Xiaopeng Qi Ph.D.
Principal Investigator,
Advanced Medical Research Institute,
Cheeloo College of Medicine,
Shandong University,
Jinan 250012, China
Honors & Awards
National Natural Science Fund for Distinguished Young Scholars (2021)
One Hundred Person Project of The Chinese Academy of Sciences (2015)
RESEARCH EXPERIENCE AND EDUCATION
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN
Research Associate January 2014 – February 2016
Supervisor: Dr. Thirumala-Devi Kanneganti
Department of Medicine, National Jewish Health, Denver, CO
Research Associate June 2010 – December 2013
Supervisor: Dr. Hua Huang
Zhejiang University, Hangzhou, CHINA
Ph.D. in Genetics, 2007
Supervisor: Dr. Ping Wu
RESEARCH INTEREST
Infectious diseases and host immune responses
My lab is interested in studying the molecular mechanisms underlying bacterial infection triggered host immune responses, and the modulation of innate immunity in host defense and immune evasion strategies of pathogens. We are currently pursuing several avenues of research, such as:
1) Understanding the different roles of Inflammation in response to extracellular versus intracellular bacterial infection.
2) Assessing the dynamics of inflammatory response in sepsis and chronic inflammatory disorders, and Immune interference.
3) Investigating the immune metabolism in host defense against bacterial infection.
SELECTED PEER-REVIEWED PUBLICATIONS (* Co-Corresponding author)
1. Yu Guo#, Longjun Li#, Tao Xu#, Xiaomin Guo#, Chaoming Wang, Yihui Li, Yanan Yang, Dong Yang, Bin Sun, Xudong Zhao, Genze Shao, and Xiaopeng Qi. 2020. HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection. Journal of Clinical Investigation, 130(12):6301-6316.
2. Xiaomin Guo#, Pengcheng Ma#, Yuwei Li, Yanan Yang, Chaoming Wang, Tao Xu, Huishan Wang, Chaocui Li, Bingyu Mao*, and Xiaopeng Qi*. 2021. RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense. Cell Death & Differentiation, 28(2): 640-656.
3. Xiaomin Guo, Chaoming Wang, Tao Xu, Lu Yang, Chaohong Liu, and Xiaopeng Qi. 2021. SiO2 prompts host defense against Acinetobacter baumannii infection by mTORC1 activation. Sci China-Life Sci, 64(6): 982-990.
4. Christopher R. Lupfer, Paras K. Anand, Xiaopeng Qi, and Hasan Zaki. Editorial: Role of NOD-Like Receptors in Infectious and Immunological Diseases. Front. Immunol, 19 May 2020 | https://doi.org/10.3389/fimmu.2020.00923.
5. Yang Li, Chaoming Wang, Xiangyu Wu, Hongbo Tian, Shanqun Jiang, Tao Xu, Zhiping Liu*, Jin-Lu Sun*, and Xiaopeng Qi*. 2020. IRF3 and IRF7 contribute to diesel exhaust particles-induced pulmonary inflammation by mediating mTORC1 activation and restraining autophagy in mice. European Journal of Immunology, 50: 1142–1153. (Cover Story)
6. Tao Xu, Yu Guo, and Xiaopeng Qi. 2019. Ubiquitination-Mediated Inflammasome Activation during Bacterial Infection. International Journal of Molecular Sciences, 20(9):2110.
7. Li Zhang, Zhi-Li Shen, Yue Feng, Dao-Qun Li, Na-Na Zhang, Yong-Qiang Deng, Xiaopeng Qi, Xiao-Mei Sun, Jie-Jie Dai, Chun-Guang Yang, Zi-Feng Yang, Cheng-Feng Qin & Xue-Shan Xia. 2019. Infectivity of Zika virus on primary cells support tree shrew as animal model. Emerging Microbes & Infections, 8:1, 232-241, doi: 10.1080/22221751.2018.1559707.
8. Na-Na Zhang, Li Zhang, Yong-Qiang Deng, Yue Feng, Feng Ma, Qi Wang, Qing Ye, Yuanyuan Han, Xiaomei Sun, Fu-Chun Zhang, Xiaopeng Qi, Guoqing Wang, Jiejie Dai, Xueshan Xia, Cheng-Feng Qin. 2019. Zika virus infection in Tupaia belangeri causes dermatological manifestations and confers protection against secondary infection. Journal of Virology, 93(8). pii: e01982-18. doi: 10.1128/JVI.01982-18.
9. Xiaomin Guo, Huan Wang, Yang Li, Xiaopeng Leng, Weiwei Huang, Yanbing Ma, Tao Xu, and Xiaopeng Qi. 2019. Transfection reagent Lipofectamine triggers type I interferon signaling activation in macrophages. Immunology & Cell Biology, 97(1):92-96.
10. Fubing Li#, Yang Li#, Huichun Liang#, Tao Xu#, Yanjie Kong, Maobo Huang, Ji Xiao, Xi Chen, Houjun Xia, Yingying Wu, Zhongmei Zhou, Xiaomin Guo, Chunmiao Hu, Chuanyu Yang, Xu Cheng, Ceshi Chen*, and Xiaopeng Qi*. 2018. HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. Journal of Clinical Investigation, 128(9): 4148-4162.
11. Lin Jin#, Xiaomin Guo#, Chuanbin Shen#, Xue Hao#, Peng Sun#, Pengpeng Li, Tao Xu, Chunmiao Hu, Ombati Rose, Hongning Zhou, Mingdong Yang, Cheng-Feng Qin, Jingya Guo, Hua Peng, Mingzhao Zhu, Gong Cheng*, Xiaopeng Qi*, and Ren Lai*. 2018. Salivary factor LTRIN from Aedes aegypti facilitates Zika virus transmission by interfering with the lymphotoxin-b receptor. Nature Immunology, 19: 342-353.
12. Yang Li#, Xiaomin Guo#, Chunmiao Hu, Yan Du, Chuansheng Guo, Di Wang, Weiheng Zhao, Gonghua Huang, Chunliang Li, Qiumin Lu, Ren Lai*, Tao Xu*, and Xiaopeng Qi*. 2018. Type I IFN operates pyroptosis and necroptosis during multidrug-resistant A. baumannii infection. Cell Death & Differentiation, 25: 1304–1318.
13. Yan-Hu Liu#, Lu Wang#, Tao Xu#，Xiaomin Guo, Yang Li, Ting-Ting Yin, He-Chuan Yang, Yang Hu, Adeniyi C. Adeola, Oscar J. Sanke, Newton O. Otecko, Meng Wang, Yaping Ma, Olaogun S. Charles, Mikkel-Holger S. Sinding, Shyam Gopalakrishnan, José Alfredo Samaniego, Anders J. Hansen, Carlos Fernandes, Philippe Gaubert, Jane Budd, Philip M. Dawuda, Lubin Jiang, M.T.P Gilbert, Weiwei Zhai, Xiaopeng Qi*, Guo-Dong Wang*, and Ya-Ping Zhang*. 2018. Whole-genome sequencing of African dogs provides insights into adaptations against tropical parasites. Molecular Biology and Evolution, 35(2): 287-298.
14. Qiang Shao, Stephanie Herrlinger, Ya-Nan Zhu, Mei Yang, Forrest Goodfellow, Steven L. Stice, Xiaopeng Qi, Melinda A. Brindley, Jian-Fu Chen. 2017. The African Zika virus MR-766 is more virulent and causes more severe brain damage than current Asian lineage and Dengue virus. Development, 144(22): 4114-4124.
15. Xiaopeng Qi. 2016. Formation of membrane pores by gasdermin-N causes pyroptosis. Sci China-Life Sci, 07.26, 59(10): 1071-1073.
16. Xiaopeng Qi#, Si Ming Man#, R K Subbarao Malireddi, Rajendra Karki, Christopher Lupfer, Prajwal Gurung, Geoffrey Neale, Clifford Guy, Mohamed Lamkanfi, and Thirumala-Devi Kanneganti. 2016. Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection. The Journal of Experimental Medicine, 213(10): 2081-97.
17. Rajendra Karki,Si Ming Man, Subbarao Malireddi,Sannula Kesavardhana, Qifan Zhu, Amanda R. Burton,Bhesh Raj Sharma, Xiaopeng Qi, Stephane Pelletier, Peter Vogel, Philip Rosenstiel & Thirumala-Devi Kanneganti. 2016. NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer. Nature, 540: 583–587.
18. Xiaopeng Qi, Prajwal Gurung, R. K. Subbarao Malireddi, Peer W. F. Karmaus, Deepika Sharma, Peter Vogel, Hongbo Chi, Douglas R. Green, and Thirumala-Devi Kanneganti. 2016. Critical role of caspase-8–mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis. Mucosal Immunology, 10(1): 128-138.
19. Yapeng Li, Xiaopeng Qi, Bing Liu, Hua Huang. 2015. The STAT5–GATA2 Pathway Is Critical in Basophil and Mast Cell Differentiation and Maintenance. The Journal of Immunology, 194(9): 4328-38.
20. Xiaopeng Qi, Jessie Hong, Lee Chaves, Yonghua Zhuang, Yuhong Chen, Demin Wang, Jacob Chabon, Brian Graham, Keitaro Ohmori, Yapeng Li, and Hua Huang. 2013. Antagonistic regulation by the transcription factors C/EBPa and MITF specifies basophil and mast cell fates. Immunity, 39 (1): 97-110.
21. Roza I. Nurieva, Andrew Podd, Yuhong Chen, Andrei M. Alekseev, Mei Yu, Xiaopeng Qi, Hua Huang, Renren Wen, Junmei Wang, Haiyan S. Li, Stephanie S. Watowich, Hai Qi, Chen Dong and Demin Wang. 2012. STAT5 Protein Negatively Regulates T Follicular Helper (Tfh) Cell Generation and Function. The Journal of Biological Chemistry, 287 (14): 11234-11239.
22. Xiaopeng Qi#, Jun Nishida#, Lee Chaves, Keitaro Ohmori and Hua Huang. 2011. C/EBPα is critical for interleukin-4 expression in response to FcεR1 receptor cross-linking. The Journal of Biological Chemistry, 286 (18): 16063-16073.
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