Xuetian Yue，PhD，is a professor in Department of Cell Biology, School of Basic Medical Sciences.

• 2009/09/01-2012/06/30
  Shandong University
  Immunology
  Postgraduate (Doctoral)
• 2006/09/01-2009/04/13
  Zhejiang SCI-TECH University
  Biochemistry and Molecular Biology
  Postgraduate (Master's Degree)
• 2001/09/01-2005/07/01
  Liaocheng University
  Bioengineering

• 2013-01 — 2018-01
  Radiation OncologyRutgers Cancer Institute of New Jersey
  Post Doc
• 2018-03 — Now
  Department of Cell BiologySchool of Basic Medical Sciences, Shandong University
  Professor

Tumor Nutrient Stress and Response

1. Tumor Metabolism

(1)孙敏. SHMT2 promotes papillary thyroid cancer metastasis through epigenetic activation of AKT signaling .Cell Death & Disease .2024 ,15 (1)

(2) Urolithin A Hijacks ERK1/2-ULK1 Cascade to Improve CD8+ T Cell Fitness for Antitumor Immunity .Advanced Science .2024

(3) Identification of a small-molecule Tim-3 inhibitor to potentiate T cell-mediated antitumor immunotherapy in preclinical mouse models .SCIENCE TRANSLATIONAL MEDICINE .2023 ,15 (722)

(4)张言坤. ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury .NATURE COMMUNICATIONS .2023 ,14 (1)

(5)Kong, Youzi. Lipophagy-mediated cholesterol synthesis inhibition is required for the survival of hepatocellular carcinoma under glutamine deprivation .Redox Biology .2023 ,63

(6)王晓静. 齐鲁医学院研究生细胞生物学教学改革探索 .基础医学教育 .2021 (23（3）)

(7)张晓东. TIPE1 promotes liver regeneration by enhancing ROS-FoxO1 axis mediated autophagy. .FEBS JOURNAL .2022 (4)

(8)丁璐. Zhx2 maintains islet β-cell mass and function by transcriptionally regulating Pax6 .iScience .2023 ,26 (2348 –0874):106871

(9)王玉珍. TIM-4 orchestrates mitochondrial homeostasis to promote lung cancer progression via ANXA2/PI3K/AKT/OPA1 axis .2023 ,14 (2)

(10)焦德雁. Lipid accumulation-mediated histone hypoacetylation drives persistent NK cell dysfunction in anti-tumor immunity .Cell Reports .2023 ,42 (10)

(11)王樱淳. Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages .cell reports .2022 (9)

(12)岳学田. SREBF2-STARD4 axis confers sorafenib resistance in HCC by regulating mitochondrial cholesterol homeostasis. .CANCER SCIENCE .2022

(13)逯景辉. Multi-Omics Analysis of Fatty Acid Metabolism in Thyroid Carcinoma .FRONTIERS IN ONCOLOGY .2021 ,11

(14)张言坤. ZHX2 inhibits thyroid cancer metastasis through transcriptional inhibition of S100A14 .CANCER CELL INTERNATIONAL .2022 ,22 (1)

(15) ZHX2 inhibits SREBP1c-mediated de novo lipogenesis in hepatocellular carcinoma via miR-24-3p .Journal of Pathology .2020

(16) Tumor suppressor ZHX2 inhibits NAFLD-HCC progression via blocking LPL-mediated lipid uptake .Cell Death and Differentiation .2020

(17) Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression .Genes & Development .2017

(18) BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function .Elife .2015

(19) Zinc fingers and homeoboxes 2 inhibits hepatocellular carcinoma cell proliferation and represses expression of Cyclins A and E .Gastroenterology .2012

1. 一种人可溶性TIM-4蛋白在制备抗肿瘤药物中的应用

2. 胆固醇转运抑制剂U18666A作为增敏剂在制备抗肿瘤产品中的应用

3. 一种 i-CS/HAp-NK 复合体及其制备方法和应用

4. 一种TIM-3棕榈酰化修饰及靶向多肽在肿瘤免疫治疗中的应用

5. ABCF1或其激动剂在制备抗DNA病毒制剂中的应用

1. PRMT5介导Parkin精氨酸甲基化调控线粒体自噬在NASH中的作用和机制研究, 2024/08/23-2028/12/31

2. 益生菌及关键代谢物促进 HBV特异性T细胞免疫清除的作用和分子机制, 2022/12/01-2025/11/30

3. 肿瘤免疫逃逸关键抑制分子的鉴定及多靶向纳米抗体制备, 2020/12/16-2023/12/31

4. （包干项目）肿瘤代谢重塑与肿瘤表观遗传, 2020/12/12-2023/12/31

5. 能量代谢失衡介导肿瘤浸润NK细胞功能耗竭的机制和干预策略研究, 2020/01/01-2022/12/31

6. Tumor Metabolism Reprogramming and Tumor Epigenetics, 2021/01/01-2023/12/31

7. ZHX2 regulates lipid metabolism reprogramming to inhibit Sorafenib resistance in HCC, 2020/01/01-2023/12/31