陈晨
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一、基本情况
陈 晨，博士，山东大学公共卫生学院教授，营养与食品卫生学博士生导师，山东大学齐鲁青年学者。曾任美国密歇根州立大学助理教授。
从事营养与食品安全风险评估理论、方法及应用基础研究，饮食模式、营养因素与认知健康研究，探索营养、食品安全与人类健康之间的科学问题。研究揭示了食品中天然毒素是影响儿童发育的关键因素，提出的食品安全干预措施成功改善了儿童健康状况；在探明多种食源性危害混合污染联合效应规律的基础上，提出了国家食品安全标准建议值；开展了一系列食品安全风险评估研究，为我国和国际食品安全管理部门实施风险管理提供了科学依据。在Nature Food, PNAS, Trends in Food Science & Technology, Comprehensive Review in Food Science and Food Safety, Global Food Security, Food Chemistry, Journal of Hazardous Materials, Environment International 等国内外知名期刊发表论文70余篇；获得省部级科技奖3项，授权国家发明专利3项，参编英文著作1部、中文著作3部。
招生学科：营养与食品卫生学
通讯地址：山东省济南市文化西路44号山东大学趵突泉校区公共卫生学院
E-maill: chenc@sdu.edu.cn
二、学习经历
2000.09–2004.06 南京农业大学 生物技术 理学学士
2004.09–2007.06 南京农业大学 植物保护 农学硕士
2011.09–2014.06 中国农业科学院研究生院 农产品质量与食物安全 农学博士
三、工作经历
2021.07 至今 山东大学公共卫生学院 教授/博士生导师，齐鲁青年学者
2020.07-2021.05 美国密歇根州立大学食品科学与人类营养系 Research Assistant Professor
2016.03–2020.06 美国密歇根州立大学食品科学与人类营养系 访问学者，Research Associate
2012.02–2012.04 荷兰国家环境健康研究院 （RIVM） 访问学者
2007.07–2021.06 中国农业科学院农业质量标准与检测技术研究所 研究实习员、助理研究员、副研究员
四、研究领域
探索营养、食品安全与人类健康之间的相互联系，研发可持续性的营养与食品安全解决方案，旨在提升我国食品安全和全民营养健康水平。主要研究方向包括：
1. 营养、食品安全对健康作用路径及解决方案研究
2. 营养、食品安全与健康风险—效益评估
3. 食品中天然毒素等食源性污染物危害效应和风险评估
4. 食品中混合污染物联合效应及累积性风险评估
五、专业协会、同行评议
山东省食品安全风险评估专家委员会委员
国际风险分析学会 (Society for Risk Analysis, SRA)，Full Member
美国毒理学会 (Society of Toxicology, SOT)，Full Member
Comprehensive Reviews in Food Science and Food Safety, Food and Chemical Toxicology, Journal of Hazardous Materials等期刊审稿人
六、近年承担的主要科研项目
主持国家自然科学基金3项、山东省优秀青年科学基金（海外）、国家重点研发计划食品安全关键技术研发课题及子课题、山东省自然科学基金面上项目，以及公益性行业（农业）科研专项子任务等科研项目。
七、主要学术论文
2023-2024:
• Shu F, Yang G, Liu S, Huang N, Wang R, Chen C*. A Comprehensive Review on Arsenic Exposure and Risk Assessment in Infants and Young Children Diets: Health Implications and Mitigation Interventions in a Global Perspective. Comprehensive Reviews in Food Science and Food Safety. In Production.
• Huang N, Wang B, Liu S, Wang K, Wang R, Liu F*, Chen C*. Cadmium exposure in infants and children: Toxicity, health effects, dietary risk assessment and mitigation strategies. Critical Reviews in Food Science and Nutrition 2024 Sep 12:1-23. Online ahead of print.
• Wang Y†, Liu P†, Liu X, Wang T, Li Z, Qian Y, Qiu J*, Chen C*. An integrated approach for assessing the health risks of pesticide residues on apple: From field dynamics to human exposure. Science of The Total Environment 2024, 954:176721
• Wang Y†, Li Z†, Ji C, Wang Y, Chu Z, Zhang T, Chen C*. Synergistic toxic effects and mechanistic insights of beta-cypermethrin and pyraclostrobin exposure on hook snout carp (Opsariichthys bidens): A biochemical, transcriptional, and molecular approach. Environmental Pollution 2024, 358:124535
• An X†, Wang R†, Cao C, Wang D, Chen C*, Y Wang Y*. Synergistic risk in the gut and liver: Insights into the toxic mechanisms and molecular interactions of combined exposure to triazophos and fenvalerate in zebrafish. Science of The Total Environment 2024:948, 174710
• Wang Y†, Liu P†, Yang G, Shu F, Chen C*. Exploring the dynamic behaviors of five pesticides in lettuce: Implications for consumer health through field and modeling experiments. Food Chemistry 2024, 452:139510
• Yang M, Wang Y, Yang G, Wang Y, Liu F*, Chen C*. A review of cumulative risk assessment of multiple pesticide residues in food: Current status, approaches and future perspectives. Trends in Food Science & Technology 2024, 144:104340
• Wang R†, Yang M†, Zheng Y, Song F, Zhao X, Chen C*. Interactive transgenerational effects of parental co-exposure to prochloraz and chlorpyrifos: Disruption in multiple biological processes and induction of genotoxicity. Pesticide Biochemistry and Physiology 2024, 198:105713
• Chen C, Patil CL, ER Mduma ER, Groopman JD, Riley RT, Wu F*. Mycotoxins were not associated with environmental enteropathy in a cohort of Tanzanian children. Risk Analysis 2023, 43:860-866
• Wang R†, Huang N†, Ji J, Chen C*. An integrated approach for evaluating the interactive effects between azoxystrobin and ochratoxin a: Pathway-based in vivo analyses. Pesticide Biochemistry and Physiology 2023, 195:105556
• Wang R, Yang X, Wang T, Kou R, Liu P, Huang Y*, Chen C*. Synergistic effects on oxidative stress, apoptosis and necrosis resulting from combined toxicity of three commonly used pesticides on HepG2 cells. Ecotoxicology and Environmental Safety 2023, 263:115237
• Wang R, Liu N, Huang N, Shu F, Lou Y, Zhang S, Zhu H, Chen C*. Combined toxicity assessment of a naturally occurring toxin and a triazole fungicide on different biological processes through toxicogenomic data mining with mixtures. Pesticide Biochemistry and Physiology 2023, 193:105440
Prior to 2022:
Chen C, Kashala-Abotnes E, Banea JP, et al. Cost-effectiveness of a wetting method intervention to reduce cassava cyanide-related cognitive impairment in children. Nature Food, 2021, 2, 469-472.
Wu F, Wesseler J, Zilberman C, Russell RM, Chen C, Dubock AC. Opinion: Allow Golden Rice to save lives. PNAS, 2021, 118, e2120901118
Chen C, Frank K, Wang T, Wu F. Global wheat trade and Codex Alimentarius guidelines for deoxynivalenol: A mycotoxin common in wheat. Global Food Security, 2021, 29, 100538
Di S, Wang Y, Xu H, Wang X, Chen C*, Yang X, Qian Y*. Comparison the dissipation behaviors and exposure risk of carbendazim and procymidone in greenhouse strawberries under different application method: Joint application and individual application. Food Chemistry, 2021, 354, 129502.
Wang T, Ma M, Chen C*, Yang X, Qian Y. Three widely used pesticides and their mixtures induced cytotoxicity, apoptosis and DNA damage in HepG2 cells. Food and Chemical Toxicology, 2021, 152, 112162.
Chen C, Wu F. Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) colonization and infection among livestock workers and veterinarians: a systematic review and meta-analysis. Occupational and Environmental Medicine, 2021, 78:530-540.
Chen C, Saha Turna N, Wu F. Risk Assessment of Dietary Deoxynivalenol Exposure in Wheat Products Worldwide: Are New Codex DON Guidelines Adequately Protective? Trends in Food Science & Technology. 2019, 89:11-25.
Ma M, Chen C*, Yang G, Wang Y, Wang T, Li Y, Qian Y*. Combined anti-androgenic effects of mixtures of agricultural pesticides using in vitro and in silico methods. Ecotoxicol Environ Saf. 2019, 186:109652.
Chen C, Riley RT, Wu F. Dietary Fumonisin and Growth Impairment in Children and Animals: A Review. Comprehensive Reviews in Food Science and Food Safety 2018, 17:1448-64.
Chen C, Mitchell NJ, Gratz J, Houpt ER, Gong Y, Egner P, Groopman JD, Riley RT, Showker JL, Svensen E, Mduma ER, Patil C, Wu F. Mycotoxin exposure and growth outcomes in children from Haydom, Tanzania: Extension of the MAL-ED study. Environment International, 2018, 115: 29-37.
Chen C, Wu F. The need to revisit ochratoxin A risk in light of diabetes, obesity, and chronic kidney disease prevalence. Food Chem Toxicol. 2017, 103:79-85.
Mitchell NJ, Chen C, Palumbo JD, Bianchini A, Cappozzo J, Stratton J, Ryu D, Wu F. A risk assessment of dietary Ochratoxin A in the United States. Food Chem Toxicol. 2017,100:265-273.
Spink J, Ortega DL, Chen C, Wu F. Food fraud prevention shifts the food risk focus to vulnerability. Trends in Food Science & Technology. 2017, 62: 215-220.
Yang G†, Chen C†, Wang Y, Peng Q, Zhao H, Guo D, Wang Q, Qian Y*. Mixture toxicity of four commonly used pesticides at different effect levels to the epigeic earthworm, Eisenia fetida. Ecotoxicol Environ Saf, 2017, 142:29-39. (†Equally contributing authors)
Guo D, Wang Y, Qian Y, Chen C, Jiao B, Cai L, Wang Q. Joint acute and endocrine disruptive toxicities of malathion, cypermethrin and prochloraz to embryo-larval zebrafish, Danio rerio. Chemosphere. 2017, 166:63-71.
Ma M, Chen C*, Yang G, Li Y, Chen Z, Qian Y*. Combined cytotoxic effects of pesticide mixtures present in the Chinese diet on human hepatocarcinoma cell line. Chemosphere. 2016, 159:256-66. (*Corresponding authors)
Chen C†, Wang Y†, Zhao X, Wang Q, Qian Y. The synergistic toxicity of the multiple pollutant mixtures: implications for risk assessment in the terrestrial environment. Environment International, 2015, 77: 95-105. (†Equally contributing authors)
Wang Y†, Chen C†, Zhao X, Wang Q, Qian Y. Assessing joint toxicity of four organophosphate and carbamate insecticides in common carp (Cyprinus carpio) using acetylcholinesterase activity as an endpoint. Pesticide Biochemistry and Physiology, 2015, 122:81-85. (†Equally contributing authors)
Wang Y†, Chen C†, Zhao X, Wang Q, Qian Y. Ternary toxicological interactions of insecticides, herbicides, and a heavy metal on the earthworm Eisenia fetida. Journal of Hazardous Materials, 2015, 284: 233–240. (†Equally contributing authors)
Wang Y†, Chen C†, Zhao X, Wang Q, Qian Y. Toxicity of mixtures of λ-cyhalothrin, imidacloprid and cadmium on the earthworm Eisenia fetida by combination index (CI)-isobologram method. Ecotoxicology and Environmental Safety, 2015, 111: 242–247. (†Equally contributing authors)
Chen C, Mi X, Yuan Y, Chen G, Ren L, Wang K, Zhu D, Qian Y. A preliminary risk assessment of potential exposure to naturally occurring estrogens from Beijing (China) market milk products. Food and Chemical Toxicology, 2014,71:74-80.
Chen C†, Wang Y†, Zhao X, Wang Q, Qian Y. Combined toxicity of butachlor, atrazine and λ-cyhalothrin on the earthworm Eisenia fetida by combination index (CI)-isobologram method. Chemosphere, 2014, 112:393-401. (†Equally contributing authors)
Chen C†, Wang Y†, Zhao X, Wang Q, Qian Y. Comparative and combined acute toxicity of butachlor, imidacloprid and chlorpyrifos on earthworm, Eisenia fetida. Chemosphere, 2014,100:111-115. (†Equally contributing authors)
Yuan Y, Chen C*, Zheng C, Wang X, Yang G, Wang Q, Zhang Z*. Residue of chlorpyrifos and cypermethrin in vegetables and probabilistic exposure assessment for consumers in Zhejiang Province, China. Food Control, 2014, 36: 63-68.
Yang L, Qian Y, Chen C, Wang F. Assessing the establishment of agro-food control systems based on a relevant officials’ survey in China. Food Control, 2012, 26: 223-230
Chen C, Qian Y, Liu X, Tao C, Liang Y, Li Y. Risk assessment of chlorpyrifos on rice and cabbage in China. Regulatory Toxicology and Pharmacology, 2012, 62: 125-130.
Chen C, Qian Y, Chen Q, Tao C, Li C, Li Y. Evaluation of pesticide residues in fruits and vegetables from Xiamen, China. Food Control, 2011, 22:1114–1120.
Chen C, Qian Y, Chen Q, Li C. Assessment of daily intake of toxic elements due to consumption of vegetables, fruits, meat, and seafood by inhabitants of Xiamen, China. Journal of Food Science, 2011, 76: 181-188.
Qian Y†, Chen C†, Zhang Q, Li Y, Chen Z, Li M. Concentrations of cadmium, lead, mercury and arsenic in Chinese market milled rice and associated population health risk. Food Control, 2010, 21: 1757-1763. (†Equally contributing authors)
Chen C, Yun Li Y, Chen M, Chen Z, Qian Y. Organophosphorus pesticide residues in milled rice (Oryza sativa) on the Chinese market and dietary risk assessment. Food additives & contaminants, 2009, 26: 340-347.
会议论文
Chen C, Boivin MJ, Wu F. Burden of disease of neurodevelopment impairment associated with cassava cyanide in the Democratic Republic of the Congo (DRC). ePoster. Society of Toxicology (SOT) 2020 Annual Meeting.
Chen C, Wu F. Global burden of disease caused by cassava cyanide, and cost-effectiveness of interventions to reduce its presence in food. Abstract accepted by Society for Risk Analysis (SRA) 2019 Annual Meeting.
Chen C, Mitchell N, Wu F, and MAL-ED Tanzania Team. The association between dietary toxins and microbial infection in Tanzanian children. Poster presentation. Society for Risk Analysis (SRA) 2018 Annual Meeting. December 2-6 New Orleans, LA.
Chen C, Wu F. Antibiotic Resistance: The Need for a New Risk Assessment Framework. Society for Risk Analysis (SRA) 2017 Annual Meeting. December 10-14 Arlington, VA
