吴霞，女，理学博士，教授。 院教指委委员会委员。长期从事光谱分析、高效稀土发光分析、生物分析和纳米分析化学研究。先后在Anal Chim Acta、Talanta、Microchim Acta等国际学术期刊发表研究论文130余篇。主持及参加国家级及省部级科研项目十余项。为主参加国家级、省级教研（教改）以及校级教学研究项目5项；参编普通高等教育“十一五”国家级规划教材《基础化学实验（Ι）--无机及分析化学实验》和《仪器分析实验》等（化学工业出版社）等，为主编写（第三位）《基础化学实验（Ι）--无机及分析化学实验》教材配套实验操作演示课件（2007年化学工业出版社）。主讲的《无机及分析化学实验》课程2008年6月被评为山东省省级精品课程（第四位），2009年被评为国家级精品课程(第三位)，2013年12月获得国家级精品资源共享课程立项(2014.01-2015.12年，第五位)。《无机及分析化学实验》2016年7月获得国家级精品资源共享课称号排名第五位。

【研究方向】光谱分析化学

【研究兴趣】

高效稀土发光分析和纳米分析方法研究及应用。主要从事稀土上/下转换（共）发光、纳米（贵金属、氧化石墨烯）增强荧光、生物分析（核酸、蛋白质、儿茶酚胺、药物、黄酮）、环境分析（POPs、重金属）等方面的分析研究。构建高灵敏、高选择性的生物大分子、有机小分子、环境污染物的荧光及共振光散射分析新方法。

【主讲课程】

研究生课程：高等分析化学、现代仪器应用（荧光、圆二色）、分析化学实验技术、现代光电分析

本科生课程：生化分析、无机及分析化学实验（生命、临床医学）、仪器分析实验、物理化学实验和综合化学实验等课程（蛋白质分析、荧光部分）

【主要论著】

• 2022 年发表的主要论文

1. XueQin Li, Xingcen Liu, Yujie Liu, Ran Gao, Xia Wu*, Xibao Gao. Highly sensitive detection of dopamine based on gold nanoflowers enhanced-Tb(III) fluorescence. Talanta 249(2022)123700

• 2021 年发表的主要论文

1. Jia Sun, Aili Feng, Xia Wu*, Xiaowen Che, Weizhi Zhou. Enhanced Tb(III) fluorescence on gelatin-coated silver nanoparticles in dopamine detection. Talanta 231(2021)122334

• 2020 年发表的主要论文 

2. Hui Zhang, Xingcen Liu, Jia Sun,  Xia Wu∗. A ratiometric fluorescence method for detection of Fe3+ based on longer wavelength excitation luminescence of homovanillic acid. Microchemical Journal 157 (2020) 105051.

1. Fangzheng Yuan, Xia Wu∗, Hui Zhang. Luminescence of Eu (III) complex under near-infrared light excitation for curcumin detection.  Talanta 218 (2020) 121104.

• 2019 年发表的主要论文 

2. Rongwei Cui, Kai Zhang, Xia Wu*, Hui Zhang, and Chuankui Wang. Determination of Fe3+ upon Special “Upconversion Luminescence”of Dopamine. ACS Omega 2019, 4, 9918−9924.

1. Chongmei Sun, Jin Shen, Rongwei Cui, Fangzheng Yuan, Hui Zhang, Xia Wu*. Silver nanoflowers-enhanced Tb(III)/La(III) co-luminescence for the sensitive detection of dopamine. Analytical and Bioanalytical Chemistry (2019) 411:1375–1381.

• 2018 年发表的主要论文 

1.Chongmei Sun, Fangzheng Yuan, Huihui Li, Xia Wu*. A specific fluorescent nanoprobe for dopamine based on the synergistic action of citrate and gold nanoparticles on Tb(III) luminescence. Microchimica Acta (2018) 185: 317

• 2017年发表的主要论文

2. Huihui Li, Jin Shen, Rongwei Cui, Chongmei Sun,Yanyan Zhao, Xia Wu*, Na Li and Bo Tang*. A highly selective and sensitive fluorescent nanosensor for dopamine based on formate bridged Tb(III) complex and silver nanoparticles."Analyst (back cover) 2017, 142, 4240-4246.

1. Jin Shen, Chongmei Sun, Xia Wu*. Silver nanoprisms-based Tb(III) fluorescence sensor for highly selective detection of dopamine. Talanta 2017，165,  369–376.

•2016年发表的主要论文

2. Yanyan Zhao, Haiping Zhou, Jin Shen, Minqin Wang and Xia Wu*. Study on the interaction of berberine with nucleic acids in the presence of silver nanoparticles, and the fluorometric determination of nucleic acids. RSC Advances 2016, 6, 29612–29618.

1. Yanyan Zhao, Xia Wu* Yingjun Wang，Ruijie Jing and Fengli Yue. COMPARING PHYSICOCHEMICAL PROPERTIES OF HAWTHORN SUPERFINE AND FINE POWDERS.  Journal of Food Processing and Preservation DOI: 10.1111/jfpp.12834(2016.06)

•2015年发表的主要论文

3. Fei Huang, Fanhui Meng, Mengdi Fan, Yanyan Zhao, Xia Wu*, Lin Shen. Fluorescence enhancement effect of Eu(III)–thenoyltrifluoroacetone–cetyltrimethyl ammonium bromide in water-dissolved organic matter extracted from wheat straw.  Spectrochimica Acta Part A 2015, 151,302–307.

2. Huihui Li, Xia Wu*.Silver nanoparticles-enhanced rare earth co-luminescence effect of Tb(III)–Y(III)–dopamine system. Talanta 2015,138, 203–208.

1. Xiaodan Liu and Xia Wu*. Fluorescence enhancement of fisetin by silver nanoparticles with cetyltrimethyl ammonium bromide micelles. RSC Adv., 2015, 5, 7433–7439.

• 2014年发表的主要论文

2. Fanhui Meng, Ping Liu, Fei Huang, Liwei Wang,  Xia Wu*, Lin Shen. Synchronous fluorescence determination of ferulic acid with Ce(IV) and sodium tripolyphosphate. Luminescence 2014; 29(3): 243–247.

1.Ping Liu, Liangliang Zhao, Xia Wu*, Fei Huang, Minqin Wang, Xiaodan Liu. Fluorescence enhancement of quercetin complexes by silver nanoparticles and its analytical application. 2014,122 (6), 238–245.

• 2011年发表的主要论文
  

4. Fengju Zhang, Xia Wu*, Jinhua Zhan. Resonance light scattering technique for determination of polychlorinated biphenyls with silver nanoparticles. Luminescence 2011, 26(6): 656–661.

3. Fengju Zhang, Xia Wu*, Jinhua Zhan. Fluorescence Enhancement Effect for the Determination of Polychlorinated Biphenyls with Bovine Serum Albumin. Journal of Fluorescence, 2011, 21(5): 1857-1864.

2.  Yinghua Cao, Xia Wu*, Minqin Wang. Silver nanoparticles fluorescence enhancement effect for determination of nucleic acids with kaempferol–Al  (III) . Talanta 2011,84  (4) 1188–1194.

1.Haiping Zhou, Xia Wu*, Fanhui Meng, Jinghe Yang, Minqin Wang. Nucleic acids determination using the complex of eriochrome black T and silver nanoparticles in a resonance light scattering technique.   Spectrochimica Acta Part A 2011, 78 (2) 681–686.

• 2010年发表的主要论文
  

2.Haiping Zhou, Xia Wu*, Wei Xu, Jinghe Yang and Qiuxia Yang. Fluorescence Enhancement of the Silver Nanoparticales – Curcumin - Cetyltrimethylammonium Bromide-nucleic Acids System and its Analytical Application.  Journal of Fluorescence, 2010, 20(4): 843 - 850.

1. Xiaoyu Liu, Xia Wu*, Jinghe Yang. Protein determination using methylene blue in a synchronous fluorescence technique. Talanta, 2010, 81  (3) : 760-765  . 

2009年发表的主要论文

1.Haiping Zhou, Xia Wu*, Jinghe Yang Study on the interaction of nucleic acids with silver nanoparticles—Al(III) by resonance light scattering technique and its analytical application Talanta 78 (2009) 809–813

2.Changxia Sun, Xia Wu*, Honghong Ding, Liangliang Zhao, Fei Wang, Jinghe Yang* and Xiaoyu Liu. The Fluorescence Enhancement of the Protein Adsorbed on the Surface of Ag Nanoparticle. Journal of Fluorescence 2009, 19(1):111-117.

2008年发表的主要论文

4.Changying Guo, Xia Wu*, Wei Xu, Jinghe Yang Resonance light-scattering enhancement effect of the protein-Y3+-TTA-SLS system and its analytical application. Luminescence, 2008, 23(6): 404-409. 

3.Chang Xia Suna, Xia Wu*, Hai Ping Zhou, FeiWang, Hong Hong Ding, Liang Liang Zhao, Jing He Yang*. Ag island film-enhanced rare earth co-luminescence effect of Tb–Gd–protein–sodium dodecyl benzene sulfonate system and sensitive detection of protein. Talanta 76 (2008) 1047–1052(3.374)

2.Liangliang Zhao, Xia Wu*, Honghong Ding and Jinghe Yang* Fluorescence enhancement effect of morin-nucleic acid-L-cysteine-capped nano-ZnS system and the determination of nucleic acid. Analyst, 2008, 133, 896–902(3.553)

1.Jinhua Zheng, Xia Wu*, Minqin Wang, Dehuan Ran, Wei Xu and Jinhe Yang*  Study on the interaction between silver nanoparticles and nucleic acids in the presence of cetyltrimethylammonium bromide and its analytical application Talanta 2008,74(4): 526-532 (3.374)

2007年发表的主要论文

3.Dehuan Ran, Xia Wu*, Jinhua Zheng ,Jinghe Yang*, Haiping Zhou, Meifeng Zhang,Yongjun Tang. Study on the Interaction between Florasulam and Bovine Serum Albumin. J Fluoresc (2007) 17:721–726

2.Xia Wu*, Jinhua Zheng, Honghong Ding, Dehuan Ran,Wei Xu, Yuanyuan Song, Jinghe Yang*  Study on the interaction between oxolinic acid aggregates and protein and its analytical application. Analytica Chimica Acta 596 (2007) 16–22

1. Xia Wu, Jinhua Zheng, ChangYing Guo, Jinghe Yang , Honghong Ding ,Zhiyong Hu, Chao Li. Determination of albumins by its quenching effect on the fluorescence of Tb3+-oxolinic acid complex in presence of sodium dodecyl sulphate. Journal of Luminescence, 2007,126():171-176 2006年

2006年发表的主要论文

5. Xia Wu，Changying Guo，Fei Wang，Jinghe Yang*，Dehuan Ran，Jinhua Zheng，Jinbo Wu. Fluorescence enhancement of yttrium(III)–rutin by nucleic acids in the presence of cetyltrimethylammonium bromide. Spectrochimica Acta Part A 2006,65 (): 543-548

4.Xia Wu, Jing He Yang,* Shuna Sun, Changying Guo, Dehuan Ran and Jinhua zheng Determination of nucleic acids based on the quenching effect on resonance light scattering of the Y(III)–1,6-bi(1′-phenyl-3′-methyl-5′-pyrazolone-4′-)hexane-dione system. Luminescence 2006, 21: 129–134

3.Changying Guo, Xia Wu*, Jinghe Yang, Fei Wang, Zhen Jia, Dehuan Ran and Jinhua Zheng Determination of proteins using fluorescence enhancement of Tb3+–benzoylacetone–sodium dodecyl benzene sulfonate–protein system. Journal of Photochemistry and Photobiology A: Chemistry 2006,181(): 50-55

2.Xia Wu, Shuna Sun, Changying Guo, Jinghe Yang,* Changxia Sun, Chengrong Zhou and Tao Wu Resonance light scattering technique for the determination of proteins with Congo red and Triton X-100. Luminescence 2006, 21: 56–61

1.Feng Wang, Xia Wu, Fei Wang, Shufang Liu, Zhen Jia and Jinghe Yang. The Sensitive Fluorimetric Method for the Determination of Curcumin Using the Enhancement of Mixed Micelle. Journal of Fluorescence 2006, 16(1):53-59

2005年发表的主要论文

11. Xia Wu, Changying Guo, Jinghe Yang, Minqin Wang, Yanjing Chen, Jian Liu, The sensitive determination of nucleic acids using fluorescence enhancement of Eu3+-Benzoylacetone-Cetyltrimethyl ammonium Bromide-nucleic acid system Journal of Fluorescence 2005, 15(5), 655-660

10.Xia Wu, Jinghe Yang*, Dehuan Ran, Changying Guo, Suna Sun, Jinghua Zheng, Leilei Xu,STUDY ON THE FLUORESCENCE SYSTEM OF OXOLINIC ACID-TB(III) AND THE DETERMINATION OF OXOLINIC ACID Analtical Letters 38(14),(2005),2345 - 2354 

9.Xia Wu, Shuna Sun, Jinghe Yang, Minqin Wang, Liyan Liu and Changying Guo, Study on the interaction between nucleic acid and Eu3+–oxolinic acid and the determination of nucleic acid using the resonance light scattering technique. Spectrochimica Acta Part A 2005,62(4-5):896-901(SCI)

8.Xia Wu, Jinghe Yang*, Changxia Sun, Shuna Sun, Changying Guo and Yanjing Chen A fluorimetric method for the determination of nucleic acids using Ce(IV) and sodium triphosphate. Luminescence 2005; 20: 41–45

7.Xia Wu, Yuebo Wang, Minqin Wang, Shuna Sun, Jinghe Yang yuxia Luan. Determination of nucleic acids at nanogram level using resonance light scattering technique with Congo Red Spectrochimica Acta Part A 61 (2005) 361–366

6.Yunxiao Han, Xia Wu*, Jinghe Yang, Shuna Sun The fluorescence characteristic of the yttrium–norfloxacin system and its analytical application.Journal of Pharmaceutical and Biomedical Analysis 38 (2005) 528–531

5.Feng Wang, Jinghe Yang, Xia Wu and Shufang Liu. Study of the interaction of proteins with curcumin and SDS and its analytical.Spectrochimica Acta Part A 2005,61(11-12),2650-2656

4.Changxia Sun, Jinghe Yang, Xia Wu, Xirong Huang, Fei Wang, and Shufang Liu.Unfolding and Refolding of Bovine Serum Albumin Induced by Cetylpyridinium Bromide.Biophysical Journal Volume 88 May 2005 1–7

3.Fei Wang, Jinghe Yang, Xia Wu, Changxia Sun, Shufang Liu, Changying Guo and Zhen Jia, The interaction mechanism and fluorescence enhancement in morin–Al3+–sodium dodecyl benzene sulfonate-protein system. Chemical Physics Letters 409 (2005) 14–22

2. Fei Wang, Jinghe Yang*, Xia Wu, Changxia Sun, Shufang Liu,Changying Guo, Feng Wang. Fluorescence enhancement effect for the determination of proteins with morin–Al3+–cetyltrimethylammonium bromide Talanta 67 (2005) 836–842

1. Lei Li, Jinghe Yang*, Xia Wu, Changxia Sun, Yang Liu, Shufang Liu a, Benyu SubThe fluorescence enhancement effect of Tb–Gd–adenosine triphosphate–phen system and its analytical application Talanta 65 (2005) 201–205

【科研项目】

主持

酚胺类物质发光分析新方法研究及分析应用 山东省自然科学基金（ZR2018MB031）2018.03-2021.06

基于金属表面增强稀土(共)发光的荧光传感构建及生物分析应用 国家自然科学基金（21545001）2016.01-2016.12

纳米银敏化稀土共发光检测激素肿瘤标志物  山东省自然科学基金（ZR2013BM025）2013.10-2016.12

银纳米晶-核酸-药物体系荧光增强效应的研究 山东自然科学基金（重点 Z2008B04） 2008.12-2011.12 

华东地区主要秸秆物性分析与评价（国家公益性行业科研专项专题）

生物粉体分析应用 (国科发农) 

生物物质纳米粒子发光探针的研究及应用 山东省自然科学基金（Y2003B02）2003.12-2006.12

蛋白质与药物多元体系的自组装作用、能量转移和光谱性质的研究  胶体与界面化学教育部重点实验室开放课题 2005.1-2006.12

参加：

二维纳米材料的原位合成及其电分析化学应用研究（21475076）国家自然科学基金 (第二位)2015.1-2018.12

蛋白质纳米发光性能和分子识别作用的研究（20575035）国家自然科学基金 (第二位)2006.1-2008.12