李福川简历 山东大学教授，博士生导师，泰山产业领军人才。2000年和2003年先后于山东大学和中国海洋大学获硕士和博士学位。2003年获日本学术振兴会（JSPS）博士后奖学金，先后在日本神户药科大学和北海道大学做博士后研究。2007至2011年在加拿大多伦多大学做博士后研究。2011年6月至今被山东大学以“985”特聘教授引进，于山东大学国家糖工程技术研究中心开展蛋白聚糖生物学领域的研究工作。长期从事蛋白聚糖生物学研究，在海洋微生物来源糖胺聚糖降解酶，糖胺聚糖及蛋白聚糖生物学，药用糖胺聚糖及类似物的分离纯化、结构鉴定和构效关系研究等方面有丰富研究经验并取得了一系列国际领先的研究成果。已在J. Cell Biol., Chem. Sci., J. Biol. Chem., Ana. Chem., Dev. Cell等相关国际著名期刊上发表系列蛋白聚糖生物学相关论文。曾承担和参与日本文部省、加拿大CIHR支持的各类科研项目十余项。近五年主持和承担包括863计划（2012AA021504，负责人）、973重大专项（2012CB822100，骨干）、国家自然科学基金（31570071，负责人）、山东省科技计划（2013GSF12106，负责人）等多个国家及省部级课题。与多个蛋白聚糖领域国际知名的实验室保持着长期良好的合作。此外，在糖类相关医药生物产品开发上，与国内相关企业也有着长期深入的合作。研究方向：（1）海洋微生物来源新型多糖特别是糖胺聚糖降解酶的资源开发、催化机制研究、分子酶学改造与应用；（2）糖胺聚糖构效关系研究及相关医药产品的研发；（3）基于新型酶和探针的糖相关新型分析检测技术研发和应用；（4）细胞表面蛋白聚糖在胚胎发育和癌变过程中的细胞信号转导调控机制研究；。学术贡献：（1）在世界上首次开展了海洋来源糖胺聚糖降解酶的研究，发现和鉴定了一系列海洋微生物来源的新型糖胺聚糖裂解酶。（2）在世界上首次发现和全面鉴定了第一个内切型硫酸软骨素/硫酸皮肤素硫酸酯酶。这些研究为糖胺聚糖的构效关系研究和功能寡糖的制备和结构改造提供了重要的工具酶。荣誉与奖励：2016年入选山东省“泰山产业（战略性新兴产业类）领军人才计划”，还入选东营市“黄河三角洲学者”、济南市“5150”等地方性人才计划。3、代表性论文1. Chune Peng, Qingbin Wang, Shumin Wang, Wenshuang Wang, Runmiao Jiao, Wenjun Han, and Fuchuan Li*. A chondroitin sulfate and hyaluronic acid lyase with poor activity to glucuronyl 4,6-O-disulfated N-acetylgalactosamine (E-type)-containing structures. J. Biol. Chem. 2018, 293(12):4230-4243.2. Chune Peng, Qingbin Wang, Danrong Lu, Wenjun Han, and Fuchuan Li*. A Novel Bifunctional Endolytic Alginate Lyase with Variable Alginate-Degrading Modes and Versatile Monosaccharide-Producing Properties. Front. Microbiol. 2018, 9:167.3. Naihan Han, Wenshuang Wang, Danrong Lu, Han Wang, Xinying Ma, Xiaopeng Fan, and Fuchuan Li*. A novel, rapid, and sensitive homogeneous sandwich detection method of Glypican-3 as a serum marker for hepatocellular carcinoma. Chem. Commun (Camb)., 2017, 53(90):12209-12212.4. Wenshuang Wang, Xiaojuan Cai, Naihan Han, Wenjun Han, Kazuyuki Sugahara, and Fuchuan Li*. Sequencing of chondroitin sulfate oligosaccharides using a novel exolyase from a marine bacterium that degrades hyaluronan and chondroitin sulfate/dermatan sulfate. Biochem. J., 2017, 474(22):3831-3848.5. Wenshuang Wang, Junhong Wang, and Fuchuan Li*. Hyaluronidase and Chondroitinase. Adv. Exp. Med. Biol., 2017, 925:75-87. Invited review. 6. Shumin Wang, Kazuyuki Sugahara, and Fuchuan Li*. Chondroitin sulfate/dermatan sulfate sulfatases from mammals and bacteria. Glycoconj. J., 2016, 33(6):841-851. Invited Review.7. Xiaoru Zhang, Ruijuan Li, Yuanyuan Chen, Shusheng Zhang, Wenshuang Wang, and Fuchuan Li*. Applying DNA rolling circle amplification in fluorescence imaging of cell surface glycans labeled by a metabolic method. Chem. Sci., 2016, 7, 6182-6189.8. Wenjun Han, Yuanyuan Cheng, Dandan Wang, Shumin Wang, Huihui Liu, Jingyan Gu, Zhihong Wu, and Fuchuan Li *. Biochemical Characteristics and Substrate Degradation Pattern of a Novel Exo-Type β-Agarase from the Polysaccharide-Degrading Marine Bacterium Flammeovirga sp. Strain MY04. Appl. Environ. Microbiol. 2016, pii: AEM.00393-16.9. Wenjun Han, Jingyan Gu, Yuanyuan Cheng, Huihui Liu, Yuezhong Li, and Fuchuan Li*. Novel Alginate Lyase (Aly5) from a Polysaccharide-Degrading Marine Bacterium, Flammeovirga sp. Strain MY04: Effects of Module Truncation on Biochemical Characteristics, Alginate Degradation Patterns, and Oligosaccharide-Yielding Properties. Appl. Environ. Microbiol. 2015, 82(1):364-74.10. Wenshuang Wang, Naihan Han, Ruijuan Li, Wenjun Han, Xiaoru Zhang, and Fuchuan Li*. Supercharged Fluorescent Protein as a Versatile Probe for the Detection of Glycosaminoglycans in Vitro and in Vivo. Anal. Chem. 2015, 87(18):9302-7.11. Wenshuang Wang, Wenjun Han, Xingya Cai, Xiaoyu Zheng, Kazuyuki Sugahara, and Fuchuan Li*. Cloning and characterization of a novel chondroitin sulfate/dermatan sulfate 4-O-endosulfatase from a marine bacterium. J. Biol. Chem. 2015, 290(12):7823-32.12. Wenjun Han, Wenshuang Wang, Mei Zhao, Kazuyuki Sugahara, and Fuchuan Li*. A novel eliminase from a marine bacterium that degrades hyaluronan and chondroitin sulfate. J. Biol. Chem. 2014, 289(40):27886-98.13. Han Wen-jun, Gu Jing-yan, Liu Hui-hui, Li Fu-chuan, Wu Zhi-hong, and Li Yue-zhong. An extra peptide within the catalytic module of a β-agarase affects the agarose degradation pattern. (2013) J. Biol. Chem., 2013 288(13):9519-9531.14. Fuchuan Li, Wen Shi, Mariana I Capurro and Jorge Filmus. Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating hedgehog signaling. (2011) J. Cell Biol., 192(4):691-704.15. Fuchuan Li, Chilkunda D. Nandini, Tomohide Hattori, Xingfeng Bao, Daisuke Murayama, Toshikazu Nakamura, Nobuhiro Fukushima, and Kazuyuki Sugahara. Structure of pleiotrophin- and hepatocyte growth factor-binding sulfated hexasaccharide determined by biochemical and computational approaches. (2010) J. Biol. Chem., 285(36):27673-85.16. Mariana I Capurro, Fuchuan Li and Jorge Filmus. Overgrowth of a mouse model of Simpson-Golabi-Behmel syndrome is partly mediated by Indian hedgehog. (2009) EMBO Rep., 10(8):901-7. 17. Fuchuan Li, Gerdy B. ten Dam, Sengottuvelan Murugan, Shuhei Yamada, Taishi Hashiguchi, Shuji Mizumoto, Kayoko Oguri, Minoru Okayama, Toin H. van Kuppevelt, and Kazuyuki Sugahara. Involvement of Highly Sulfated Chondroitin Sulfate in the Metastasis of the Lewis Lung Carcinoma Cells. (2008) J. Biol. Chem., 283(49):34294-304. 18. Mariana I Capurro, Ping Xu, Wen Shi, Fuchuan Li, Angela Jia and Jorge Filmus. Glypican-3 Inhibits Hedgehog Signaling During Development by Competing with Patched for Hedgehog Binding. (2008) Dev. Cell, 14(5):700-11. 19. Fuchuan Li, Ajaya Kumar Shetty and Kazuyuki Sugahara. Neuritogenic activity of chondroitin/dermatan sulfate hybrid chains of embryonic pig brain and their mimicry from shark liver. Involvement of the pleiotrophin and hepatocyte growth factor signaling pathways. (2007) J. Biol. Chem., 282(5): 2956-2966.20. Meiyu Geng1, Fuchuan Li1, Xianliang Xin, Jing Li, Zuowei Yan, and Huashi Guan. The potential molecular targets of marine sulfated polymannuroguluronate interfering with HIV-1 entry. Interaction between SPMG and HIV-1 rgp120 and CD4 molecule. (2003) Antiviral. Res. 59(2):127-135. 4、授权发明专利1. 一株弧菌FC509菌株及其培养方法与应用，李福川，韩文君，王文爽等，国家发明专利，专利号：ZL201410159983.32. 一种内切型硫酸软骨素硫酸皮肤素4-O-硫酸酯酶及其编码基因与应用，李福川，王文爽，郑小煜等，国家发明专利，专利号：ZL201410209975.53. 一种糖胺聚糖降解酶及其编码基因与应用，李福川，韩文君，王文爽等，国家发明专利，专利号：ZL2014101,60095.34. 一种高表达水溶性肝素酶I融合蛋白及其编码基因， 李福川，赵梅，韩文君等，国家发明专利，专利号：ZL201410246947.05. 一种外切型琼胶酶及其编码基因与应用，李福川，韩文君等，国家发明专利，专利号：ZL201410396060.X 6. 高正电荷荧光蛋白在糖胺聚糖分析检测中的应用，李福川，王文爽等，国家发明专利，专利号：ZL201510044900.07. 一种用于蛋白聚糖高灵敏度检测的试剂盒及其制备方法，李福川，韩乃寒等，国家发明专利，专利号：ZL201610143751.88. 一种高硫酸化硫酸软骨素及其制备方法与应用，李福川，王庆彬等，国家发明专利，专利号：ZL201610323540.2 5、产品研发1. 各种糖胺聚糖裂解酶，包括商品化肝素酶Heparinase I，II，III；硫酸软骨素酶CSase ABC， ACI，ACII，B等，以及自主研发的HCLase，HCLase Er，HCDase等新型硫酸软骨素/硫酸皮肤素/透明质酸降解酶，和一系列新型肝素酶等；2. 低分子硫酸软骨素及寡糖规模化酶法制备工艺（863及山东省重点研发计划支持项目）；3. 肝素及其副产物提取分离和综合开发利用新技术（泰山产业领军人才计划支持项目）4. 依诺肝素钠，那曲肝素钙，汀肝素等低分子肝素生产工艺（泰山产业领军人才计划支持项目）；5. 多组分糖胺聚糖抗血栓药物（舒络地特）生产工艺（泰山产业领军人才计划支持项目）；6. 抗Glypican-3高亲和力抗体的制备及肝癌体外早期诊断技术（973及山东省重点研发计划支持项目）7. 羧基麦芽糖铁生产工艺。