王春燕，女，博士，研究员，山东大学齐鲁青年学者。博士毕业于荷兰乌特勒支大学，后在本单位从事博士后研究。2023年6月全职加入山东大学基础医学院病原生物学系。
近年来主要从事冠状病毒的基础与应用研究：1）挖掘β属冠状病毒纤突蛋白的抗体库，绘制纤突蛋白的表位图谱；2）筛选并鉴定纤突蛋白特异性（广谱）中和单克隆抗体；3）解析抗体的中和机制；4）利用挖掘的抗体库揭示纤突蛋白的抗原进化规律。相关研究成果以第一作者（含共同）身份发表在Nature Communications、Science Advances等国际高水平期刊。
代表性论文：
1. Wang C, Emma L. Hesketh, Tatiana M. Shamorkina, Wentao Li, Peter J. Franken, Dubravka Drabek, Rien van Haperen, Sarah Townend, Frank J.M. van Kuppeveld, Frank Grosveld, Neil A. Ranson, Joost Snijder, Raoul J. de Groot, Daniel L. Hurdiss, and Berend-Jan Bosch*. Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes. Nature Communications, 2022, 13(1): 1-15.
2. Wang C, van Haperen R, Gutiérrez-Álvarez J, Li W, Okba NMA, Albulescu I, Widjaja I, van Dieren B, Fernandez-Delgado R, Sola I, Hurdiss DL, Daramola O, Grosveld F, van Kuppeveld FJM, Haagmans BL, Enjuanes L, Drabek D, Bosch BJ*. A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies. Nature Communications, 2021, 12(1): 1-15.
3. Fedry J#, Hurdiss DL#, Wang C#, Li W#, Obal G, Drulyte I, Du W, Howes SC, van Kuppeveld FJM, Forster F*, Bosch BJ*. Structural insights into the cross-neutralization of SARS-CoV and SARS-CoV-2 by the human monoclonal antibody 47D11. Science Advances, 2021, 7(23): eabf5632. (#共同第一作者)
4. Wang C#, Li W#, Drabek D#, Okba NMA, van Haperen R, Osterhaus ADME, van Kuppeveld FJM, Haagmans BL, Grosveld F, Bosch BJ*. A human monoclonal antibody blocking SARS-CoV-2 infection. Nature Communications, 2020, 11(1): 1-6. (#共同第一作者，ESI高被引论文）
5. Widjaja I, Wang C, van Haperen R, Gutiérrez-Álvarez J, van Dieren B, Okba NMA, Raj VS, Li W, Fernandez-Delgado R, Grosveld F, van Kuppeveld FJM, Haagmans BL, Enjuanes L, Drabek D, Bosch BJ*. Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein. Emerging Microbes & Infections, 2019, 8(1): 516-530.
6. Chatterjee M#, Huang LZX#, Mykytyn AZ#, Wang C, Lamers MM, Westendorp B, Wubbolts RW, van Putten JPM, Bosch BJ, Haagmans BL*, Strijbis K*. Glycosylated extracellular mucin domains protect against SARS-CoV-2 infection at the respiratory surface. PLoS Pathogens. 2023 Aug 10;19(8):e1011571.
7. Tortorici MA, Walls AC, Lang Y, Wang C, Li Z, Koerhuis D, Boons GJ, Bosch BJ, Rey FA, de Groot RJ, Veesler D*. Structural basis for human coronavirus attachment to sialic acid receptors. Nature Structural & Molecular Biology, 2019, 26(6): 481-489.
8. Sauer MM, Tortorici MA, Park YJ, Walls AC, Homad L, Acton O, Bowen J, Wang C, Xiong X, de van der Schueren W, Quispe J, Hoffstrom BG, Bosch BJ, McGuire AT, Veesler D*. Structural basis for broad coronavirus neutralization. Nature Structural & Molecular Biology, 2021, 28: 478–486.
9. Okba NMA#, Müller MA#, Li W#, Wang C, GeurtsvanKessel CH, Corman VM, Lamers MM, Sikkema RS, de Bruin E, Chandler FD, Yazdanpanah Y, Le Hingrat Q, Descamps D, Houhou-Fidouh N, Reusken CBEM, Bosch BJ, Drosten C, Koopmans MPG, Haagmans BL*. Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibody Responses in Coronavirus Disease Patients. Emerging Infectious Diseases, 2020, 26(7): 1478-1488. (ESI高被引论文)
10. Haagmans BL, Noack D, Okba NMA, Li W, Wang C, Bestebroer T, de Vries R, Herfst S, de Meulder D, van Run P, Lamers MM, Rijnders B, Rokx C, van Kuppeveld FJM, Grosveld F, Drabek D, GeurtsvanKessel C, Koopmans MPG, Bosch BJ, Kuiken T, Rockx B. SARS-CoV-2 neutralizing human antibodies protect against lower respiratory tract disease in a hamster model. Journal of Infectious Diseases, 2021, 223(12): 2020-2028.
