中文
  • 胡慧丽
  • Doctor
  • Professor
  • School of Medicine
 

Educational Experience

  • 2008.92014.6

     山东大学   遗传学   Doctor 

  • 2004.92008.6

     山东大学   生物科学   Bachelor 

Work Experience

  • 2019.1Now

    山东大学基础医学院      教授

  • 2015.122018.6

    荷兰皇家科学院      Hubrecht研究所      博士后

  • 2014.72018.12

    山东大学基础医学院      讲师

Research Group

 

Personal Information

胡慧丽,山东济南人。国家优青、国家重点研发计划青年科学家首席、山东省杰出青年基金获得者,青年泰山专家。山东大学基础医学院系统生物医学系主任,干细胞及再生医学研究中心主任(兼)。

    本科毕业于山东大学生命科学院,博士毕业于山东大学基础医学院遗传学专业,博士后师从于荷兰皇家科学院成体干细胞与类器官专家Hans Clevers教授。2019年3月成立PI团队,目前从事成体干细胞与再生相关研究,应用三维类器官模型和生物信息学、基因功能筛选技术相结合,进行肝脏再生相关研究,明确成体干祖细胞命运调控的新机制并探索多种类器官在疾病治疗和仿生器官构建当中的转化应用。

    以第一作者或通讯作者身份在国际知名期刊Cell、Cancer Cell、Cell Discovery、CDD、Oncogenesis,以及共同作者身份在Cell Stem Cell、Nature Protocols、JCI、Cancer Research 等发表文章20余篇。主持国家重点研发计划、国家自然基金重大项目培育等国家基金4项,省部级基金5项。担任中国生物物理学会代谢分会副秘书长,青年理事。山东大学交叉学科群体带头人。身为热爱科研的普通人,期盼自强不息的你加入。上善若水,厚德载物,携手同行。


代表性论文:


1. Yujia Fan, Xiaohan Huo, Beibei Guo, Xiaohui Zhang, Yang Yang, Jiabei Lian, Xinyuan Meng, Yiwen Shao, Yongxin Zou, Haiyang Guo, Haitao Wang, Gongping Sun, Hao Dou, Jinshen Wang, Changshun Shao, Yaoqin Gong* and Huili Hu*. Cullin 4b-RING ubiquitin ligase targets IRGM1 to regulate Wnt signaling and intestinal homeostasis. Cell Death & Differentiation. 2022 Feb 23.


2. Huili Hu, Helmuth Gehart, Benedetta Artegiani, Carmen Lopez-Iglesias, Florijn Dekkers, Onur Basak, Johan van Es, Susana M. Chuva de Sousa Lopes, Harry Begthel, Jeroen Korving, Maaike van den Born, Chenhui Zou, Corrine Quirk, Luis Chiriboga, Charles M. Rice, Stephanie Ma, Anne Rios, Peter J. Peters, Ype P. de Jong, and Hans Clevers*. Long-term expansion of functional mouse and human hepatocytes as 3D organoids. Cell. 2018. 175(6): 1591-1606.


3. Huili Hu, Yang Yang, Qinghong Ji, Wei Zhao, Baichun Jiang, Ruiqiong Liu, Jupeng Yuan, Qiji Liu, Xi Li, Yongxin Zou, Changshun Shao, Yongfeng Shang, Yan Wang*, and Yaoqin Gong*. CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis. Cancer Cell. 2012. 22(6): 781-795.


4. Jihan Osborne*, Evgenia Salta*, Huili Hu*, Brett Shook*, Yun Li*, Nagarajan Kannan*. Introductions to the Community: Early-Career Researchers in the Time of COVID-19. Cell Stem Cell. 2021 28(3):367-369.


5. Yanjun Li, Huili Hu*, Yuxing Wang, Yujia Fan, Yang Yang, Beibei Guo, Xueyong Xie, Jiabei Lian, Baichun Jiang, Bo Han, Changshun Shao, Yaoqin Gong. CUL4B contributes to cancer stemness by repressing tumor suppressor miR34a in colorectal cancer. Oncogenesis. 2020 Feb 13;9(2):20.


6. Fan Yang, Huili Hu*, Yuanyuan Liu, Ming Shao, Changshun Shao and Yaoqin Gong*. Cul4a promotes zebrafish primitive erythropoiesis via upregulating scl and gata1 expression. Cell Death and Disease. 10:388.2019.


7. Jingyu Lin, Jie Cheng, Yaqin Du, Wei Pan, Zhong Zhang, Jin Wang, Jie An, Fan Yang, Yunfei Xu, Hui Lin, Wentao An, Jia Wang, Zhao Yang, Renjie Chai, Xueying Sha, Huili Hu*, Jinpeng Sun*, Xiao Yu*. In vitro expansion of pancreatic islet clusters facilitated by hormones and chemicals. Cell Discovery. 2020 6 (1):0-20.


课题组招聘优秀人才加盟,欢迎青年教师、博士后、科研助理和研究生加盟,请将应聘资料发送至邮箱huhuili@sdu.edu.cn



  • Gender:Female
  • Alma Mater:Shandong University
  • Education Level:Postgraduate (Doctoral)
  • Degree:Doctor
  • Status:Employed
  • Date of Employment:2014-07-16
  • Business Address:济南市文化西路44号电镜楼(校友门附近)305房间
  • Contact Information:883882080
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