徐莉，山东大学，国家糖工程技术研究中心，副教授

主持或参加科研项目（课题）情况:

1.国家科学技术部, 国家重点研发计划, 2021YFC2103101, 医用多糖生物合成共性机制及透明质酸高产关键技术,子课题5，2021-12 至 2025-11,在研

2.国家科学技术部，国家重点研发计划，2018YFA0902000，以增加水溶性为导向的合成生物学创制课题2，子课题2， 2019-07至2024-06，在研

3.山东省自然科学基金委，面上项目，ZR2021MC104，聚黄酮的酶法合成及其肿瘤细胞靶向递药机制与应用研究，2022-01至2024-12,在研，主持

4.山东省科技厅，山东省重点研发计划，2017GSF21115, 光热与活性氧联合治疗肿瘤的纳米材料的研究结题，2017-01至2018-12,结题，主持

5.国家自然科学基金委员会，青年项目，31301155，细胞外人酪氨酰氧化酶家族蛋白在乳腺癌细胞转移过程中的作用和协同性研究，2014-01至2016-12，结题，主持

6.山东省自然科学基金委员会，青年项目，ZR2013CQ043，人赖氨酰氧化酶类2（hLOXL2）的表达、糖基化和蛋白酶的修饰及其在乳腺癌细胞侵袭过程中的作用， 2013-10至2016-10，结题，主持

代表性论著

(1) Jiasheng Shi, Henan Zhang, Qian Wang, Zhengyu Duan, Li Xu*, Fenghao Guo, Yunfeng Xie*, Zhiyong Chen*; Biomimetic rigid cryogels with aligned micro-sized tubular structures prepared by conventional redox-induced cryopolymerization in a freezer, Chemical Engineering Journal, 2022, 427, 131903

(2) Weiying Hong, Chang-Cheng Liu, Henan Zhang, Zhiyong Chen, Min Xiao*, and Li Xu*; Cancer cell preferential penetration and pH-responsive drug delivery of oligorutin, Biomacromolecules, 2021, DOI:10.1021/acs.biomac.1c00268

(2) Yinping Li^#; Weiying Hong^#; Henan Zhang^#; Tian Tian Zhang; Zhiyong Chen; Shiling Yuan; Peng Peng^*; Min Xiao^*; Li Xu^*; Photothermally triggered cytosolic drug delivery of glucose functionalized polydopamine nanoparticles in response to tumor microenvironment for the GLUT1-targeting chemo-phototherapy, Journal of Controlled Release, 2020, 317: 232-245.

(3) Tiantian Zhang^#; Yinping Li^#; Weiying Hong; Zhiyong Chen; Peng Peng; Shiling Yuan; Jingyao Qu; Min Xiao^*; Li Xu^*; Glucose oxidase and polydopamine functionalized iron oxide nanoparticles: combination of the photothermal effect and reactive oxygen species generation for dual-modality selective cancer therapy, Journal of Materials Chemistry B, 2019, 7: 2190-2200.

(3) Li Xu^#; Xiaohong Liu^#; Yinping Li^#; Zhenhao Yin; Lan Jin; Lili Lu; Jingyao Qu; Min Xiao^*; Enzymatic rhamnosylation of anticancer drugs by an α-L-rhamnosidase from Alternaria sp. L1 for cancer targeting and enzyme activated prodrug therapy, Applied Microbiology and Biotechnology, 2019, 103: 7997-8008.

(4) Li Xu^#; Xiaohong Liu^#; Zhenhao Yin^#; Qian Liu; Lili Lu; Min Xiao^*; Sitedirected mutagenesis of α-L-rhamnosidase from Alternaria sp. L1 to enhance synthesisyield of reverse hydrolysis based on rational design, Applied Microbiology and Biotechnology, 2016, 100: 10385-10394.

(5) Li Xu; Eden P. Go; Joel Finney; HeeJung Moon; Mason Lantz; Kathryn Rebecchi; Heather Desaire^*; Minae Mure^*; Post-translational modifications of recombinant human lysyl oxidase-like 2 (rhLOXL2) secreted from drosophila S2 cells, Journal of Biological Chemistry, 2013, 288(8): 5357-5363.

专利

(1) 徐莉; 张甜甜; 肖敏; 李银萍; 洪伟英; 一种光热与活性氧联合治疗肿瘤的复合纳米材料的制备方法及应用, 2018-2-27, 中国, 授权公告号CN108273059B

(2) 徐莉; 肖敏; 李银萍; 洪伟英; 张赫男; 一种具有靶向光热治疗和可控释药的多重作用纳米材料的制备方法及应用, 2019-01-18, 中国, 授权公告号CN109589402B

(3)徐莉、肖敏、洪伟英、张赫男、王洋；寡聚芦丁在制备肿瘤靶向产品中的应用及寡聚芦丁-硼替佐米肿瘤靶向递药系统，2021-01-26，中国, 受理号202110098831.7