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Biography

蒋绪恺，副研究员/博士生导师，泰山学者青年专家、山东省海外优青；中国药学会智能药物专业委员会青年委员、中国药理学会海洋药物药理专业委员会青年委员、山东省生物化学与分子生物学学会理事。主要从事细胞膜系统的结构-动态-功能研究、细胞膜靶向药物设计与作用机制研究，构建了革兰氏阴性细菌和人体肠道、肾脏、肺泡、皮肤、血脑屏障等结构数字孪生模型，用于抗菌药物、抗肿瘤药物、神经系统药物等的设计与研发。以第一/通讯（含共同）在Nature Communications、Advanced Science、Journal of Medicinal Chemistry、Chemical Science等杂志发表学术论文20余篇，论文引用1000余次，H指数15。

Education Background
  • 2013-09-01-2018-06-30
    山东大学
    微生物学
    博士研究生
  • 2009-09-01-2013-06-30
    山东大学
    生物科学
    本科
Work Experience
  • 2021-04 — Now
    山东大学 国家糖工程技术研究中心
    副研究员
  • 2018-10 — 2020-10
    莫纳什大学 生物医药研发中心
    博士后
Publication
Research direction

1. 蛋白质结构功能关系研究

2. 生物膜系统与药物智能化设计

Papers

(1)Zhao, Sha. Loop Dynamics Perturbation Enhances the Catalytic Stability of GH18 Family Chitinases .Journal of Agricultural and Food Chemistry .2025

(2)赵沙. Loop Dynamics Perturbation Enhances the Catalytic Stability of GH18 Family Chitinases .Journal of Agricultural and Food Chemistry .2025 (315)

(3)许立美. Interaction of polyethylene nanoplastics with the plasma, endoplasmic reticulum, Golgi apparatus, lysosome and endosome membranes: A molecular dynamics study .Ecotoxicology and Environmental Safety .2025 (16):118680

(4)崔錾. In Silico-Guided Discovery of Polysaccharide Derivatives as Adjuvants in Nanoparticle Vaccines for Cancer Immunotherapy .ACS nano .2025

(5)马振宇. Membrane lipid homeostasis dually regulates conformational transition of phosphoethanolamine transferase EptA .NATURE COMMUNICATIONS .2024 ,15 (1):10166

(6)刘卓. Enhanced Sampling Molecular Dynamics Simulations Reveal Transport Mechanism of Glycoconjugate Drugs through GLUT1 .INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES .2024 (25)

(7) Engineering the substrate preference of glucose oxidase for the enzymatic oxidation of xylose .GREEN CHEMISTRY .2024 ,26 (8):4851

(8)朱景一. Molecular Dynamics Simulations Reveal Octanoylated Hyaluronic Acid Enhances Liposome Stability, Stealth and Targeting .ACS Omega .2024

(9)赵沙. Engineering the Relatively Conserved Residues in Active Site Architecture of Thermophilic Chitinase SsChi18A Enhanced Catalytic Activity .Biomacromolecules .2023 ,25 (1)

(10)蒋绪恺. Structure-Interaction Relationship of Polymyxins with Lung Surfactant .Journal of Medicianal Chemistry .2023 ,66 (23):16109

(11)马振宇. Molecular dynamics simulations identify the topological weak spots of a protease CN2S8A .《JOURNAL OF MOLECULAR GRAPHICS & MODELLING》 .2023 ,124

(12)吴秀芸. Dynamics of loops surrounding the active site architecture in GH5_2 subfamily TfCel5A for cellulose degradation .BIOTECHNOLOGY FOR BIOFUELS AND BIOPRODUCTS .2023 (16)

(13)Zhong Li. Molecular insights into the catalytic promiscuity of a bacterial diterpene synthase .NATURE COMMUNICATIONS .2023 ,14 (1)

(14)许立美. Gasdermin E regulates the stability and activation of EGFR in human non-small cell lung cancer cells .CELL COMMUNICATION AND SIGNALING .2023 (1)

(15)蒋绪恺. 分子模拟在多粘菌素药理机制研究中的应用 .Progress in Biochemistry and Biophysics .2023 ,50 (05):1-8

(16)曹雪婷. Molecular Dynamics Simulations Reveal the Conformational Transition of GH33 Sialidases .INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES .2023 ,24 (7)

(17)窦智欣. Data-driven strategies for the computational design of enzyme thermal stability: trends, perspectives, and prospects .Acta Biochimica et Biophysica Sinica .2023 ,55 (3):343-355

(18) 壳聚糖与细菌细胞膜相互作用的分子动力学研究 .Progress in Biochemistry and Biophysics .2023 ,50 (8):1-12

(19)蒋绪恺. An Intelligent Strategy with All-Atom Molecular Dynamics Simulations for the Design of Lipopeptides against Multidrug- Resistant Pseudomonas aeruginosa .Journal of Medicianal Chemistry .2022 ,65 (14):10001

(20)张鹏. Docking-guided rational engineering of a macrolide glycosyltransferase glycodiversifies epothilone B .COMMUNICATIONS BIOLOGY .2022 ,5 (1)

(21)刘晓宇. Molecular Insights into the Assembly and Functional Diversification of Typhoid Toxin .MBIO .2022 ,13 (1)

(22)杨世达. Novel dTDP- l -Rhamnose Synthetic Enzymes (RmlABCD) From Saccharothrix syringae CGMCC 4.1716 for One-Pot Four-Enzyme Synthesis of dTDP-L-Rhamnose. .Frontiers in Microbiology .2021 (12)

(23)阎振鑫. A Novel β-Glucosidase from Chryseobacterium scophthalmum 1433 for Efficient Rubusoside Production from Stevioside. .Frontiers in Microbiology .2021 (12)

(24)蒋绪恺. A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threatening Acinetobacter baumannii .Chemical Science .2021

(25)蒋绪恺. Coarse-grained simulations uncover Gram-negative bacterial defense against polymyxins by the outer membrane .Computational and Structural Biotechnology Journal .2021 ,19 :3885

(26)宋宇轩. Comparative molecular dynamics simulations identify a salt-sensitive loop responsible for the halotolerant activity of GH5 cellulases .JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS .2021

(27)宋宇轩. Comparative molecular dynamics simulations identify a salt-sensitive loop responsible for the halotolerant activity of GH5 cellulases .JOURNAL OF BIOMOLECULAR STRUCTURE AND DYNAMICS .2021 (27)

(28)宋宇轩. Comparative molecular dynamics simulations identify a salt-sensitive loop responsible for the halotolerant activity of GH5 cellulases .JOURNAL OF BIOMOLECULAR STRUCTURE AND DYNAMICS .2021 (27)

(29)蒋绪恺. Molecular dynamics simulations informed by membrane lipidomics reveal the structure-interaction relationship of polymyxins with the lipid A-based outer membrane of Acinetobacter baumannii .J Antimicrob Chemother .2020 ,75 (12):3534

(30)蒋绪恺. Molecular dynamics simulations informed by membrane lipidomics reveal the structure-interaction relationship of polymyxins with the lipid A-based outer membrane of Acinetobacter baumannii .Journal of Antimicrobial Chemotherapy .2020 (12):3534

(31)蒋绪恺. Simulations of octapeptin-outer membrane interactions reveal conformational flexibility is linked to antimicrobial potency .Journal of biological chemistry .2020 ,295 (47):15902

(32)蒋绪恺. Outer Membranes of Polymyxin-Resistant Acinetobacter baumannii with Phosphoethanolamine-Modified Lipid A and Lipopolysaccharide Loss Display Different Atomic-Scale Interactions with Polymyxins .ACS INFECTIOUS DISEASES .2020 ,6 (10):2698

(33)蒋绪恺. Structure-Interaction Relationship of Polymyxins with the Membrane of Human Kidney Proximal Tubular Cells .ACS INFECTIOUS DISEASES .2020 ,6 (8):2110

(34)Zhu, Yan. Polymyxins Bind to the Cell Surface of Unculturable Acinetobacter baumannii and Cause Unique Dependent Resistance .Advanced Science .2020 ,7 (15)

(35)朱珠. Three glycoside hydrolase family 12 enzymes display diversity in substrate specificities and synergistic action between each other .Molecular Biology Reports .2019 (46)

Student Information
  • 宋宇扬  2025-10-15 Hits:[] Times
  • 曹雪婷  2025-07-05 Hits:[] Times
  • 穆凯洁  2025-07-05 Hits:[] Times
  • 刘卓  2023-09-23 Hits:[] Times
  • 杨乐天  2025-07-05 Hits:[] Times
  • 朱景一  2025-07-05 Hits:[] Times
  • 宋宇扬  2023-09-23 Hits:[] Times
  • 马雪  2025-07-05 Hits:[] Times
  • 马振宇  2023-09-23 Hits:[] Times
  • 祁静微  2025-07-05 Hits:[] Times
  • 阮子琳  2025-07-05 Hits:[] Times
  • 杨春屹  2025-07-05 Hits:[] Times
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