目前主要利用iPSC体外造血发育模型、3D生物材料和微流控剪切力模拟系统,结合斑马鱼、小鼠胚胎造血发育模型,研究造血干/祖细胞发育与再生过程中的细胞力生物学分子机制。
1.细胞骨架力生物学
2.造血干细胞发育与再生
3.基于3D水凝胶的干细胞分化和细胞力生物学调控
(1) 刘中乾等.Hydrogel platform facilitating astrocytic differentiation through cell mechanosensing and YAP-mediated transcription.Materials Today Bio.2023,22
(2) 邵晓薇等.Unraveling the Mechanobiology Underlying Traumatic Brain Injury with Advanced Technologies and Biomaterials.Advanced Healthcare Materials.2022,11 (19)
(3) 邵晓薇等.Mechanical Stress Induces a Transient Suppression of Cytokine Secretion in Astrocytes Assessed at the Single-Cell Level with a High-Throughput Microfluidic Chip.Advanced Healthcare Materials.2021,10 (21)
(4) 邵晓薇.Protective role of NF-κB in inflammatory demyelination.Journal of Neuroscience.2018,38 (10)
(5) 邵晓薇等.Mechanical stimulation induces formin-dependent assembly of a perinuclear actin rim.Proc Natl Acad Sci U S A.2015,112 (20)
(6) 邵晓薇等.Novel localization of formin mDia2: importin beta-mediated delivery to and retention at the cytoplasmic side of the nuclear envelope.Biology Open.2015,4 (11)
1. 一种简便、快捷的星形胶质细胞分化方法
1. 力学信号对星形胶质细胞炎症激活的调控作用及其力转导分子机制研究, 2020/09/18-2023/12/31
2. 基于外力信号调控星形胶质细胞活性的单细胞分析与研究, 2020/07/01-2023/06/30
3. 肿瘤和脑血管疾病标记物高通量低成本检测芯片与系统的研发-1, 2021/05/01-2024/06/30
4. 渤海湾生态环境监测评估及污染控制技术研究, 2019/12/01-2021/12/31
5. 山东大学青年学者未来计划, 2019/07/01-2024/06/30
1. 休闲英语口语(通选)
1.毛世杰
2.刘中乾
1.生命科学学院 细胞生物学、生物与医药 2024