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Current strategies and progress for targeting the "undruggable" transcription factors

Transcription fac...

查看详情 2022-02-07
Identification of oleoylethanolamide as an endogenous ligand for HIF-3α

Hypoxia-inducible...

查看详情 2022-05-09
Structural basis for the allosteric inhibition of hypoxia-inducible factor (HIF)-2 by belzutifan

Hypoxia-inducible...

查看详情 2022-09-27
Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the b...

Neuronal PER-ARNT...

查看详情 2022-11-07
SAR study of 1,2-benzisothiazole dioxide compounds that agonize HIF-2 stabilization and EPO produ...

Benzisothiazole d...

查看详情 2023-01-01
Discovery of a highly potent NPAS3 heterodimer inhibitor by covalently modifying ARNT

Neuronal PAS doma...

查看详情 2023-10-01

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