• 1998/09/01-2004/01/01
  Fudan University
  Genetics
  With Certificate of Graduation for Doctorate Study
• 1995/09/01-1998/07/01
  Yantai University
  Biochemistry
  University graduated

• 2009-05 — Now
  School of Life SciencesShandong University
• 2005-10 — 2009-04
  School of MedicineStanford University
• 2005-01 — 2005-09
  Harvard Medical School
• 2004-01 — 2004-12
  Chinese National Human Genome Center at Shanghai

1. Hearing transduction and deafness

2. Stereocilia development and maintenance

(1)Nana Li,Shuang Liu,Dange Zhao. Disruption of Cdh23 exon 68 splicing leads to progressive hearing loss in mice by affecting tip-link stability .Proc Natl Acad Sci U S A .2024 ,121 (10):e2309656121

(2)Ying Guan,Hai-Bo Du,Zhao Yang,Yu-Zhu Wang,Rui Ren,Wen-Wen Liu. Deafness-associated ADGRV1 mutation impairs USH2A stability through improper phosphorylation of WHRN and WDSUB1 recruitment .Advanced Science .2023 ,10 (16):e2205993

(3)Xiaoying Wang,Shuang Liu. CIB2 and CIB3 regulate stereocilia maintenance and mechanoelectrical transduction in mouse vestibular hair cells .Journal of Neuroscience .2023 ,43 (18):3219-3231

(4)Rui Ren. Loss of TMCC2 activates endoplasm reticulum stress and causes auditory hair cell death .Human Molecular Genetics .2023 ,32 (10):1622-1633

(5)Huang Wang,Haibo Du. Temporal and spatial assembly of inner ear hair cell ankle link condensate through phase separation .Nature Communications .2023 ,14 (1):1657

(6)Xiaoyan Zhai. FCHSD2 is required for stereocilia maintenance in mouse cochlear hair cells .Journal of Cell Science .2022 ,135 (16):jcs259912

(7)Haibo Du,Linzhi Zou. Lack of PDZD7 long isoform disrupts ankle-link complex and causes hearing loss in mice .FASEB Journal .2020 ,34 (1):1136

(8)Xiao-Ning Cheng,Ming Shao,Ji-Tong Li. Leucine repeat adaptor protein 1 interacts with Dishevelled to regulate gastrulation cell movements in zebrafish .Nature Communications .2017 ,8 :1353

(9)Qiao-Xia Hu,Jun-Hong Dong,Hai-Bo Du. Constitutive Gαi coupling activity of very large G protein-coupled receptor 1 (VLGR1) and its regulation by PDZD7 protein .Journal of Biological Chemistry .2014 ,289 (35):24215-24225