吴文贤，研究员，山东大学齐鲁青年学者。

在德国海涅-杜塞尔多夫大学医学院取得博士学位，随后在海涅-杜塞尔多夫大学医学院做博士后和研究助理的研究工作。

研究方向主要运用分子生物学，细胞生物学，生物化学及模式生物来研究细胞自噬，线粒体自噬，细胞自噬和细胞坏死的交叉调控机制及与疾病的关系，并在国际权威期刊发表多篇学术论文，EMBO Journal (封面文章，一作)，Cell Reports（一作），Autophagy (3篇，一作)，EMBO Reports（一作）等，总的文章他引用次数已经超过800多次，并且参与了国内外重大课题的研究，比如德国研究基金会 (DFG) 项目 （3项），科技部973项目，国自然项目等。

代表性论文：

1. Wenxian Wu, Xiaojing Wang, Yadong Sun, Niklas Berleth, Jana Deitersen, David Schlütermann, Fabian Stuhldreier, Nora Wallot-Hieke, Maria José Mendiburo, Christoph Peter & Björn Stork. TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy.

Autophagy. 2021 Mar 28:1-18 (IF: 11.059)

2. Wenxian Wu and Björn Stork. Regulating RIPK1 – another way how ULK1 contributes to survival.

Autophagy  2020 Jun 24;1-3. (IF: 11.059)

3. Wenxian Wu and Björn Stork. The phospho-barcode of RIPK1: complementarity or redundancy? 

Molecular & Cellular Oncology.  2020 Jul 16;7(5):1776085 (IF: 1.47)

4. Wenxian Wu, Xiaojing Wang, Niklas Berleth,  Jana Deitersen, Nora Wallot-Hieke, Philip Böhler, David Schlütermann, Fabian Stuhldreier, Jan Cox, Katharina Schmitz, Sabine Seggewiß, Christoph Peter, Anja Stefanski, Kai Stühler, Astrid Tschapek, Axel Gödecke & Björn Stork. The autophagy-initiating kinase ULK1 controls RIPK1-mediated  cell death.  

Cell Reports.   2020 Apr 21;31(3):107547. (IF: 7.815)

5. Wenxian Wu, Wen Li, Hao Chen, Lei Jiang, Runzhi Zhu & Du Feng. FUNDC1 is a novel mitochondrial-associated-membrane (MAM) protein required for hypoxia-induced mitochondrial fission and mitophagy.

Autophagy. 2016 Sep;12(9):1675-6. (IF: 11.059)

6. Wenxian Wu, Chunxia Lin, Keng Wu, Lei Jiang,  Xiaojing Wang, Wen Li, Haixia Zhuang, Xingliang Zhang, Hao Chen, Shupeng  Li, Yue Yang, Yue Lu, Jingjing Wang, Runzhi Zhu, Liangqing Zhang, Senfang Sui, Ning Tan, Bin Zhao, Jingjing Zhang, Longxuan Li, Du Feng. FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact  site under hypoxic conditions.

EMBO J. 2016 Jul 1;35(13):1368-84. (IF: 11.227，cover)

7. Wenxian Wu, Weili Tian, Zhe Hu, Guo Chen, Lei  Huang, Wen Li, Xingli Zhang, Peng Xue, Changqian Zhou, Lei Liu, Yushan Zhu, Xingliang Zhang, Longxuan Li, Liangqing Zhang, Senfang Sui, Bin Zhao,   Du Feng. Ulk1 translocates to mitochondria and phosphorylates FUNDC1 to regulate  mitophagy.

EMBO Reports. 2014 May;15(5):566-575. (IF: 8.383)

8. Wenxian Wu, Wei Wei, Maryem Ablimit, Yuan Ma, Tao Fu, Kaiyu Liu, Jianxin Peng, Yi Li and Huazhu Hong. Responses of two insect cell lines to starvation: Autophagy prevents them from undergoing apoptosis and necrosis, respectively. Journal of Insect Physiology.  2011 Jun;57(6):723-34. (IF: 2.862)  

9. Wallot-Hieke N, Verma N, Schlütermann D, Berleth N, Deitersen J, Böhler P, Stuhldreier F, Wu W, Seggewiß S, Peter C, Gohlke H, Mizushima N and Stork B. Systematic Analysis of ATG13 Domain Requirements for Autophagy Induction. Autophagy.  2018;14(5):743-763. (IF: 11.059)

10. Schlütermann D, Skowron MA, Berleth N, Böhler P, Deitersen J,  Stuhldreier F, Wallot-Hieke N, Wu W, Peter C, Hoffmann MJ,  Niegisch G and Stork B. Targeting Urothelial Carcinoma Cells by Combining Cisplatin with a Specific Inhibitor of the Autophagy-Inducing Class III PtdIns3K Complex.

Urol Oncol. 2018 Apr;36(4):160.e1-160.e13.   (IF: 2.863)

11. Böhler P, Stuhldreier F, Anand R, Kondadi AK, Schlütermann D, Berleth  N, Deitersen J, Wallot-Hieke N, Wu W, Frank M, Niemann H,   Wesbuer E, Barbian A, Luyten T, Parys JB, Weidtkamp-Peters S, Borchardt A, Reichert AS, Peña-Blanco A, García-Sáez AJ, Itskanov S, van der Bliek AM,  Proksch P, Wesselborg S and Stork B. The Mycotoxin Phomoxanthone A  Disturbs the Form and Function of the Inner Mitochondrial Membrane.

Cell Death Dis. 2018 Feb 19;9(3):286. (IF: 5.959)

12. Guo, B., Huang, J., Wu, W.X., Feng, D., Wang, X.C.,  Chen Y.Y., and Zhang, H. The nascent polypeptide associated complex is  essential for autophagic flux.

Autophagy. 2014 Jul 18;10(10). (IF: 11.059)

13. Li W, Zhang X, Zhuang H, Chen HG, Chen Y, Tian W, Wu W,  Li Y, Wang S, Zhang L, Chen Y, Li L, Zhao B, Sui S, Hu Z, Feng D. MicroRNA-137 is a Novel Hypoxia-responsive MicroRNA that Inhibits Mitophagy via Regulation of Two Mitophagy Receptors FUNDC1 and NIX.

Journal of Biological Chemistry. 2014 Apr 11;289(15):10691-701. (IF: 4.106，F1000Prime)

14. Wei Wei., Zhongchao Gai., Hui Ai., Wenxian Wu, Yongbo  Yang, Jianxin Peng, Huazhu Hong, Yi Li, Kaiyu Liu. Baculovirus Infection Triggers a Shift from Amino Acid Starvation-Induced Autophagy to Apoptosis.

PLoS ONE. 2012;7(5):e37457. (IF: 2.776)  

15. Tian W, Li W, Chen Y, Yan Z, Huang X, Zhuang H, Zhong W, Chen Y, Wu  W, Lin C, Chen H, Hou X, Zhang L, Sui S, Zhao B, Hu Z, Li L, Feng D. Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy.

FEBS Lett. 2015 Jul 8;589(15):1847-54. (IF: 2.675)