山东大学未来计划青年学者, 主持国家自然科学基金、山东省自然科学基金、博士后特别资助项目等省部级项目5项,国家重点实验室开放课题多项.在nature review neuroscience、food hydrocolloids、food chemistry等发表论文50余篇,含高被引论文1篇,封面论文1篇.申请发明专利10余项.获2023 USERN medical prize, 2023 山东省优秀创新创业导师、2024山东省科技创业大赛优秀指导教师等荣誉称号.指导本科生获得挑战杯、互联网+、节能减排大赛国家、省级级奖项多项.组内本科生多人保送清华大学、中科院、浙江大学、上海交通大学等国内知名高校,多名同学赴帝国理工大学、鲁汶大学、新国立、剑桥大学等国外一流高校深造.
研究方向
基于药食同源特性的海洋多糖结构功能解析与精准生物医学应用:
1.药食同源海洋多糖的精细化结构解析、构效关系及其作用机制研究
2. 海洋多糖通过“肠-X”轴调控免疫微环境治疗慢性炎症性疾病的机制与应用研究
3. 海洋多糖在创面修复与组织工程中的智能材料开发
4. 海洋多糖靶向载药微纳系统构建及克服生物学屏障的研究
主持项目
2022.01-2026.12 入选第七批“山东大学青年学者未来计划 ”
2022.01-2024.12 国家自然科学基金 主持
2019.07-2022.12 山东省自然科学基金 主持
2018.01-2019.07 中国博士后科学基金特别资助 主持
2017.07-2018.12 山东省自然科学基金 主持
2017.03-2018.07中国博士后科学基金 主持
其他省部级项目十余项
代表性论文
2025
Zheng, Z., Sun, L., Li, Y., Wang, S., Wang, P., Qiu, S., . . . Chen, H. (2025). Gelatin-dopamine-based dual-responsive nanogels for tumor-targeted bortezomib delivery: Minimizing systemic toxicity and enhancing breast cancer therapy. Int J Biol Macromol, 318(Pt 4), 145084. doi:10.1016/j.ijbiomac.2025.145084 (IF 8.5, Q1)
Wang, P., Zhang, Q., Wang, S., Wang, D., Yip, R. C. S., Xie, W., & Chen, H. (2025). Injectable Salecan/hyaluronic acid-based hydrogels with antibacterial, rapid self-healing, pH-responsive and controllable drug release capability for infected wound repair. Carbohydrate Polymers, 347. https://doi.org/10.1016/j.carbpol.2024.122750. (IF 12.5,Q1)
Wang, D., Li, K., Zhang, J., Zhou, K., Wang, K., Wang, Y., . . . Chen, H. (2025). Schiff-base crosslinked gelatin-mycosporine-like amino acids/dialdehyde starch composite film: a UV-resistant, biodegradable food packaging material. Chemical Engineering Journal, 514. doi:10.1016/j.cej.2025.163182 (IF 13.4,Q1)
2024
Gao, J., Gunasekar, S., Xia, Z., Shalin, K., Jiang, C., Chen, H., . . . Joshi, N. (2024). Gene therapy for CNS disorders: modalities, delivery and translational challenges. Nature Reviews Neuroscience. https://doi.org/10.1038/s41583-024-00829-7. (IF 28.7,Q1)
Wang, S., Guan, C., Wang, P., Wang, D., Wang, H., Yip, R. C. S., & Chen, H. (2024). A thiolated oxidized guar gum and sodium lginate dual-network microspheres with enhanced gastric acid resistance and mucoadhesion for delivery of probiotics. International Journal of Biological Macromolecules, https://doi.org/10.1016/j.ijbiomac.2024.133395. (IF 8.5, Q1)
Wang, S., Wang, P., Wang, D., Shen, S., Wang, S., Li, Y., & Chen, H. (2024). Postbiotics in inflammatory bowel disease: efficacy, mechanism, and therapeutic implications. J Sci Food Agric. https://doi.org/10.1002/jsfa.13721. (IF:4.1，Q1)
Wang, P., Wang, S., Wang, D., Li, Y., Yip, R. C. S., & Chen, H. (2024). Postbiotics-peptidoglycan, lipoteichoic acid, exopolysaccharides, surface layer protein and pili proteins-Structure, activity in wounds and their delivery systems. International Journal of Biological Macromolecules, 133195. https://doi.org/10.1016/j.ijbiomac.2024.133195. (IF 8.5.Q1)
2023
Yige Song, Shuxin Li, Hao Gong, Ryan Chak Sang Yip, Hao Chen.* (2023). Biopharmaceutical applications of microbial polysaccharides as materials: A review. International Journal of Biological Macromolecules. https://doi.org/10.1016/j.ijbiomac.2023.124259. (IF:8.2，Q1, TOP)
Wang, D., Guan, C., Sun, L., Zhang, Q., Pan, S., & Chen, H.* (2023). Improvement of the UV-resistance capability of the fish gelatin-oxidized starch film via inserting mycosporine-like amino acids. Journal Of The Science Of Food And Agriculture. https://doi.org/10.1002/jsfa.12587. (IF:4.1，Q1, 封面论文)
Wang, Z., Xu, Z., Yang, X., Li, M., Yip, R. C. S., Li, Y., & Chen, H*. (2023). Current application and modification strategy of marine polysaccharides in tissue regeneration: A review. Biomater Adv, 154, 213580. https://doi.org/10.1016/j.bioadv.2023.213580. (IF: 7.9, Q1, TOP)
2022
Yan, W., Sun, H., Liu, W., & Chen, H*. (2022). Preparation and Properties of Blended Composite Film Manufactured Using Walnut-Peptide-Chitosan-Sodium Alginate. Foods, 11(12).（IF:5.56，Q1）
Zhe Wang, Juanjuan Wu, Zichen Tian, Yue Si, Chen*, H., & Gan*, J. (2022). The Mechanisms of the Potential Probiotic Lactiplantibacillus plantarum against Cardiovascular Disease and the Recent Developments in Its Fermented Foods. Foods, https://doi.org/10.3390/foods11172549.
Shen, S., Deng, L., Du, Y., Gao, J., Zhang, C., Wang, Y., Chen, H*. (2022). Analyzing and mapping the research status, hotspots, and frontiers of biological wound dressings: An in-depth data-driven assessment. Intenational Journal of Pharmaceutics, 629. https://doi.org/10.1016/j.ijpharm.2022.122385. (IF: 5.8, Q1, TOP)
Jing Gan, Chenxia Guan, Xiaoyu Zhang, Lirong Sun, Qinling Zhang, Shihui Pan, Qian Zhang, Hao Chen*. (2022). The Preparation of Anti-Ultraviolet Composite Films Based on Fish Gelatin and Sodium Alginate Incorporated with Mycosporine-like Amino Acids. Polymers (Basel), 14, 1-14. https://doi.org/10.3390/polym14152980.
Jing Gan, Lirong Sun, Chenxia Guan, Ren, T., Qinling Zhang, Shihui Pan, Chen, H*. (2022). Preparation and Properties of Salecan–Soy Protein Isolate Composite Hydrogel Induced by Thermal Treatment and Transglutaminase. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms23169383.
Zhang, Q., Ren, T., Gan, J., Sun, L., Guan, C., Zhang, Q., Pan, S., Chen, H*. (2022). Synthesis and Rheological Characterization of a Novel Salecan Hydrogel. Pharmaceutics, 14(7). https://doi.org/10.3390/pharmaceutics14071492.
