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所属单位：国家糖工程技术研究中心

发表刊物：Organic Letters

刊物所在地：American Chemical Society

摘要：A successful synthesis of O-sulfated syndecan-1-like (Q23−
E120) glyco-polypeptide was accomplished. The synthesis features the integration of an O-sulfated carbohydrate-bearing glycopeptide cassette with efficient protein ligation strategies, overcoming the acid lability of carbohydrate sulfates as a major hurdle in solid-phase peptide synthesis. Crucial to the synthesis is the microwave-assisted Ag(I) ligation, which afforded the ligation product in improved overall yield. This O-sulfated syndecan-1 (Q23−E120) is the longest O-sulfated glyco-polypeptide prepared to date.

论文类型：基础研究

是否译文：否

发表时间：2020-08-01

收录刊物：SCI