王培会，男，2019年入职山东大学高等医学研究院，聘为教授、博士生导师、泰山学者青年专家、齐鲁青年学者。

 

教育背景

香港大学      香港          博士          抗病毒免疫学                2011/09-2015/08         

中山大学      广州   硕士          生物学         2008/09-2011/06                   

中山大学      广州   学士   生物技术       -2004/09-2008/06              

 

工作经历

教授PI              山东大学    高等医学研究院                2019/04-

博士后             香港大学    李嘉诚医学院                    2016/01-2019/02

研究助理   香港大学    李嘉诚医学院      2015/10-2015/12

博士后招聘

本实验室实施精英教育，提供国际接轨的科研平台、一流的学术环境和氛围、顶级的实验条件，以及高水平的研究课题。欢迎生命科学、医学、农学等生命科学相关方向博士加盟团队，进行博士后研究(常年有效、2-3名、择优录取)。 

研究生招生

实验室现有教授1名、博士后2名、博士4名、硕士6名。欢迎有志青年报考硕士和博士研究生，报考前请提前与导师联系，确认当年是否有招生名额。 

研究方向

1. 病毒逃逸宿主免疫建立感染的机制。以病毒与宿主相互作用为切入点，揭示病毒与宿主相互作用的关键节点分子，为开发抗病毒药物提供新的思路和靶点。代表性成果：发现新冠病毒的感染机制以及与抗病毒免疫的相互作用 (Cell Chem Biol 2022; Signal Transduct Target Ther 2022, 2021, 2020a, 2020b; Nat Biotechnol 2022; Nat Metab 2021; Nat Chem Biol 2022; Sci Adv 2021)。

 

                            

                           

                         

2.  抗病毒免疫的调控机制。通过大规模、高通量的筛选技术，鉴定在抗病毒免疫中，发挥调控作用的蛋白，并揭示这些蛋白在宿主识别病毒、免疫激活中挥发的作用。代表性成果：发现了病毒DNA在细胞质内的主要识别通路AIM2和cGAS-STING的新调控分子及其作用机制 (EMBO Rep 2018 封面文章; Nucleic Acids Res 2018)。 

                            

 

  学术影响

  在Nature Biotechnology、Signal Transduction and Targeted Therapy、Nature Metabolism、Nature Chemical Biology、Nucleic Acids Research、Cell Chemical Biology、Science Advances、Cell Research、EMBO Reports等期刊累计发表学术论文50余篇，被Nature、Science、Cell、Lancet及其子刊等引用6000余次，H指数43。

   媒体报道

研究成果被山东电视台、人民日报海外版、央广网、凤凰网、香港文汇网、光明日报、搜狐网、网易、新浪微博、腾讯网、中国教育在线、中华网、齐鲁网、齐鲁壹点等数十家媒体采访和报道。

1.   山东新闻联播，视频采访-山东大学科研团队取得新进展 揭示新冠病毒如何实现免疫逃逸

     (http://sd.iqilu.com/share/video/4870355)

2.   山东电视台《民生实验室》，视频采访-新冠病毒是如何进入我们身体的？

     (http://sd.iqilu.com/share/video/4771911)

3. 济南广播电视台天下泉城新闻，视频采访-山东大学：传承百年齐鲁医学 汇聚磅礴发展力量 

     (https://jntxqc.tianxiaquanchengapp.com/webshare/yw/202447.shtml?share=true)

4.   凤凰网-山大团队发现冠状病毒感染诱导其受体ACE2上调 

     (https://ishare.ifeng.com/c/s/7uSW3uDoUzL)

5.  人民日报海外版-研究人员：新冠病毒或通过诱导其受体ACE2的表达增强感染传播力

     (http://m.haiwainet.cn/middle/3541434/2020/0229/content_31730390_1.html)

6.  香港文汇网-山東大學聯合港大發現冠狀病毒感染誘導其受體ACE2上調 

     (http://news.wenweipo.com/2020/02/29/IN2002290025.htm)

7. 光明日报-山东大学高等医学研究院无偿提供新型冠状病毒编码基因表达载体

    (https://overseas.weibo.com/detail/4467560139093209 ;

    https://new.qq.com/omn/20200202/20200202A0HJK400.html)

8.  央广网-研究人员：新冠病毒或通过诱导其受体ACE2的表达增强感染传播力 

    (http://www.cnr.cn/sd/gd/20200229/t20200229_524996973.shtml)

9.  大众日报-山东大学团队发现冠状病毒感染诱导其受体ACE2上调

     ( http://dzrb.dzng.com/articleContent/1176_730304.html)

10. 光明日报-科技战疫彰显高校担当 

    (https://news.gmw.cn/2020-03/25/content_33681654.htm)

 

 学术服务

Front Immunol (IF 8.786) 副主编 (Associate Editor)

Front Pharmacol (IF 5.988) 副主编 (Associate Editor)

Front Bioeng Biotechnol (IF 6.064) 副主编 (Associate Editor)

Comp Immunol Microb (IF 2.729) 副主编 (Associate Editor)

 审稿服务

Signal Transduction and Targeted Therapy (IF 38.104)

ACS Nano (IF 17.1)

Biomaterials (IF 13.8)

EMBO Molecular Medicine  (IF 11.4)

Cell systems (IF 10.9)

Cell Reports (IF 9.9)

EMBO Reports (IF 8.6) 等期刊

 基金评审

欧洲研究理事会European Research Council (ERC)国际评审人

奥地利科学基金会(Austrian Science Fund, FWF)国际评审人

国家重点研发计划评审人

Google Scholar 个人主页：

https://scholar.google.com/citations?user=NdwuOG0AAAAJ&hl=en 

Web of Science个人主页：

https://www.webofscience.com/wos/author/record/696976 

代表性论著（*通讯作者，#共同第一作者，2025年3月更新）  

  

009.   Jinxiu Hou#, Shengnan Zheng#, Xuejing Zhang#, Mengwei Zhuang, Xianghe Zhao,  Jian Deng, Huiyu Yang, Xiaojing Xia, Chengjiang Gao, Pei-Hui Wang*, Yi Zheng*. IDR-driven TOLLIP condensates antagonize the innate antiviral immunity by promoting the deSUMOylation of MAVS. Cell Reports 2025, 44, 115348 DOI: 10.1016/j.celrep.2025.115348 (IF 8.5)

008.   Yi Zheng#, Jian Deng#, Lulu Han#, Meng-Wei Zhuang, Yanwen Xu, Jing Zhang, Mei-Ling Nan, Yang Xiao, Peng Zhan, Xinyong Liu, Chengjiang Gao*, Pei-Hui Wang*. SARS-CoV-2 NSP5 and N Protein Counteract the RIG-I Signaling Pathway by Suppressing the Formation of Stress Granules. Signal Transduct Target Ther. 2022 Jan 24;7(1):22.  (IF 38.104；ESI高被引论文)

007.   Yuehui Zhang#, Limin Shang#, Jing Zhang#, Yuchen Liu#, Chaozhi Jin#, Yanan Zhao#, Xiaobo Lei#, Wenjing Wang, Xia Xiao, Xiuyuan Zhang, Yujiao Liu, Linlin Liu, Meng-Wei Zhuang, Qingkun Mi, Chunyan Tian, Jianwei Wang*, Fuchu He*, Pei-Hui Wang*, Jian Wang*. An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity. Cell Chem Biol. 2022 Jan 20;29(1):5-18.e6. (Featured as a cover story, IF 9.039)

006.   Zhuanchang Wu#,*, Zhaoying Zhang#, Xin Wang#, Jing Zhang#, Caiyue Ren, Yuming Li, Lifen Gao, Xiaohong Liang, Peihui Wang*, Chunhong Ma*. Palmitoylation of SARS-CoV-2 S protein is essential for viral infectivity. Signal Transduct Target Ther. 2021 Jun 11;6(1):231. (IF 38.104)

005.   Yi Zheng#, Meng-Wei Zhuang#, Lulu Han, Jing Zhang, Mei-Ling Nan, Peng Zhan, Dongwei Kang, Xinyong Liu, Chengjiang Gao*, Pei-Hui Wang*. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling. Signal Transduct Target Ther. 2020 Dec 28;5(1):299. (IF 38.104；ESI高被引论文)

004.   Jing Zhang#, Ruth Cruz-Cosme#, Meng-Wei Zhuang, Dongxiao Liu, Yuan Liu, Shaolei Teng, Pei-Hui Wang*, Qiyi Tang*. A systemic and molecular study of subcellular localization of SARS-CoV-2 proteins. Signal Transduct Target Ther. 2020 Nov 17;5(1):269. (IF 38.104)

003.   Pei-Hui Wang, Sin-Yee Fung, Wei-Wei Gao, Jian-Jun Deng, Yun Cheng, Vidyanath Chaudhary, Kit-San Yuen, Ting-Hin Ho, Ching-Ping Chan, Yan Zhang, Kin-Hang Kok, Wanling Yang, Chi-Ping Chan, Dong-Yan Jin*. Identification and characterization of a novel transcript isoform of STING that dominantly inhibits innate immune response. Nucleic Acids Res. 2018 May 4;46(8):4054-4071. (IF 19.16) 

002.   Pei-Hui Wang, Zi-Wei Ye, Jian-Jun Deng, Kam-Leung Siu, Wei-Wei Gao, Vidyanath Chaudhary, Yun Cheng, Sin-Yee Fung, Kit-San Yuen, Ting-Hin Ho, Ching-Ping Chan, Yan Zhang, Kin-Hang Kok, Wanling Yang, Chi-Ping Chan, Dong-Yan Jin*. Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16. EMBO Rep. 2018 Otc;19(10). (Featured as a cover story, IF 9.071)

001.   Pei-Hui Wang*, Zhi-Hua Gu, Ding-Hui Wan, Bo-Du Liu, Xian-De Huang, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. The shrimp IKK-NF-κB signaling pathway regulates antimicrobial peptide expression and may be subverted by white spot syndrome virus (WSSV) to facilitate viral gene expression. Cell Mol Immunol. 10(5):423-36, 2013. (IF=21.8)

 

其他主要论著

026.  Jin-Xin Li, Jing Zhang, Cheng-Hao Li, Yun-Fang Li, Hui-Min Chen, Tao Li, Qing Zhang, Bei-Hua Kong, Pei-Hui Wang*. Human papillomavirus E1 proteins inhibit RIG-I/MDA5-MAVS, TLR3-TRIF, cGAS-STING, and JAK-STAT signaling pathways to evade innate antiviral immunity. Front Immunol. 2025 Apr 22:16:1549766. (IF 7.3) 

025.  Sheng-Nan Zheng#, Jing Zhang#, Tao Li#, Cheng-Hao Li#, Jian Deng, Jin-Xin Li, Pei-Hui Wang*. STING-∆C, a novel splice isoform of STING, inhibits DNA virus-induced innate immunity and autophagy. Int J Biol Macromol. 2025 May 2;311(Pt 3):143894. (IF 7.7) 

024.  Jin-Xin Li, Jing Zhang, Cheng-Hao Li, Qing Zhang, Beihua Kong, Pei-Hui Wang*. Human papillomavirus E2 proteins suppress innate antiviral signaling pathways. Front Immunol. 2025 Apr 8:16:1555629. (IF 7.3) 

023.   Jian Deng^#, Sheng-Nan Zheng^#, Yang Xiao^#, Mei-Ling Nan, Jing Zhang, Lulu Han, Yi Zheng, Yanying Yu, Qiang Ding, Chengjiang Gao, Pei-Hui Wang*. SARS-CoV-2 NSP8 suppresses type I and III IFN responses by modulating the RIG-I/MDA5, TRIF, and STING signaling pathways. J Med Virol. 2023 Mar 17. DOI: 10.1002/jmv.28680. (IF 20.693) 

022.   Jian Deng^#, Yi Zheng^#, Sheng-Nan Zheng^#, Mei-Ling Nan^#, Lulu Han, Jing Zhang, Yunyun Jin, Ji-An Pan, Chengjiang Gao*, Pei-Hui Wang*. SARS-CoV-2 NSP7 inhibits type I and III IFN production by targeting the RIG-I/MDA5, TRIF, and STING signaling pathways. J Med Virol. 2023 Feb 8. doi: 10.1002/jmv.28561. (IF 20.693)

021.   Lulu Han^#, Yi Zheng^#, Jian Deng^#, Mei-Ling Nan, Yang Xiao, Meng-Wei Zhuang, Jing Zhang, Wei Wang, Chengjiang Gao*, Pei-Hui Wang*. SARS-CoV-2  ORF10 antagonizes STING-dependent interferon activation and autophagy. J Med Virol. 2022 Nov;94(11):5174-5188.(IF 20.693) 

020.    Lulu Han^#, Meng-Wei Zhuang^#, Jian Deng^#, Yi Zheng, Jing Zhang, Mei-Ling Nan, Xue-Jing Zhang, Chengjiang Gao*, Pei-Hui Wang*. SARS-CoV-2 ORF9b antagonizes type I and III interferons by targeting multiple components of the RIG-I/MDA-5-MAVS, TLR3-TRIF, and cGAS-STING signaling pathways. J Med Virol. 2021 Apr 29;10.1002/jmv.27050. (IF 20.693；ESI高被引论文)

019.    Meng-Wei Zhuang^#, Yun Cheng^#, Jing Zhang^#, Xue-Mei Jiang, Li Wang, Jian Deng, Pei-Hui Wang*. Increasing host cellular receptor-angiotensin-converting enzyme 2 expression by coronavirus may facilitate 2019-nCoV (or SARS-CoV-2) infection. J Med Virol. 2020 Nov;92(11):2693-2701. (IF 20.693)

018.    Meng-Wei Zhuang^#, Yun Cheng^#, Jing Zhang^#, Xue-Mei Jiang, Li Wang, Jian Deng, Pei-Hui Wang*. Increasing host cellular receptor-angiotensin-converting enzyme 2 expression by coronavirus may facilitate 2019-nCoV (or SARS-CoV-2) infection. J Med Virol. 2020 Nov;92(11):2693-2701. (IF 20.693)

017.    Bin Wang^#, Li Wang^#, Xianggen Kong, Jin Geng, Di Xiao, Chunhong Ma, Xue-Mei Jiang, Pei-Hui Wang*. Long-term coexistence of SARS-CoV-2 with antibody response in COVID-19 patients. J Med Virol. 2020 Sep;92(9):1684-1689. (IF 20.693；ESI高被引论文)

016.    Pei-Hui Wang^#, Tianzhi Huang^#, Xiaobo Zhang*, Jian-Guo He*. Antiviral defense in shrimp: from innate immunity to antiviral infection. Antiviral Res 2014 Aug;108:129-41. (IF 10.103)

015.    Pei-Hui Wang*, Li-Shi Yang, Zhi-Hua Gu, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Nucleic acid-induced antiviral immunity in shrimp. Antiviral Res. 2013 Sep;99(3):270-80. (IF 10.103)

014.    Fei Li^#, Jingyao Li^#, Pei-Hui Wang^#, Nanyan Yang, Junyu Huang, Jinxin Ou, Ting Xu, Xin Zhao, Taoshu Liu, Xueying Huang, Qinghuan Wang, Miao Li, Le Yang, Yunchen Lin, Ying Cai, Haisheng Chen, Qing Zhang*. SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling. Biochim Biophys Acta Mol Basis Dis. 2021 Aug 27;1867(12):166260. (IF 6.633)

013.    Yun Zhu, Jian Deng, Mei-Ling Nan, Jing Zhang, Akinkunmi Okekunle, Jiang-Yuan, Xiao-Qiang Yu, Pei-Hui Wang*. The Interplay Between Pattern Recognition Receptors and Autophagy in Inflammation. Adv Exp Med Biol. 2019;1209:79-108. (IF 2.622)

012.    Pei-Hui Wang* and Jian-Guo He*. Nucleic acid sensing in invertebrates. Int Rev Cel Mol Bio. 2019;345:287-360. (IF 6.42)

011.    Jian Deng and Pei-Hui Wang*. Inflammasome Activation and Th17 responses. Mol Immunol 2019 Mar;107:142-164. (IF 4.174)

010.   Pei-Hui Wang*, Shao-Ping Weng, Jian-Guo He*. Nucleic acid-induced antiviral immunity in invertebrates: An evolutionary perspective. Dev Comp Immunol. 2015 Feb;48(2):291-6. (IF 3.605)

009.    Pei-Hui Wang*, Ding-Hui Wan, Yong-Gui Chen, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Characterization of four novel caspases from Litopenaeus vannamei (Lvcaspase2-5) and their role in WSSV infection through dsRNA-mediated gene silencing. PLoS One. 2013 Dec 23;8(12):e80418. (IF 3.752)

008.    Pei-Hui Wang*, Ding-Hui Wan, Zhi-Hua Gu, Wei Qiu, Yong-Gui Chen, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Analysis of expression, cellular localization, and function of three inhibitors of apoptosis (IAPs) from Litopenaeus vannamei during WSSV infection and in regulation of antimicrobial peptide genes (AMPs). PLoS One. 2013 Aug 14;8(8):e72592. (IF 3.752)

007.    Pei-Hui Wang*, Zhi-Hua Gu, Ding-Hui Wan, Wei-Bin Zhu, Wei Qiu, Yong-Gui Chen, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Litopenaeus vannamei Toll-interacting protein (LvTollip) is a potential negative regulator of the shrimp Toll pathway involved in the regulation of the shrimp antimicrobial peptide gene penaeidin-4 (PEN4). Dev Comp Immunol. 2013 Jul-Aug;40(3-4):266-77. (IF 3.605)

006.    Pei-Hui Wang*, Zhi-Hua Gu, Ding-Hui Wan, Wei-Bin Zhu, Wei Qiu, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Litopenaeus vannamei Sterile-Alpha and Armadillo Motif Containing Protein (LvSARM) Is Involved in Regulation of Penaeidins and antilipopolysaccharide factors. PLoS One. 2013;8(2):e52088. (IF 3.752)

005.    Pei-Hui Wang*, Jian-Ping Liang, Zhi-Hua Gu, Ding-Hui Wan, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Molecular cloning, characterization and expression analysis of two novel Tolls (LvToll2 and LvToll3) and three putative Spätzle-like Toll ligands (LvSpz1-3) from Litopenaeus vannamei. Dev Comp Immunol. 2012 Feb;36(2):359-71. (IF 3.605)

004.    Pei-Hui Wang, Ding-Hui Wan, Li-Ran Pang, Zhi-Hua Gu, Wei Qiu, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Molecular cloning, characterization and expression analysis of the tumor necrosis factor (TNF) superfamily gene, TNF receptor superfamily gene and lipopolysaccharide-induced TNF-α factor (LITAF) gene from Litopenaeus vannamei. Dev Comp Immunol. 2012 Jan;36(1):39-50. (IF 3.605)

003.    Pei-Hui Wang, Zhi-Hua Gu, Ding-Hui Wan, Ming-Yan Zhang, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. The shrimp NF-κB pathway is activated by white spot syndrome virus (WSSV) 449 to facilitate the expression of WSSV069 (ie1), WSSV303 and WSSV371. PLoS One. 2011;6(9):e24773. (IF 3.752)

002.    Pei-Hui Wang, Ding-Hui Wan, Zhi-Hua Gu, Xie-Xiong Deng, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Litopenaeus vannamei tumor necrosis factor receptor-associated factor 6 (TRAF6) responds to Vibrio alginolyticus and white spot syndrome virus (WSSV) infection and activates antimicrobial peptide genes. Dev Comp Immunol. 2011 Jan;35(1):105-14. (IF 3.605)

001.    Pei-Hui Wang^#, Zhi-Hua Gu^#, Xian-De Huang, Bo-Du Liu, Xie-xiong Deng, Hua-Shui Ai, Jing Wang, Zhi-Xin Yin, Shao-Ping Weng, Xiao-Qiang Yu*, Jian-Guo He*. An immune deficiency homolog from the white shrimp, Litopenaeus vannamei, activates antimicrobial peptide genes. Mol Immunol. 2009 May;46(8-9):1897-904. (IF 4.174)

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