生命历程纵向队列研究兴趣：

* 生命历程轨迹分析

* 生命历程因果图

* 动态预测

该方向的课题组成员：范冰冰；李春霞；于文浩；高超男；曲彦霖；刘莹；贺力；车志强；潘柯宇；吴秉杰；陈家豪

该方向的代表性成果列表：

²  Zhang T, Li S, Bazzano L, He J, Whelton P, Chen W. Trajectories of Childhood Blood Pressure and Adult Left Ventricular Hypertrophy: the Bogalusa Heart Study. Hypertension, 2018;72(1):93-101.

²  Zhang T, et al. Temporal Relationship Between Childhood Body Mass Index and Insulin and Its Impact on Adult Hypertension: The Bogalusa Heart Study. Hypertension, 2016;68:818-823.

²  Zhang T, et al. Impact of Adiposity on Incident Hypertension Is Modified by Insulin Resistance in Adults: Longitudinal Observation from the Bogalusa Heart Study. Hypertension, 2016; 67(1):56-62.

²  Zhang T, Xu J, Li S, Bazzano L, He J, Whelton P, Chen W. Trajectories of childhood BMI and adult diabetes: the Bogalusa Heart Study. Diabetologia, 2018. 62(1):70-77.

²  Sun D*, Zhang T*, Su S*, …, Li S#, Chen W#. Body Mass Index Drives Changes in DNA Methylation: A Longitudinal Study. Circulation Research. 2019;125(9):824-833.

²  Zhang H*, Zhang T*, …, Chen W#. Long-term Excessive Body Weight and Adult Left Ventricular Hypertrophy are Linked Through Later Life Body Size and Blood Pressure: The Bogalusa Heart Study. Circulation Research. 2017;120(10):1614-1621.

²  Li Z, Li C, et al. Trajectories of perioperative serum carcinoembryonic antigen and colorectal cancer outcome: A retrospective, multicenter longitudinal cohort study. Clinical and translational medicine. 2021, 11 (2), e293. DOI: 10.1002/ctm2.293.

²  Shen W*, Zhang T*, Li S, Zhang H, Xi B, Shen H, Fernandez C, Bazzano L, He J, Chen W. Race and Sex Differences of Long-Term Blood Pressure Profiles From Childhood and Adult Hypertension: The Bogalusa Heart Study. Hypertension. 2017, 70 (1):66-74.

²  Fan B*, Yang Y*,Dayimu A,Zhou G, Liu Y, Li S, Chen W, Zhang T# (corresponding author), Xue F. Body Mass Index Trajectories During Young Adulthood and Incident Hypertension: A Longitudinal Cohort in Chinese Population. J Am Heart Assoc. 2019 Apr 16;8(8):e011937.

²  Zhang T, Whelton P, Xi B, Krousel-Wood M, Bazzano L, He J, Chen W, Li S. Rate of Change in Body Mass Index at Different Ages during Childhood and Adult Obesity Risk. Pediatric Obesity, 2019, doi: 10.1111/ijpo.12513

²  Lv J*, Fan B*, Wei M, Zhou G, Dayimu A, Wu Z, Su C#, Zhang T#. Trajectories of early to mid-life adulthood BMI and incident diabetes: the China Health and Nutrition Survey. BMJ Open Diabetes Res Care. 2020 Apr;8(1):e000972.

²  Li Y*, Zhang T*, …, Chen W#. Impact of Cigarette Smoking on the Relationship between BMI and Insulin: Longitudinal Observation from the Bogalusa Heart Study. Diabetes Obes Metab. 2018, 20(7):1578-1584.

²  Zhang T, …, Chen W#. Insulin-sensitive Adiposity is associated with a Relatively Lower Risk of Diabetes than Insulin-resistant Adiposity: The Bogalusa Heart Study. Endocrine. 2016; 54(1):93-100.

²  Yun M, …, Zhang T#, Chen W. Age-related suppression effect of current body weight on the association between birthweight and blood pressure: The Bogalusa heart study. Pediatric obesity. 2020:e12716.

²  Xu C*, Zhou G*, …, Zhang T#, Zhao J#. Bidirectional Temporal Relationship between Obesity and Hyperinsulinemia: Longitudinal Observation from a Chinese Cohort. BMJ Open Diabetes Res Care. 2021.

²  Yun M, Zhang T#, et al. Temporal Relationship between Body Mass Index and Uric Acid and Their Joint Impact on Blood Pressure in Children and Adults: The Bogalusa Heart Study. Int J Obes. 2021.