Gender:Male
Date of Employment:2018-05-16
E-Mail:baobingzh@sdu.edu.cn
Business Address:44 Wenhuaxi Road,Jinan,Shandong
Contact Information:0531-88382176
Discipline:Pharmacology
Discipline:Pharmacology

Baobing Zhao

Professor

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Degree:Doctor
Education Level:With Certificate of Graduation for Doctorate Study
Alma Mater:Xiamen University
Status:Employed
Title:Professor
School/Department:School of Pharmaceutical Sciences of Shandong University

Profile

赵保兵,男,博士;山东大学药学院教授,药理学博士生导师;山东省泰山学者青年专家。博士毕业于厦门大学,从事天然产物化学生物学研究;美国留学5年,从事血液学研究,专注红系细胞发育和造血干细胞自我更新的调控机制,发掘恶性血液病的潜在药物靶标;2017年回国加盟山东大学药学院,开展先导化合物筛选和药理学研究。近五年,在J Clin Invest、Dev Cell、Blood、Leukemia、Haematologica和Biochemical Pharmacology等发表SCI论文20余篇。其中以第一作者(含共同第一作者)发表论文12篇,通讯作者(含共同通讯)论文2篇,论文总影响因子118,他引127次。2018年入选山东省“泰山学者青年专家”和山东大学“齐鲁青年学者”。研究方向主要从事活性先导化合物和潜在药物靶标发现研究,包括:1)靶向小分子先导化合物筛选;2)干细胞自我更新与分化的分子调控机制研究;3)血液等相关疾病致病机理研究,发掘和确证新的潜在药物靶标。承担科研项目情况金属离子依赖性蛋白磷酸酶PPM1B特异性抑制剂的设计、合成及其在造血干细胞功能调节的分子机制研究(81874294),国家自然科学基金面上项目,2019/01 – 2022/12,57万,项目负责人;山东省“泰山学者青年专家”计划,2018/12 – 2023/12,50万;山东大学“齐鲁青年学者”科研基金,2018/05 – 2023/05,150万;荣誉奖励山东大学“齐鲁青年学者” 2018年山东省“泰山学者青年专家” 2018年代表性论著论文(限10篇)1. Baobing Zhao#, Hui Liu, Yang Mei, Xu Han, Jing Yang, Amittha Wickrema, Peng Ji#. Disruption of erythroid nuclear opening and histone release in myelodysplastic syndromes. Cancer Medicine, 2019. 8(3): 1169-1174.2. Mengjia Guan, Jin Qiu, Chunhua Lu, Baobing Zhao#, Yuemao Shen. Design and Synthesis of Natural Product-Like Terphenyl as Potent Topoisomerase IIα Inhibitors. Chinese Journal of Organic Chemistry, 2018. 38(11): 3039-3047.3. Baobing Zhao, Yang Mei, Ronen Sumagin, Jing Yang, Chelsea Thorsheim, Liang Zhao, Timothy Stalker, Qiang Jeremy Wen, John D. Crispino, Charles S. Abrams, and Peng Ji. Loss of Pleckstrin-2 reverts vascular occlusions through the reduction of red cell mass in JAK2V617F-positive myeloproliferative neoplasms. Journal of clinical investigation, 2017. 128(1):125-140.4. Baobing Zhao, Yang Mei, Matthew J Schipma, Eric Wayne Roth, Reiner Bleher, Joshua Z Rappoport, Amittha Wickrema, Jing Yang, and Peng Ji, Nuclear Condensation during Mouse Erythropoiesis Requires Caspase-3-Mediated Nuclear Opening. Developmental Cell, 2016. 36(5): 498-510. (Cover Story, and highlighted as previews)5. Baobing Zhao, Timothy L. Tan, Yang Mei, Jing Yang, Yiting Yu, Amit Verma, Ying Liang, Juehua Gao, and Peng Ji, H2AX deficiency is associated with erythroid dysplasia and compromised haematopoietic stem cell function. Scientific Reports, 2016. 6: 19589.6. Baobing Zhao, Yang Mei, Jing Yang and Peng Ji. Erythropoietin regulated oxidative stress negatively affects enucleation in erythropoiesis. Experimental hematology, 2016. 44(10): 975-981.7. Qiu Jin*, Baobing Zhao*, Zhon W, Shen Y, and Lin H. Synthesis, biological evaluation and modeling studies of terphenyl topoisomerase IIalpha inhibitors as anticancer agents. European journal of medicinal chemistry, 2015. 94: 427-435.8. Ganesan Keerthivasan, Yang Mei, Baobing Zhao, Ling Zhang, Chad E. Harris, Juehua Gao, Ashley A. Basiorka, Matthew J. Schipma, James McElherne, Jing Yang, Amit K. Verma, Andrea Pellagatti, Jacqueline Boultwood, Alan F. List, David A. Williams, and Peng Ji. Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) myelodysplastic syndromes. Blood, 2014. 124(5): 780-790.9. Baobing Zhao*, Ganesan Keerthivasan*, Jing Yang, James McElherne, Piu Wong, John Doench, Gang Feng, David Root, and Peng Ji. Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis. Haematologica, 2014. 99(7): 1157-1167.10. Jifeng Wang*, Baobing Zhao*, Yuting Yi, Wei Zhang, Xuan Wu, Lianru Zhang, Yuemao Shen. Mycoepoxydiene, a fungal polyketide induces apoptosis in MCF-7 cells through simultaneously targeting p53 and NF-κB pathways. Biochemical Pharmacology, 2012. 84(7): 891-899.

Educational Experience
  • 2006.9 -- 2011.12
    厦门大学 , 生物化学与分子生物学  , Doctoral Degree in Science
  • 2002.9 -- 2006.7
    西北农林科技大学 , 生物工程  , Bachelor's Degree in Engineering
Work Experience
  • 2018.6 -- Now
    山东大学
  • 2018.5 -- Now
    山东大学 , 药学院 , 教授
  • 2017.12 -- 2018.5
    山东大学 , 药学院 , 研究员
  • 2017.7 -- 2017.8
    美国西北大学 , Feinberg医学院 , 研究助理教授
  • 2012.8 -- 2017.6
    美国西北大学 , Feinberg医学院 , 博士后
Social Affiliations
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Research Focus
Research Group