一、基本情况介绍
杨小叶，博士，硕士生导师，山东大学青年学者未来计划入选人。主要从事肿瘤多模态治疗智能纳米体系的研究、新型生物材料的合成及应用等方面的研究。作为项目负责人承担国家自然科学基金青年基金，中国博士后科学基金，山东省自然科学基金等项目。作为第一作者或通讯作者在ACS Nano,Biomaterials, Journal of Controlled Release, Coordination Chemistry Reviews, Biomacromolecules 等国际一流期刊发表学术论文近20篇。作为第一发明人授权中国发明专利1项。
通讯地址：山东省济南市文化西路44号山东大学药学院，250012
邮箱：yangxiaoye@sdu.edu.cn
二、工作和学习经历
2023.09-至今 山东大学，药学院，副教授
2020.07-2023.09 山东大学，药学院，副研究员
2018.07-2020.07 山东大学，基础医学院，博士后
2016.08-2017.08 曼彻斯特大学(University of Manchester)，联合培养博士
2013.09-2018.06 山东大学，药学院，药剂学，硕博连读，博士
2009.09-2013.06 山东大学（威海），药学，学士
三、研究方向
1. 高效铁死亡调控型递药系统的开发及其在疾病治疗中的应用
2. 肿瘤多模态治疗智能纳米体系的设计与开发
3. 新型生物材料的合成及应用
四、主要承担科研项目
1. 国家自然科学基金青年项目
2. 山东省自然科学基金青年项目
3. 山东大学青年学者未来计划
4. 中国博士后科学基金面上资助
5. 山东大学基本科研业务经费
五、教学工作
1. 2023 年山东省研究生创新成果奖：基于铁死亡激活的抗肿瘤联合治疗体系的研究（指导教师）
2. 承担课程：
《药剂学》（本科）；《现代药物制剂技术》（研究生）
六、代表性学术论文
（#第一作者，*通讯作者）
1. Y. Zhang#, X. Du, Z. He, S. Gao, L. Ye, J. Ji, X. Yang*, G. Zhai*. A vanadium-based nanoplatform synergizing ferroptotic-like therapy with glucose metabolism intervention for enhanced cancer cell death and antitumor immunity. ACS Nano. 2023;17(12):11537-56.
2. J. Ding#, Z. He, Y. Zhai, L. Ye, J. Ji, X. Yang*, G. Zhai*. Advances in metal-based nano drugs and diagnostic probes for tumor. Coordination Chemistry Reviews. 2024;501:215594.
3. Z. He#, H. Zhou, Q. Feng, Y. Zhang, S. Gao, S. Liu, L. Ye , J. Ji, Y. Xi, X. Yang*, G. Zhai*. A bimetallic dual-targeting nanoplatform for combinational ferroptosis activation/epigenetic regulation/photothermal therapy against breast cancer and tumor microenvironment remodeling. Chemical Engineering Journal. 2024;479:147466.
4. X. Kong#, Z. He, Y. Zhang, Y. Fang, D. Liu, H. Wu, J. Ji, Y. Xi, L. Ye, X. Yang*, G. Zhai*. Intelligent Self-amplifying Ferroptosis-inducible nanoplatform for enhanced tumor microenvironment reconstruction and combination therapy. Chemical Engineering Journal. 2023;468:143729.
5. Z. He#, H. Zhou, Y. Zhang, X. Du, S. Liu, J. Ji, X. Yang*, G. Zhai*. Oxygen-boosted biomimetic nanoplatform for synergetic phototherapy/ferroptosis activation and reversal of immune-suppressed tumor microenvironment. Biomaterials. 2022;290:121832.
6. Y. Zhang#, X. Du, S. Liu, H. Yan, J. Ji, Y. Xi, X. Yang*, G. Zhai*, NIR-triggerable ROS-responsive cluster-bomb-like nanoplatform for enhanced tumor penetration, phototherapy efficiency and antitumor immunity, Biomaterials, 278 (2021) 121135.
7. X. Yang#, X. Shi, Y. Zhang, J. Xu, J. Ji, L. Ye, F. Yi, G. Zhai*, Photo-triggered self-destructive ROS-responsive nanoparticles of high paclitaxel/chlorin e6 co-loading capacity for synergetic chemo-photodynamic therapy, Journal of Controlled Release, 323 (2020) 333-349. (IF: 9.776)
8. X. Yang#, X. Shi, R. D'Arcy, N. Tirelli*, G. Zhai*, Amphiphilic polysaccharides as building blocks for self-assembled nanosystems: molecular design and application in cancer and inflammatory diseases, Journal of Controlled Release, 272 (2018) 114-144.
9. Y. Zhang#, N. Qiu, Y. Zhang, H. Yan, J. Ji, Y. Xi, X. Yang*, X. Zhao*, G. Zhai*, Oxygen-carrying nanoparticle-based chemo-sonodynamic therapy for tumor suppression and autoimmunity activation, Biomaterials Science, 9 (2021) 3989-4004.
10. L. Wang#, Y. Zhang, Y. Ma, Y. Zhai, J. Ji*, X. Yang*,G. Zhai*, Cellular drug delivery system for disease treatment. International Journal of Pharmaceutics, 2023;641:123069.
11. D. Liu#, S. Gao, Y. Zhai, X. Yang*, G. Zhai*, Research progress of tumor targeted drug delivery based on PD-1/PD-L1, International Journal of Pharmaceutics, 616 (2022) 121527.
12. X. Yang#, H. Du, J. Liu, G. Zhai*, Advanced nanocarriers based on heparin and its derivatives for cancer management, Biomacromolecules, 16 (2015) 423-436.
13. X. Yang#, X. Cai, A. Yu, Y. Xi, G. Zhai*, Redox-sensitive self-assembled nanoparticles based on alpha-tocopherol succinate-modified heparin for intracellular delivery of paclitaxel, Journal of Colloid and Interface Science, 496 (2017) 311-326.
14. X. Yang#, X. Shi, J. Ji, G. Zhai*, Development of redox-responsive theranostic nanoparticles for near-infrared fluorescence imaging-guided photodynamic/chemotherapy of tumor, Drug Delivery, 25 (2018) 780-796.
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