚 , 陈子江 , 刘洪彬  and 赵涵. RNA-Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator in Early Zygotic Genome Activation.  Advanced Science,  2019. 

57.  赵世刚 , 陈子江 , 刘洪彬  and 赵涵. An association study between USP34 and polycystic ovary syndrome.  JOURNAL OF OVARIAN RESEARCH,  2015. 

58.  赵世刚 , 陈子江 , 高选 , 刘洪彬 , 赵涵 , 刘晓满  and 张玉超. STMN1 Promotes Progesterone Production Via StAR Up-regulation in Mouse Granulosa Cells.  Scientific Reports,  2016. 

59.  赵世刚 , 刘洪彬 , 马金龙  and 赵涵. Growth Hormone Promotes in vitro Maturation of Human Oocytes.  Frontiers in Endocrinology,  2019. 

60.  赵世刚 , 吴克良 , 刘洪彬 , 陈子江 , 马金龙  and 赵涵. Melatonin promotes human oocyte maturation and early embryo development by enhancing clathrin-mediated endocytosis.  JOURNAL OF PINEAL RESEARCH,  2019. 

61.  刘昕 , 刘洪彬 , 石玉华  and 贺婷婷. 多囊卵巢综合征患者颗粒细胞FOXO1 mRNA的表达与意义.  山东大学学报(医学版),  2018. 

62.  刘洪彬 , 赵世刚 , 窦云德 Integrated microRNA and mRNA signatures in peripheral blood lymphocytes of familial epithelial ovarian cancer.  Biochemical and Biophysical Research Communications,  496,  191, 2018. 

63.  赵世刚 , 李梅 , 赵涵 , 刘洪彬  and 刘美菊. Resveratrol improves in vitro maturation of oocytes in aged mice and humans.  Fertility and Sterility,  109,  900, 2018. 

64.  刘洪彬 , 陈子江 , 赵涵 , 李梅 , 吴克良 , 边月红  and 于梦汝. Mutational analysis of IZUMO1R in women with fertilization failure and polyspermy after in vitro fertilization.  Journal of assisted reproduction and genetics,  35,  539, 2018. 

65.  赵涵 , 陈子江 , 赵世刚 , 吴克良 , 颜磊 , 李梅 , 刘洪彬  and 陈泰来. A Recurrent Missense Mutation in ZP3 Causes Empty Follicle Syndrome and Female Infertility.  AMERICAN JOURNAL OF HUMAN GENETICS,  101,  459, 2017. 

66.  马金龙 , 赵世刚 , 边月红 , 刘洪彬 , 赵涵  and 吕跃. Association study of HNF1A in women with polycystic ovary syndrome.  Journal of assisted reproduction and genetics,  34,  677, 2017. 

67.  赵世刚 , 马金龙 , 刘洪彬  and 吕跃. Identification of reference genes for qRT-PCR in granulosa cells of healthy women and polycystic ovarian syndrome patients.  scientific reports,  7,  2017. 

68.  赵涵 , 刘洪彬  and 刘涛. The role of fructose-1,6-bisphosphatase 1 in abnormal development of ovarian follicles caused by high testosterone concentration.  MOLECULAR MEDICINE REPORTS,  16,  6489, 2017. 

69.  陈子江  and 刘洪彬. STMN1 Promotes Progesterone Production Via StAR Up-regulation in Mouse Granulosa Cells.  SCI REP,  2016. 

70.  陈子江 , 高选 , 刘洪彬 , 游力  and 赵涵. Family-based analysis of eight susceptibility loci in polycystic ovary syndrome.  SCI REP,  2015. 

71.  陈子江 , 赵涵 , 刘洪彬  and 赵世斗. High levels of testosterone inhibit ovarian follicle development by repressing the FSH signaling pathway.  J Huazhong Univ Sci Technolog Med Sci,  2015. 

72.  刘洪彬. Association of AQP8 in women with PCOS.  Reprod Biomed online,  2013. 

73.  刘洪彬  and 陈子江. Genome-Wide Association Studies for Polycystic Ovary Syndrome.  Semin Reprod Med,  2016. 

74.  陈子江 , 刘洪彬 , 赵涵  and 李梅. Hypomethylation of the LH/Choriogonadotropin Receptor Promoter Region Is a Potential Mechanism Underlying Susceptibility to Polycystic Ovary Syndrome.  Endocrinology,  2014. 

75.  陈子江 , 边月红 , 赵涵 , 游力 , 崔琳琳  and 刘洪彬. Common variant rs9939609 in gene FTO confers risk to polycystic ovary syndrome.  Plos one,  2013. 

76.  赵世刚 , 刘洪彬 , 石玉华  and 贺婷婷. Comprehensive assessment the expression of core elements related to IGFIR/PI3K pathway in granulosa cells of women with polycystic ovary syndrome.  《European Journal of Obstetrics and Gynecology》,  233,  134, 2019. 

77.  刘洪彬 , 马金龙 , 赵涵  and 赵世刚. Growth Hormone Promotes in vitro Maturation of Human Oocytes.  Frontiers in Endocrinology,  2019. 

78.  高选 , 刘洪彬 , 游力 , 赵涵  and 陈子江. Family-based analysis of eight susceptibility loci in polycystic ovary syndrome.  SCI REP,  2015. 

79.  赵涵 , 刘洪彬 , 赵世斗  and 陈子江. High levels of testosterone inhibit ovarian follicle development by repressing the FSH signaling pathway.  J Huazhong Univ Sci Technolog Med Sci,  2015. 

80.  刘洪彬 , 赵涵 , 李梅  and 陈子江. Hypomethylation of the LH/Choriogonadotropin Receptor Promoter Region Is a Potential Mechanism Underlying Susceptibility to Polycystic Ovary Syndrome.  Endocrinology,  2014. 

81.  边月红 , 赵涵 , 游力 , 崔琳琳 , 刘洪彬  and 陈子江. Common variant rs9939609 in gene FTO confers risk to polycystic ovary syndrome.  Plos one,  2013. 

82.  刘洪彬 , 陈子江 , 赵涵 , 魏代敏 , 赵跃然 , 颜磊  and 赵世刚. The HMGA2-IMP2 Pathway Promotes Granulosa Cell Proliferation in Polycystic Ovary Syndrome.  J Clin Endocrinol Metab,  2019. 

83.  陈子江 , 刘洪彬 , 赵涵  and 赵世刚. RNA-Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator in Early Zygotic Genome Activation.  Advanced Science,  2019. 

84.  陈子江 , 刘洪彬 , 赵涵  and 赵世刚. An association study between USP34 and polycystic ovary syndrome.  JOURNAL OF OVARIAN RESEARCH,  2015. 

85.  高选 , 刘洪彬 , 陈子江 , 赵涵 , 刘晓满 , 张玉超  and 赵世刚. STMN1 Promotes Progesterone Production Via StAR Up-regulation in Mouse Granulosa Cells.  Scientific reports,  2016. 

86.  赵涵 , 陈子江 , 高选 , 刘洪彬 , 游力  and 赵世刚. Family-based analysis of eight susceptibility loci in polycystic ovary syndrome.  Scientific reports,  2016. 

87.  刘洪彬 , 马金龙 , 赵涵  and 赵世刚. Growth Hormone Promotes in vitro Maturation of Human Oocytes.  Frontiers in Endocrinology,  2019. 

88.  吴克良 , 刘洪彬 , 陈子江 , 马金龙 , 赵涵  and 赵世刚. Melatonin promotes human oocyte maturation and early embryo development by enhancing clathrin-mediated endocytosis.  JOURNAL OF PINEAL RESEARCH,  2019. 

89.  刘昕 , 刘洪彬 , 石玉华  and 贺婷婷. 多囊卵巢综合征患者颗粒细胞FOXO1 mRNA的表达与意义.  山东大学学报(医学版),  2018. 

90.  赵世刚 , 刘洪彬 , 石玉华  and 贺婷婷. Comprehensive assessment the expression of core elements related to IGFIR/PI3K pathway in granulosa cells of women with polycystic ovary syndrome.  《European Journal of Obstetrics and Gynecology》,  233,  134, 2019. 

91.  赵世刚 , 马金龙 , 刘洪彬  and 吕跃. Identification of reference genes for qRT-PCR in granulosa cells of healthy women and polycystic ovarian syndrome patients.  scientific reports,  7,  2017. 

92.  赵世刚 , 李梅 , 赵涵 , 刘洪彬  and 刘美菊. Resveratrol improves in vitro maturation of oocytes in aged mice and humans.  Fertility and Sterility,  109,  900, 2018. 

93.  赵涵 , 陈子江 , 赵世刚 , 吴克良 , 颜磊 , 李梅 , 刘洪彬  and 陈泰来. A Recurrent Missense Mutation in ZP3 Causes Empty Follicle Syndrome and Female Infertility.  AMERICAN JOURNAL OF HUMAN GENETICS,  101,  459, 2017. 

94.  赵涵 , 刘洪彬  and 刘涛. The role of fructose-1,6-bisphosphatase 1 in abnormal development of ovarian follicles caused by high testosterone concentration.  MOLECULAR MEDICINE REPORTS,  16,  6489, 2017. 

95.  马金龙 , 赵世刚 , 边月红 , 刘洪彬 , 赵涵  and 吕跃. Association study of HNF1A in women with polycystic ovary syndrome.  Journal of assisted reproduction and genetics,  34,  677, 2017. 

96.  赵涵 , 李梅 , 刘洪彬  and 陈子江. Hypomethylation of the LH/Choriogonadotropin Receptor Promoter Region Is a Potential Mechanism Underlying Susceptibility to Polycystic Ovary Syndrome.  Endocrinology,  2014. 

97.  游力 , 崔琳琳 , 刘洪彬 , 边月红 , 赵涵  and 陈子江. Common variant rs9939609 in gene FTO confers risk to polycystic ovary syndrome.  Plos one,  2013. 

98.  赵涵 , 刘洪彬 , 赵世斗  and 陈子江. High levels of testosterone inhibit ovarian follicle development by repressing the FSH signaling pathway.  J Huazhong Univ Sci Technolog Med Sci,  2015. 

99.  高选 , 刘洪彬 , 游力 , 赵涵  and 陈子江. Family-based analysis of eight susceptibility loci in polycystic ovary syndrome.  SCI REP,  2015. 

100.  刘洪彬. Association of AQP8 in women with PCOS.  Reprod Biomed online,  2013. 

101.  陈子江  and 刘洪彬. STMN1 Promotes Progesterone Production Via StAR Up-regulation in Mouse Granulosa Cells.  SCI REP,  2016. 

102.  陈子江  and 刘洪彬. Genome-Wide Association Studies for Polycystic Ovary Syndrome.  Semin Reprod Med,  2016. 

103.  刘洪彬 , 陈子江 , 赵涵 , 李梅 , 吴克良 , 边月红  and 于梦汝. Mutational analysis of IZUMO1R in women with fertilization failure and polyspermy after in vitro fertilization.  Journal of assisted reproduction and genetics,  35,  539, 2018. 

104.  窦云德. Integrated microRNA and mRNA signatures in peripheral blood lymphocytes of familial epithelial ovarian cancer.  Biochemical and biophysical research communications,  496,  191, 2018. 

专利

1. 一种细胞表型诊断系统、介质、设备及程序产品

2. 一种基于深度学习与高光谱图像的肿瘤早期识别系统