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胡慧丽，国家优青、国家重点研发计划首席科学家（主持2项）、山东省杰出青年基金获得者，青年泰山专家。山东大学基础医学院系统生物医学系主任，干细胞及再生医学研究中心主任（兼）。

   本科毕业于山东大学生命科学院，博士毕业于山东大学基础医学院遗传学专业，博士后师从于荷兰皇家科学院成体干细胞与类器官专家Hans Clevers教授。2019年3月成立PI团队，目前从事成体干细胞与再生相关研究，应用三维类器官模型和生物信息学、基因功能筛选技术相结合，进行肝脏再生相关研究，明确成体干祖细胞命运调控的新机制并探索多种类器官在疾病治疗和仿生器官构建当中的转化应用。

    以第一作者或通讯作者身份在国际知名期刊Cell、Cancer Cell、Cell Reports、Cell Discovery、CDD、Oncogenesis，以及共同作者身份在Cell Stem Cell、Nature Protocols、JCI、Cancer Research 等发表文章40余篇，引用2900余次，申请专利10项（授权3项）。担任中国细胞生物学会分会委员。山东大学交叉学科群体带头人。身为热爱科研的普通人，期盼自强不息的你加入。上善若水，厚德载物，携手同行。

课题组招聘优秀人才加盟，欢迎青年教师、博士后、科研助理和研究生加盟，请将应聘资料发送至邮箱huhuili@sdu.edu.cn。

代表性论文：

1. Jiabei Lian, Yachun An, Wenjing Wei, Yao Lu, Xiyu Zhang, Gongping Sun, Haiyang Guo, Longjin Xu, Xuena Chen, Huili Hu*. Transcriptional landscape and chromatin accessibility reveal key regulators for liver regenerative initiation and organoid formation. Cell Reports, 2025 May 27;44(5):115633

2. Yunuo Mao and Huili Hu*. (2024). "Establishment of Advanced Tumor Organoids with Emerging Innovative Technologies." Cancer Letters 598:217122.

3. Haoran Du; Liqiang Guo; Jiabei Lian; Huanlu Qiu; Yunuo Mao; Fan Yi* and Huili Hu* Establishment of epithelial inflammatory injury model using adult kidney organoids. Life Medicine, Volume 3, Issue 3, June 2024

4. Yujia Fan, Xiaohan Huo, Beibei Guo, Xiaohui Zhang, Yang Yang, Jiabei Lian, Xinyuan Meng, Yiwen Shao, Yongxin Zou, Haiyang Guo, Haitao Wang, Gongping Sun, Hao Dou, Jinshen Wang, Changshun Shao, Yaoqin Gong* and Huili Hu*. Cullin 4b-RING ubiquitin ligase targets IRGM1 to regulate Wnt signaling and intestinal homeostasis. Cell Death & Differentiation. 2022 Feb 23.

5. Huili Hu, Helmuth Gehart, Benedetta Artegiani, Carmen Lopez-Iglesias, Florijn Dekkers, Onur Basak, Johan van Es, Susana M. Chuva de Sousa Lopes, Harry Begthel, Jeroen Korving, Maaike van den Born, Chenhui Zou, Corrine Quirk, Luis Chiriboga, Charles M. Rice, Stephanie Ma, Anne Rios, Peter J. Peters, Ype P. de Jong, and Hans Clevers*. Long-term expansion of functional mouse and human hepatocytes as 3D organoids. Cell. 2018. 175(6): 1591-1606.

6. Huili Hu, Yang Yang, Qinghong Ji, Wei Zhao, Baichun Jiang, Ruiqiong Liu, Jupeng Yuan, Qiji Liu, Xi Li, Yongxin Zou, Changshun Shao, Yongfeng Shang, Yan Wang*, and Yaoqin Gong*. CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis. Cancer Cell. 2012. 22(6): 781-795.

7. Jihan Osborne*, Evgenia Salta*, Huili Hu*, Brett Shook*, Yun Li*, Nagarajan Kannan*. Introductions to the Community: Early-Career Researchers in the Time of COVID-19. Cell Stem Cell. 2021 28(3):367-369.

8. Fan Yang, Huili Hu*, Yuanyuan Liu, Ming Shao, Changshun Shao and Yaoqin Gong*. Cul4a promotes zebrafish primitive erythropoiesis via upregulating scl and gata1 expression. Cell Death and Disease. 10:388.2019.

9. Jingyu Lin, Jie Cheng, Yaqin Du, Wei Pan, Zhong Zhang, Jin Wang, Jie An, Fan Yang, Yunfei Xu, Hui Lin, Wentao An, Jia Wang, Zhao Yang, Renjie Chai, Xueying Sha, Huili Hu*, Jinpeng Sun*, Xiao Yu*. In vitro expansion of pancreatic islet clusters facilitated by hormones and chemicals. Cell Discovery. 2020 6 (1):0-20.