汪正品：博士，研究员，博士/硕士生导师。山东大学齐鲁青年学者，山东省优秀青年科学基金项目（海外）获得者。博士毕业于中国农业大学，师从夏国良教授。博士后于美国国立卫生研究院（NIH，NIDDK），师从Jurrien Dean教授。长期从事哺乳动物配子发生发育的相关研究工作，目前以第一作者/通讯作者身份在Nature Communications， Nucleic Acids Research，Theranostics，Development，Journal of Biological Chemistry等杂志发表多篇生殖领域研究论文。应邀担任The FASEB Journal，Journal of Urology，Scientific Reports，Archives of Virology等杂志审稿人。曾荣获NIH Nancy Nossal Fellowship Award，NIH Fellows Award for Research Excellence (FARE) 等奖励。实验室主要通过基因编辑技术构建小鼠模型，结合细胞生物学、发育生物学、生物化学以及生物信息学等手段，研究遗传因素在两性生殖细胞发育过程中的分子调控机制，即精子发生和卵子发生的调控机制研究。目前主持国家自然科学基金面上项目，山东省海外优青项目以及山东省自然科学基金面上项目等。
发表文章 (#第一作者，*通讯作者)
1. Yu, J., Li, N., Li, H., Wang, X. and Wang, Z*. (2025) Genetic deficiency of EXOSC10 ribonuclease disrupts spermatogenesis and male fertility in mice. J. Biol. Chem., 110364.
2. Li, N., Yu, J., Feng, Y.Q., Xu, P., Wang, X., Zhou, M., Li, H., Xu, Y. and Wang, Z*. (2024) Conditional ablation of DIS3L2 ribonuclease in pre-meiotic germ cells causes defective spermatogenesis and infertility in male mice. Theranostics, 14, 5621-5642.
3. Wang, Z., Wu, D., Xu, X., Yu, G., Li, N., Wang, X., Li, J.L. and Dean, J. (2024) DIS3 ribonuclease is essential for spermatogenesis and male fertility in mice. Development, 151.
4. Wang, Z., Liu, C.Y., Zhao, Y. and Dean, J. (2020) FIGLA, LHX8 and SOHLH1 transcription factor networks regulate mouse oocyte growth and differentiation. Nucleic Acids Res., 48, 3525-3541.
5. Wang, Z., Xu, X., Li, J.L., Palmer, C., Maric, D. and Dean, J. (2019) Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice. Nat Commun, 10, 5196.
6. Wang, Z., Mu, X.Y., Guo, M., Wang, Y.J., Teng, Z., Mao, G.P., Niu, W.B., Feng, L.Z., Zhao, L.H. and Xia, G.L. (2014) Transforming growth factor-β signaling participates in the maintenance of the primordial follicle pool in the mouse ovary. J. Biol. Chem., 289, 8299-8311.
7. Zhou, M., Yu, J., Xu, Y., Li, H., Feng, Y.Q., Wang, X., Qiu, F., Li, N. and Wang, Z*. (2024) Exosc10 deficiency in the initial segment is dispensable for sperm maturation and male fertility in mice. Zygote, 32, 437-445.
8. Wang, X., Feng, Y.Q., Li, H., Xu, Y., Yu, J., Zhou, M., Qiu, F., Li, N. and Wang, Z*. (2024) Loss of DIS3L in the initial segment is dispensable for sperm maturation in the epididymis and male fertility. Reprod. Biol., 24, 100914.
9. Wang, X., Qiu, F., Yu, J., Zhou, M., Zuo, A., Xu, X., Sun, X.Y. and Wang, Z*. (2023) Transcriptome profiling of the initial segment and proximal caput of mouse epididymis. Front. Endocrinol. (Lausanne), 14, 1190890.
10. Qiu, F., Wang, X., Zhou, M., Yu, J. and Wang, Z*. (2023) Epididymal DIS3 exosome ribonuclease is not necessary for mouse sperm maturation or fertility. Biochem Biophys Res Commun, 666, 36-44.
11. Li, N., Yu, J., Zhou, M., Qiu, F., Wang, X. and Wang, Z*. (2023) MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice. Biochem Biophys Res Commun, 675, 46-53.
12. Wang, Z. and Xu, X. (2020) scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells. Cells, 9.
13. Wang, Z., Niu, W., Wang, Y., Teng, Z., Wen, J., Xia, G. and Wang, C. (2015) Follistatin288 Regulates Germ Cell Cyst Breakdown and Primordial Follicle Assembly in the Mouse Ovary. PLoS One, 10, e0129643.
Name of Research Group: |
生殖细胞发育课题组 |
Description of Research Group: |
团队包含博士后，博士，硕士等一批朝气蓬勃的青年人才。 |
Members： |
