韩秋菊
副教授
所属院部: 齐鲁医学院
访问次数:
基本信息
  • 教师拼音名称:
    hanqiuju
  • 入职时间:
    2012-04-26
  • 所在单位:
    药学院
  • 学历:
    研究生(博士后)
  • 性别:
  • 联系方式:
    hanqiuju@sdu.edu.cn
  • 学位:
    医学博士学位
  • 在职信息:
    在职
  • 毕业院校:
    山东大学
  • 博士生导师
  • 硕士生导师
学科:
免疫药物学;
曾获荣誉:

2012-10-10    中国免疫学会青年学者奖;
教师简介

韩秋菊,副教授,博士生导师。2011年毕业于山东大学药学院,师承我国著名免疫学家田志刚院士。2012年起任教于山东大学药学院免疫药物学研究所。曾获中国免疫学会青年学者奖,担任JBCJECC、《生物化学与生物物理进展》、《中国免疫学》审稿专家。

主要研究领域为免疫耗竭机制及免疫治疗策略开发,目前以第一作者/通讯作者在Hepatology、Nature communication等发表SCI论文16篇,合作发表SCI论文20余篇,授权专利5项。为首承担国家自然基金面上项目、国家自然基金青年基金、山东省优秀青年基金、山东省重点研发计划、山东省自然基金、中国博士后基金面上项目、中国博士后特别资助、高校基本科研业务费交叉学科研究项目等课题。

在教学方面,承担多门本科和研究生课程,承担4项校级教研课题。获得全国药学类青年教师教学能力大赛一等奖、全国药学专业微课比赛一等奖、山东省高等医学教育中心优秀论文二等奖、山东大学讲课比赛一等奖,山东大学课程思政案例设计一等奖,山东大学青年教师教学能手称号。


教育经历
  • 2005-9 — 2011-6
    山东大学
    微生物与生化药学
    医学博士学位
  • 2001-9 — 2005-6
    山东大学
    药学
    理学学士学位
  • 1998-9 — 2001-7
    临清一中
工作经历
  • 2012-4-至今
    山东大学药学院
  • 2012-4-至今
    山东大学生命学院
科研成果
论文

1.  赵华俊. CpG-C ODN M362 as an immunoadjuvant for HBV therapeutic vaccine reverses the systemic tolerance against HBV.  International Journal of Biological Sciences,  2022. 

2.  赵华俊. Cholesterol accumulation on dendritic cells reverses chronic hepatitis B virus infection-induced dysfunction.  CELLULAR & MOLECULAR IMMUNOLOGY,  19,  1347, 2022. 

3.  赵华俊. Cholesterol accumulation on dendritic cells reverses chronic hepatitis B virus infection-induced dysfunction.  CELLULAR & MOLECULAR IMMUNOLOGY,  2022. 

4.  张建. Cholesterol accumulation on dendritic cells reverses chronic hepatitis B virus infection-induced dysfunction.  Cell Mol Immunol,  2022. 

5.  张建. Sorafenib combined with STAT3 knockdown triggers ER stress-induced HCC apoptosis and cGAS-STING-mediated anti-tumor immunity.  Cancer Letters,  2022. 

6.  张建. MERS-CoV nsp1 regulates autophagic flux via mTOR signalling and dysfunctional lysosomes.  EMERGING MICROBES & INFECTIONS,  2022. 

7.  战仁慧. Toll-Like Receptor 2 (TLR2) and TLR9 Play Opposing Roles in Host Innate Immunity against Salmonella enterica Serovar Typhimurium Infection.  INFECTION AND IMMUNITY,  83,  1641-1649, 2015. 

8.  隋强君. NK Cells Are the Crucial Antitumor Mediators When STAT3-Mediated Immunosuppression Is Blocked in Hepatocellular Carcinoma.  J Immunol ,  193,  2016-2023, 2014. 

9.  赵恒利. Homeobox containing 1 inhibits liver cancer progression by promoting autophagy as well as inhibiting stemness and immune escape.  Ocology Report,  40,  1657-1665, 2018. 

10.  孙晓霞. miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti-tumor immune suppression.  cell Cycle,  14,  243-252, 2015. 

11.  杨丹. 肿瘤雌激素受体信号通路及其与肿瘤免疫应答间的交互作用.  《中国免疫学杂志》,  32,  748-751, 2016. 

12.  王亚群. 靶向阻断STAT3增强肝癌细胞H22对化疗药物阿霉素的敏感性.  《中国免疫学杂志》,  31,  1304-1309, 2015. 

13.  李雅. Targeted inhibition of STAT3 induces immunogenic cell death of hepatocellular carcinoma cells via glycolysis..  MOLECULAR ONCOLOGY,  16,  2861-2880, 2022. 

14.  韩秋菊. 5 '-triphosphate siRNA targeting HBx elicits a potent anti-HBV immune response in pAAV-HBV transfected mice.  Antiviral Research,  161,  36-45, 2019. 

15.  赵荣荣. Edaravone protects against liver fibrosis progression via decreasing the IL-1β secretion of macrophages.  Chemico-Biological Interactions,  2022. 

16.  李浩浩. Targeting T-cell metabolism to boost immune checkpoint inhibitor therapy.  Frontiers in Immunology,  2022. 

17.  赵华俊. CpG-C ODN M362 as an immunoadjuvant for HBV therapeutic vaccine reverses the systemic tolerance against HBV.  INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,  18,  154-165, 2022. 

18.  赵华俊. Innate and adaptive immune escape mechanisms of hepatitis B virus.  WORLD JOURNAL OF GASTROENTEROLOGY,  28,  881-896, 2022. 

19.  陆楠. Enhancing anti-tumor efficacy and immune memory by combining 3p-GPC-3 siRNA treatment with PD-1 blockade in hepatocellular carcinoma.  ONCOIMMUNOLOGY,  11,  2010894, 2022. 

20.  潘召义. MERS-CoV nsp1 impairs the cellular metabolic processes by selectively downregulating mRNAs in a novel granules.  VIRULENCE,  13,  355, 2022. 

21.  周岳. Downregulation of Renal MRPs Transporters in Acute Lymphoblastic Leukemia Mediated by the IL-6/STAT3/PXR Signaling Pathway.  JOURNAL OF INFLAMMATION RESEARCH,  14,  2239, 2021. 

22.  姜鹏. miR-590-5p affects chondrocyte proliferation, apoptosis, and inflammation by targeting FGF18 in osteoarthritis.  American journal of translational research,  13,  8728, 2021. 

23.  姜雨. Promotion of epithelial-mesenchymal transformation by hepatocellular carcinoma-educated macrophages through Wnt2b/beta-catenin/c-Myc signaling and reprogramming glycolysis.  JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,  40,  2021. 

24.  韩秋菊. Fasudil prevents liver fibrosis via activating natural killer cells and suppressing hepatic stellate cells.  WORLD JOURNAL OF GASTROENTEROLOGY Journal,  27,  3581, 2021. 

25.  郑冰清. HBsAg Dampened STING Associated Activation of NK Cells in HBeAg-Negative CHB Patients.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES ,  22,  2021. 

26.  姜雨. The Mechanisms of HBV-Induced Hepatocellular Carcinoma.  JOURNAL OF HEPATOCELLULAR CARCINOMA,  8,  435, 2021. 

27.  赵华俊. Chitosan Nanovaccines as Efficient Carrier Adjuvant System for IL-12 with Enhanced Protection Against HBV.  International Journal of Nanomedicine ,  16,  4913, 2021. 

28.  周岳. Downregulation of Renal MRPs Transporters in Acute Lymphoblastic Leukemia Mediated by the IL-6/STAT3/PXR Signaling Pathway.  Journal of Inflammation Research,  2021. 

29.  赵家鑫. Emission behavior, enol-keto tautomerism and bioactivity of hydroxy-substituted cyclic chalcone derivatives.  材料化学期刊C,  9,  1000, 2021. 

30.  韩秋菊. 外泌体在肿瘤免疫逃逸和耐受中的作用.  《生物化学与生物物理进展》,  2019. 

31.  韩秋菊. 肝癌细胞异位过表达IL-12的抗肿瘤作用研究.  《中国免疫学杂志》,  35,  2019. 

32.  张建. STAT3 directly regulates NKp46 transcription in NK cells of HBeAg-negative CHB patients..  J Leukoc Biol.,  2019. 

33.  胡芮. STAT3: A key signaling molecule for converting cold to hot tumors.  Cancer letters,  489,  29, 2020. 

34.  李雅. Napabucasin Reduces Cancer Stem Cell Characteristics in Hepatocellular Carcinoma.  FRONTIERS IN PHARMACOLOGY,  11,  2020. 

35.  张建. Hepatocellular carcinoma: Mechanisms of progression and immunotherapy..  World J Gastroenterol.,  2019. 

36.  韩秋菊. Androgen Receptor (AR)-TLR4 Crosstalk Mediates Gender Disparities in Hepatocellular Carcinoma Incidence and Progression.  journal of cancer,  11,  1094, 2020. 

37.  周岳. Drug Elimination Alteration in Acute Lymphoblastic Leukemia Mediated by Renal Transporters and Glomerular Filtration.  PHARMACEUTICAL RESEARCH,  37,  2020. 

38.  韩秋菊. Emission behavior, enol–keto tautomerism and bioactivity of hydroxy-substituted cyclic chalcone derivatives.  JOURNAL OF MATERIALS CHEMISTRY C,  2020. 

39.  张建  and 韩秋菊. Androgen Receptor (AR)-TLR4 Crosstalk Mediates.  J Cancer,  11,  2020. 

40.  赵华俊 , 韩秋菊 , 张建  and 王冠. TLR2 Promotes Monocyte/Macrophage Recruitment Into the Liver and Microabscess Formation to Limit the Spread of Listeria Monocytogenes.  Frontiers in Immunology,  10,  2019. 

41.  张建 , 韩秋菊  and 尹春来. Progress of Mechanism of Tumor Immune Escape and Tolerance Mediated by Exosome.  PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS Journal,  46,  433, 2019. 

42.  韩秋菊 , 张建  and 郑冰清. STAT3 directly regulates NKp46 transcription in NK cells of HBeAg-negative CHB patients.  JOURNAL OF LEUKOCYTE BIOLOGY,  106,  987, 2019. 

43.  赵华俊 , 韩秋菊  and 张建. Poly I:C-based rHBVvac therapeutic vaccine eliminates HBV via generation of HBV-specific CD8(+) effector memory T cells.  68,  2032, 2019. 

44.  韩秋菊 , 张建  and 姜雨. Hepatocellular carcinoma: Mechanisms of progression and immunotherapy.  WORLD JOURNAL OF GASTROENTEROLOGY Journal,  25,  3151, 2019. 

45.  韩秋菊 , 张建  and 沈文姝. The Effects of Immune Microenvironment on Cancer Stem Cells.  PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS Journal,  46,  654, 2019. 

46.  韩秋菊 , 赵华俊  and 张建. HCC-Derived Exosomes: Critical Player and Target for Cancer Immune Escape.  CELLS,  8,  2019. 

47.  赵华俊 , 韩秋菊  and 张建. Poly I:C-based rHBVvac therapeutic vaccine eliminates HBV via generation of HBV-specific CD8+ effector memory T cells..  Gut,  68,  2032, 2019. 

48.  韩秋菊 , 赵华俊  and 张建. HCC-Derived Exosomes: Critical Player and Target for Cancer Immune Escape..  CELLS,  2019. 

49.  赵华俊 , 韩秋菊  and 张建. TLR2 Promotes Monocyte/Macrophage Recruitment Into the Liver and Microabscess Formation to Limit the Spread of Listeria Monocytogenes..  Front Immunol.,  2019. 

50.  张彩 , 韩秋菊 , 张建  and 刘静. Pim-3 enhances melanoma cell migration and invasion by promoting STAT3 phosphorylation.  Cancer Biology & Therapy,  19,  160, 2018. 

51.  韩秋菊 , 张建 , 张彩  and 于馨. Intestinal Lamina Propria CD4(+) T Cells Promote Bactericidal Activity of Macrophages via Galectin-9 and Tim-3 Interaction during Salmonella enterica Serovar Typhimurium Infection.  INFECTION AND IMMUNITY,  86,  2018. 

52.  韩秋菊 , 赵华俊 , 张建  and 王冠. IFN-gamma protects from apoptotic neutrophil-mediated tissue injury during acute Listeria monocytogenes infection.  《European Journal of Immunology》,  48,  1470, 2018. 

53.  韩秋菊 , 张建  and 尹春来. SALL4-mediated upregulation of exosomal miR-146a-5p drives T-cell exhaustion by M2 tumor-associated macrophages in HCC.  ONCOIMMUNOLOGY,  8,  2019. 

54.  张彩 , 韩秋菊 , 张建  and 田志刚. The role of innate immunity in HBV infection.  Semin Immunopathol,  35,  23, 2013. 

55.  张彩 , 韩秋菊  and 张建. Pim-3 enhances melanoma cell migration and invasion by promoting STAT3 phosphorylation.  1538-4047,  2018. 

56.  张彩 , 韩秋菊 , 张建  and 田志刚. Intestinal lamina propria CD4+T cells promote bactericidal activity of macrophages via galectin-9 and Tim-3 interaction during Salmonella typhimurium infection..  Infection and Immunity,  2018. 

57.  韩秋菊 , 张建  and 赵荣荣. RNAi技术靶向HBV相关宿主因子治疗慢性乙肝的研究进展.  《生物化学与生物物理进展》,  2018. 

58.  韩秋菊 , 张彩  and 张建. 5'-triphosphate siRNA targeting HBx elicits a potent anti-HBV immune response in pAAV-HBV transfected mice..  抗病毒研究,  23, 2019. 

59.  韩秋菊 , 田志刚 , 张建  and 王冠. IFN-γ protects from apoptotic neutrophil-mediated tissue injury during acute Listeria monocytogenes infection..  《Eur J Immunol》,  2018. 

60.  韩秋菊 , 张建  and 郭全娟. CRISPR/Cas9技术的脱靶效应及优化策略.  《生物化学与生物物理进展》,  2018. 

61.  韩秋菊 , 陆楠 , 张建  and 赵恒利. HMBOX1 in hepatocytes attenuates LPS/D-GalN-induced liver injury by inhibiting macrophage infiltration and activation.  Molecular Immunology,  101,  303, 2018. 

62.  韩秋菊 , 张建  and 王海刚. Single dose HBsAg CS-gamma-PGA nanogels induce potent protective immune responses against HBV infection.  European Journal of Pharmaceutics and Biopharmaceutics,  124,  82, 2018. 

63.  张建 , 张彩 , 韩秋菊  and Sun, Cheng. Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.  NATURE COMMUNICATIONS,  9,  2018. 

64.  韩秋菊 , 张建  and 赵恒利. Homeobox containing 1 inhibits liver cancer progression by promoting autophagy as well as inhibiting stemness and immune escape..  Oncol Rep.,  2018. 

65.  田志刚 , 侯旭奔 , 韩秋菊 , 陆楠 , 张建 , 张彩 , 于馨 HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1 beta production via suppressing the NF-kappa B pathway and ROS production.  Journal of Hepatology,  66,  693, 2017. 

66.  张彩 , 韩秋菊 , 张建  and 田志刚. HBV suppresses expression of MICA/B on hepatoma cells through up-regulation of transcription factors GATA2 and GATA3 to escape from NK cell surveillance.  ONCOTARGET,  7,  56107, 2016. 

67.  韩秋菊 , 张建  and 雷虹. Trx系统与肿瘤细胞凋亡及免疫微环境的关系研究.  生命的化学,  37,  810, 2017. 

68.  韩秋菊  and 张建. STAT3-blocked whole-cell hepatoma vaccine induces cellular and humoral immune response against HCC.  Journal of Experimental & Clinical Cancer Research,  36,  2017. 

69.  韩秋菊 , 张彩  and 张建. 面向高校文科类专业学生开设《免疫学》通选课的探索.  《中国免疫学杂志》,  33,  922, 2017. 

70.  韩秋菊 , 张建 , 田志刚  and 张彩. Reversal of hepatitis B virus-induced systemic immune tolerance by intrinsic innate immune stimulation..  J Gastroenterol Hepatol.,  2013. 

71.  张建 , 韩秋菊  and 张彩. TLR2 and TLR9 play opposing roles in host innate immunity against Salmonella enterica Serovar Typhimurium infection..  Infect Immun,  2015. 

72.  张建 , 韩秋菊  and 张彩. Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a..  SCI REP,  2016. 

73.  张建 , 韩秋菊 , 张彩  and 田志刚. Poly(I:C) exhibits an anti-cancer effect in human gastric adenocarcinoma cells which is dependent on RLRs..  Int Immunopharmacol.,  17,  814, 2013. 

74.  韩秋菊 , 张建  and 王亚群. 靶向阻断STAT3 增强肝癌细胞H22 对化疗药物阿霉素的敏感性.  《中国免疫学杂志》,  2015. 

75.  张建  and 韩秋菊. 肿瘤雌激素受体信号通路及其与肿瘤免疫应答间的交互作.  《中国免疫学杂志》,  2016. 

76.  张建 , 韩秋菊  and 张彩. TLR4 signaling promotes a COX-2/PGE2/STAT3 positive feedback loop in hepatocellular carcinoma (HCC) cells..  Oncoimmunology,  5,  e1074376., 2016. 

77.  张建 , 韩秋菊  and 张彩. Targeting blockage of STAT3 inhibits hepatitis B virus-related hepatocellular carcinoma.  Cancer Biol Ther,  2016. 

78.  张建 , 韩秋菊  and 张彩. miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti-tumor immune suppression..  Cell Cycle,  2015. 

79.  张建 , 韩秋菊  and 张彩. Intracellular poly(I:C) initiated gastric adenocarcinoma cell apoptosis and subsequently ameliorated NK cell functions.  J Interferon Cytokine Res,  34,  52, 2014. 

80.  张建 , 张彩  and 韩秋菊. NK cells are the crucial antitumor mediators when STAT3-mediated immunosuppression is blocked in hepatocellular carcinoma..  J Immunol,  193,  2016, 2014. 

81.  韩秋菊 , 张建 , 田志刚  and 张彩. The role of innate immunity in HBV infection.  Semin Immunopathol,  35,  23, 2013. 

82.  张彩 , 韩秋菊 , 张建  and 田志刚. Therapeutic recovery of HBV-induced hepatocyte-intrinsic immune defect reverses systemic adaptive immune tolerance. .  Hepatology,  2013. 

83.  张建 , 韩秋菊  and 张彩. The anti-HBV effect mediated by a novel recombinant eukaryotic expression vector for IFN-α..  Virol J.,  10,  2013. 

84.  韩秋菊 , 张彩 , 张建  and 徐东青. miR-146a negatively regulates NK cell functions via STAT1 signaling.  CELLULAR & MOLECULAR IMMUNOLOGY,  14,  712, 2017. 

85.  张建 , 韩秋菊  and 雷虹. Inhibiting TrxR suppresses liver cancer by inducing apoptosis and eliciting potent antitumor immunity.  Oncology reports,  40,  3447, 2018. 

86.  张建 , 韩秋菊  and 张彩. miR146a impairs the IFN-induced anti-HBV immune response by downregulating STAT1 in hepatocytes.  Liver Int.,  34,  58, 2014. 

87.  韩秋菊 , 张建  and 张彩. Pim-3 enhances melanoma cell migration and invasion by promoting STAT3 phosphorylation.  1538-4047,  2018. 

88.  韩秋菊 , 张建 , 田志刚  and 张彩. Intestinal lamina propria CD4+T cells promote bactericidal activity of macrophages via galectin-9 and Tim-3 interaction during Salmonella typhimurium infection..  Infection and Immunity,  2018. 

89.  张建 , 张彩 , 韩秋菊  and Sun, Cheng. Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.  NATURE COMMUNICATIONS,  9,  2018. 

90.  韩秋菊 , 张建 , 田志刚  and 张彩. HBV suppresses expression of MICA/B on hepatoma cells through up-regulation of transcription factors GATA2 and GATA3 to escape from NK cell surveillance.  ONCOTARGET,  7,  56107, 2016. 

91.  韩秋菊 , 张彩  and 张建. Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a..  SCI REP,  2016. 

92.  韩秋菊  and 张建. 肿瘤雌激素受体信号通路及其与肿瘤免疫应答间的交互作.  《中国免疫学杂志》,  2016. 

93.  韩秋菊 , 张彩  and 张建. miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti-tumor immune suppression..  Cell Cycle,  2015. 

94.  韩秋菊 , 张彩  and 张建. Intracellular poly(I:C) initiated gastric adenocarcinoma cell apoptosis and subsequently ameliorated NK cell functions.  J Interferon Cytokine Res,  34,  52, 2014. 

95.  张彩 , 韩秋菊  and 张建. NK cells are the crucial antitumor mediators when STAT3-mediated immunosuppression is blocked in hepatocellular carcinoma..  J Immunol,  193,  2016, 2014. 

96.  韩秋菊 , 张建 , 田志刚  and 张彩. Therapeutic recovery of HBV-induced hepatocyte-intrinsic immune defect reverses systemic adaptive immune tolerance. .  Hepatology,  2013. 

97.  韩秋菊 , 张彩  and 张建. TLR4 signaling promotes a COX-2/PGE2/STAT3 positive feedback loop in hepatocellular carcinoma (HCC) cells..  Oncoimmunology,  5,  e1074376., 2016. 

98.  韩秋菊 , 张建 , 田志刚  and 张彩. HBV suppresses expression of MICA/B on hepatoma cells through up-regulation of transcription factors GATA2 and GATA3 to escape from NK cell surveillance.  ONCOTARGET,  7,  56107, 2016. 

99.  张彩 , 韩秋菊  and 张建. NK cells are the crucial antitumor mediators when STAT3-mediated immunosuppression is blocked in hepatocellular carcinoma..  J Immunol,  193,  2016, 2014. 

100.  韩秋菊 , 张彩  and 张建. Targeting blockage of STAT3 inhibits hepatitis B virus-related hepatocellular carcinoma.  Cancer Biol Ther,  2016. 

101.  韩秋菊 , 张彩  and 张建. miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti-tumor immune suppression..  Cell Cycle,  2015. 

102.  韩秋菊 , 张彩  and 张建. Intracellular poly(I:C) initiated gastric adenocarcinoma cell apoptosis and subsequently ameliorated NK cell functions.  J Interferon Cytokine Res,  34,  52, 2014. 

103.  韩秋菊 , 张彩  and 张建. The anti-HBV effect mediated by a novel recombinant eukaryotic expression vector for IFN-α..  Virol J.,  10,  2013. 

104.  韩秋菊 , 张彩 , 田志刚  and 张建. Poly(I:C) exhibits an anti-cancer effect in human gastric adenocarcinoma cells which is dependent on RLRs..  Int Immunopharmacol.,  17,  814, 2013. 

105.  张建 , 张彩  and 于馨. HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1 beta production via suppressing the NF-kappa B pathway and ROS production.  Journal of Hepatology,  66,  693, 2017. 

106.  张建 , 韩秋菊  and 雷虹. Inhibiting TrxR suppresses liver cancer by inducing apoptosis and eliciting potent antitumor immunity.  Oncology reports,  40,  3447, 2018. 

107.  韩秋菊  and 张建. 肿瘤雌激素受体信号通路及其与肿瘤免疫应答间的交互作.  《中国免疫学杂志》,  2016. 

108.  韩秋菊 , 张彩  and 张建. Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a..  SCI REP,  2016. 

109.  韩秋菊 , 张彩  and 张建. TLR2 and TLR9 play opposing roles in host innate immunity against Salmonella enterica Serovar Typhimurium infection..  Infect Immun,  2015. 

110.  韩秋菊 , 张彩  and 张建. miR146a impairs the IFN-induced anti-HBV immune response by downregulating STAT1 in hepatocytes.  Liver Int.,  34,  58, 2014. 

111.  张建 , 张彩 , 韩秋菊  and Sun, Cheng. Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.  NATURE COMMUNICATIONS,  9,  2018. 

112.  韩秋菊 , 张建  and 赵恒利. Homeobox containing 1 inhibits liver cancer progression by promoting autophagy as well as inhibiting stemness and immune escape..  Oncol Rep.,  2018. 

113.  张建 , 韩秋菊  and 张彩. Pim-3 enhances melanoma cell migration and invasion by promoting STAT3 phosphorylation.  1538-4047,  2018. 

114.  韩秋菊 , 田志刚 , 张建  and 王冠. IFN-γ protects from apoptotic neutrophil-mediated tissue injury during acute Listeria monocytogenes infection..  《Eur J Immunol》,  2018. 

115.  韩秋菊 , 张建  and 王亚群. 靶向阻断STAT3 增强肝癌细胞H22 对化疗药物阿霉素的敏感性.  《中国免疫学杂志》,  2015. 

116.  韩秋菊 , 张建 , 田志刚  and 张彩. Therapeutic recovery of HBV-induced hepatocyte-intrinsic immune defect reverses systemic adaptive immune tolerance. .  Hepatology,  2013. 

117.  韩秋菊 , 张建 , 田志刚  and 张彩. The role of innate immunity in HBV infection.  Semin Immunopathol,  35,  23, 2013. 

118.  韩秋菊 , 张建  and 雷虹. Trx系统与肿瘤细胞凋亡及免疫微环境的关系研究.  生命的化学,  37,  810, 2017. 

119.  韩秋菊 , 张建 , 田志刚  and 张彩. Intestinal lamina propria CD4+T cells promote bactericidal activity of macrophages via galectin-9 and Tim-3 interaction during Salmonella typhimurium infection..  Infection and Immunity,  2018. 

120.  韩秋菊 , 陆楠 , 张建  and 赵恒利. HMBOX1 in hepatocytes attenuates LPS/D-GalN-induced liver injury by inhibiting macrophage infiltration and activation.  Molecular Immunology,  101,  303, 2018. 

121.  韩秋菊 , 张建  and 赵荣荣. RNAi技术靶向HBV相关宿主因子治疗慢性乙肝的研究进展.  《生物化学与生物物理进展》,  2018. 

122.  韩秋菊 , 张建  and 郭全娟. CRISPR/Cas9技术的脱靶效应及优化策略.  《生物化学与生物物理进展》,  2018. 

123.  韩秋菊 , 张彩 , 张建  and 徐东青. miR-146a negatively regulates NK cell functions via STAT1 signaling.  CELLULAR & MOLECULAR IMMUNOLOGY,  14,  712, 2017. 

124.  韩秋菊 , 张建  and 王海刚. Single dose HBsAg CS-gamma-PGA nanogels induce potent protective immune responses against HBV infection.  European Journal of Pharmaceutics and Biopharmaceutics,  124,  82, 2018. 

125.  张建 , 张彩 , 田志刚  and 韩秋菊. Reversal of hepatitis B virus-induced systemic immune tolerance by intrinsic innate immune stimulation..  J Gastroenterol Hepatol.,  2013. 

126.  张彩 , 张建  and 韩秋菊. 面向高校文科类专业学生开设《免疫学》通选课的探索.  《中国免疫学杂志》,  33,  922, 2017. 

127.  张彩 , 张建  and 韩秋菊. 5'-triphosphate siRNA targeting HBx elicits a potent anti-HBV immune response in pAAV-HBV transfected mice..  抗病毒研究,  23, 2019. 

128.  张建  and 韩秋菊. STAT3-blocked whole-cell hepatoma vaccine induces cellular and humoral immune response against HCC.  Journal of Experimental & Clinical Cancer Research,  36,  2017. 

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