汪正品：博士，研究员，博士/硕士生导师。山东大学齐鲁青年学者，山东省优秀青年科学基金项目（海外）获得者。长期从事哺乳动物配子发生发育的相关研究工作，目前以第一作者/通讯作者身份在Nature Communications, Nucleic Acids Research, Theranostics, Development, Journal of Biological Chemistry等杂志发表多篇生殖领域研究论文。应邀担任The FASEB Journal，Journal of Urology，Scientific Reports，Archives of Virology等杂志审稿人。曾荣获NIH Nancy Nossal Fellowship Award，NIH Fellows Award for Research Excellence (FARE) 等奖励。实验室主要通过基因编辑技术构建小鼠模型，结合细胞生物学、发育生物学、生物化学以及生物信息学等手段，研究遗传因素在两性生殖细胞发育过程中的分子调控机制。目前主持国家自然科学基金面上项目，山东省海外优青项目以及山东省自然科学基金面上项目等。

• 2008/09/01-2014/07/01
  中国农业大学
  生理学
  With Certificate of Graduation for Doctorate Study
• 2004/09/01-2008/06/30
  华中农业大学
  水族科学与技术

• 2021-09 — Now
  山东大学生命科学学院
  研究员
• 2015-02 — 2021-07
  NIDDK美国国立卫生研究院
  博士后研究员

1. 精子发生的遗传调节机制

2. 卵子发生的调控机制

3. 生殖生物学

4. 发育生物学

(1) Conditional ablation of DIS3L2 ribonuclease in pre-meiotic germ cells causes defective spermatogenesis and infertility in male mice .Theranostics .2024

(2) DIS3 ribonuclease is essential for spermatogenesis and male fertility in mice .Development .2024

(3) Loss of DIS3L in the initial segment is dispensable for sperm maturation in the epididymis and male fertility .Reproductive Biology .2024

(4) MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice .Biochemical and Biophysical Research Communications .2023 ,675 :46-53

(5) Epididymal DIS3 exosome ribonuclease is not necessary for mouse sperm maturation or fertility .Biochemical and Biophysical Research Communications .2023 ,666 :36-44

(6) Transcriptome profiling of the initial segment and proximal caput of mouse epididymis .Frontiers in Endocrinology .2023 ,14

(7) scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells .Cells .2020

(8) FIGLA, LHX8 and SOHLH1 transcription factor networks regulate mouse oocyte growth and differentiation .Nucleic Acids Research .2020

(9) Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice .Nature Communications .2019

(10) Transforming growth factor-β signaling participates in the maintenance of the primordial follicle pool in the mouse ovary .Journal of Biological Chemistry .2014

1. 核糖核酸酶DIS3调控小鼠精子发生与雄性生育力的分子机制研究, 2023/08/24-2027/12/31

2. （包干项目）核糖核酸酶DIS3L2在精子发生与雄性不育中的功能研究, 2022/11/01-2025/12/30

3. （包干项目）精子发生与雄性不育, 2022/04/01-2025/03/31