• 1998/09/01-2004/01/01
  Fudan University
  Genetics
  With Certificate of Graduation for Doctorate Study
• 1995/09/01-1998/07/01
  Yantai University
  Biochemistry
  University graduated

• 2009-05 — Now
  School of Life SciencesShandong University
• 2005-10 — 2009-04
  School of MedicineStanford University
• 2005-01 — 2005-09
  Harvard Medical School
• 2004-01 — 2004-12
  Chinese National Human Genome Center at Shanghai

1. Hearing transduction and deafness

2. Stereocilia development and maintenance

(1)Keji Yan. BAIAP2L1 and BAIAP2L2 differently regulate hair cell stereocilia morphology .FASEB J .2024 ,38 (15):e23860

(2)Nana Li,Shuang Liu,Dange Zhao. Disruption of Cdh23 exon 68 splicing leads to progressive hearing loss in mice by affecting tip-link stability .Proc Natl Acad Sci U S A .2024 ,121 (10):e2309656121

(3)Ying Guan,Hai-Bo Du,Zhao Yang,Yu-Zhu Wang,Rui Ren,Wen-Wen Liu. Deafness-associated ADGRV1 mutation impairs USH2A stability through improper phosphorylation of WHRN and WDSUB1 recruitment .Advanced Science .2023 ,10 (16):e2205993

(4)Xiaoying Wang,Shuang Liu. CIB2 and CIB3 regulate stereocilia maintenance and mechanoelectrical transduction in mouse vestibular hair cells .Journal of Neuroscience .2023 ,43 (18):3219-3231

(5)Rui Ren. Loss of TMCC2 activates endoplasm reticulum stress and causes auditory hair cell death .Human Molecular Genetics .2023 ,32 (10):1622-1633

(6)Huang Wang,Haibo Du. Temporal and spatial assembly of inner ear hair cell ankle link condensate through phase separation .Nature Communications .2023 ,14 (1):1657

(7)Xiaoyan Zhai. FCHSD2 is required for stereocilia maintenance in mouse cochlear hair cells .Journal of Cell Science .2022 ,135 (16):jcs259912

(8)Haibo Du,Linzhi Zou. Lack of PDZD7 long isoform disrupts ankle-link complex and causes hearing loss in mice .FASEB Journal .2020 ,34 (1):1136

(9)Xiao-Ning Cheng,Ming Shao,Ji-Tong Li. Leucine repeat adaptor protein 1 interacts with Dishevelled to regulate gastrulation cell movements in zebrafish .Nature Communications .2017 ,8 :1353

(10)Qiao-Xia Hu,Jun-Hong Dong,Hai-Bo Du. Constitutive Gαi coupling activity of very large G protein-coupled receptor 1 (VLGR1) and its regulation by PDZD7 protein .Journal of Biological Chemistry .2014 ,289 (35):24215-24225