Institution:国家糖工程技术研究中心

Title of Paper:Synthesis of O-Sulfated Human Syndecan-1-like Glyco-polypeptides by Incorporating Peptide Ligation and O-Sulfated Glycopeptide Cassette Strategies

Journal:Organic Letters

Place of Publication:American Chemical Society

Summary:A successful synthesis of O-sulfated syndecan-1-like (Q23−
E120) glyco-polypeptide was accomplished. The synthesis features the integration of an O-sulfated carbohydrate-bearing glycopeptide cassette with efficient protein ligation strategies, overcoming the acid lability of carbohydrate sulfates as a major hurdle in solid-phase peptide synthesis. Crucial to the synthesis is the microwave-assisted Ag(I) ligation, which afforded the ligation product in improved overall yield. This O-sulfated syndecan-1 (Q23−E120) is the longest O-sulfated glyco-polypeptide prepared to date.

Translation or Not:No

Date of Publication:2020-08

Included Journals:SCI

Release Time:2020-12-24