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刘敏 副研究员


2020.04-          山东大学微生物技术研究院  副研究员

2016.08-2020.04  中国科学院青岛生物能源与过程研究所  博士后 助理研究员

2013.08-2016.07   中国科学院大学  生物化学  博士

2010.09-2013.07   南开大学  生物化学与分子生物学  硕士

2006.09-2010.07   鲁东大学  生物科学  学士

 

研究方向:

生物基化学品合成,微生物代谢调控

联系方式:

电话:0532-58632386

邮箱:liumin88(AT)sdu.edu.cn     (将“(AT)”替换为“@”)

 

发表论文:

1.   Min Liu#, Meitong Huo#, Changshui Liu, Likun Guo, Yamei Ding, Qingjun Ma, Qingsheng Qi, Mo Xian* and Guang Zhao*. Lysine acetylation of Escherichia coli lactate dehydrogenase regulates enzyme activity and lactate synthesis. Frontiers in Bioengineering and Biotechnology. 2022,10:966062.

2.   Min Liu,#, , Meitong Huo#, Likun Guo, Yingxin Fu, Mo Xian, Qingsheng Qi, Wei Liu*, Guang Zhao*. Lysine acetylation decreases enzyme activity and protein level of Escherichia coli lactate dehydrogenase. Engineering Microbiology,2022, 2:10045.

3.   Min Liu#, Likun Guo#, Yingxin Fu, Meitong Huo, Qingsheng Qi, Guang Zhao*. Bacterial protein acetylation and its role in cellular physiology and metabolic regulation. Biotechnology Advances, 2021, 53:107842.

4.    Min Liu, Yingxin Fu, Wenjie Gao, Mo Xian,* and Guang Zhao* Highly efficient biosynthesis of hypoxanthine in Escherichia coli and transcriptome-based analysis of the purine metabolism. ACS Synthetic Biology, 2020, 9(3):525-535.

5.     Zhe Zhao, Mo Xian, Min Liu* and Guang Zhao*. Biochemical routes for uptake and conversion of xylose by microorganisms. Biotechnol Biofuels ,2020, 13:21.

6.    Min Liu, Yamei Ding, Mo Xian* Guang Zhao*Metabolic engineering of a xylose pathway for biotechnological production of glycolate in Escherichia coli. Microbial Cell Factories. 2018,17:51-62.

7.    Yuhui Wang, Mo Xian, Xinjun Feng, Min Liu* Guang Zhao*. Biosynthesis of ethylene glycol from d-xylose in recombinant Escherichia coli. Bioengineered. 2018, 9(1): 233-241.

8.    Min Liu, Yamei Ding, Hailin Chen, Zhe Zhao, Huizhou Liu, Mo Xian* and Guang Zhao*.Improving the production of acetyl-CoAderived chemicals in Escherichia coli BL21(DE3) through iclR and arcA deletion. BMC Microbiology. 2017,17(1):10-19.

9.    Min Liu, Xueping Han, Mo Xian, Yamei Ding, Huizhou Liu*, Guang Zhao*. Development of a 3-hydroxypropionate resistant Escherichia coli strain. Bioengineered. 2016,7(1):21-27.

10. Min Liu, Lan Yao, Mo Xian, Yamei Ding, Huizhou Liu, Guang Zhao. Deletion of arcA increased the production of acetyl-CoA-derived chemicals in recombinant Escherichia coli. Biotechnology letter, 2016, 38(4): 97-101.

11.  Min Liu, Xinjun Feng, Yamei Ding, Guang Zhao, Huizhou Liu, Mo Xian. Metabolic engineering of Escherichia coli to improve recombinant protein production. Applied Microbiology and Biotechnology, 2015, 99(24): 10367-10377.

主持项目:

1.  高碳原子经济性乙酰辅酶A衍生品底盘细胞的构建和调控机理研究,国家自然科学基金面上项目(22277068),54万元,2023.01-2026.12,主持。

2.  山东大学青年学者未来计划,山东大学,50万元,2020.09-2025.08,主持。

3.  HN材料生物合成高效底盘细胞的设计与构建,中央JW科学技术委员会,100万元,2019.01-2020.12,主持。

4.  乙酰辅酶A衍生产品生物合成平台细胞的构建与调控机理研究,国家自然科学基金青年基金项目(21807101),27.5万元,2019.01-2021.12,主持。

5.  大肠杆菌高效转化木糖合成乙醇酸的研究,中国博士后面上基金一等资助项目(2016M600564),8.0万元,2016.07-2018.07,主持。

6.  木糖为底物高效合成乙醇酸的研究,青岛市博士后应用基础研究项目,5.0万,2016.07-2018.07, 主持。

 

 

 

 

 


细菌代谢与调控团队