Yong-Qiang Zhang

Professor of Organic Chemistry

School of Chemistry and Chemical Engineering, Shandong University

Address: Shanda South Rd 27, Jinan, 250100, China

Email: yongqzhang@sdu.edu.cn

Education & Work Experience

2019-          Professor, Shandong University

2018-2018  Postdoc, Pharmaceutical Institute, Bonn University

2014-2018  Humboldt Fellow, Kekulé-Institute, Bonn University

2012-2013  Postdoc, Georgia State University 

2002-2011  B.S. & Ph.D. Lanzhou University 

Research Interests

1. Asymmetric Titanium Radical Catalysis

2. Natural Product Synthesis and Pharmaceutical Chemistry

Publications @ Shandong University

1. Li, Longfei; Yang, Shuo; Xu, Zhongyun; Li, Shengxiao; Jiang, Jie; Zhang, Yong-Qiang*

Dinuclear Titanium(III)-Catalyzed Radical-Type Kinetic Resolution of Epoxides for Enantioselective Synthesis of cis-Glycidic Esters

J. Am. Chem. Soc. 2024, 146, 13546-13557.

2. Shen, Jian; Xu, Zhongyun; Yang, Shuo; Li, Shengxiao; Jiang, Jie;* Zhang, Yong-Qiang*

Quaternary Stereocenters via Catalytic Enantioconvergent Allylation of Epoxides

J. Am. Chem. Soc. 2023, 145, 21122-21131.

3. Li, Shengxiao; Zhu, Hui; Li, Longfei; Chen, Wanjiao; Jiang, Jie; Qu, Zheng-Wang;* Grimme, Stefan; Zhang, Yong-Qiang*

A Nuclearity-Dependent Enantiodivergent Epoxide Opening via Enthalpy-Controlled Mononuclear and Entropy-Controlled Dinuclear (Salen)Titanium Catalysis

Angew. Chem. Int. Ed. 2023, 62, e202309525.

4. Li, Longfei; Chen, Wanjiao; Xu, Zhongyun; Jiang, Jie; Zhang, Yong-Qiang*

Enantioselective Synthesis of (R)-Tiagabine via Asymmetric Hydrogen Atom Transfer Protocol

Synthesis. 2023, 55, 2005-2010.

Highlighted in the Thieme news section Apr. 6, 2023.

5. Xu, Zhongyun; Shen, Jian; Li, Longfei,; Chen, Wanjiao; Li, Shengxiao; Jiang, Jie; Zhang, Yong-Qiang*

(Salen)Titanium-Catalyzed Asymmetric Hydrogen Atom Transfer for Epoxides Reduction

Angew. Chem. Int. Ed. 2022, 61, e202214111.

Highlighted by Org. Chem. Portal July 17, 2023.

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Publications before Shandong University

21. Zhang, Y. –Q.; Bohle. F.; Bleith, R.; Schnakenburg, G.; Grimme, S.*; Gansäuer, A.*. Synthesis of 1,3-amino alcohols by hydroxyl-directed aziridination and aziridine hydrosilylation.

Angew. Chem. Int. Ed. 2018, 57, 13528-13532.

20. Zhang, Y. -Q.; Vogelsang, E.; Qu, Z.-W.; Grimme, S.; Gansäuer, A.*. Titanocene-catalyzed radical opening of N-acylated aziridines.

Angew. Chem. Int. Ed. 2017, 56, 12654-12657.

(Highlighted by Synfacts, 2017, 13, 1303.)

19. Zhang, Y. -Q.; Poppel, C.; Panfilova, A.; Bohle, F.; Gansäuer, A.*. SN2 at tertiary carbon centers in epoxides.

Angew. Chem. Int. Ed. 2017, 56, 9851-9854.

18. Zhang, Y. -Q.; Jakoby, V.; Stainer, K.; Schmer, A.; Klare, S.; Bauer, M.; Grimme, S.; Cuerva, J. M.; Gansäuer, A.*. Amide-substituted titanocenes in HAT-catalysis.

Angew. Chem. Int. Ed. 2016, 55, 1523-1526.

(Front cover, hot paper)

17. Zhang, Y. -Q.; Funken, N.; Winterscheid, P.; Gansäuer, A.* Hydroxy-directed, fluoride-catalyzed epoxide Hydrosilylation for the synthesis of 1,4-Diols.

Angew. Chem. Int. Ed. 2015, 54, 6931-6934.

(Highlighted by Org. Chem. Highlights 2016, March 21)

16. Funken, N.#; Zhang, Y. –Q. #; Gansäuer, A.*. Regiodivergent catalysis: A powerful tool for selective catalysis. (#equal contribution)

Chem. Eur. J. 2017, 23, 19-32.

15. Zhang, Y. -Q.; Yuan, Y. –A.; Liu, G. –S.; Xu, H.*. Iron(II)-catalyzed intramolecular asymmetric aminohydroxylation of indoles.

Org. Lett. 2013, 15, 3910-3913.

(Highlighted by Synfacts 2013, 9, 1204.)

14. Zhang, Y. -Q.; Zhu, D. -Y.; Li, B. -S.; Tu, Y. -Q.*; Liu, J. -X.; Lu, Y.; Wang,S. –H.. Palladim-Catalyzed cascade process to construct 1,2,5-trisubstituted pyrroles.

J. Org. Chem. 2012, 77, 4167-4170.

13. Zhang, Y. -Q.; Zhu, D. -Y.; Jiao, Z. -W.; Li, B. -S.; Zhang, F. -M.; Tu, Y. -Q.*; Bi, Z.. Regiodivergent annulations of alkynyl indoles to construct spiro-pseudoindoxyl and tetrahydro-β-carbolines.

Org. Lett. 2011, 13, 3458-3461.

12. Zhang, Y. -Q.; Chen, Z. -H.; Tu, Y. -Q.*; Fan, C. -A.; Zhang, F. -M.; Wang, A. -X.; Yuan, D. -Y.. Gold-catalyzed reaction of enynols by a dimerization-fragmentation process: An expeditious assembly of enyne molecular architecture.

Chem. Commun. 2009, 45, 2706-2708.

11. Zhang, Y. -Q.#; Liu, J. –D.#; Xu, H.*. Copper(II)-catalyzed trifluoromethylation of N-aryl imines. (# equal contribution)

Org. Biomol. Chem. 2013, 11, 6242-6245.

10. Zhu, C.#; Zhang, Y. -Q.#;Yuan, Y.-A.; Xu, H.*. Copper-catalyzed aerobic C-H trifluoromethylation of phenanthrolines.  (# equal contribution)

Synlett 2015, 26, 345-349.

9. Liu, G. -S.; Zhang, Y. -Q.; Yuan, Y. -A.; Xu, H.*. Iron (II) catalyzed intramolecular aminohydroxylation of olefins with functionalized hydroxylamines.

J. Am. Chem. Soc. 2013, 135, 3343-3346.

8. Chen, Z.-H.; Zhang, Y. -Q.; Chen, Z.-M.; Tu, Y. -Q.*; Zhang, F. -M.. Total synthesis of (±)-maistemonine and (±)-stemonamide.

Chem. Commun. 2011, 47, 1836-1838.

7. Chen, Z.-H.; Chen, Z.-M.; Zhang, Y. -Q.; Tu, Y. -Q.*; Zhang, F. -M.. Total synthesis of (±)-maistemonine, (±)-stemonamide, and (±)-isomaistemonine.

J. Org. Chem. 2011, 76, 10173-10186.

6. Li, B. -S.; Yang, B. -M.; Wang, S. -H.; Zhang, Y. -Q.; Cao, X. -P.; Tu, Y. -Q.* Copper(I)-catalyzed intramolecular [2 + 2] cycloaddition of 1,6-enyne-derived ketenimine: An efficient construction of strained and bridged 7-substituted-3-heterobicyclo[3.1.1]heptan-6-one.

Chem. Sci. 2012, 3, 1975-1979.

5. Jiao, Z. –W; Zhang, S. -Y.; Tu, Y. -Q.*; Wang, S. -H.; Zhang, F. -M.; Zhang, Y. -Q.; Li, H.; He, C. Organocatalytic Asymmetric Direct C-H Functionalization of Ethers: A highly efficient approach to chiral spiroethers.

Angew. Chem., Int. Ed. 2012, 51, 8811-8815.

4. Zhao, X.; Zhang, E.; Tu, Y. -Q.*; Zhang, Y. -Q.; Yuan, D. -Y.; Cao, K.; Fan, C. -A.; Zhang, F. -M.. Au(I)-catalyzed rearrangement reaction of propargylic aziridine: synthesis of trisubstituted and cycloalkene-fused Pyrroles.

Org. Lett. 2009, 11, 4002-4004.

3. Zhang, X. -M.; Tu, Y. -Q.*; Jiang, Y. -J.; Zhang, Y. -Q.; Fan, C. -A.; Zhang, F. -M.. Tandem reactions of cis-2-acyl-1-alkynyl-1-aryl cyclopropanes tuned by gold(I) and silver(I) catalysts: Efficient synthesis of pyran-fused indene cores and 2,4,6-trisubstituted phenols.

Chem. Commun. 2009, 45, 4726 -4728.

2. Liu, J. -D.; Wang, S. -H.; Zhang, F. -M.; Tu, Y. -Q.*; Zhang, Y. -Q.. Concise total synthesis of (±)-crinine. 

Synlett 2009, 18, 3040 -3042.

1. Zhang, F. -M.; Tu, Y. -Q.*; Liu, J. -D.; Fan, X. -H.; Shi, L.; Hu, X. -D.; Wang, S. -H.; Zhang, Y. -Q.. A general approach to crinine-type Amaryllidaceae alkaloids: total syntheses of (±)-haemanthidine, (±)-pretazettine, (±)-tazettine, and (±)-crinamine. 

Tetrahedron 2006, 62, 9446-9455.