Institution:山东大学数学学院

Title of Paper:Prediction of driver modules via balancing exclusive coverages of mutations in cancer samples

Journal:Advanced Science

Summary:Mutual exclusivity of cancer driving mutations is a frequently observed phenomenon in the mutational landscape of cancer. The long tail of rare mutations complicates the discovery of mutually exclusive driver modules. The existing methods usually suffer from the problem that only few genes in some identified modules cover most of the cancer samples. To overcome this hurdle, an efficient method UniCovEx is presented via identifying mutually exclusive driver modules of balanced exclusive coverages. UniCovEx first searches for candidate driver modules with a strong topological relationship in ...

First Author:Gao, B.

Correspondence Author:Li*, G.,Su*, Z.

All the Authors:Liu, J.,Li, Y.,Zhao, Y.

Indexed by:Journal paper

Discipline:Natural Science

First-Level Discipline:Mathematics

Document Type:J

Volume:6

Issue:4

Translation or Not:No

Date of Publication:2018-12

Included Journals:SCI

Release Time:2019-07-09