RDMiP8mizwz8sNVxwRxjbCWbxYmf1IhAn8IAkPQ7FHFUBWhO2FgqD7IzIpqu
高翔
Professor
Visit:次
Personal Information
  • Name (Pinyin):
    gaoxiang
  • Date of Employment:
    2017-07-31
  • School/Department:
    微生物技术研究 院（微生物改造技术全国重点实验室）
  • Education Level:
    With Certificate of Graduation for Doctorate Study
  • Gender:
    Male
  • Degree:
    Doctor
  • Status:
    Employed
  • Alma Mater:
    清华大学
Education
  • 2007-09 — 2012-01
    清华大学
    Biology
    Doctoral Degree in Science
  • 2003-09 — 2007-06
    山东大学
    生物科学
    Bachelor's Degree in Science
  • 2000-09 — 2003-06
    山西大学附属中学
Publication
Paper Publications

1. . Unexpected Activities of CYP152 Peroxygenases towards Non carboxylic Substrates Reveal Novel Substrate Recognition Mechanism and Catalytic Versatility .ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.2025 (未出)

2. . Interbacterial warfare in the human gut: insights from Bacteroidales' perspective .GUT MICROBES.2025,17 (1)

3. . A highly conserved SusCD transporter determines the import and species-specific antagonism of Bacteroides ubiquitin homologues .NATURE COMMUNICATIONS.2024,15 (1)

4. 李颖杰. 基于综合能力培养的“结构生物学”教学改革 .Progress in Biochemistry and Biophysics.2024

5. 姜昆. Current advances on Vip3 highlight the promising potential of bacterial insecticidal proteins .TRENDS IN MICROBIOLOGY.2024

6. . Bacteroides fragilis ubiquitin homologue drives intraspecies bacterial competition in the gut microbiome .NATURE MICROBIOLOGY.2023 (DOI10.1038/s41564-023-01541-5)

7. 陈喆. Structural insight into Bacillus thuringiensis Sip1Ab reveals its similarity to ETX_MTX2 family beta-pore-forming toxin .PEST MANAGEMENT SCIENCE.2023 (无)

8. 高翔. Evolution of host adaptation in the Salmonella typhoid toxin .NATURE MICROBIOLOGY.2017 (vol2)

9. . 沙门氏菌III型分泌系统抗感染类抑制剂的筛选 .微生物学通报.2023,50 (05):1-20

10. . Unnatural activities and mechanistic insights of cytochrome P450 PikC gained from site-specific mutagenesis by non-canonical amino acids .NATURE COMMUNICATIONS.2023 (2023)

11. . Rates of Mutations and Transcript Errors in the Foodborne Pathogen Salmonella enterica subsp. enterica .MOLECULAR BIOLOGY AND EVOLUTION.2022 (Volume 39, Issue 4)

12. . SAFA facilitates chromatin opening of immune genes through interacting with antiviral host RNAs .PLOS Pathogens.2022 (June 3, 2022)

13. . A strategy to enhance the insecticidal potency of Vip3Aa by introducing additional cleavage sites to increase its proteolytic activation efficiency .Engineering Microbiology.2023 (3（2023）)

14. . Functional characterization of Vip3Aa from Bacillus thuringiensis reveals the contributions of specific domains to its insecticidal activity .Journal of biological chemistry.2023 (3)

15. 陈喆. Structural insight into Bacillus thuringiensis Sip1Ab reveals its similarity to ETX_MTX2 family beta-pore-forming toxin .PEST MANAGEMENT SCIENCE.2023 (11)

16. . The GRA15 protein from Toxoplasma gondii enhances host defense responses by activating the interferon stimulator STING .Journal of biological chemistry.2019,294 (45):16494-16508

17. 刘晓宇. Molecular Insights into the Assembly and Functional Diversification of Typhoid Toxin .MBIO.2022,13 (1)

18. 徐京华. Structural and Functional Analysis of SsaV Cytoplasmic Domain and Variable Linker States in the Context of the InvA-SsaV Chimeric Protein .MICROBIOLOGY SPECTRUM.2021 (3)

19. Yiqiao Bao. A Common Pathway for Activation of Host-Targeting and Bacteria-Targeting Toxins in Human Intestinal Bacteria .MBIO.2021 (4)

20. 姜昆. Structural and Functional Insights into the C-terminal Fragment of Insecticidal Vip3A Toxin ofBacillus thuringiensis .TOXINS.2020,12 (7)

21. Lian, Huan. The Salmonella effector protein SopD targets Rab8 to positively and negatively modulate the inflammatory response .NATURE MICROBIOLOGY.2021,6 (5):658

22. 高翔. The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers. .Cell Host & Microbe.2019

23. 高翔. The GRA15 protein from？Toxoplasma gondii？enhances host defense responses by activating the interferon stimulator STING. .J Biol Chem..2019

Patents

1. 一种活性提高的Vip3突变蛋白及其应用

2. 一种高效杀伤产肠毒素脆弱拟杆菌的细菌素及其应用

3. 羟基茜草素在作为T3SS小分子抑制剂中的应用

4. T3SS小分子抑制剂及其筛选方法和应用

5. 多环大环内酰胺类化合物及其制备方法和应用

Research Projects

1. 底盘细胞及微生物群落的设计与构建, 2024-12-01-2029-11-30

2. 细菌六型分泌系统介导菌间拮抗的新机制, 2025-01-01-2027-12-31

3. 基于CRISPR相关转座酶开发针对拟杆菌的菌群编辑方法, 2024-09-01-2026-06-30

4. 肠道噬菌体在腹主动脉瘤中的病因学作用和应用转化价值的多模态研究, 2024-01-01-2026-12-31

5. 双亚利桑那沙门氏菌类伤寒毒素组装模式及致病机制研究, 2023-08-24-2027-12-31

6. SK10-ARG-2, 2023-09-01-2024-08-31

7. 转录因子新靶标确证和新靶向分子发现, 2023-01-01-2025-12-31

8. 功能微生物（群）及其代谢产物调控动物发育和抗病分子机制, 2022-12-01-2027-11-30

9. （包干项目）肠道菌群互作, 2021-12-23-2024-12-31

10. （包干项目）肠道菌群互作, 2021-10-12-2024-12-31

11. 肠道菌群互作, 2021-08-18-2024-12-31

12. 致病微生物Ⅲ型分泌系统结构与功能的研究（补助）, 2020-12-11-2022-10-31

13. 致病微生物Ⅲ型分泌系统结构与功能的研究（奖励）, 2020-12-11-2022-12-11

14. 新型冠状病毒现场快速联合检测技术及装备开发, 2020-12-01-2023-12-31

15. K-微生物技术国家重点实验室开放运行费自主设置课题009, 2020-05-14-2020-12-31

16. 沙门氏菌SopD效应蛋白家族功能的研究以及人伤寒沙门氏菌动物模型的优化, 2017-08-17-2021-12-31

17. Y微生物技术国家重点实验室基本科研业务费自主设置课题-髙翔, 2017-09-01-2025-12-31

18. 致病微生物Ⅲ型分泌系统结构与功能的研究, 2019-11-05-2022-10-31

19. 奶牛乳腺炎病原学研究及新型疫苗研制, 2019-11-18-2024-12-18

Copyright All Rights Reserved Shandong University Address: No. 27 Shanda South Road, Jinan City, Shandong Province, China: 250100
Information desk: (86) - 0531-88395114
On Duty Telephone: (86) - 0531-88364731 Construction and Maintenance: Information Work Office of Shandong University