个人简历

 

个人信息

姓名：李洪凯 

邮箱：lihongkaiyouxiang@163.com

联系地址：济南市市中区二环东路12550号国家健康医疗大数据研 

                    究院

主要研究方向包括未知混杂的控制方法、因果推断框架下的数据整合，中介效应分析，测量误差和选择性偏倚的控制方法以及时间序列框架下的因果推断问题。主要研究成果发表在American Journal of Epidemiology，Epidemiology, Statistics in Medicine，BMC Medical Research Methodology, Journal of American Heart Association, Atherosclerosis等生物统计方法和应用杂志上发表30余篇文章，其中第一或通讯作者文章(包含共同)近20篇。同时也是International Journal of Epidemiology, BMC Medical Research Methodology，Journal of Applied Statistics，BMC Genetics等杂志的特约审稿人。中国临床肿瘤学会（CSCO）统计专家组成员，国际数理统计学会会员，参编书籍3部。

教育背景和工作经历

2019.3-现在 国家健康医疗大数据研究院    因果推断研究中心   PI

2017.4-2019.3 北京大学数学与信息科学学院 博士后 导师 耿直

研究方向： 因果推断和数据融合

2011.9-2016.12山东大学流行病与卫生统计学（生物统计）硕博连读 导师 薛付忠

研究方向：系统流行病学框架下的因果推断理论与方法研究

2013.12-2014.6纽约城市大学生物统计系联合培养博士 导师 杨晓伟

研究方向：生物统计学。基于多种组学数据（基因表达、甲基化，GWAS，蛋白数据等）的贝叶斯变量选择。

2007.9-2011.6烟台大学数学与应用数学理学学士

研究兴趣

（1）多个数据库的因果数据融合方法研究；

（2）测量偏倚、选择性偏倚和混杂偏倚的控制方法研究；

（3）迁移学习，尤其是实验研究向目标人群的迁移和两个观察人群的迁移方法研究；

（4）孟德尔随机化方法和多中介以及结构学习方法研究；

（5）因果框架下的meta分析和网络meta分析方法研究；

（6）遗传关联与共定位方法研究

（7）时间序列框架下的因果推断方法研究

项目经历

（1）国家自然基金青年基金项目，82003557，因果机制下系统流行病学的跨组学因果调控网络特定通路推断和多重靶向干预的方法研究，2021.1-2023.12, 24万，在研，主持

（2）国家自然科学基金面上项目，11771028，因果推断方法研究及在食品安全及在生物医学中的应用，2018.01-2021.12，48万，在研，参与

（3）国家自然科学基金面上项目，81573259，系统流行病学中网络差异比较的统计分析方法研究，2016.01-2019.12，72万，在研，参与

（4）国家自然科学基金面上项目，81273177，基于贝叶斯竞争风险理论的农村人群脑卒中发生和转归的适宜性风险预警策略与方法研究，2013.01-2016.12，60万元，已结题，参与

（5）国家自然科学基金青年项目，31200994，全基因组关联分析中基因-基因交互网络比较的统计推断方法研究，2013.01-2015.12，20万，已结题，参与

学术会议

2020年11月，中国人民大学临床统计会议，会议报告

2020年10月，首都医科大学健康大数据会议，会议报告

2019年9月，苏鲁皮肤会议（镇江），会议报告

2019年9月，健康管理学会议（北京），会议报告 

2019年8月，中国生物统计年会（广州），会议报告

2018年6月，京津冀概率论与统计学术研讨会（北京）， 参加

2016年7月，中国卫生统计学术年会（天津），会议报告和poster

2015年6月，参加泛华统计学年会（上海），会议报告

2015年6月，中国卫生统计学术年会（太原），会议报告

2015年5月，统计遗传与基因组学国际研讨会（太原），参加

2014年7月，中国卫生统计（生物统计）学术年会（广州），参加

2013年8月，中国卫生统计学术年会（济南），参加

学术活动

山东省齐鲁医院血液科学术报告：控制测量误差和未知混杂的工具辅助变量方法

山东省千佛山医院麻醉科：因果推断方法简介

山东省省立医院护理学：临床统计方法培训及SPSS实现

山东省眼科医院：临床研究中的统计方法

山东大学第二医院：因果推断方法简介

广东省汕头大学医学院：因果推断中心介绍

山东省省立医院内分泌科：因果推断

山东省精神卫生中心 流行病学设计和因果推断

山东大学第二医院内分泌科： 观察性研究中的因果推断

山东大学基础医学院 创新论坛  因果推断

山东大学护理与康复学院  医学研究中的统计方法

方法方面文章

[1] R Yan#, YY Yu#,HK Li*, FZ Xue*. Selection bias in Negative control study and its correction method.

[2] YY Yu#, Lei Hou#,HK Li*, FZ Xue*, Methods comparison for the selection bias in two-sample Mendelian randomization.Frontiers in genetics. [Revision] [JCR 二区]

[3] Li H#, YY Yu#, FZ Xue, et al. A negative control outcome regression method for controlling unobserved confounding and lagged effect in time series. American Journal of Epidemiology [Accepted]. [JCR 一区]

[4] Xinhui Liu#,Li H#, et al. Unmasking substantial carcinogenesis of environmental factors hidden by measurement error in the number of stem cell divisions.BMC cancer. [Under Review]

[5] Li H，Jia JZ, Geng Z, Xue, F. A causal data fusion method for a general outcome. Statistics in Medicine. [Accepted]  [JCR 二区]

[6] Li H#,Hou L#, Xue F*et al. A multiple negative control regression to control unobserved confounding. Epidemiology.[Under Review]

[7] Li H#,Xinhui Liu#,Hou L, Xue F*. A novel instrumental variable to control measurement error and unobserved confounding.Statistical Method in Medical Research.[Under Reveiw]

[8] YuanyuanYu#,Li H#,Hou L, Xu M, Yu Y, Sun X, Liu X, Liu L, Li Y, Yuan T, Li W, Xue F*.The identification and estimation of causal effect using a Negative control exposure in time series studies with application to environment epidemiology. American Journal of Epidemiology. 2020 Aug 24;kwaa172. [JCR 一区]

[9] Hou L, Xu M, Yu Y, Sun X, Liu X, Liu L, Li Y, Yuan T, Li W,Li H*, Xue F*.Causal Mediation Analysis with Multiple Causally Ordered and Non-ordered Mediators based on Summarized Genetic Data. Epidemiology.[Revision][JCR一区]

[10] Lu Liu#,Hou L#, Xu M, Yu Y, Sun X, Liu X, Liu L, Li Y, Yuan T, Li W,Li H*, Xue F*. A novel method for controlling unobserved confounding using double confounders.BMC medical research methodology. (2020) 20:195 [JCR一区]

[11] Li H,Xu M, Yu Y, Sun X, Liu X,Xue F. A novel path-specific effect statistic for identifying the differential specific paths in systems epidemiology.BMC Genetics. 21,85 (2020).

[12] Li H, Miao W, Cai Z, Liu X, Zhang T, Xue F, Geng Z. Causal data fusion methods using summary-level statistics for a continuous outcome. Statistics in Medicine. 2020 Apr 15;39(8):1054-1067.[JCR二区]

[13] Yu Y#,Li H#,Sun X, Su P, Wang T, Liu Y, Yuan Z, Liu Y, Xue F. The alarming problems of confounding equivalence using logistic regression models in the perspective of causal diagrams. BMC Med Res Methodol. 2017 Dec 28;17(1):177. doi: 10.1186/s12874-017-0449-7.[JCR一区]

[14] Wang T#,Li H#, Su P, Yu Y, Sun X, Liu Y, Yuan Z, Xue F. Sensitivity analysis for mistakenly adjusting for mediators in estimating total effect in observational studies.BMJ Open. 2017 Nov 20;7(11):e015640.

[15] Li H, Zhongshang Yuan, Jiadong Ji, Jing Xu, Tao Zhang, Xiaoshuai Zhang, and Fuzhong Xue. A novel Markov Blanket-based repeated-fishing strategy for capturing phenotype-related biomarkers in big omics data.BMC Genet. 2016; 17: 51.

[16] Li H, Zhongshang Yuan, Ping Su, Tingting Wang, Yuanyuan Yu, Xiaoru Sun, Fuzhong Xue. A simulation study on matched case-control designs in the perspective of causal diagrams. BMC Medical Research Methodology. 2016; 16:102.[JCR一区]

[17] Xu J, Yuan Z, Ji J, Zhang X,Li H, Wu X, Xue F, Liu Y. A powerful score-based test statistic for detecting gene-gene co-association.BMC Genet.2016;17(1):31.

[18] Xiaoshuai Zhang; Zhongshang Yuan; Jiadong Ji;Li H; Fuzhong Xue. Network orregression-based methods for disease discrimination A comparison study. BMC Medical Research Methodology.BMC Medical ResearchMethodology, 2016;16(1): 100.[JCR一区]

[19] Ji J, Yuan Z, Zhang X, Li F, Xu J, Liu Y,Li H, Wang J, Xue F. Detection for pathway effect contributing to disease in systems epidemiology with a case-control design.BMJ Open. 2015 Jan 16;5(1):e006721. 2014.

[20] Xinhui Liu#, Hongkai Li#, Fuzhong Xue. Detection, reduction and correlation of unobserved confounding in the presence of an error-prone negative control exposure: bias analysis and correction methods. Epidemiology. [Revision] .[JCR一区]

应用方面文章

[1] H Xue,HK Li, FZH Xue, Gang Li et al.Evaluation the liquid biopsy efficacy of cerebrospinal fluid small extracellular vesicles miRNAs as biomarkers of glioma early recurrence monitoring.

[2] Lei Hou#，Li H#, et al.Causal Effects of Bilirubin on CVD and Diabetes in the UKBiobank Cohort Study: Observational findings and Mendelianrandomization studies.Atherosclerosis. [Accept] [JCR 一区]

[3] Li H#,Lei Hou#,et al.Education and risks of breast cancer in women: a Mendelian randomisation analysis.Cancer medicine. [Submitted]

[4]Shucheng Si,Li H, Fuzhong Xue, et al. Causal pathways from body components and regional fat to extensive metabolic phenotypes: Mendelian randomization study.Obesity. [Accepted] [JCR一区]

[5] Wenchao Li,Li H, et al.基于孟德尔随机化探索臀围与2型糖尿病的因果关系.2020.中华疾病控制杂志。

[6] Xinhui Liu,Li H, et al.腰围和冠心病因果关系的孟德尔随机化研究。2020，山东大学学报。

[7] Chuan Wang,Li H, et al.Serum Metrnl Level is Correlated with Insulin Resistance, But Not withb-Cell Function in Type 2 Diabetics. November 2019.Medical science monitor: international medical journal of experimental and clinical research25:8968-8974.

[8] Hou L, Xu M, Yu Y, Sun X, Yuan T, Li W,Li H*, Xue F*.Exploring the causal pathway from ischemic stroke to atrial fibrillation: a network Mendelian randomization study.Mol Med. 2020 Jan 15;26(1):7.[JCR二区]

[9] Zhang D, Yang Y, Wu M, Zhao X, Sun Y, Xie H,Li H, Li Y, Wang K, Zhang J, Jia J, Su Y. The moderating effect of social support on the relationship between physical health and suicidal thoughts among Chinese rural elderly: A nursing home sample. Int J Ment Health Nurs. 2018 Oct;27(5):1371-1382.[JCR一区]

[10] Zhang Y, Zhang T, Zhang C, Tang F, Zhong N,Li H, Song X, Lin H, Liu Y, Xue F. Identification of reciprocal causality between non-alcoholic fatty liver disease and metabolic syndrome by a simplified Bayesian network in a Chinese population.BMJ Open. 2015 Sep 22;5(9):e008204.

[11] Liu Y, Wang X, Pang C, Yuan Z,Li H, Xue F. Spatio-temporal analysis of the relationship between climate and hand, foot, and mouth disease in Shandong province, China, 2008-2012.BMC Infect Dis. 2015 Mar 24;15:146. doi: 10.1186/s12879-015-0901-4.

[12] Zhang T, Zhang C, Zhang Y, Tang F,Li H, Zhang Q, Lin H, Wu S, Liu Y, Xue F. Metabolic syndrome and its components as predictors of nonalcoholic fatty liver disease in a northern urban Han Chinese population: a prospective cohort study.Atherosclerosis. 2015 May;240(1):144-8.[JCR一区]

[13] Ni W, Ding G, Li Y,Li H, Jiang B. Impacts of floods on dysentery in Xinxiang city, China, during 2004-2010: a time-series Poisson analysis.Glob Health Action. 2014 Aug 5;7:23904.

[14] Ni W, Ding G, Li Y,Li H, Liu Q, Jiang B. Effects of the floods on dysentery in north central region of Henan Province, China from 2004 to 2009.J Infect. 2014 Nov;69(5):430-9.[JCR一区]

[15] Zhang T, Zhang Y, Zhang C, Tang F,Li H, Zhang Q, Lin H, Wu S, Liu Y, Xue F. Prediction of metabolic syndrome by non-alcoholic fatty liver disease in northern urban Han Chinese population: a prospective cohort study.PLoS One. 2014 May 6;9(5):e96651.

[16] Jiate Wei, Yunxia Liu, HK,Li, et al.Impacts of Transportation and Meteorological Factors on the Transmission of COVID-19 August 2020. International Journal of Hygiene and Environmental Health 230:113610. [JCR一区]

[17] Shucheng Si, Lei Hou, Hongkai Li, Fuzhong Xue, etc. Causal effect of triglyceride-glucose index, joint exposure of higher glucose and triglyceride with extensive cardio-cerebrovascular metabolic outcomes in the UK Biobank: Mendelian Randomization study. Frontiers in Cardiovascular Medicine. [Accept] [JCR二区]

[18] Shucheng Si, Lei Hou, Xiaolu Chen, Hongkai Li, Fuzhong Xue et al. Exploring the causal roles of circulating remnant lipid profile on cardiovascular and cerebrovascular diseases: Mendelian randomization study. Journal of Epidemiology. [JCR二区]

[19] Qing Wang, Hongkai Li, Fuzhong Xue, et al. Effects on Hypertension Control of Distributing Essential Medicines at No Charge: A Quasi-Experimental Study In Rural Communities Of China.SSRN Electronic Journal.

[20] Liu X, Li C, Li H*, Xue F*. Genetically predicted insomnia in relation to 14 cardiovascular conditions and 17 cardiometabolic risk factors: a Mendelian randomization study. Journal of the American Heart Association. 2021 [Accept]  [JCR 一区]