2025年

1.Cong Shi, Ruihua Liu,* Zemin Wang, Chenxia Gao, Jia-Shu Chen, Hongyun Qin, Wenlong Shan, Wenli Zhuang, Nan Zhou, Xiangqian Li, and Dayong Shi*Anaerobic 1,2-/1,3-Hydroxytrifluoromethylation of Unactivated Alkenes Enabled by Photoexcited Nitroarenes.Org. Lett. XXXX, XXX, XXX−XXX

2024年

1.Zemin Wang , Chao-Xian Yan , Ruihua Liu , Xiaowei Li, Jiajia Dai, Xiangqian Li, Dayong Shi*Photo-induced versatile aliphatic C–H functionalization via electron donor–acceptor complex.Science Bulletin2024, 3, 69,345-353

2.Yiting Zhang, Xiangqian Li, Fang Liu, Xiaoyi Bai, Xiaochun Liu, Hao Sun, Chenxia Gao, Yuxi Lin, Pan Xing, Jiqiang Zhu, Ruihua Liu, Zemin Wang, Jiajia Dai, and Dayong Shi* .Design of Selective PARP1 Inhibitors and Antitumor Studies.J. Med. Chem. 2024, 67, 8877−8901

3.Cong Shi, Ruihua Liu, Zemin Wang, Xiaowei Li, Hongyun Qin, Leifeng Yuan, Wenlong Shan, Wenli Zhuang, Xiangqian Li, and Dayong Shi* Radical Addition-Enabled C−C σ‑Bond Cleavage/Reconstruction to Access Functional Indanones: Total Synthesis of Carexane L.Org. Lett. 2024, 26, 2913−2917

4.Wenlong Shan, Zemin Wang, Chenxia Gao, Xiaowei Li, Wenli Zhuang, Ruihua Liu, Cong Shi, Hongyun Qin,Xiangqian Li and Dayong Shi *Visible light-induced cobalt-catalyzed 1,3-diphosphination of alkenes.Green Chem., 2024, 26,9749

5.Leifeng Yuan, Zemin Wang, Wenli Zhuang, Xiaowei Li, Cong Shi, Xiangqian Li, and Dayong Shi*.Visible-Light-Driven Iron-Catalyzed 1,2-Difluoroalkylthiolation of Alkenes.Org. Lett. 2024, 26, 7066−7071.

6.Xiaowei Li, Wenlong Shan, Nan Zhou, Zemin Wang, Ruihua Liu, Wenli Zhuang, Leifeng Yuan,Cong Shi, Hongyun Qin, Jiashu Chen, Xiangqian Li, and Dayong Shi*.Nickel-Catalyzed Stereoconvergent C(sp2)−F Alkenylation ofMonofluoroalkenes.Org. Lett. 2024, 26, 8521−8526.

7.Hongyun Qin, Ruihua Liu,Zemin Wang,Feng Xu,Xiaowei Li,Cong Shi,Jiashu Chen,Wenlong Shan,Chao Liu,Pan Xing, Jiqiang Zhu,Xiangqian Li,and Dayong Shi*Photoinduced Bartoli Indole Synthesis by the Oxidative Cleavage of Alkenes with Nitro(hetero)arenes.Angew. Chem. Int. Ed. 2024, e202416923

8.Chenxia Gao, Wenpeng Hu, Feng Xu, Yuxi Lin, Jiashu Chen, Dayong Shi , Pan Xing,Jiqiang Zhu, Xiangqian Li *Allosteric inhibition of PTP1B by bromocatechol-chalcone derivatives.European Journal of Medicinal Chemistry 282 (2025) 117053

2023年

1.Xiaowei Li, Yuxiu Li, Zemin Wang, Wenlong Shan, Ruihua Liu, Cong Shi, Hongyun Qin, Leifeng Yuan, Xiangqian Li, and Dayong Shi*.Nickel-Catalyzed Stereoselective Cascade C−F Functionalizations of gem-Difluoroalkenes. ACS Catal. 2023, 13, 2135−2141

2.Xiaowei Li, Yuxiu Li,Wenlong Shan, Zemin Wang, Ruihua Liu,Zhong Zhang, Xiangqian Li and Dayong Shi *.Nickel-catalyzed stereoselective reductive cross-coupling of gem-difluoroalkenes with alkenyl electrophiles.Chem. Commun., 2023, 59, 6893

3.Zhong Zhang, Yang Tian, Xiaowei Li, Zemin Wang, Ruihua Liu, Ping Chen, Xiangqian Li, Jiajia Dai and Dayong Shi*.S-Trifluoromethyl thioesters as bifunctional reagents for acyl-trifluoromethylthiolation of alkenes and 1,3-enynes via photoredox/copper dual catalysis.Green Chem., 2023, 25, 2723–2729

4.Xueju Qi, Jing Wang, Fengshu Fei, Xintao Gao, Xiaochen Wu, Dayong Shi,* and Chuanlong Guo*Myricetin-Loaded Nanomicelles Protect against Cisplatin-Induced Acute Kidney Injury by Inhibiting the DNA Damage-cGAS−STING Signaling Pathway.Mol. Pharmaceutics 2023, 20, 136−146

5.Kehong Dong, Mei Zhang, Ying Liu, Xintao Gao, Xiaochen Wu, Dayong Shi,* Chuanlong Guo,*and Jing Wang*.Pterostilbene-Loaded Soluplus/Poloxamer 188 Mixed Micelles for Protection against Acetaminophen-Induced Acute Liver Injury.Mol. Pharmaceutics 2023, 20, 1189−1201.

6.Shuo Li# , Jia-shu Chen# , Xiangqian Li, Xiaoyi bai, Dayong Shi *.MNK, mTOR or eIF4E-selecting the best anti-tumor target for blocking translation initiation.European Journal of Medicinal Chemistry 260 (2023) 115781

7.Fang Liu#, Jiashu Chen# , Xiangqian Li, Ruihua Liu, Yiting Zhang, Chenxia Gao, Dayong Shi *Advances in Development of Selective Antitumor Inhibitors That Target PARP-1.J. Med. Chem. 2023, 66, 16464−16483

8.Ting Shi, Yan-Jing Li , Ze-Min Wang, Yi-Fei Wang, Bo Wang * and Da-Yong Shi *New Pyrroline Isolated from Antarctic Krill-Derived Actinomycetes Nocardiopsis sp. LX-1 Combining with Molecular Networking .Mar. Drugs 2023, 21, 127.

2022年

1.Yan-yan Yu #, Xiang-qian Li #, Wen-peng Hu , Shi-chao Cu , Jia-jia Dai , Ya-nan Gao , Yi-ting Zhang , Xiao-yi Bai , Da-yong Shi *.Self-developed NF-κB inhibitor 270 protects against LPS-induced acute kidney injury and lung injury through improving inflammation, Biomedicine & Pharmacotherapy 2022,147 :112615

2.Jiajia Dai , Yiting Zhang , Yanan Gao , Xiaoyi Bai , Fang Liu , Shuo Li , Yanyan Yu , Wenpeng Hu ,Ting Shi , Dayong Shi * and Xiangqian Li*.Toward a treatment of cancer: design and in vitro/in vivo evaluation of uncharged pyrazoline derivatives as a series of novel SHP2 inhibitors, Int. J. Mol. Sci. 2022, 23:3497

3.Ting Shi, Xiang-Qian Li , Ze-Min Wang ,Li Zheng, Yan-Yan Yu , Jia-Jia Dai and Da-Yong Shi *.Bioactivity-Guided Screening of Antimicrobial SecondaryMetabolites from Antarctic Cultivable Fungus Acrostalagmusluteoalbus CH-6 Combined with Molecular Networking，Mar. Drugs ,2022, 20, 334.

4.Ruihua Liu , Yang Tian, Jie Wang, Zemin Wang, Xiangqian Li, Chenyang Zhao, Ruoyu Yao, Shuo Li, Leifeng Yuan, Jinbo Yang*, Dayong Shi*.Visible light–initiated radical 1,3-difunctionalization of β,γ-unsaturated ketones. Sci. Adv.2022, 8, 49, eabq8596

2021年

1.Xiaolin Shi, Zemin Wang, Yuxiu Li, Xiaowei Li, Xiangqian Li, and Dayong Shi*,Palladium-Catalyzed Remote C-H Phosphonylation of Indoles at the C4 and C6 Positions by a Radical Approach, Angew. Chem. Int. Ed. 2021, 60, 13990–13995 

2.Yuxiu Li, Xiangqian Li, Xiaowei Li and Dayong Shi*,Visible-light-promoted E-selective synthesisof a-fluoro-b-arylalkenyl sulfides via the deoxygenation/isomerization process, Chem. Commun., 2021, 57, 2152-2155

3.Yuxiu Li, Xiangqian Li, Xiaowei Li, and Dayong Shi*,Highly E‑Selective Synthesis of α‑Fluoro β-arylalkenyl Sulfones from gem-Difluoroalkenes with Sodium Sulfinates，J. Org. Chem. 2021, 86, 6983−6993

4.Zhong Zhang, Xiangqian Li, and Dayong Shi*,Visible-Light-Promoted Oxy-difluoroalkylation of Aryl Alkynes for the Synthesis of β-Fluoroenones and α-Difluoroalkyl Ketones， Adv. Synth. Catal. 2021, 363, 3348-3353

5.Ting Shi , Yan-Yan Yu , Jia-Jia Dai , Yi-Ting Zhang , Wen-Peng Hu , Li Zheng* and Da-Yong Shi *,New Polyketides from the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11, Mar. Drugs 2021, 19, 168.

6.Ting Shi , Li Zheng, Xiang-Qian Li, Jia-Jia Dai , Yi-Ting Zhang , Yan-Yan Yu , Wen-Peng Hu and Da-Yong Shi * Nitrogenous Compounds from the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11, Molecules 2021, 26, 2636.

7.Ting Shi, Xiang-Qian Li, Li Zheng, Ya-Hui Zhang, Jia-Jia Dai, Er-Lei Shang, Yan-Yan Yu, Yi-Ting Zhang, Wen-Peng Hu, Da-Yong Shi* Sesquiterpenoids From the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11, Front. Microbiol. 2021，12：688202 (IF= 5.640)

8.Xiangqian Li, Xiaowei Li, Fang Liu, Shuo Li, and Dayong Shi*，Rational Multitargeted Drug Design Strategy from the Perspective of a Medicinal Chemist，J. Med. Chem. 2021, 64, 15, 10581–10605 

9.Xiaowei Li#, Yuxiu Li#, Zhong Zhang, Xiaolin Shi, Ruihua Liu, Zemin Wang, Xiangqian Li, Dayong Shi*, Nickel-Catalyzed Arylation of C(sp 3)-O Bonds in Allylic Alkyl Ethers with Organoboron Compounds. Org. Lett. 2021, 23, 17, 6612–6616 

10.Ping Chen, Wei Cao, Xiangqian Li, and Dayong Shi* A Unified Approach for Divergent Synthesis of Heterocycles via TMSOTf-Catalyzed Formal [3+2] Cycloaddition of Electron Rich Alkynes. Adv. Synth. Catal. 2021，363，4789-4794

11.Jiajia Zhang, Ning Wu* and Dayong Shi*,The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review. Mini-Reviews in Medicinal Chemistry, 2021, 21, 803-815

2020年

1、Jiajia Zhang , Jiajia Dai, Qingxuan Zheng, Shuju Guo, Yanyan Yu, Wenpeng Hu, Yanan Gao and Dayong Shi * The Fluoro-Thiazolylhydrazone Compound TSC-3C Inhibits Triple Negative Breast Cancer (TNBC) Cell Line Activity by Promoting Apoptosis, Regulating the MAPK Pathway and Inducing Mitochondrial Dysfunction，Int. J. Mol. Sci. 2020, 21, 1038-1053

2、Haonan Zhang, Zhengquan Gao, Chunxiao Meng*, Xiangqian Li* and Dayong Shi*. Inhibitor Binding Sites in the Protein Tyrosine Phosphatase SHP-2. Mini-Rev Med Chem. 2020, 21, 1038-1053

3、Jiao Luo, Yufei Hou, Mengyue Xie, Wanli Ma, Dayong Shi * and Bo Jiang *. CYC31, A Natural Bromophenol PTP1B Inhibitor, Activates Insulin Signaling and Improves Long Chain-Fatty Acid Oxidation in C2C12 Myotubes. Mar. Drugs. 2020, 18, 267-280

4、Chuanlong Guo*, Fan Zhang, Xiaochen Wu, Xuemin Yu, Xianggen Wu, Dayong Shi*, Lijun Wang*.BTH-8, a novel poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor, causes DNA double-strand breaks and exhibits anticancer activities in vitro and in vivo. Int. J. Biol. Macromol. 2020,150,238-245（IF= 6.953）

5、Xiuxue Li, Lijun Wang, Xiaoling Jia, Chuanlong Guo, Chao Li, Jiajia Zhang and Dayong Shi*An UHPLC-TOF-MS method for quantifying novel brominated anticancer compound bromophenol-thiosemicarbazone hybrid and its application to in vivo pharmacokinetic study. Journal of Analytical Science and Technology. 2020;11(1):1-7

6、Liang Zhang#, Jiao Luo #, Xiangqian Li , Shuju Guo * and Dayong Shi*. 16S rRNA sequencing and metagenomics study of gut microbiota: implications of BDB on type 2 .Mar. Drugs. 2020, 18, 469-486

7、Xiaowei Li, Yuxiu Li, Ruihua Liu, Zemin Wang, Xiangqian Li, Dayong Shi*. AcOH-mediated aerobic oxidative synthesis of 2-thioalkylbenzothiazoles via a three-component reaction. Tetrahedron Letters. 2020,61(26) ,152054

8、Jiao Luo, Meiling Zheng, Bo Jiang, Chao Li, Shuju Guo, Lijun Wang, Xiangqian Li, Rilei Yu, Dayong Shi*. Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, from Rhodomela confervoides. Br J Pharmacol. 2020; 177(19):4464-4480 

2019年

1、Chuanlong Guo, Lijun Wang,* Xiuxue Li, Shuaiyu Wang, Xuemin Yu,Kuo Xu, Yue Zhao, Jiao Luo, Xiangqian Li, Bo Jiang, and Dayong Shi* Discovery of  Novel Bromophenol−Thiosemicarbazone Hybrids as Potent Selective Inhibitors of Poly(ADP-ribose) Polymerase‑1 (PARP-1) for Use in Cancer. J. Med. Chem. 2019, 62, 3051−3067

2、Chao Li, Jiao Luo, Shuju Guo, Xiaoling Jia, Chuanlong Guo, Xiangqian Li,Qi Xu, and Dayong Shi*Highly Selective Protein Tyrosine Phosphatase Inhibitor, 2,2′,3,3′- Tetrabromo-4,4′,5,5′-tetrahydroxydiphenylmethane, Ameliorates Type 2 Diabetes Mellitus in BKS db Mice. Mol. Pharmaceutics. 2019, 16, 1839-1850

3、Xiaolin Shi, Xiaowei Li , Lina Ma and Dayong Shi *.Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base. Catalysts. 2019, 9, 278

4、Hua Liu #, Chuanlong Guo# , Shuju Guo , Lijun Wang* and Dayong Shi *Design and Synthesis of a Fluorescent Probe with a Large Stokes Shift for Detecting Thiophenols and Its Application in Water Samples and Living Cells. Molecules. 2019, 24, 375

5、Xiangqian Li, Qi Xu, Chao Li , Jiao Luo, Xiuxue Li , Lijun Wang , Bo Jiang，Dayong Shi  *Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors. European Journal of Medicinal Chemistry. 2019,166,178-185

6、Kuo Xu, Chuanlong Guo , Jie Meng , Haiying Tian , Shuju Guo *and Dayong Shi * Discovery of natural dimeric naphthopyrones as potential cytotoxic agents through ROS-mediated apoptotic pathway. Mar. Drugs. 2019, 17, 207

7、Qi Xu, Ning Wu, Xiangqian Li, Chuanlong Guo, Chao Li, Bo Jiang, Huaizhi Wang and Dayong Shi*Inhibition of PTP1B blocks pancreatic cancer progression by targeting the PKM2/AMPK/mTOC1 pathway. Cell Death and Disease. 2019,10:874

8、Lijun Wang *, Chuanlong Guo , Xiuxue Li , Xuemin Yu , Xiangqian Li ,Kuo Xu, Bo Jiang , Xiaoling Jia , Chao Li , Dayong Shi *Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment. European Journal of Medicinal Chemistry. 2019, 177,153-170

9、Hua Liu, Chuanlong Guo, Shuju Guo, Junting Fan, Lijun Wang*,Dayong Shi *Chalcone-analogue fluorescent probes for detecting thiophenols in seawater  samples. Talanta. 2019, 201, 301–308

10、Chuanlong Guo , Lijun Wang ,Yue Zhao,Bo Jiang, Jiao Luo, Dayong Shi* . BOS‑93, a novel bromophenol derivative, induces apoptosis and autophagy in human A549 lung cancer cells via PI3K/Akt/mTOR and MAPK signaling pathway. Experimental and therapeutic medicine.2019, 17(5): 3848–3858

11、Chuanlong Guo, Lijun Wang, Xiuxue Li, Shuaiyu Wang, Xuemin Yu, Kuo Xu, Yue Zhao, Jiao Luo, Xiangqian Li, Bo Jiang, and Dayong Shi* Chalcone-analogue fluorescent probes for detecting thiophenols in seawater samples. Talanta.2019, 62, 3051-3067

12、Xiaowei Li , Xiaolin Shi, Xiangqian Li, Dayong Shi*. Recent advances in transition-metal-catalyzed incorporation of fluorine-containing groups. Beilstein J Org Chem. 2019; 15: 2213–2270. 

13、Jiao Luo#, Bo Jiang#, Chao Li, Xiaoling Jia and Dayong Shi*CYC27 Synthetic Derivative of Bromophenol from Red Alga Rhodomela confervoides: Anti-Diabetic Effects of Sensitizing Insulin Signaling Pathways and Modulating RNA Splicing-Associated RBPs. Mar. Drugs. 2019, 17(1), 49. 

14、Xiaolin Shi, Xiaowei Li, Xiangqian Li* and Dayong Shi*Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions. Front. Chem. 2019; 7: 613. 

15、Chao Li, Dayong Shi*.Structural and Bioactive Studies of Halogenated Constituents from Sponges .Current Medicinal Chemistry, 2019, 26, 1-26 .

16、Yuanyuan Zhang, Junhong Liu*, Dayong Shi* and Zheng Li. Halogenated Compounds from Corals: Chemical Diversity and Biological Activities, Mini-Reviews in Medicinal Chemistry, 2019, 19, 1204-1218.