liang tie jun


Paper Publications

P-glycoprotein expression in ulcerative colitis patients and its role in intestinal barrier

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Affiliation of Author(s):Shandong Provincial Hospital Affiliated to Shandong University

Teaching and Research Group:中医教研室

Journal:Int J Clin Exp Pathol

Place of Publication:欧洲

Funded by:山东省重点研发计划.项目编号2016GSF201018

Key Words:Ulcerative colitis, p-glycoprotein, multidrug resistance gene, intestinal mucosa barrier

Abstract:Aims: Efflux transporters such as P-glycoprotein (Pgp; MDR1/ABCB1) protect the enterocytes from potentially toxic substances. The aim of this study was to evaluate Pgp expression in inflamed mucosa of patients with active Ulcerative Colitis (UC), and to compare the results of Pgp expression with healthy subjects. We also explored the relationship between Pgp expression and the pathogenesis of UC in this study. Methods: Pgp expression was determined with real-time PCR (SYBR GREEN), immunohistochemistry (IHC-SP method) and Western blot in inflamed mucosa of newly diagnosed (n = 102) patients wi

Indexed by:Applied Research

Discipline:Medicine

First-Level Discipline:Clinical Medicine

Document Type:S

Volume:10(4)

Issue:2017;10(4)

Page Number::4552-4558

ISSN No.:1936-2625

Translation or Not:no

Date of Publication:2017-04-15

Included Journals:SCI

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