山东大学教师主页陈洁 Home Home

Biography

个人简介

医学博士，副教授，山东大学公共卫生学院儿少卫生与妇幼保健学系副主任，妇幼保健专业硕士生导师，山东省妇幼保健协会生育保健分会副主任委员，山东预防医学会儿童青少年健康专业委员。近年来承担国家级课题2项，省部级课题4项。以第一作者或通讯作者在国内外发表论文10余篇。主要从事妇科肿瘤早期诊断与预防，青春期常见病、多发病防治，及孕产妇遗传咨询、产前诊断、生殖内分泌疾病的研究。

教育经历

2015.08-2016.08 斯坦福大学，访问学者

2014.07-2016.09 山东大学，博士后,公共卫生与预防医学

2000.09-2005.07 山东大学，博士，妇产科

1995.09-2000.07 山东大学，本科，临床医学

工作经历

2013.07至今山东大学公共卫生学院副教授/硕士生导师

2005.07-2013.07 山东大学公共卫生学院讲师

研究领域

1.妇科肿瘤防治，肿瘤分子标志物鉴定与早期筛查，恶性肿瘤发生转移的分子监测及机制研究。

2.青春期常见病、多发病防治，及孕产妇遗传咨询、产前诊断、生殖内分泌疾病的研究。

承担的主要研究课题

1、横向课题，1320019009，女性产后盆底功能缺陷的综合性康复研究，2019.10-2022.10，在研，主持

2、山东省重点研发计划，2018GSF118049，EFEMP1-STEAP1受体系统在卵巢癌发生发展及防治中作用的研究，2018.01-2019.12，15万，已结题，主持

3、山东省自然科学基金，ZR2017MH060，STEAP1在卵巢癌发生发展和血管生成中作用机制的研究，2017/08-2020/06，13万，结题，主持

4、中国博士后科学基金，2014M551919，fibulin-4在卵巢癌发生发展中作用机制的研究，2014/06-2016/06，5万元，已已结题，主持

5、国家自然基金青年科学基金，81202056，EFEMP1对卵巢癌细胞侵袭转移和血管生成作用的研究，2013/01-2015/12，23万元，已结题，主持

6、山东大学自主创新基金，2012TS088，HMGB1促进卵巢癌细胞侵袭转移分子机制的研究，2012/01-2014/12，7万元，已结题，主持

7、山东省优秀中青年科学家科研奖励基金，2007BS03025，轴突导向分子Semaphorins及其受体与卵巢癌转移关系的研究，2007/01-2009/12，6万元，已结题，主持

主要学术论文

1. Liu T, Niu X, Li Y, Xu Z, Chen J (Corresponding author), Xu G. Expression and prognostic analyses of the significance of STEAP1 and STEAP2 in lung cancer. World J Surg Oncol. 2022 Mar 28;20(1):96.

2. Yan M, Lv X, Jin X, Li S, Shen X, Zhang M, Su S, Chen J (Corresponding author), Yang H. The mediating effect of the prolonged second stage of labor on delivery mode and urinary incontinence among postpartum women: evidence from Shandong, China. Int Urogynecol J. 2021 Nov 29.

3. Jiao Z, Huang L, Sun J, Xie J, Wang T, Yin X, Zhang H, Chen J (Corresponding author). Six-transmembrane epithelial antigen of the prostate 1 expression promotes ovarian cancer metastasis by aiding progression of epithelial-to-mesenchymal transition. Histochem Cell Biol. 2020 Aug;154(2):215-230.

4. Jin X, Liu G, Jiao Z, Sun J, Yan M, Lv X, Zhang H, Chen J (Corresponding author). Pregnancy Outcome Difference between Fresh and Frozen Embryos in Women without Polycystic Ovary Syndrome: a Systematic Review and Meta-Analysis. Reprod Sci. 2021 May;28(5):1267-1276.

5. Xie J, Yang Y, Sun J, Jiao Z, Zhang H, Chen J (Corresponding author). STEAP1 Inhibits Breast Cancer Metastasis and Is Associated With Epithelial-Mesenchymal Transition Procession. Clin Breast Cancer. 2019 Feb;19(1):e195-e207.

6. Sun J, Ji G, Xie J, Jiao Z, Zhang H, Chen J (Corresponding author). Six-transmembrane epithelial antigen of the prostate 1 is associated with tumor invasion and migration in endometrial carcinomas. J Cell Biochem. 2019 Feb 3. doi: 10.1002/jcb.28393.

7. Wang T, Wang M, Fang S, Wang Q, Fang R, Chen J (Corresponding author). Fibulin-4 is associated with prognosis of endometrial cancer patients and inhibits cancer cell invasion and metastasis via Wnt/β-catenin signaling pathway. Oncotarget. 2017 Mar 21;8(12):18991-19012.

8. Yin X, Fang S, Wang M, Wang Q, Fang R, Chen J (Corresponding author). EFEMP1 promotes ovarian cancer cell growth, invasion and metastasis via activated the AKT pathway. Oncotarget. 2016 Jul 26;7(30):47938-47953.

9. Chen J, Liu Z, Fang S, Fang R, Liu X, Zhao Y, Li X, Huang L, Zhang J. Fibulin-4 is associated with tumor progression and a poor prognosis in ovarian carcinomas. BMC Cancer. 2015 Mar 4;15:91.

10. Chen J, Zhang J, Liu X, Fang R, Zhao Y, Ma D. Overexpression of fibulin-4 is associated with tumor progression and poor prognosis in patients with cervical carcinoma. Oncol Rep. 2014 Jun;31(6):2601-10.

11. Chen J, Wei D, Zhao Y, Liu X, Zhang J. Overexpression of EFEMP1 Correlates with Tumor Progression and Poor Prognosis in Human Ovarian Carcinoma. PLoS One. 2013 Nov 13;8(11):e78783.

12. Chen J, Shi D, Liu X, Fang S, Zhang J, Zhao Y. Targeting SPARC by lentivirus-mediated RNA interference inhibits cervical cancer cell growth and metastasis. BMC Cancer. 2012 Oct 10;12(1):464.

13. Chen J, Wang M, Xi B, Xue J, He D, Zhang J, Zhao Y. SPARC is a key regulator of proliferation, apoptosis and invasion in human ovarian cancer. PLoS One. 2012;7(8):e42413.

14. Chen J, Zhang J, Zhao Y, Li J, Fu M. Integrin beta3 down-regulates invasive features of ovarian cancer cells in SKOV3 cell subclones. J Cancer Res Clin Oncol. 2009; 135(7): 909-917.

Education Background