The main goal of our team is to understand the cell interaction, metabolic and functional homeostasis of liver immune microenvironment (such as macrophages, NK cells, T cells) in both physiological and pathological conditions; to explore the roles of important immune regulatory molecules (including TIM, TIPE1 and ZHX2) in maintaining liver homeostasis and mediating the pathogenesis of chronic inflammation, HBV infection, metabolic liver diseases and liver cancer; to reveal the crosstalk among liver, gut, fat and other tissues and its effect in whole body homeostasis; to discover the potential value of key immune cells and molecules in the diagnosis and therapeutic intervention strategies for related liver diseases.