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研究方向

动态组学研究

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动态组学研究兴趣:

* 代谢组学、微生物组学、影像组学研究

* 动态组学分析方法

* 多组学整合分析

该方向的课题组成员吕嘉丽;樊哲;张帅;谷冰冰;车佳婧;韩昕月;孙甜甜;李淑婷;李云飞;马晓燕

该方向的代表性成果列表

²  Lv J*, Wang J*, Shen X, Liu J, Zhao D, Wei M, Li X, Fan B, Sun Y, Xue F, Zhu Z-J#, Zhang T#. A serum metabolomics analysis reveals a panel of screening metabolic biomarkers for esophageal squamous cell carcinoma. Clinical and Translational Medicine. 2021;11. 10.1002/ctm2.419.

²  Li X, Zhao L, Wei M, Lv J, Sun Y, Shen X, Zhao D, Xue F, Zhang T#, Wang J#. Serum metabolomics analysis for the progression of esophageal squamous cell carcinoma. J. Cancer. 2021;12:3190–3197.

²  Wei M, Zhao L, Lv J, Li X, Zhou G, Fan B, Shen X, Zhao D, Xue F, Wang J, Zhang T#. The mediation effect of serum metabolites on the relationship between long-term smoking exposure and esophageal squamous cell carcinoma. BMC cancer. 2021;21:415.

²  Wang J*, Zhang T*, Shen X*, …, Zhu Z-J#, Xue F#, Serum Metabolomics for Early Diagnosis of Esophageal Squamous Cell Carcinoma by UHPLC-QTOF/MS, Metabolomics, 2016;12:116.

²  Zhang T*, Wu X*, …, Lou G#, Li K#. Identification of potential biomarkers for ovarian cancer by urinary metabolomic profiling. J Proteome Res. 2013. 12(1): 505-512.

²  Zhang T, Wu X, …, Lou G#, Li K#. Discrimination between malignant and benign ovarian tumors by plasma metabolomic profiling using ultra performance liquid chromatography/mass spectrometry. Clin Chim Acta. 2012. 413(9-10): 861-868.

²  Sun Y, Zhang T, …, Wang J#. Risk Factors Associated with Precancerous Lesions of Esophageal Squamous Cell Carcinoma: a Screening Study in a High Risk Chinese Population. J Cancer 2019; 10(14):3284-3290.

²  Shen X, Gong X, Cai Y, Guo Y, Tu J, Li H, Zhang T, Xue F, Zhu Z-J#. Normalization and integration of large-scale metabolomics data using support vector regression. Metabolomics, 2016, 12(5), 89.

²  一种食管癌初步筛查用血清代谢组学分析模型的构建方法(专利号 ZL 2015 1 0149599.X)(授权公告日2017412日)

²  一种血清代谢组学分析模型的构建方法(专利号 ZL 2015 1 0150409.6)(授权公告日2017315日)

²  一种利用食管癌初步筛查用血清代谢组学分析模型分析血清代谢组学的方法 (专利号 ZL 2015 1 0150499.9)(授权公告日2017329日)

²  一种食管鳞状细胞癌诊断模型的构建方法、所得诊断模型及模型的使用方法(专利号 ZL 2015 1 0497792.2)(授权公告日201738日)

²  一种适合于食管鳞状细胞癌早期诊断的诊断标记物 (专利号 ZL 2015 1 0498042.7)(授权公告日201766日)

²  一种适合于食管癌早期诊断的诊断标记物(专利号 ZL 2015 1 0497782.9)(授权公告日201766日)

²  一种适合于食管鳞状细胞癌早期诊断的诊断标记物及其筛选方法(专利号 ZL 2015 1 0497914.8)(授权公告日2017728日)