徐政虎

个人信息Personal Information

教授 博士生导师 硕士生导师

性别:男

毕业院校:中科院上海有机化学研究所

学历:研究生(博士后)

学位:博士生

在职信息:在职

所在单位:化学与化工学院

入职时间:2011-01-14

办公地点:老数学楼101-4

电子邮箱:Xuzh@sdu.edu.cn

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个人简介Personal Profile

徐政虎,教授,博士生导师,山东省泰山学者特聘教授

一直致力于绿色、经济、高效的有机合成反应的研究,从仿生学模拟酶催化的角度出发,发展了协同串联金属接力催化合成方法学,广泛应用于一系列复杂环系有机分子的合成,在点击化学反应等领域取得了一系列有特色的研究成果。近五年以通讯作者在国际主流杂志发表SCI论文50余篇,通讯作者论文他引3000余次,7篇论文引用超过百次,H指数40。入选山东省杰青,山东大学齐鲁学者,仲英学者,主持国家自然科学基金面上项目、手性重大研究计划培育项目、山东省重点等各级项目20余项。 2020年获德国“Thieme Chemistry Journal Award”国际学术奖,同年以第一完成人获得山东省自然科学二等奖(获奖项目:串联的金属接力催化的发展与应用)。2022年入选山东省泰山学者特聘教授,2023年被评为山东大学泰山学堂卓越教师。


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发表文章

2025

1. Xue Zhang, Yi Zhou, Zhi-Xiang Yu, Chen-Ho Tung and Zhenghu Xu*, Strained Dehydro-[2,2]-paracyclophane Enabled Planar Chirality Construction and [2.2]Paracyclophane Functionalization. Angew. Chem. Int. Ed. 2025, 64, e202420667.

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2. Yunlong Liu, Kang Zhang, Chen-Ho Tung and Zhenghu Xu*Enantioselective [2+2+2] Cycloaddition of Internal Alkynes to Access Axially Chiral Biaryl Hexasubstituted Benzene. ACS Catal. 2025, 15, 2939–2949.

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3. Shuai Huang, Yumin Zhang, Yuekai Li, Chen-Ho Tung, Xin Li* and Zhenghu Xu*, Copper-catalyzed alkynyldisulfuration of arynes: efficient access to unsymmetrical disulfides, Org. Chem. Front. 2025, 12, 530-535.

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2024

1. Linxuan Wang, Jialin Qi, Haoyu Li and Zhenghu Xu*, Modular Synthesis of α-Quaternary Chiral β-Lactams via Three-Component Asymmetric Kinugasa/Aldol or Kinugasa/Mannich Cascade Reactions, Chem. Eur. J. 2024, e202403722.

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2. Synthesis of Axially and Centrally Chiral N-Alkenyl Indoles by Asymmetric Rh-Catalyzed [2 +2+2] Cycloaddition, Xuan Zhang, Qi Teng, Chen-Ho Tung and Zhenghu Xu*, ChemCatChem 2024, 17, e202401143.

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3. Xuan Zhang, Qi Teng, * Yanru Ren, Baitong Wei, Chen-Ho Tung and Zhenghu Xu*Neighboring group-directed asymmetric [2+2+2] cycloaddition to access C–N axially chiral indoles. Org. Chem. Front. 2024, 11, 2857.

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4. Dong Chen, Yi Zhou, Chen-Ho Tung, Zhi-Xiang Yu,* Zhenghu Xu*, A Desymmetric Dearomatization Cyclopropanation of [2.2]Paracyclophane, CCS Chem. 2024, DOI: 10.31635/ccschem.024.202404067.

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5. Pengfei Sun , Fang Wei , Chen-Ho Tung and Zhenghu Xu*, Copper(I)-catalyzed interrupted click/radical relay: A four-component modular synthesis of triazole sulfones. Chin. Chem. Lett. 2024, 35, 108478.

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2023

1. Li Zhou, Yankun Li, Shunian Li, Zhenwei Shi, Xue Zhang, Chen-Ho Tung and Zhenghu Xu*, Asymmetric Rhodium-Catalyzed Click Cycloaddition to Access C-N Axial Chiral N-Triazolyl Indoles, Chem. Sci. 2023, 14, 5182.

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2. Shuzhe Sun, Linxuan Wang, Jialin Qi and Zhenghu Xu*, Copper(I)-Catalyzed Kinugasa Reactions in an Undergraduate Organic Chemistry Laboratory, J. Chem. Educ. 2023, 100, 2986.

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3. Pengfei Sun , Weiguo Wang, Jilong Lai, Huang, Yan, Chen-Ho Tung and Zhenghu Xu*, Copper(I)-catalyzed multicomponent interrupted click reaction: modular synthesis of triazole sulfides from elemental sulfur. Org. Chem. Front. 2023, 10, 1890.

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4. Jialin Qi, Tingting Song, Zhenning Yang, Shuzhe Sun, Chen-Ho Tung and Zhenghu Xu*, Simultaneous Dual Cu/Ir Catalysis: Stereodivergent Synthesis of Chiral βLactams with Adjacent Tertiary/Quaternary/Tertiary Stereocenters, Acs. Catal. 2023, 13, 2555-2564.

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5. Zhenwei Shi, Wenxiu Mao, Zhenning Yang, Shuzhe Sun, Chen-Ho Tung and Zhenghu Xu*, Au-catalyzed neighboring hydroxymethyl group directed cycloaddition of alkyne with diazadienes: Synthesis of polysubstituted pyrroles. Chin. Chem. Lett. 2023, 34, 107488.

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2022

1. Yankun Li, Chen-Ho Tung and Zhenghu Xu*, Synthesis of Benzofuran Derivates via a Gold-Catalyzed Claisen Rearrangement Cascade. Org. Lett. 2022, 24, 5829−5834.

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2. Wenjing Yu, Chen-Ho Tung and Zhenghu Xu*, Synthesis of Benzofurans from Sulfur Ylides and ortho-Hydroxy-Functionalized Alkynes. Adv. Synth. Catal. 2022, 364, 3749−3753.

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3. Tingting Song, Chen-Ho Tung and Zhenghu Xu*, Synthesis of α-trifluoromethyl sulfides through fluorosulfuration of gem-difluoroalkenes. Org. Chem. Front. 2022, 9, 2926-2931.

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4. Qi Teng, Dong Chen,Chen-Ho Tung and Zhenghu Xu*, Asymmetric synthesis of tricyclic 6,5,5-fused polycycles by the desymmetric Pauson–Khand reaction. Org. Chem. Front. 2022, 9, 1680. 

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5. Xue Zhang, Shunian Li, Wenjing Yu, Yufang Xie, Chen-Ho Tung and Zhenghu Xu*, Asymmetric Azide−Alkyne Cycloaddition with Ir(I)/Squaramide Cooperative Catalysis: Atroposelective Synthesis of Axially Chiral Aryltriazoles. J. Am. Chem. Soc. 2022, 144, 6200−6207.

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2021

1. Jialin Qi, Chen-Ho Tung and Zhenghu Xu*, Interrupted Kinugasa allylic alkylation, Trends in Chemistry 2021, 3, 984. (invited paper, as mechanism of the monthif = 24.08)

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2. Tingting Song and Zhenghu Xu*, Research progress of electrophilic sulfenylation of benzenethiosulfonates. Sci Sin Chim 2021, 51: 628–650, DOI: 10.1360/SSC-2021-0029(中国科学:化学,庆祝山东大学建校120周年专刊)

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3. Shunian Li., Haifeng Lu. Fang Wei* and Zhenghu Xu*, Ni-Catalyzed asymmetric hetero-Diels–Alder reactions of conjugated vinyl azides: synthesis of chiral azido polycycles. Org. Chem. Front. 2021, 8, 1770. 

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4. Jialin Qi, Fang Wei, Chen-Ho Tung and Zhenghu Xu*, Modular Synthesis of alpha-Quaternary Chiral beta-Lactams by a Synergistic Cu/Pd-Catalyzed Multicomponent Reaction. Angew. Chem. Int. Ed. 2021, 60, 13814. (Highlighted in "Organic Chemistry Portal", https://www.organic-chemistry.org/Highlights/2022/11April.shtm)

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5. Jialin Qi, Fang Wei, Shuai Huang, Chen-Ho Tung and Zhenghu Xu*, Copper(I)-Catalyzed Asymmetric Interrupted Kinugasa Reaction: Synthesis of α-Thiofunctional Chiral β-Lactams, Angew. Chem. Int. Ed. 2021, 60, 4561. 

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2020

1. Tingting Song, Lei Zhu, Haoyu Li, Chen-Ho Tung, Yu Lan* and Zhenghu Xu*, Kinetically Controlled Radical Addition/Elimination Cascade: From Alkynyl Aziridine to Fluorinated Allenes. Org. Lett. 2020, 22, 2419–2424.

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2. Wenxiu Mao, Shiquan Lin, Liang Zhang, Haifeng Lu, Jiong Jia*and Zhenghu Xu*, Gold-Catalyzed Domino Reactions of Alkynol and p-Quinone Methides: Divergent Synthesis of Fused- and Spiro-Ketals. Org. Chem. Front. 2020, 7, 856–861.

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3. Shuai Huang, Ziheng Xia, Kui Lu, Haifeng Lu, Chen-Ho Tung and Zhenghu Xu*, S-Trifluoroethyl Benzenesulfonothioate: A Bench-Stable Reagent for Electrophilic Trifluoroethylthiolation. Chin. J. Chem. 2020, 38, 1625.

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4. Weiguo Wang*, Shuai Huang, Shikun Yan, Xuejun Sun, Chen-Ho Tung and Zhenghu Xu*, Copper(I)-Catalyzed Interrupted Click/Sulfenylation Cascade: One-Pot Synthesis of Sulfur Cycle Fused 1,2,3-Triazoles. Chin. J. Chem. 2020, 38, 445.

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5. Qi Teng, Wenxiu Mao, Dong Chen, Zhen Wang, Chen-Ho Tung and Zhenghu Xu*, Asymmetric Synthesis of a Fused tricyclic Hydronaphthofuran Scaffold by Desymmetric [2+2+2] Cycloaddition. Angew. Chem. Int. Ed. 2020, 59, 2220-2224.

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2019

1. Hairui Yuan, Min Wang, Zhenghu Xu* and Hongyin Gao*, Palladium-Catalyzed Annulation of Aryltriazoles and Arylisoxazoles with Alkynes, Adv. Synth. Catal. 2019, 361, 4386-4392, DOI: 10.1002/adsc.201900435.

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2. Lidan Wei, Chengjuan Wu, Chen-Ho Tung, Wenguang Wang* and Zhenghu Xu* , Decarboxylative Sulfenylation of Amino Acids via Metallaphotoredox Catalysis, Org. Chem. Front. 2019, 6, 3224-3227, DOI: 10.1039/C9QO00817A.

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3. Nuligonda Thirupathi, Fang Wei, Chen-Ho Tung and Zhenghu Xu*, Divergent synthesis of chiral cyclic azides via asymmetric cycloaddition reactions of vinyl azides. Nat. Commun. 2019, 10, 3158.

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4. Qi Teng, Nuligonda Thirupathi, Chen-Ho Tung and Zhenghu Xu*, Hydroalkynylative cyclization of 1,6-enynes with terminal alkynes. Chem Sci. 2019, 10, 6863.

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5. Shuai Huang, Haoyu Li, Tian Xie, Fang Wei,* Chen-Ho Tung and Zhenghu Xu*,  Scandium-Catalyzed  Electrophilic Alkene Difunctionalization: Regioselective Synthesis of Thiosulfone Derivatives, Org. Chem. Front. 2019, 6, 1663–1666.

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6. Tingting Song, Haoyu Li, Fang Wei, Chen-Ho Tung and Zhenghu Xu*, Gold/photoredox-cocatalyzed atom transfer thiosulfonylation of alkynes:  Stereoselective synthesis of vinylsulfones. Tetrahedron Lett 2019, 60, 916-919.

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7. Jialin Qi, Qi Teng, Nuligonda Thirupathi, Chen-Ho Tung and Zhenghu Xu*Diastereoselective Synthesis of Polysubstituted Spirocyclopenta[c]furans by Gold-Catalyzed Cascade Reaction. Org. Lett. 2019, 21, 692-695. 

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8. Long Kong, Nuligonda Thirupathi, Jiong Jia* and Zhenghu Xu*, Synthesis of 4H-chromenes by silver (I)-catalyzed cycloaddition of ortho-quinone methides with N-allenamides. Sci. China Chem. 2019, 62, 80-86.

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2018

1. Haoyu Li, Zengrui Cheng, Chen-Ho Tung and Zhenghu Xu*, Atom Transfer Radical Addition to Alkynes and Enynes: a Versatile Gold/Photoredox Approach to Thio-Functionalized Vinylsulfones. Acs. Catal. 2018, 8, 8237-8243.

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2. Shuai Huang, Nuligonda Thirupathi, Chen-Ho Tung and Zhenghu Xu*, Copper-Catalyzed Oxidative Trifunctionalization of Olefins: An Access to Functionalized β-Keto Thiosulfones. J. Org. Chem. 2018, 83, 9449–9455.

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3. Nuligonda Thirupathi, Chen-Ho Tung and Zhenghu Xu*, Scandium (III)‐Catalyzed Cycloaddition of In SituGenerated ortho‐Quinone Methides with Vinyl Azides: An Efficient Access to Substituted 4H‐Chromenes. Adv. Synth. Catal. 2018, 360, 3585.

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4. Weiguo Wang, Yunzhi Lin, Yudao Ma, Chen-Ho Tung and Zhenghu Xu*, Cu-Catalyzed Electrophilic Disulfur Transfer: Synthesis of Unsymmetrical Disulfides. Org. Lett. 2018, 20, 3829-3832.

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5. Weiguo Wang, Yunzhi Lin, Yudao Ma, Chen-Ho Tung and Zhenghu Xu*, Copper(I)-Catalyzed Three-Component Click/Persulfuration Cascade: Regioselective Synthesis of Triazole Disulfides. Org. Lett. 2018, 20, 2956-2959.

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6. Hairui Yuan, Thirupathi Nuligonda, Hongyin Gao, Chen-Ho Tung and Zhenghu Xu*, Copper-Catalyzed Intermolecular Carbene Insertion into S-S bond of Benzenesulfonothioate. Org. Chem. Front. 2018, 5, 1371-1374.

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7. Qi Teng, Jialin Qi, Ling Zhou, Zhenghu Xu* and Chen-Ho Tung, C.-H. Synthesis of benzannulated spiroketals with gold-catalyzed cycloisomerization/spiroketalization cascade. Org. Chem. Front. 2018, 5, 990-993.

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2017

1. Haoyu Li, Cuicui Shan, Chen-Ho Tung and Zhenghu Xu*, Dual Gold and Photoredox Catalysis: Visible light-mediated Intermolecular Atom Transfer Thiosulfonylation of Alkenes. Chem. Sci. 2017, 8, 2610 –2615.

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2. Shuyao Zhang, Beiming Cheng, Shen-An Wang, Ling Zhou, Chen-Ho Tung, Jianwu Wang and Zhenghu Xu*, Gold-Catalyzed Cycloisomerization/1,5-H Migration/Diels–Alder Reaction Cascade: Synthesis of Complex Nitrogen-Containing Heterocycles. Org. Lett. 2017, 19, 1072–1075.

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3. Fang Wei, Tong Zhou, Yudao Ma, Chen-Ho Tung and Zhenghu Xu*, Bench-Stable 5-Stannyl Triazoles by a Copper(I)-Catalyzed Interrupted Click Reaction: Bridge to Trifluoromethyltriazoles and Trifluoromethylthiotriazoles. Org. Lett. 2017, 19, 2098–2101.

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4. Man Liang, Shuai Zhang, Jiong Jia*, Chen-Ho Tung, Jianwu Wang and Zhenghu Xu*, Synthesis of Spiroketals by Synergistic Gold and Scandium Catalysis. Org. Lett. 2017, 19, 2526–2529.

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2016

1. Weiguo Wang, Xianglong Peng, Fang Wei, Chen-Ho Tung and Zhenghu Xu*, Copper(I)-Catalyzed Interrupted Click Reaction: Synthesis of Diverse 5-Hetero-Functionalized Triazoles. Angew. Chem. Int. Ed. 2016, 55, 649-653.

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2. Bin Wang, Ying Chen, Ling Zhou, Jianwu Wang* and Zhenghu Xu*, Zn/Sc bimetallic relay catalysis: one pot cycloisomerization/carbonyl–ene reaction toward oxazole derivatives. Org. Biomol. Chem. 2016, 14, 826-829.

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3. Fang Wei, Lei Wei, Ling Zhou, Chen-Ho Tung, Yudao Ma* and Zhenghu Xu*, Divergent Synthesis of 3,3-Disubstituted Oxindoles Initiated by Palladium-Catalyzed Intramolecular Arylation of Unsaturated Amides. Asian J. Org. Chem. 2016, 5, 971-975.

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4. Xianglong Peng, Chen Ma, Chen-Ho Tung and Zhenghu Xu*, Cu-Catalyzed Three-Component Coupling of Aryne, Alkyne and Benzenesulfonothioate: Modular Synthesis of oAlkynyl Arylsulfides. Org. Lett. 2016, 18, 4154−4157.

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5. Weiguo Wang, Fang We, Yudao Ma*, Chen-Ho Tung and Zhenghu Xu*, Copper(I)-Catalyzed Three-Component Click/Alkynylation: One-Pot Synthesis of 5Alkynyl-1,2,3-triazoles. Org. Lett. 2016, 18, 4158−4161.

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6. Bin Wang, Man Liang, Jian Tang, Yuting Deng, Jinhong Zhao, Hao Sun, Chen-Ho Tung, Jiong Jia* and Zhenghu Xu*, Gold/Lewis Acid Catalyzed Cycloisomerization/Diastereoselective [3+2] Cycloaddition Cascade: Synthesis of Diverse Nitrogen-Containing Spiro Heterocycles. Org. Lett. 2016, 18, 4614−4617.

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7. Fang Wei, Weiguo Wang, Yudao Ma,* Chen-Ho Tung and Zhenghu Xu*, Regioselective synthesis of multisubstituted 1,2,3-triazoles. Moving beyond the copper-catalyzed azide-alkyne cycloaddition. Chem. Commun. 2016, 52, 14188-14199. (Invited feature artical)

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8. Shuyao Zhang, Chuan Shan, Shuai Zhang, Luye Yuan, Jianwu Wang,* Chen-Ho Tung, Ling-Bao Xing* and Zhenghu Xu*, Breaking Aziridines to Construct Morpholines with a Gold(I)-catalyzed Tandem Ring-opening and Cycloisomerization Reaction. Org. Biomol. Chem. 2016, 14, 10973–10980.

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2015

1. Wang,B., Chen,Y., Zhou,L., Wang,J., * Tung, C.-H., and Xu, Z.“Synthesis of Oxazoles by Tandem Cycloisomerization/Allylic Alkylation of Propargyl Amides with Allylic Alcohols: Zn(OTf)2 as π Acid and σ Acid Catalyst.”J. Org. Chem. 2015, 80, 12718-12724.

2. Wang, W., Peng, X., Qin,X., Zhao,X., Ma,C.*, Tung,C.-H.Xu, Z.*“Synthesis of Quinolinones with Palladium-Catalyzed Oxidative Annulation between Acrylamides and Arynes.”J. Org. Chem.2015, 80, 2835-2841.

3. Zhang, S., Chen, Y., Wang, J., Pan, Y., Xu, Z.*Tung, C.-H. “An Efficient Synthesis of gem-Diiodoolefins (E)-iodoalkenes from Propargylic Amides with Cu(I)/Cu(III) Cycle.”Org. Chem. Front.2015, 2, 578-2101585.

4. Wei, F., Li, H., Song, C. Ma, Y. Zhou, L. Tung, C.-H.Xu, Z.*“Cu/Pd-Catalyzed, Three-Component Click Reaction of Azide, Alkyne and Aryl Halide: One-Pot Strategy toward Trisubstituted Triazoles.”Org. Lett.2015, 17, 2860–2863.

5. Xu, Z. Han,L.-L.  Zhuang,G.-L.  Bai , J.Sun,D.* “In Situ Construction of Three Anion-Dependent Cu(I) Coordination Networks as Promising Heterogeneous Catalysts for Azide–Alkyne “Click” Reactions.” Inorg. Chem. 2015, 54, 4737–4743.

6. Song, C. Sun,Y.Wang,J.Chen,H.* Yao,J.Tung, C.-H.Xu, Z.*“Successive Cu/Pd transmetalation relay catalysis in stereoselective synthesis of tetraarylethenes.”Org. Chem. Front.2015,2, 1366-1373.

7. Wei, F., Song, C.Ma, Y.Zhou, L.Tung, C.-H.Xu, Z.* “Gold carbene chemistry from diazo compounds.”Sci. Bull.2015, 60,1479–1492.

8. Song, C.Wang,J.Xu, Z.* “Recent Advances of Cyclopropene Chemistry.”Acta Chim. Sinica. 2015, 73, 1114-1146.

2014

1. Wang, X.Dong, S.Yao, Z.Feng, L.Daka, P.Wang, H.Xu, Z.*Synthesis of Spiroaminals and Spiroketals with Bimetallic Relay Catalysis.Org. Lett. 2014, 16, 22-25.(highlighted in synfacts, 2014, 240).

2. Peng, X. Wang, W.Jiang, C.Sun, D.Xu, Z.* Tung, C.-H. “Strain Promoted Oxidative Annulation ofArynes and Cyclooctynes with Benzamides: Palladium-Catalyzed C-H/N-H Activationfor the Synthesis of N-Heterocycles” Org. Lett. 2014, 16, 5354-5357.

3. Zhang, S. Xu, Z.Jia, J.*Tung, C.-H.Xu, Z.* “Synthesisof Spiroaminals with BimetallicAu/Sc Relay Catalysis: TMS as a Traceless Controlling group.”Chem. Commun2014, 50, 12084-12087.

4. Song, C.Wang, J.Xu, Z.* “Tandem metal relay catalysis: fromcyclopropene to polysubstituted furan.” Org. Biomol. Chem.2014, 12, 5802-5806. (Invited personal perspective).

5. Wei, F.Wang, X.Peng, S.Jia, Q.Jiang, C.Liu, S.Xu, Z.* “Direct RegioselectiveTetrafunctionalization of unactivated Alkynes with Gold Catalysis.” Synthesis, 2014, 2168-2174. (special issue on gold catalysis, invited by Erick Carreira).

6. Zhang, S.Wei, F.Song, C.Jia, J.* Xu, Z.*Recent Advances of Au/Acid Combined Catalysis.”Chin. J. Chem2014, 32, 937-956. (invited paper, dedicated to Prof. Lixin Dai on occasion of his 90th birthday)

7. Liu, F.Xu, Z. Zhang, X.Wang, X.Sun, D.*“Unusual N-H Activation of 2-Aminopyrimidine: Supramolecular Assembly into an Ag Metal-Organic Framework”Chem. Asian J., 2014,9, 452-456.

8. Zhang, F.Xu, Z. Dong, S.Feng, L.Song, A.*Tung, C.-H.Hao, J.Hydrogels formed by enantioselective self-assembly of histidine derived amphiphiles wtih tartaric acids. Soft Matter2014, 10, 4855-4862.

9. Zhao, Y.Fang, M.Xu, Z. Wang, X.Wang, S.Han, L.Li, X.Sun, D.* “Construction of a crystalline Ag(I) coordination polymer based on a new ligand generated from unusual in situ aza-Michael addition reaction”, Crystengcomm2014, 16, 3015-3019.

10. Liu, F.Xu, Z. Zhang, X.Wang, X.Sun, D.* “Unusual N-H Activation of 2-Aminopyrimidine: Supramolecular Assembly into an Ag-I Metal-Organic Framework”, Chem. Asian. J., 2014, 9, 452-456.

2013

1. Song, C.Sun, D.Peng, X.Bai, J.Zhang, R.Hou, S.Wang, J.Xu, Z.*Dimerization of Cyclopropenes to Bifurans with Tandem Metal Relay Catalysis.Chem. Commun.2013, 49, 9167-9169. (highlighted in synfacts2013, 1292)

2. Wang, X.Yao, Z.Dong. S.Wei, F.Wang, H.Xu, Z.*, Synthesis of Fused Bicyclic Aminals through Sequential Gold / Lewis Acid Catalysis.Org. Lett. 2013, 15, 2234-2237.

3. Song, C.Ju, L.Wang, M.Liu, P.Zhang, Y.Wang, J.* Xu, Z.*From Cyclopropenes to Tetrasubstituted Furans: Tandem Isomerization/Alkenylation Sequence with Cu/Pd Relay Catalysis.Chem. Eur. J.2013,19, 3584-3589.

4. Song, C.Dong, S.Feng, L.Peng, X.Wang, M.Wang, J.Xu, Z.*“Modular Synthesis of All-substitued Furans through Oxidative Carbonylation of Cyclopropenes with Tandem Metal Relay Catalysis.”Org. Biomol. Chem.2013, 11, 6258-6262.(invited paper)

5. Deng, Y.Liu, L.Sarkisian, R.Wheeler, K.Wang, H.*Xu, Z.*Arylamine catalyzed Enamine Formation: Cooperative Catalysis of Arylamines with Acids.Angew. Chem. Int. Ed. 2013, 52, 3663-3667.(highlighted in synfacts, 2013, 631)

2012

1. Liu,L., Sarkisian,R.Xu, Z.*Wang, H.*“Asymmetric Michael Addition of Ketones to Alkylidene Malonates and Allylidene Malonates via Enamine-Metal Lewis Acid Bifunctional Catalysis.J. Org. Chem. 2012, 77, 7693-7699.

2. Liu,A., Liu,Y., Jin,Z., Hu,Q.Xu,Z. Wang,H.Chen,C.Lin,J. "XZH-5 Inhibits STAT3 Phosphorylation andEnhances the Cytotoxicity of chemotherapeutic Drugs in Human Breast and Pancreatic Cancer Cells". PloS ONE 2012, 7(10), e46624.

2011

1. Xu, Z.,  Liu, L., Wheeler, K., Wang, H.*Asymmetric inverse-electron-demand Hetero-Diels-Alder reaction of six-membered cyclic ketones: An enamine – metal Lewis acid bifunctional approach.Angew. Chem. Int. Ed. 2011, 50, 3484-3488. (as hot paper, highlighted in Synfacts, 2011, 747 )

2. Xu, Z.*, WangH.*“Asymmetric Inverse-Electron-Demand Hetero-Diels-Alder Reaction of Six-membered Cyclic Ketones via Enamine-Metal Lewis Acid Bifunctional Catalysis.” Synlett 2011, 2907-2912.(invited synpact paper).

3. Daka,P.Xu, Z., Wang, H.* “A new Bidentate Ligand System for Metal Lewis Acid-Primary amine Bifunctional Catalyst: Highly Stereoselective Asymmetric Direct Aldol Reactions,”Chem. Commun. 2011, 47, 224-226.

4. Liu,A., Liu,Y.Xu, Z., Yu,W., Wang,H., Li,C., Lin,J.* “A Novel Small Molecule, XZH-5, Inhibits Constitutive and Interleukin-6-Induced STAT3 Phosphorylation in Human Rhabdomyosarcoma Cells”,Cancer Science 2011, 102, 1381-1387.

5. Liu,A., Liu,Y.Xu, Z., Yu,W., Wang,H., Li,C., Lin,J.* XZH-5 Inhibits STAT3 Phosphorylation and Causes Apoptosis in Human Hepatocellular Carcinoma Cells.”Apoptosis. 2011, 16, 502-510.

2010及以前】

1. Xu, Z. Buechler, T. Wheeler,K.Wang, H.*A Three-Component Reaction Based on A Remote Group Directed Dynamic Kinetic Aza Michael Addition: Stereoselective Synthesis of Imidazolidin-4-ones.Chem. Eur. J.2010, 2972-2976.

2. Xu, Z. Daka,P.Wang,H.* “Primary Amine-metal Lewis acid bifunctional catalysts: the application to asymmetric direct aldol reaction.”Chem Commun. 2009, 6825-6827. (Highlighted in synfacts 2009, 200)

3. Xu, Z. Daka, P.Budik, I.Wang, H.* Bai, F.-Q.Zhang, H.-Y. “Enamine-Metal Lewis Acid Bifunctional Catalysis: Application to direct Asymmetric Adol Reaction of Ketones.”Eur. J. Org. Chem. 2009, 4581-4585. (Highlighted as Cover paper)

4. Qu, J.-P.Xu, Z. Zhou, J.Cao, C.-L.Sun, X.-L.Dai, L.-X.Tang, Y.* “Ligand-Accelerated Asymmetric [1,2]-Stevens Rearrangement of Sulfur Ylides via Decomposition of Diazomalonates Catalyzed by Chiral Bisoxazoline/Copper Complex.”Adv. Synth. Catal. 2009, 351, 308-312. (Highlighted in Synfacts 2009, 534)

5. Li, C.-Y.Wang, X.-B.Sun, X.-L.Tang, Y.* Zheng, J.-C.Xu, Z. Zhou, Y.-G.*Dai, L.-X. J. Am. Chem. Soc. 2007, 129, 1494-1495.

6. Xu, Z. Zhu, S.-N.Sun, X.- L., Tang, Y.*Dai, L.-X., Sidearm Effects in Enantioselective Cyclopropanation of Alkenes with Aryldiazoacetates Catalyzed by Trisoxazoline/Cu(I). Chem. Commun., 2007, 1960-1962.










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